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The map label for this gene is pcm

Identifier: 46446490

GI number: 46446490

Start: 1037781

End: 1038413

Strand: Direct

Name: pcm

Synonym: pc0856

Alternate gene names: 46446490

Gene position: 1037781-1038413 (Clockwise)

Preceding gene: 46446487

Following gene: 46446491

Centisome position: 42.98

GC content: 47.39

Gene sequence:

>633_bases
ATGGTGGAGAAACAAATAGCCGCGAGAGGAATACAAGATCCTCGAGTATTAGAGGCAATGGGAAAAGTGCCGCGCGAGAG
GTTTGTGAGTGAGCACATTGCTCCACTCGCGTATGAAGACCGACCTTTATCCATTGATGAGGGGCAAACGATTTCACAGC
CTTTCATTGTTGCAGTCATGGCTCAGCAGGCCCAAATAACTCCCCAGGATAAGGTGTTAGAGATTGGTACCGGCTCAGGC
TATTCTGCTGCCATTCTAAGTCAACTGGCCTCTCATGTCTATTCTATGGAGCGGTATCCAAAGCTTGCAGAGCTGGCAAA
AAAACGGCTGCAAGAGTTTGGCTATAATAATGTGACAGTATCAGTTGGGGATGGAAGTCTAGGATGGGAAGAGTTTGCTC
CTTATGAGGTTATTATTGTGACGGCAGGCGGGCCTCAAATTCCTCCTTCTCTTTTGAAACAGCTAGCCATAAGCGGCCGT
TTGGTGATTCCTGTGGGACCTAGTTTGGAGAGCCAGCAATTAATGCGTGTTATGCGAGAGGATGCTGATCATTATCGCTA
CGAGAACTTAGGATCTGTACAATTTGTACCGCTCGTTGGAAAAGAAGGGTGGCAAACTACAAGCTCGTCATAA

Upstream 100 bases:

>100_bases
TTCAATAATAGTTCAATAATAGTTCAATTCGGTTAAAATAGGATTAAAAAATCTTTGCCTGGAGAATTAAATGGATTCCT
ATCAAGAGATAAGAAAGCAA

Downstream 100 bases:

>100_bases
ACCTATGCATAAAACAACTCGACATGGCTTTTCCCTCATTTACAGAGGAAGCAAAAAAAATACAGAAGGTCATGGCCGAA
AAGGTGGTTGTAGAAGATCC

Product: L-isoaspartyl protein carboxyl methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MVEKQIAARGIQDPRVLEAMGKVPRERFVSEHIAPLAYEDRPLSIDEGQTISQPFIVAVMAQQAQITPQDKVLEIGTGSG
YSAAILSQLASHVYSMERYPKLAELAKKRLQEFGYNNVTVSVGDGSLGWEEFAPYEVIIVTAGGPQIPPSLLKQLAISGR
LVIPVGPSLESQQLMRVMREDADHYRYENLGSVQFVPLVGKEGWQTTSSS

Sequences:

>Translated_210_residues
MVEKQIAARGIQDPRVLEAMGKVPRERFVSEHIAPLAYEDRPLSIDEGQTISQPFIVAVMAQQAQITPQDKVLEIGTGSG
YSAAILSQLASHVYSMERYPKLAELAKKRLQEFGYNNVTVSVGDGSLGWEEFAPYEVIIVTAGGPQIPPSLLKQLAISGR
LVIPVGPSLESQQLMRVMREDADHYRYENLGSVQFVPLVGKEGWQTTSSS
>Mature_210_residues
MVEKQIAARGIQDPRVLEAMGKVPRERFVSEHIAPLAYEDRPLSIDEGQTISQPFIVAVMAQQAQITPQDKVLEIGTGSG
YSAAILSQLASHVYSMERYPKLAELAKKRLQEFGYNNVTVSVGDGSLGWEEFAPYEVIIVTAGGPQIPPSLLKQLAISGR
LVIPVGPSLESQQLMRVMREDADHYRYENLGSVQFVPLVGKEGWQTTSSS

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=202, Percent_Identity=29.2079207920792, Blast_Score=78, Evalue=6e-15,
Organism=Escherichia coli, GI1789100, Length=198, Percent_Identity=45.959595959596, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71983477, Length=201, Percent_Identity=32.3383084577114, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193207222, Length=199, Percent_Identity=31.6582914572864, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17981723, Length=199, Percent_Identity=28.1407035175879, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_PARUW (Q6MCW9)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007855.1
- ProteinModelPortal:   Q6MCW9
- SMR:   Q6MCW9
- STRING:   Q6MCW9
- GeneID:   2779821
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0856
- NMPDR:   fig|264201.1.peg.856
- eggNOG:   COG2518
- HOGENOM:   HBG699907
- OMA:   LCPVRFV
- PhylomeDB:   Q6MCW9
- BioCyc:   CPRO264201:PC0856-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 23085; Mature: 23085

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 52-52

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKQIAARGIQDPRVLEAMGKVPRERFVSEHIAPLAYEDRPLSIDEGQTISQPFIVAVM
CCCHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHH
AQQAQITPQDKVLEIGTGSGYSAAILSQLASHVYSMERYPKLAELAKKRLQEFGYNNVTV
HHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEE
SVGDGSLGWEEFAPYEVIIVTAGGPQIPPSLLKQLAISGRLVIPVGPSLESQQLMRVMRE
EECCCCCCHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHH
DADHYRYENLGSVQFVPLVGKEGWQTTSSS
HHHHHHHCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVEKQIAARGIQDPRVLEAMGKVPRERFVSEHIAPLAYEDRPLSIDEGQTISQPFIVAVM
CCCHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHH
AQQAQITPQDKVLEIGTGSGYSAAILSQLASHVYSMERYPKLAELAKKRLQEFGYNNVTV
HHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEE
SVGDGSLGWEEFAPYEVIIVTAGGPQIPPSLLKQLAISGRLVIPVGPSLESQQLMRVMRE
EECCCCCCHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHH
DADHYRYENLGSVQFVPLVGKEGWQTTSSS
HHHHHHHCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA