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The map label for this gene is dapA

Identifier: 46446320

GI number: 46446320

Start: 834792

End: 835694

Strand: Reverse

Name: dapA

Synonym: pc0686

Alternate gene names: 46446320

Gene position: 835694-834792 (Counterclockwise)

Preceding gene: 46446321

Following gene: 46446319

Centisome position: 34.61

GC content: 38.21

Gene sequence:

>903_bases
ATGTATTTAAAAGGTCTTTATACAGCCTTAATTACCCCTTTTACCCCAACTGGTCAATTAGATGAAGAAGGGTTAAAAAA
GCTTATTCAGATTCAACTTCACCATCAAGTAGATGGGGTTGTCGTCTTAGGAACAACTGGGGAATCCCCTACGTTAACAC
AAATTGAAAAAAGACGGATTATTGAAATAGCATTAGAAGAAATTCAAGGCCGAATAAAAGTGATTGTTGGCACTGGAAGC
TATTCAACGCAACAAGCAATTGAACAAACTCTTCAAGCCAAACAAATGGGTGCTGATGCTGCGTTGATTGTCACCCCTTA
TTATAATAAACCAACTCAAGAAGGAATATTCAAACACTTTGAAGCGATTAATCAAGCAGTCTCTTTTCCGATTTGTCTCT
ATAACATTCAAGGTCGAACGGGACAAAATATTCAAACGCATACGCTTAAACGAATCAGCACTCTTTCTTCGATTATTGGC
GTAAAAGAAACATCCGGAGATATCAATCAAATCATGGATGTCATCGAAGCGTTTCGCCAATCTCATCCTAACTTTGCTAT
TTTATCTGGTGATGATGCTTTAACTCTTCCTATGATTGCTTTGGGAGGGCATGGCATTATTTCTGTTGTCAGCAATTTAG
TTCCTGCCGCAATGAAATCTCTAGTGAATGCGGCACTAAATGGAAATTTCAAAAAAGCACGAATAATACATAACCAACTT
TATTCTTTCATCAAAGCTGCTTTTATCGAAACCAATCCGATTCCGATTAAAGCGGCCTTATCTTTAAGTAAACTGCCAGC
AGGTTCCTGCCGTCTCCCTTTATGTGATCTCAGTCAGAATCATTCCCAAAAGCTAGCTCAAATTCTTAATGAACTTCCTC
AAGAGTGGATCTCTCATGGTTAA

Upstream 100 bases:

>100_bases
TGCTATGGGAGCCATCAAAGCAGCTGAATGGTTGAAAGATAAACAAGGTTTTTTTACCATTGAAGATTTAGTATTTTAGA
CAGTTTAACCGAAGCAAAAT

Downstream 100 bases:

>100_bases
GCGTAATGTGCATTTGACAAAACTCCAATCAGGGTATTTATTTCCAGAAATCAATCGAAGGAAAAATGAATTTTTAAAAA
AACATCCTTCCGCTCAATTA

Product: putative dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MYLKGLYTALITPFTPTGQLDEEGLKKLIQIQLHHQVDGVVVLGTTGESPTLTQIEKRRIIEIALEEIQGRIKVIVGTGS
YSTQQAIEQTLQAKQMGADAALIVTPYYNKPTQEGIFKHFEAINQAVSFPICLYNIQGRTGQNIQTHTLKRISTLSSIIG
VKETSGDINQIMDVIEAFRQSHPNFAILSGDDALTLPMIALGGHGIISVVSNLVPAAMKSLVNAALNGNFKKARIIHNQL
YSFIKAAFIETNPIPIKAALSLSKLPAGSCRLPLCDLSQNHSQKLAQILNELPQEWISHG

Sequences:

>Translated_300_residues
MYLKGLYTALITPFTPTGQLDEEGLKKLIQIQLHHQVDGVVVLGTTGESPTLTQIEKRRIIEIALEEIQGRIKVIVGTGS
YSTQQAIEQTLQAKQMGADAALIVTPYYNKPTQEGIFKHFEAINQAVSFPICLYNIQGRTGQNIQTHTLKRISTLSSIIG
VKETSGDINQIMDVIEAFRQSHPNFAILSGDDALTLPMIALGGHGIISVVSNLVPAAMKSLVNAALNGNFKKARIIHNQL
YSFIKAAFIETNPIPIKAALSLSKLPAGSCRLPLCDLSQNHSQKLAQILNELPQEWISHG
>Mature_300_residues
MYLKGLYTALITPFTPTGQLDEEGLKKLIQIQLHHQVDGVVVLGTTGESPTLTQIEKRRIIEIALEEIQGRIKVIVGTGS
YSTQQAIEQTLQAKQMGADAALIVTPYYNKPTQEGIFKHFEAINQAVSFPICLYNIQGRTGQNIQTHTLKRISTLSSIIG
VKETSGDINQIMDVIEAFRQSHPNFAILSGDDALTLPMIALGGHGIISVVSNLVPAAMKSLVNAALNGNFKKARIIHNQL
YSFIKAAFIETNPIPIKAALSLSKLPAGSCRLPLCDLSQNHSQKLAQILNELPQEWISHG

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=290, Percent_Identity=27.5862068965517, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI13540533, Length=305, Percent_Identity=26.2295081967213, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1788823, Length=286, Percent_Identity=36.013986013986, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI1786463, Length=274, Percent_Identity=31.7518248175182, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87082415, Length=290, Percent_Identity=26.2068965517241, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1789620, Length=299, Percent_Identity=29.7658862876254, Blast_Score=126, Evalue=2e-30,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_PARUW (Q6MDD9)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007685.1
- HSSP:   Q9X1K9
- ProteinModelPortal:   Q6MDD9
- SMR:   Q6MDD9
- STRING:   Q6MDD9
- GeneID:   2780461
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0686
- NMPDR:   fig|264201.1.peg.686
- eggNOG:   NOG132040
- HOGENOM:   HBG358848
- OMA:   LAYKQDI
- PhylomeDB:   Q6MDD9
- BioCyc:   CPRO264201:PC0686-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32755; Mature: 32755

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 162-162 BINDING 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLKGLYTALITPFTPTGQLDEEGLKKLIQIQLHHQVDGVVVLGTTGESPTLTQIEKRRI
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
IEIALEEIQGRIKVIVGTGSYSTQQAIEQTLQAKQMGADAALIVTPYYNKPTQEGIFKHF
HHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHH
EAINQAVSFPICLYNIQGRTGQNIQTHTLKRISTLSSIIGVKETSGDINQIMDVIEAFRQ
HHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
SHPNFAILSGDDALTLPMIALGGHGIISVVSNLVPAAMKSLVNAALNGNFKKARIIHNQL
CCCCEEEEECCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YSFIKAAFIETNPIPIKAALSLSKLPAGSCRLPLCDLSQNHSQKLAQILNELPQEWISHG
HHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYLKGLYTALITPFTPTGQLDEEGLKKLIQIQLHHQVDGVVVLGTTGESPTLTQIEKRRI
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHH
IEIALEEIQGRIKVIVGTGSYSTQQAIEQTLQAKQMGADAALIVTPYYNKPTQEGIFKHF
HHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHH
EAINQAVSFPICLYNIQGRTGQNIQTHTLKRISTLSSIIGVKETSGDINQIMDVIEAFRQ
HHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
SHPNFAILSGDDALTLPMIALGGHGIISVVSNLVPAAMKSLVNAALNGNFKKARIIHNQL
CCCCEEEEECCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YSFIKAAFIETNPIPIKAALSLSKLPAGSCRLPLCDLSQNHSQKLAQILNELPQEWISHG
HHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA