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The map label for this gene is alr [H]

Identifier: 46446265

GI number: 46446265

Start: 771053

End: 773578

Strand: Reverse

Name: alr [H]

Synonym: pc0631

Alternate gene names: 46446265

Gene position: 773578-771053 (Counterclockwise)

Preceding gene: 46446267

Following gene: 46446264

Centisome position: 32.04

GC content: 36.14

Gene sequence:

>2526_bases
ATGGATGCGTTTGATTTAAGACAATGGGACGGATTTAACCAGGCTGGAGGGAAAGCAGAATTTCCAGTAATTATTGATCA
AATTATTATTGATTCCAGACACGTTAATTCTTCTAATGCCTTGTTTGTAGCATTAAAAGGAGAAAAACAAGATGGTCATG
ATTTTGTCCAGCAGGCGGCAGAATTAGGAGCAAAATATGCGCTTGTTTCTGAACAGTGGACTCCCCCTTTTAATCTTAAA
CCCATTTTTTTATTAAAAGTAAAAAGTCCTTTATCAGCTTTACAAGAAGTAGCTAAAGCTTACCGCTTGCAACTTCCAAC
GAAAATCATTGGTATTACCGGGACCTATGGGAAAACGATGGTTAAGGATCTTTTGTTCCAACTTTTATCCACAGAAAAAA
ATGTGTGTGCTTCTCCTGGGAGCTTTAACAGTCAAATCGGAGTTGCTCTTAGCCTCTTAACCATTCAAAAAGACCAAGAA
TTGGCGATCATTGAAGCCGCTATTTCAAAGAAACAGGAAATGGATATATTAGCAGACTTAATCCGTCCAGACTACACTAT
TTTAACACCTATTGGAAAAAAACATTTAGCTACTTTAAATGATATTGATACTATAACTTATGAAACCCTTAAGTTAGTTT
GGGCGACATCTAAAACCGGATGGGTGCTTCTTCCCAATGACATCTATCAACAGTTCCACTTAAAAAATAATTTATTTTCT
TCGTATATATGGGACCGAGACTCAAAATGTCTTCCCCATGCCATTCCCTTTTCCAAAAATTCTCCCTTCGCCTCTCATTA
TCAACTAACATTTCCTGATTCATCCCGATACGAACAGCAAATGACAAATGGCTATTCCTATTTTTTGAATTTAATCAATA
TCACTTCTAAAGCAGCCTGGTTAAGTGGAATTAAAGCAGAAAACATTAAGAAAATATTCGAGTACTACTATCCTGAACCC
TCTCGAACTGAAATCTGGAAATCCCCTATAGGAGCAACTTTTATCAATGAAACGTCCTGTTCAGACCCACATTCAATTGA
TCGTGCTTTTAAACATTTTGAACATGCTGCTCCTTCTCAACGCAAAATTTTCATTTTTGGAGGAATGAAAGGCAATATTT
CTTTTGCCCAAAACTATTATACAAAAATTGGTAAGACGATCTCTAAAGCACACCTTCGACATTTGTTATTATTTGGTCAT
CAACCTTTTAAAACTCTCATTGATGAGGTCAAAAAAATATCACCTGAAACAGAAATTTTATGTTTCAAAAGATGTGAAGA
AGCTCTTAATTATCTCCAAAAAAATCTTCAATCACAAGACCTCATCTTGATTAAAGGAGATCGTAAAATTCCTTTCGAAA
TCTTACCAGAAACTTTTAATGGGAGCTCAAACAATAATCAATGCATTATTAACTTAGCAGCGATCAAAAACAATTTAGAC
ATGATTCGCACTAAAATAACTCCTGAAACCCGTTTAATGATTATTATAAAAGCATTCGCTTACGGAACAGATGATATCCA
ATTAGGAAAATTTTTAAGTGCTTACGGCGTTGATATTTTAGGTGTTTCTTATGTAGAAGAAGGCGTAGCCCTTAAACGAG
CAGGTATTACTCTTCCTATTTTCACGATTAATGCCGCCCAATATGAAATTGCTAAAGTAGTCAAATGGGAACTTGAAGTA
GGTGTCAGCGATGTTAATTTTATTTCAGCTTTAGCTCAAGAGGCAAAAAAGAGCAGTAAATGCATTAAAGTACATTTACA
TATTAATACAGGAATGGGTCGTTTTGGATGCCGTCCTGAGGAAGCGCTAAATCTCGCTTTGTTAATTACGTCTTCTTCGC
ACCTAATTCTAGAAGGGATTATGACTCATTTTGCTTGTGCAGATGATCCTCGTCATGATTCTTTTACACAAGAGCAGATT
CAATGTTTTGATTCTGTCATTGAACAATTAAAAAGACATTGTATCCAAGCAAAATGGACGCATGCAGCTAATTCCAGCGG
CACCATTCGCTTTTCTCTTCCTCAATATAATATGGTTCGTATAGGTCTAGCGACTTATGGTCTTTATGGTTCTGATGCTG
TCAAACAAGCTTTAGATTTACGCCTGGCCTTATCTTTAACATCTCGTATAGTTGGGATTAATCACTGTCGTAAAGGGGAA
ACCATTAGCTATGGTCGAAACTACCTGATAGAAAAAGAAAATCAAACAATCGCTGTTTTACCCGTCGGATATTTTGACGG
TCTACATCGACATTATAGCGGAAAAGCTCATGTGTTAATTCATGGAAAAAAAGCTCCTATGGTGGGATCGATCTGCATGG
ATTATATGATGGTTGATATTACAGATATTCCTCATGCGAACATTGGAGATAAAGTTCTTATTTTCGGAGAAGATGAATAT
GGACATTATCTTTCCCCTGAAGAATTAGCGATGAATGGAAATTCAATCGTTCATGAATTGATTACATGCTTAGGGCCACG
CATTCAACGTATTTTTATTTATGAAGAAGGAAGCCAAGTTCGTTGA

Upstream 100 bases:

>100_bases
TTTGCTAAAAATAAACCAAAAAATGATAACCTTTTATCTTTCGGTACTGCTCGTTAACCGATCTTTGATTCTTATATTTA
TTTTTTGAATGACATTTTTT

Downstream 100 bases:

>100_bases
TCAATGAATGCGGATAAATGATTAGGAAACAGGAAGGATTTCGTATGAGTAAAACTCAAAAAGAGTATCAAAAACTACAT
GTACTTAGTAAACATGCACG

Product: putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 841; Mature: 841

Protein sequence:

>841_residues
MDAFDLRQWDGFNQAGGKAEFPVIIDQIIIDSRHVNSSNALFVALKGEKQDGHDFVQQAAELGAKYALVSEQWTPPFNLK
PIFLLKVKSPLSALQEVAKAYRLQLPTKIIGITGTYGKTMVKDLLFQLLSTEKNVCASPGSFNSQIGVALSLLTIQKDQE
LAIIEAAISKKQEMDILADLIRPDYTILTPIGKKHLATLNDIDTITYETLKLVWATSKTGWVLLPNDIYQQFHLKNNLFS
SYIWDRDSKCLPHAIPFSKNSPFASHYQLTFPDSSRYEQQMTNGYSYFLNLINITSKAAWLSGIKAENIKKIFEYYYPEP
SRTEIWKSPIGATFINETSCSDPHSIDRAFKHFEHAAPSQRKIFIFGGMKGNISFAQNYYTKIGKTISKAHLRHLLLFGH
QPFKTLIDEVKKISPETEILCFKRCEEALNYLQKNLQSQDLILIKGDRKIPFEILPETFNGSSNNNQCIINLAAIKNNLD
MIRTKITPETRLMIIIKAFAYGTDDIQLGKFLSAYGVDILGVSYVEEGVALKRAGITLPIFTINAAQYEIAKVVKWELEV
GVSDVNFISALAQEAKKSSKCIKVHLHINTGMGRFGCRPEEALNLALLITSSSHLILEGIMTHFACADDPRHDSFTQEQI
QCFDSVIEQLKRHCIQAKWTHAANSSGTIRFSLPQYNMVRIGLATYGLYGSDAVKQALDLRLALSLTSRIVGINHCRKGE
TISYGRNYLIEKENQTIAVLPVGYFDGLHRHYSGKAHVLIHGKKAPMVGSICMDYMMVDITDIPHANIGDKVLIFGEDEY
GHYLSPEELAMNGNSIVHELITCLGPRIQRIFIYEEGSQVR

Sequences:

>Translated_841_residues
MDAFDLRQWDGFNQAGGKAEFPVIIDQIIIDSRHVNSSNALFVALKGEKQDGHDFVQQAAELGAKYALVSEQWTPPFNLK
PIFLLKVKSPLSALQEVAKAYRLQLPTKIIGITGTYGKTMVKDLLFQLLSTEKNVCASPGSFNSQIGVALSLLTIQKDQE
LAIIEAAISKKQEMDILADLIRPDYTILTPIGKKHLATLNDIDTITYETLKLVWATSKTGWVLLPNDIYQQFHLKNNLFS
SYIWDRDSKCLPHAIPFSKNSPFASHYQLTFPDSSRYEQQMTNGYSYFLNLINITSKAAWLSGIKAENIKKIFEYYYPEP
SRTEIWKSPIGATFINETSCSDPHSIDRAFKHFEHAAPSQRKIFIFGGMKGNISFAQNYYTKIGKTISKAHLRHLLLFGH
QPFKTLIDEVKKISPETEILCFKRCEEALNYLQKNLQSQDLILIKGDRKIPFEILPETFNGSSNNNQCIINLAAIKNNLD
MIRTKITPETRLMIIIKAFAYGTDDIQLGKFLSAYGVDILGVSYVEEGVALKRAGITLPIFTINAAQYEIAKVVKWELEV
GVSDVNFISALAQEAKKSSKCIKVHLHINTGMGRFGCRPEEALNLALLITSSSHLILEGIMTHFACADDPRHDSFTQEQI
QCFDSVIEQLKRHCIQAKWTHAANSSGTIRFSLPQYNMVRIGLATYGLYGSDAVKQALDLRLALSLTSRIVGINHCRKGE
TISYGRNYLIEKENQTIAVLPVGYFDGLHRHYSGKAHVLIHGKKAPMVGSICMDYMMVDITDIPHANIGDKVLIFGEDEY
GHYLSPEELAMNGNSIVHELITCLGPRIQRIFIYEEGSQVR
>Mature_841_residues
MDAFDLRQWDGFNQAGGKAEFPVIIDQIIIDSRHVNSSNALFVALKGEKQDGHDFVQQAAELGAKYALVSEQWTPPFNLK
PIFLLKVKSPLSALQEVAKAYRLQLPTKIIGITGTYGKTMVKDLLFQLLSTEKNVCASPGSFNSQIGVALSLLTIQKDQE
LAIIEAAISKKQEMDILADLIRPDYTILTPIGKKHLATLNDIDTITYETLKLVWATSKTGWVLLPNDIYQQFHLKNNLFS
SYIWDRDSKCLPHAIPFSKNSPFASHYQLTFPDSSRYEQQMTNGYSYFLNLINITSKAAWLSGIKAENIKKIFEYYYPEP
SRTEIWKSPIGATFINETSCSDPHSIDRAFKHFEHAAPSQRKIFIFGGMKGNISFAQNYYTKIGKTISKAHLRHLLLFGH
QPFKTLIDEVKKISPETEILCFKRCEEALNYLQKNLQSQDLILIKGDRKIPFEILPETFNGSSNNNQCIINLAAIKNNLD
MIRTKITPETRLMIIIKAFAYGTDDIQLGKFLSAYGVDILGVSYVEEGVALKRAGITLPIFTINAAQYEIAKVVKWELEV
GVSDVNFISALAQEAKKSSKCIKVHLHINTGMGRFGCRPEEALNLALLITSSSHLILEGIMTHFACADDPRHDSFTQEQI
QCFDSVIEQLKRHCIQAKWTHAANSSGTIRFSLPQYNMVRIGLATYGLYGSDAVKQALDLRLALSLTSRIVGINHCRKGE
TISYGRNYLIEKENQTIAVLPVGYFDGLHRHYSGKAHVLIHGKKAPMVGSICMDYMMVDITDIPHANIGDKVLIFGEDEY
GHYLSPEELAMNGNSIVHELITCLGPRIQRIFIYEEGSQVR

Specific function: Provides the D-alanine required for cell wall biosynthesis [H]

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family [H]

Homologues:

Organism=Escherichia coli, GI1790487, Length=370, Percent_Identity=26.2162162162162, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1787439, Length=382, Percent_Identity=25.130890052356, Blast_Score=123, Evalue=5e-29,
Organism=Escherichia coli, GI1786274, Length=222, Percent_Identity=27.9279279279279, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622 [H]

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]

EC number: =5.1.1.1 [H]

Molecular weight: Translated: 94555; Mature: 94555

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAFDLRQWDGFNQAGGKAEFPVIIDQIIIDSRHVNSSNALFVALKGEKQDGHDFVQQAA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHH
ELGAKYALVSEQWTPPFNLKPIFLLKVKSPLSALQEVAKAYRLQLPTKIIGITGTYGKTM
HCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHH
VKDLLFQLLSTEKNVCASPGSFNSQIGVALSLLTIQKDQELAIIEAAISKKQEMDILADL
HHHHHHHHHCCCCCCCCCCCCCCCCHHEEEEEEEECCCCCHHHHHHHHHCHHHHHHHHHH
IRPDYTILTPIGKKHLATLNDIDTITYETLKLVWATSKTGWVLLPNDIYQQFHLKNNLFS
HCCCEEEECCCCHHHHCCCCCCCHHHEEEEEEEEEECCCCEEECCHHHHHHHHHHHHHHH
SYIWDRDSKCLPHAIPFSKNSPFASHYQLTFPDSSRYEQQMTNGYSYFLNLINITSKAAW
HHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHH
LSGIKAENIKKIFEYYYPEPSRTEIWKSPIGATFINETSCSDPHSIDRAFKHFEHAAPSQ
HCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCC
RKIFIFGGMKGNISFAQNYYTKIGKTISKAHLRHLLLFGHQPFKTLIDEVKKISPETEIL
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHH
CFKRCEEALNYLQKNLQSQDLILIKGDRKIPFEILPETFNGSSNNNQCIINLAAIKNNLD
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEECCCCCCCCCCCCEEEEEEEHHHCCCH
MIRTKITPETRLMIIIKAFAYGTDDIQLGKFLSAYGVDILGVSYVEEGVALKRAGITLPI
HHEEECCCCCEEEEEEEEHHCCCCCHHHHHHHHHHCCHHEEHHHHHCCCEEEECCCEEEE
FTINAAQYEIAKVVKWELEVGVSDVNFISALAQEAKKSSKCIKVHLHINTGMGRFGCRPE
EEECCCHHHHHHHHEEHEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHH
EALNLALLITSSSHLILEGIMTHFACADDPRHDSFTQEQIQCFDSVIEQLKRHCIQAKWT
HHCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
HAANSSGTIRFSLPQYNMVRIGLATYGLYGSDAVKQALDLRLALSLTSRIVGINHCRKGE
CCCCCCCEEEEECCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
TISYGRNYLIEKENQTIAVLPVGYFDGLHRHYSGKAHVLIHGKKAPMVGSICMDYMMVDI
EEECCCCEEEEECCCEEEEEEEHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHEEE
TDIPHANIGDKVLIFGEDEYGHYLSPEELAMNGNSIVHELITCLGPRIQRIFIYEEGSQV
ECCCCCCCCCEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCEEEEEEEECCCCC
R
C
>Mature Secondary Structure
MDAFDLRQWDGFNQAGGKAEFPVIIDQIIIDSRHVNSSNALFVALKGEKQDGHDFVQQAA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHH
ELGAKYALVSEQWTPPFNLKPIFLLKVKSPLSALQEVAKAYRLQLPTKIIGITGTYGKTM
HCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHH
VKDLLFQLLSTEKNVCASPGSFNSQIGVALSLLTIQKDQELAIIEAAISKKQEMDILADL
HHHHHHHHHCCCCCCCCCCCCCCCCHHEEEEEEEECCCCCHHHHHHHHHCHHHHHHHHHH
IRPDYTILTPIGKKHLATLNDIDTITYETLKLVWATSKTGWVLLPNDIYQQFHLKNNLFS
HCCCEEEECCCCHHHHCCCCCCCHHHEEEEEEEEEECCCCEEECCHHHHHHHHHHHHHHH
SYIWDRDSKCLPHAIPFSKNSPFASHYQLTFPDSSRYEQQMTNGYSYFLNLINITSKAAW
HHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHH
LSGIKAENIKKIFEYYYPEPSRTEIWKSPIGATFINETSCSDPHSIDRAFKHFEHAAPSQ
HCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCC
RKIFIFGGMKGNISFAQNYYTKIGKTISKAHLRHLLLFGHQPFKTLIDEVKKISPETEIL
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHH
CFKRCEEALNYLQKNLQSQDLILIKGDRKIPFEILPETFNGSSNNNQCIINLAAIKNNLD
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEECCCCCCCCCCCCEEEEEEEHHHCCCH
MIRTKITPETRLMIIIKAFAYGTDDIQLGKFLSAYGVDILGVSYVEEGVALKRAGITLPI
HHEEECCCCCEEEEEEEEHHCCCCCHHHHHHHHHHCCHHEEHHHHHCCCEEEECCCEEEE
FTINAAQYEIAKVVKWELEVGVSDVNFISALAQEAKKSSKCIKVHLHINTGMGRFGCRPE
EEECCCHHHHHHHHEEHEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHH
EALNLALLITSSSHLILEGIMTHFACADDPRHDSFTQEQIQCFDSVIEQLKRHCIQAKWT
HHCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
HAANSSGTIRFSLPQYNMVRIGLATYGLYGSDAVKQALDLRLALSLTSRIVGINHCRKGE
CCCCCCCEEEEECCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
TISYGRNYLIEKENQTIAVLPVGYFDGLHRHYSGKAHVLIHGKKAPMVGSICMDYMMVDI
EEECCCCEEEEECCCEEEEEEEHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHEEE
TDIPHANIGDKVLIFGEDEYGHYLSPEELAMNGNSIVHELITCLGPRIQRIFIYEEGSQV
ECCCCCCCCCEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCEEEEEEEECCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA