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The map label for this gene is kbl [C]

Identifier: 46446445

GI number: 46446445

Start: 992567

End: 993757

Strand: Reverse

Name: kbl [C]

Synonym: pc0811

Alternate gene names: 46446445

Gene position: 993757-992567 (Counterclockwise)

Preceding gene: 46446446

Following gene: 46446444

Centisome position: 41.16

GC content: 38.96

Gene sequence:

>1191_bases
ATGGATGAAAATTTTTTATCACATATTGAAGCCCAACTTGAAGATTTAAAAACACAGGGTTTATATAAACAAGAGCAAGA
AATCACTTCACCTCAAGATGCTAAAATTACTATTGCTGGCGGAAAAGAGGTTTTAAATTTTTGTTCTAATAATTATTTAG
GTCTTGCAAATCACCCCGAAATTATTCAAGCAGCTGAAAAAAGCTATTCAGACTATGGTTTTGGGCTCTCCTCTGTGAGA
TTTATCTGCGGAACCCAAACTGTACACAAACAGCTAGAAAGGCGCCTTTCTCAATTTTTAGAAACAGATGATACAATCCT
TTATTGCTCTTGTTTTGATGCTAATGGGGGTCTTTTCGAAACACTTCTTAGTGCTGAAGATGCCGTAATTAGTGATGCTC
TAAATCATGCTAGTATTATTGATGGAATTCGATTATCCAAAGCAAAACGTTTGCGTTACGACACGAATGACATGGCTAGC
TTAGAGCAACAACTGAAAGTAGCTAAAGACTCACGCTTCCGTTTGATTGCAACAGATGGTGTCTTTTCAATGGATGGAAC
AATTGCGAATTTAAGAGCCATCTGCGATTTAGCGGATGAATATCAAGCCCTTGTCATGGTGGATGACTGTCATGCAGTTG
GCTTCATGGGAGTAAAAGGAAAAGGAACTTCTGAGTTTTGTGATGTCATGGGTCGCGTCGATTTGATCACAGGAACCCTT
GGAAAAGCTCTTGGAGGAGCACTTGGTGGATATACTTCGGGCCGCAAACCTTTAATTGATTGGTTAAGACAGCGCTCGAG
ACCTTACCTATTTTCTAACACCCTAGCTCCTAGCATTGCTGCTGCTTCTTTAACTGTATTAGATTTGATTGAAAAGTCTG
ATGATCGACGAGAAAAACTAAAGGCTAATGCGCTCTACTTTCGAGAAAAAATGACTGCTCTTGGCTTTGACCTTATTCCT
GGCTCTCATCCTATTATTCCTATTATGCTAGGAGATGCTAAACTTGCCCAAAATTTTGCGGCTAAAATGTTAGAACAAGG
AGTTTACGTGATTGGATTTGCTTATCCAGTTGTTCCCCAAGGTAAAGCTCGTATTCGCACACAAATGTGTGCCAATCATA
CGCGAGAAAATTTAAATCAAGCCATTCAAGCTTTTGAAAAAGTAGGAAAAGAACTGAAGATCATTTCTTAA

Upstream 100 bases:

>100_bases
CGTGTTAAATGCTATTCAGACTTTAAGCCAAAGTCATGAAGAAACTAGTAAATAAATATGATTAACAATTTAATAAAAAA
GCTACTGAAATAAAACAGCT

Downstream 100 bases:

>100_bases
TAACCGAAACTATAGCCTAAATCAAACTATACTTCACTAACCTAGAGTTTGAAATTTTATCCCAACTCTAGCAGTGATAT
CTTTTGCTTCACTCCAATCC

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MDENFLSHIEAQLEDLKTQGLYKQEQEITSPQDAKITIAGGKEVLNFCSNNYLGLANHPEIIQAAEKSYSDYGFGLSSVR
FICGTQTVHKQLERRLSQFLETDDTILYCSCFDANGGLFETLLSAEDAVISDALNHASIIDGIRLSKAKRLRYDTNDMAS
LEQQLKVAKDSRFRLIATDGVFSMDGTIANLRAICDLADEYQALVMVDDCHAVGFMGVKGKGTSEFCDVMGRVDLITGTL
GKALGGALGGYTSGRKPLIDWLRQRSRPYLFSNTLAPSIAAASLTVLDLIEKSDDRREKLKANALYFREKMTALGFDLIP
GSHPIIPIMLGDAKLAQNFAAKMLEQGVYVIGFAYPVVPQGKARIRTQMCANHTRENLNQAIQAFEKVGKELKIIS

Sequences:

>Translated_396_residues
MDENFLSHIEAQLEDLKTQGLYKQEQEITSPQDAKITIAGGKEVLNFCSNNYLGLANHPEIIQAAEKSYSDYGFGLSSVR
FICGTQTVHKQLERRLSQFLETDDTILYCSCFDANGGLFETLLSAEDAVISDALNHASIIDGIRLSKAKRLRYDTNDMAS
LEQQLKVAKDSRFRLIATDGVFSMDGTIANLRAICDLADEYQALVMVDDCHAVGFMGVKGKGTSEFCDVMGRVDLITGTL
GKALGGALGGYTSGRKPLIDWLRQRSRPYLFSNTLAPSIAAASLTVLDLIEKSDDRREKLKANALYFREKMTALGFDLIP
GSHPIIPIMLGDAKLAQNFAAKMLEQGVYVIGFAYPVVPQGKARIRTQMCANHTRENLNQAIQAFEKVGKELKIIS
>Mature_396_residues
MDENFLSHIEAQLEDLKTQGLYKQEQEITSPQDAKITIAGGKEVLNFCSNNYLGLANHPEIIQAAEKSYSDYGFGLSSVR
FICGTQTVHKQLERRLSQFLETDDTILYCSCFDANGGLFETLLSAEDAVISDALNHASIIDGIRLSKAKRLRYDTNDMAS
LEQQLKVAKDSRFRLIATDGVFSMDGTIANLRAICDLADEYQALVMVDDCHAVGFMGVKGKGTSEFCDVMGRVDLITGTL
GKALGGALGGYTSGRKPLIDWLRQRSRPYLFSNTLAPSIAAASLTVLDLIEKSDDRREKLKANALYFREKMTALGFDLIP
GSHPIIPIMLGDAKLAQNFAAKMLEQGVYVIGFAYPVVPQGKARIRTQMCANHTRENLNQAIQAFEKVGKELKIIS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=383, Percent_Identity=54.3080939947781, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI284448556, Length=409, Percent_Identity=51.1002444987775, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI83977442, Length=364, Percent_Identity=33.5164835164835, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI83977440, Length=364, Percent_Identity=33.5164835164835, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI83977444, Length=364, Percent_Identity=33.5164835164835, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4502025, Length=361, Percent_Identity=32.409972299169, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI40316939, Length=361, Percent_Identity=32.409972299169, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI119220554, Length=372, Percent_Identity=32.7956989247312, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4758668, Length=372, Percent_Identity=32.5268817204301, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI5454084, Length=277, Percent_Identity=31.0469314079422, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1790046, Length=398, Percent_Identity=62.0603015075377, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1786993, Length=357, Percent_Identity=31.3725490196078, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=394, Percent_Identity=55.5837563451777, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=30.7065217391304, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17560914, Length=367, Percent_Identity=31.8801089918256, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17560912, Length=367, Percent_Identity=31.8801089918256, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71982617, Length=305, Percent_Identity=25.9016393442623, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=305, Percent_Identity=25.9016393442623, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=377, Percent_Identity=34.2175066312997, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320267, Length=371, Percent_Identity=29.9191374663073, Blast_Score=169, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6323954, Length=269, Percent_Identity=27.5092936802974, Blast_Score=105, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24662918, Length=385, Percent_Identity=58.7012987012987, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI17137420, Length=382, Percent_Identity=31.413612565445, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=30.9973045822102, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24653280, Length=355, Percent_Identity=27.0422535211268, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653276, Length=355, Percent_Identity=27.0422535211268, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653278, Length=355, Percent_Identity=27.0422535211268, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43627; Mature: 43627

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDENFLSHIEAQLEDLKTQGLYKQEQEITSPQDAKITIAGGKEVLNFCSNNYLGLANHPE
CCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEECCHHHHHHHCCCCCCCCCCHH
IIQAAEKSYSDYGFGLSSVRFICGTQTVHKQLERRLSQFLETDDTILYCSCFDANGGLFE
HHHHHHHCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHH
TLLSAEDAVISDALNHASIIDGIRLSKAKRLRYDTNDMASLEQQLKVAKDSRFRLIATDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECC
VFSMDGTIANLRAICDLADEYQALVMVDDCHAVGFMGVKGKGTSEFCDVMGRVDLITGTL
EEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCEEEECCCCCHHHHHHHHCCHHHHHHHH
GKALGGALGGYTSGRKPLIDWLRQRSRPYLFSNTLAPSIAAASLTVLDLIEKSDDRREKL
HHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCHHHHHH
KANALYFREKMTALGFDLIPGSHPIIPIMLGDAKLAQNFAAKMLEQGVYVIGFAYPVVPQ
HHHHHHHHHHHHHHCCEECCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCC
GKARIRTQMCANHTRENLNQAIQAFEKVGKELKIIS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCC
>Mature Secondary Structure
MDENFLSHIEAQLEDLKTQGLYKQEQEITSPQDAKITIAGGKEVLNFCSNNYLGLANHPE
CCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEECCHHHHHHHCCCCCCCCCCHH
IIQAAEKSYSDYGFGLSSVRFICGTQTVHKQLERRLSQFLETDDTILYCSCFDANGGLFE
HHHHHHHCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHH
TLLSAEDAVISDALNHASIIDGIRLSKAKRLRYDTNDMASLEQQLKVAKDSRFRLIATDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECC
VFSMDGTIANLRAICDLADEYQALVMVDDCHAVGFMGVKGKGTSEFCDVMGRVDLITGTL
EEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCEEEECCCCCHHHHHHHHCCHHHHHHHH
GKALGGALGGYTSGRKPLIDWLRQRSRPYLFSNTLAPSIAAASLTVLDLIEKSDDRREKL
HHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCCHHHHHH
KANALYFREKMTALGFDLIPGSHPIIPIMLGDAKLAQNFAAKMLEQGVYVIGFAYPVVPQ
HHHHHHHHHHHHHHCCEECCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCC
GKARIRTQMCANHTRENLNQAIQAFEKVGKELKIIS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]