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The map label for this gene is dnaX [H]

Identifier: 46446112

GI number: 46446112

Start: 614128

End: 615696

Strand: Reverse

Name: dnaX [H]

Synonym: pc0478

Alternate gene names: 46446112

Gene position: 615696-614128 (Counterclockwise)

Preceding gene: 46446114

Following gene: 46446111

Centisome position: 25.5

GC content: 36.97

Gene sequence:

>1569_bases
ATGTCTGAATATCAAGTTATTGCCAGAAAGTTTCGACCACAAACGTTCAAAGAAGTATTTGGACAAGAGGCTGTTGTAAC
AACTCTTAAAAATGCGATCAAATTTAAAAGACTTGCCCAAGCTTATCTTTTTTGTGGATCTCGAGGGACAGGAAAAACAA
CATTAGCACGCATTTTTGCAAAAGCGATTAATTGTCAAAATTCTACAGAAGATTTTGAACCTTGTAATCAATGCACTTCT
TGCCGGGAAATCACTTCTGGCTCTTCCTTAGATGTGCTAGAAATTGATGGTGCTTCCCATCGAGGAATTGAAGATATTAG
ACAAATTAATGAAACTGTAGGTTACGCAGCAACCTCTGGTCAATATAAAGTCTATATCATTGATGAAGTACATATGCTAA
CTAAAGAGGCTTTTAATGCCCTTCTTAAGACGTTGGAAGAACCTCCCCCCAAAGTCAAATTCATCTTTGCAACAACAGAA
GCTCACAAGGTCTTACCTACGATTTTATCTCGCTGCCAACGGTTTAACTTAAGTCGTATTCCTCTTTCTCAGATCATGAT
TAAATTAAAATTGATTGCCGACCAACTTGAAATCGATGTTGAAGAAGAAGCACTGCAATTACTTGCATACAAAGCAGAAG
GTGGATTGAGAGATGCCGAATCTTTATTTGATCAAATTGTGGCCTTTTCTGAAGGAAAAATTAATGCAGCAACTGTCCAG
TCCATTTTAGGGCTAATGCCTCGAGAAGCTTATTTTGAATTAGATTTAGCGGGTAAGGAAGGCAATTTCGTAAAGGCTTT
TGAAATTGCTTATCGTATTTTTGCTGAAGGAAAAGATTTAAATCACTTTATTGAAGGTTTAATTGATCACTTCCGTCATA
TTTTGTTGATTCAATTAGCAGGCATAACTTCTCCACTCCTAACTATTTCTCCTAAAGAAAAACAATTTTATGAGAGAGCG
GCTCATCTTTATACCCAAGAACAATGTTTAGATTTAATCGATTATTTAATTGAATCTGCCCAACAAATTCGTTTCACTCA
TTCAGGAAAAATTGCATTAGAAGCTATTTTACTTCATGTCATACGTAGTCATTTTCGACTACCGATCGAAGTATTAGTTC
AACGTCTAGGAGAGCTGGAGCAAATGTTAGGAGAAGCCTCTCTTGTAAATTCTTCAGTCTTTCCTCCCTTATCGAAATCA
ACTCCTCAATCTTCGCTTTCTACGGAAGTAAAAAATCCGCCTTTAACACCTCCTGTACCACTGACAAACAACAAACCCTC
GCAAAATCTGACGACCTCTCCTATTGAAAAGAATTTGAATTCTTCAACTGCTACCTCGTTACTTTCCCCTTCAACAAATA
ATTGTTCTTTATTTGATCACTTTGTCAGCGAAGATCCAACACCTACACAGTCCGATTTAGGGCGATCTACTCAAAAACTT
CCCAACAAAGATTCCCCTTCTCTAGTCGCTAAATTAAATGGAGATAATCCAACTCCTGTTCACCAATATGACACTCTTTT
TCAATTTGCAGCCATTGAGCTAGAAGGAAAATTACAAAGAAAAGCTTAA

Upstream 100 bases:

>100_bases
ACTTTAAAATTTATTTTTTACCATGAGCTGCTATTCTATATTTGCATAAATTCAACCAGCACATTAAAATCAATGACATT
AACTAAATTTAATGTAGATC

Downstream 100 bases:

>100_bases
AATAACATATGATCTATGGAGAGAAAAAACTTTAAGAACTACGCTAGGAACTAAATATTATCTCTTGCTACCTTGTACAA
GTTTTATACTGACTTTTGTT

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MSEYQVIARKFRPQTFKEVFGQEAVVTTLKNAIKFKRLAQAYLFCGSRGTGKTTLARIFAKAINCQNSTEDFEPCNQCTS
CREITSGSSLDVLEIDGASHRGIEDIRQINETVGYAATSGQYKVYIIDEVHMLTKEAFNALLKTLEEPPPKVKFIFATTE
AHKVLPTILSRCQRFNLSRIPLSQIMIKLKLIADQLEIDVEEEALQLLAYKAEGGLRDAESLFDQIVAFSEGKINAATVQ
SILGLMPREAYFELDLAGKEGNFVKAFEIAYRIFAEGKDLNHFIEGLIDHFRHILLIQLAGITSPLLTISPKEKQFYERA
AHLYTQEQCLDLIDYLIESAQQIRFTHSGKIALEAILLHVIRSHFRLPIEVLVQRLGELEQMLGEASLVNSSVFPPLSKS
TPQSSLSTEVKNPPLTPPVPLTNNKPSQNLTTSPIEKNLNSSTATSLLSPSTNNCSLFDHFVSEDPTPTQSDLGRSTQKL
PNKDSPSLVAKLNGDNPTPVHQYDTLFQFAAIELEGKLQRKA

Sequences:

>Translated_522_residues
MSEYQVIARKFRPQTFKEVFGQEAVVTTLKNAIKFKRLAQAYLFCGSRGTGKTTLARIFAKAINCQNSTEDFEPCNQCTS
CREITSGSSLDVLEIDGASHRGIEDIRQINETVGYAATSGQYKVYIIDEVHMLTKEAFNALLKTLEEPPPKVKFIFATTE
AHKVLPTILSRCQRFNLSRIPLSQIMIKLKLIADQLEIDVEEEALQLLAYKAEGGLRDAESLFDQIVAFSEGKINAATVQ
SILGLMPREAYFELDLAGKEGNFVKAFEIAYRIFAEGKDLNHFIEGLIDHFRHILLIQLAGITSPLLTISPKEKQFYERA
AHLYTQEQCLDLIDYLIESAQQIRFTHSGKIALEAILLHVIRSHFRLPIEVLVQRLGELEQMLGEASLVNSSVFPPLSKS
TPQSSLSTEVKNPPLTPPVPLTNNKPSQNLTTSPIEKNLNSSTATSLLSPSTNNCSLFDHFVSEDPTPTQSDLGRSTQKL
PNKDSPSLVAKLNGDNPTPVHQYDTLFQFAAIELEGKLQRKA
>Mature_521_residues
SEYQVIARKFRPQTFKEVFGQEAVVTTLKNAIKFKRLAQAYLFCGSRGTGKTTLARIFAKAINCQNSTEDFEPCNQCTSC
REITSGSSLDVLEIDGASHRGIEDIRQINETVGYAATSGQYKVYIIDEVHMLTKEAFNALLKTLEEPPPKVKFIFATTEA
HKVLPTILSRCQRFNLSRIPLSQIMIKLKLIADQLEIDVEEEALQLLAYKAEGGLRDAESLFDQIVAFSEGKINAATVQS
ILGLMPREAYFELDLAGKEGNFVKAFEIAYRIFAEGKDLNHFIEGLIDHFRHILLIQLAGITSPLLTISPKEKQFYERAA
HLYTQEQCLDLIDYLIESAQQIRFTHSGKIALEAILLHVIRSHFRLPIEVLVQRLGELEQMLGEASLVNSSVFPPLSKST
PQSSLSTEVKNPPLTPPVPLTNNKPSQNLTTSPIEKNLNSSTATSLLSPSTNNCSLFDHFVSEDPTPTQSDLGRSTQKLP
NKDSPSLVAKLNGDNPTPVHQYDTLFQFAAIELEGKLQRKA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=292, Percent_Identity=27.3972602739726, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI31881687, Length=292, Percent_Identity=27.3972602739726, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI6677723, Length=239, Percent_Identity=25.9414225941423, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI194306571, Length=244, Percent_Identity=26.6393442622951, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI194306567, Length=244, Percent_Identity=26.6393442622951, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI194306569, Length=159, Percent_Identity=27.6729559748428, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1786676, Length=372, Percent_Identity=38.4408602150538, Blast_Score=260, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17554730, Length=217, Percent_Identity=26.7281105990783, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71986063, Length=255, Percent_Identity=29.8039215686275, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17541988, Length=224, Percent_Identity=24.5535714285714, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=180, Percent_Identity=31.6666666666667, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324478, Length=240, Percent_Identity=25, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859927, Length=298, Percent_Identity=24.496644295302, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19921076, Length=212, Percent_Identity=26.4150943396226, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17647857, Length=215, Percent_Identity=26.5116279069767, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 58172; Mature: 58041

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEYQVIARKFRPQTFKEVFGQEAVVTTLKNAIKFKRLAQAYLFCGSRGTGKTTLARIFA
CCHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KAINCQNSTEDFEPCNQCTSCREITSGSSLDVLEIDGASHRGIEDIRQINETVGYAATSG
HHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCEECCC
QYKVYIIDEVHMLTKEAFNALLKTLEEPPPKVKFIFATTEAHKVLPTILSRCQRFNLSRI
CEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCC
PLSQIMIKLKLIADQLEIDVEEEALQLLAYKAEGGLRDAESLFDQIVAFSEGKINAATVQ
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
SILGLMPREAYFELDLAGKEGNFVKAFEIAYRIFAEGKDLNHFIEGLIDHFRHILLIQLA
HHHHHCCCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
GITSPLLTISPKEKQFYERAAHLYTQEQCLDLIDYLIESAQQIRFTHSGKIALEAILLHV
CCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHH
IRSHFRLPIEVLVQRLGELEQMLGEASLVNSSVFPPLSKSTPQSSLSTEVKNPPLTPPVP
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCC
LTNNKPSQNLTTSPIEKNLNSSTATSLLSPSTNNCSLFDHFVSEDPTPTQSDLGRSTQKL
CCCCCCCCCCCCCHHHHCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHCCHHHHC
PNKDSPSLVAKLNGDNPTPVHQYDTLFQFAAIELEGKLQRKA
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
SEYQVIARKFRPQTFKEVFGQEAVVTTLKNAIKFKRLAQAYLFCGSRGTGKTTLARIFA
CHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KAINCQNSTEDFEPCNQCTSCREITSGSSLDVLEIDGASHRGIEDIRQINETVGYAATSG
HHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCEECCC
QYKVYIIDEVHMLTKEAFNALLKTLEEPPPKVKFIFATTEAHKVLPTILSRCQRFNLSRI
CEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCC
PLSQIMIKLKLIADQLEIDVEEEALQLLAYKAEGGLRDAESLFDQIVAFSEGKINAATVQ
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
SILGLMPREAYFELDLAGKEGNFVKAFEIAYRIFAEGKDLNHFIEGLIDHFRHILLIQLA
HHHHHCCCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
GITSPLLTISPKEKQFYERAAHLYTQEQCLDLIDYLIESAQQIRFTHSGKIALEAILLHV
CCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHH
IRSHFRLPIEVLVQRLGELEQMLGEASLVNSSVFPPLSKSTPQSSLSTEVKNPPLTPPVP
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCC
LTNNKPSQNLTTSPIEKNLNSSTATSLLSPSTNNCSLFDHFVSEDPTPTQSDLGRSTQKL
CCCCCCCCCCCCCHHHHCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHCCHHHHC
PNKDSPSLVAKLNGDNPTPVHQYDTLFQFAAIELEGKLQRKA
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]