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The map label for this gene is lon

Identifier: 46446096

GI number: 46446096

Start: 590741

End: 593248

Strand: Reverse

Name: lon

Synonym: pc0462

Alternate gene names: 46446096

Gene position: 593248-590741 (Counterclockwise)

Preceding gene: 46446103

Following gene: 46446095

Centisome position: 24.57

GC content: 36.52

Gene sequence:

>2508_bases
ATGCTGGAAGAACCAATTGACGCACTAGAAACAGAATTTGAAAATGCTTTGAATTCCCTGGAAGATAATCAGCTTAGTAA
AATAAATGGACAGCTTCCAGAACAAGTTCATGTTTTTCCTCTTTTACGTCGTCCTTTCTTTCCAGGAATGGCAGCTCCTT
TAGTCATTGAGCCAGGTCCTTTTTACGAGGTATTAAAGGTTGTTGCTAAATCTGATCACAAATGTGTGGGTTTAGTACTA
ACGCGTTCCGAACAAGCAGAAATTTATAAGGTGGGATTCTCCGATCTTTATCAAATTGGTGTATTGGCTAGAGTTTTGAG
AATTATTCCCATGGAACAAGGGGGTGCGCAAGTTATCCTGAACATGGAACGACGAATTAAAATTGAAAAACCCACCTCAG
AAACAAAAACTCTTAAAGCCAATGTTAGCTATATAGAAGACGATCCTATTCTGACCACCGAATTAAAAGCTTATGCTATT
AGTATTCTTTCAACTATTAAAGAACTTTTAAAACTCAACCCTCTCTTTAAAGAAGAGCTTCAAATCTTCTTAGGACACTC
TGACTTTACAGAACCTGGTAAATTGGCTGACTTCGCAGTTGCTTTGACAACTGCTTCTAGAGAAGAGTTGCAAGATGTTT
TAGAAACATTTGATATTCGAAAACGTATCGATAAAGCCTTGATTTTACTTAAAAAAGAGCTCGATATTAGTATCTTACAA
CACAATATCAATCAAAAAATTGAAGCAACGATTAATAAAAGCCAAAAAGATTTTTTCTTAAGAGAACAGCTTAAAACAAT
TAAAAAAGAATTGGGAATTGAGCGAGATGATAAATCGCTTGATCGAGAAAAATTCGAGGCAAGATTAAAAGAAAGAGTTG
TCCCTTCTGATGTTATGAAAGTGATTACAGAAGAACTTGAGAAATTAAGCGTTTTAGACATGCAATCAGCTGAATATAGC
GTAGTAAGAGGATATTTAGATTGGCTAACAACAATACCTTGGGGTATTTATAGTCAAGAAAACCACAATTTAGAAGAAGC
TGAAAAAATTTTAGCTCATGATCATTATGGCTTAGAAGATATCAAGCAAAGGATTTTAGAGTTTATTGGTGTGGGTAAAT
TAGCTAAAGGTGTTCGAGGTAGTATTATTTGTTTAGTTGGCCCTCCAGGTGTAGGTAAAACCAGCATTGGAAAAAGTATA
GCCAGAGCTCTTAATAGGAAATTTTATCGTTTTTCTGTTGGAGGAATGCGAGATGAGGCGGAAATCAAAGGGCATCGTCG
TACTTATGTAGGCGCTATGCCTGGAAAAATGATTCAAGCCTTAAAATATTGTCAAACAATGAATCCTGTTATCATGCTTG
ATGAAGTGGATAAAATGGGAAAAAGTTTTCAGGGAGACCCAGCATCTGCCCTTTTAGAAGTTTTAGATCCGGAACAAAAT
GCTGAGTTTTTAGATCATTACCTTGATGTACGCTGCAATCTATCCGAGGTGTTATTTATCGTAACTGCAAACGTTTTAGA
TACCATTCCCGAACCCTTAAAAGATCGAATGGATATTCTTCGCTTATCTGGTTACATCATGCAAGAAAAATTAGAAATAG
CGAAAAAGTACCTCATTCCTCGCAATCGAAAAGAAATGGGATTAAAAGCATTAGAAGTTTCCTTCACTCAAGAAGCGCTT
CGATCTATTATCAATGGCTATGCTAGAGAATCTGGGGTACGTAATCTCGAAAATCTGCTCAAAAAAATATTGCGAAAACT
TGCTGTCAACATTGTTAGAGAACAAGAAGAACACGATAAAGAGCAGGCTAAAAAGAAAAAATCTTCCAGAAGCAAAAAAC
CTATCGCATTTGTTCCTACTAAACATTCAATTACTCCCTCAAATTTAAAAGATTTTTTAGGTAAACCAGTCTTCACCAGC
GACCGCTTTTATGAAAGAACGCCTGTCGGAGTTTGCATGGGATTAGCCTGGACGGCAATGGGAGGAGCTACACTTTATAT
TGAATCCATCAAAGTTGCCGGCGAAAAAACAGTTATGAAATTAACAGGTCAAGCAGGTGATGTGATGAAGGAGTCGGCTG
AGATAGCTTGGAGCTATGTCCATTCTTCAATTCACAAATACGCTCCTGGATATACATTTTTTGAAAAATCGCAAGTTCAT
ATTCATATCCCTGAAGGAGCTACACCAAAAGATGGGCCTTCAGCTGGAATAACTATGGTGACTTCTTTACTTTCTTTAAT
TTTAGATACCCCTGTCTTAGATAATTTAGGGATGACGGGAGAACTTACTTTAACAGGCCGCGTTCTTCCAATTGGTGGAG
TGAAAGAAAAACTTGTTGCCGCTAGACGTTCGGGACTAAAAGTTTTAATCTTTCCAAAAGATAATCTTAGAGATTATGAA
GAACTCCCAGAATATATTCGAAAAGGAATTACCGTGCATTTTGTTGACCATTATGATCAAGTCTTTAAAATTTCTTTTCC
TAATAAACACCAAATGAAGCTTTGTTAA

Upstream 100 bases:

>100_bases
CTAGATATTCAACACTTATCTTTATAGGGAAAAATACACTCCCAAAAATAAACTAAATGTTTAGAAAGAAATCCATTAAC
TTTCTTTATTAGGATGCTAA

Downstream 100 bases:

>100_bases
GTGAAGGGTAAGTGATGAGCAAAACAATTGAGCTAGTTCCGTGGTCAATTGCCTATAAACAAAAAGTCATTGTTCCTGAG
GAATTGAATCAGAAAATTAC

Product: putative endopeptidase (ATP-dependent serine protease) La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 835; Mature: 835

Protein sequence:

>835_residues
MLEEPIDALETEFENALNSLEDNQLSKINGQLPEQVHVFPLLRRPFFPGMAAPLVIEPGPFYEVLKVVAKSDHKCVGLVL
TRSEQAEIYKVGFSDLYQIGVLARVLRIIPMEQGGAQVILNMERRIKIEKPTSETKTLKANVSYIEDDPILTTELKAYAI
SILSTIKELLKLNPLFKEELQIFLGHSDFTEPGKLADFAVALTTASREELQDVLETFDIRKRIDKALILLKKELDISILQ
HNINQKIEATINKSQKDFFLREQLKTIKKELGIERDDKSLDREKFEARLKERVVPSDVMKVITEELEKLSVLDMQSAEYS
VVRGYLDWLTTIPWGIYSQENHNLEEAEKILAHDHYGLEDIKQRILEFIGVGKLAKGVRGSIICLVGPPGVGKTSIGKSI
ARALNRKFYRFSVGGMRDEAEIKGHRRTYVGAMPGKMIQALKYCQTMNPVIMLDEVDKMGKSFQGDPASALLEVLDPEQN
AEFLDHYLDVRCNLSEVLFIVTANVLDTIPEPLKDRMDILRLSGYIMQEKLEIAKKYLIPRNRKEMGLKALEVSFTQEAL
RSIINGYARESGVRNLENLLKKILRKLAVNIVREQEEHDKEQAKKKKSSRSKKPIAFVPTKHSITPSNLKDFLGKPVFTS
DRFYERTPVGVCMGLAWTAMGGATLYIESIKVAGEKTVMKLTGQAGDVMKESAEIAWSYVHSSIHKYAPGYTFFEKSQVH
IHIPEGATPKDGPSAGITMVTSLLSLILDTPVLDNLGMTGELTLTGRVLPIGGVKEKLVAARRSGLKVLIFPKDNLRDYE
ELPEYIRKGITVHFVDHYDQVFKISFPNKHQMKLC

Sequences:

>Translated_835_residues
MLEEPIDALETEFENALNSLEDNQLSKINGQLPEQVHVFPLLRRPFFPGMAAPLVIEPGPFYEVLKVVAKSDHKCVGLVL
TRSEQAEIYKVGFSDLYQIGVLARVLRIIPMEQGGAQVILNMERRIKIEKPTSETKTLKANVSYIEDDPILTTELKAYAI
SILSTIKELLKLNPLFKEELQIFLGHSDFTEPGKLADFAVALTTASREELQDVLETFDIRKRIDKALILLKKELDISILQ
HNINQKIEATINKSQKDFFLREQLKTIKKELGIERDDKSLDREKFEARLKERVVPSDVMKVITEELEKLSVLDMQSAEYS
VVRGYLDWLTTIPWGIYSQENHNLEEAEKILAHDHYGLEDIKQRILEFIGVGKLAKGVRGSIICLVGPPGVGKTSIGKSI
ARALNRKFYRFSVGGMRDEAEIKGHRRTYVGAMPGKMIQALKYCQTMNPVIMLDEVDKMGKSFQGDPASALLEVLDPEQN
AEFLDHYLDVRCNLSEVLFIVTANVLDTIPEPLKDRMDILRLSGYIMQEKLEIAKKYLIPRNRKEMGLKALEVSFTQEAL
RSIINGYARESGVRNLENLLKKILRKLAVNIVREQEEHDKEQAKKKKSSRSKKPIAFVPTKHSITPSNLKDFLGKPVFTS
DRFYERTPVGVCMGLAWTAMGGATLYIESIKVAGEKTVMKLTGQAGDVMKESAEIAWSYVHSSIHKYAPGYTFFEKSQVH
IHIPEGATPKDGPSAGITMVTSLLSLILDTPVLDNLGMTGELTLTGRVLPIGGVKEKLVAARRSGLKVLIFPKDNLRDYE
ELPEYIRKGITVHFVDHYDQVFKISFPNKHQMKLC
>Mature_835_residues
MLEEPIDALETEFENALNSLEDNQLSKINGQLPEQVHVFPLLRRPFFPGMAAPLVIEPGPFYEVLKVVAKSDHKCVGLVL
TRSEQAEIYKVGFSDLYQIGVLARVLRIIPMEQGGAQVILNMERRIKIEKPTSETKTLKANVSYIEDDPILTTELKAYAI
SILSTIKELLKLNPLFKEELQIFLGHSDFTEPGKLADFAVALTTASREELQDVLETFDIRKRIDKALILLKKELDISILQ
HNINQKIEATINKSQKDFFLREQLKTIKKELGIERDDKSLDREKFEARLKERVVPSDVMKVITEELEKLSVLDMQSAEYS
VVRGYLDWLTTIPWGIYSQENHNLEEAEKILAHDHYGLEDIKQRILEFIGVGKLAKGVRGSIICLVGPPGVGKTSIGKSI
ARALNRKFYRFSVGGMRDEAEIKGHRRTYVGAMPGKMIQALKYCQTMNPVIMLDEVDKMGKSFQGDPASALLEVLDPEQN
AEFLDHYLDVRCNLSEVLFIVTANVLDTIPEPLKDRMDILRLSGYIMQEKLEIAKKYLIPRNRKEMGLKALEVSFTQEAL
RSIINGYARESGVRNLENLLKKILRKLAVNIVREQEEHDKEQAKKKKSSRSKKPIAFVPTKHSITPSNLKDFLGKPVFTS
DRFYERTPVGVCMGLAWTAMGGATLYIESIKVAGEKTVMKLTGQAGDVMKESAEIAWSYVHSSIHKYAPGYTFFEKSQVH
IHIPEGATPKDGPSAGITMVTSLLSLILDTPVLDNLGMTGELTLTGRVLPIGGVKEKLVAARRSGLKVLIFPKDNLRDYE
ELPEYIRKGITVHFVDHYDQVFKISFPNKHQMKLC

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI21396489, Length=860, Percent_Identity=46.046511627907, Blast_Score=745, Evalue=0.0,
Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=41.1347517730496, Blast_Score=465, Evalue=1e-131,
Organism=Escherichia coli, GI1786643, Length=796, Percent_Identity=38.5678391959799, Blast_Score=567, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17505831, Length=698, Percent_Identity=48.1375358166189, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17556486, Length=639, Percent_Identity=34.8982785602504, Blast_Score=406, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6319449, Length=731, Percent_Identity=48.4268125854993, Blast_Score=701, Evalue=0.0,
Organism=Drosophila melanogaster, GI221513036, Length=687, Percent_Identity=51.528384279476, Blast_Score=714, Evalue=0.0,
Organism=Drosophila melanogaster, GI24666867, Length=687, Percent_Identity=51.528384279476, Blast_Score=713, Evalue=0.0,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_PARUW (Q6ME13)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007461.1
- ProteinModelPortal:   Q6ME13
- STRING:   Q6ME13
- MEROPS:   S16.002
- GeneID:   2780671
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0462
- NMPDR:   fig|264201.1.peg.462
- eggNOG:   COG0466
- HOGENOM:   HBG566281
- OMA:   LPWGNYS
- PhylomeDB:   Q6ME13
- ProtClustDB:   CLSK2459232
- BioCyc:   CPRO264201:PC0462-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 94307; Mature: 94307

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 734-734 ACT_SITE 777-777

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEEPIDALETEFENALNSLEDNQLSKINGQLPEQVHVFPLLRRPFFPGMAAPLVIEPGP
CCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCC
FYEVLKVVAKSDHKCVGLVLTRSEQAEIYKVGFSDLYQIGVLARVLRIIPMEQGGAQVIL
HHHHHHHHHCCCCCEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
NMERRIKIEKPTSETKTLKANVSYIEDDPILTTELKAYAISILSTIKELLKLNPLFKEEL
EHHHEEEEECCCCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
QIFLGHSDFTEPGKLADFAVALTTASREELQDVLETFDIRKRIDKALILLKKELDISILQ
HHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HNINQKIEATINKSQKDFFLREQLKTIKKELGIERDDKSLDREKFEARLKERVVPSDVMK
HHHCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
VITEELEKLSVLDMQSAEYSVVRGYLDWLTTIPWGIYSQENHNLEEAEKILAHDHYGLED
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
IKQRILEFIGVGKLAKGVRGSIICLVGPPGVGKTSIGKSIARALNRKFYRFSVGGMRDEA
HHHHHHHHHCCHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHH
EIKGHRRTYVGAMPGKMIQALKYCQTMNPVIMLDEVDKMGKSFQGDPASALLEVLDPEQN
HHCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCCC
AEFLDHYLDVRCNLSEVLFIVTANVLDTIPEPLKDRMDILRLSGYIMQEKLEIAKKYLIP
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RNRKEMGLKALEVSFTQEALRSIINGYARESGVRNLENLLKKILRKLAVNIVREQEEHDK
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQAKKKKSSRSKKPIAFVPTKHSITPSNLKDFLGKPVFTSDRFYERTPVGVCMGLAWTAM
HHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHC
GGATLYIESIKVAGEKTVMKLTGQAGDVMKESAEIAWSYVHSSIHKYAPGYTFFEKSQVH
CCCEEEEEEHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEE
IHIPEGATPKDGPSAGITMVTSLLSLILDTPVLDNLGMTGELTLTGRVLPIGGVKEKLVA
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCEEEEEEEEEEECCCHHHHHHH
ARRSGLKVLIFPKDNLRDYEELPEYIRKGITVHFVDHYDQVFKISFPNKHQMKLC
HHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MLEEPIDALETEFENALNSLEDNQLSKINGQLPEQVHVFPLLRRPFFPGMAAPLVIEPGP
CCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCC
FYEVLKVVAKSDHKCVGLVLTRSEQAEIYKVGFSDLYQIGVLARVLRIIPMEQGGAQVIL
HHHHHHHHHCCCCCEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
NMERRIKIEKPTSETKTLKANVSYIEDDPILTTELKAYAISILSTIKELLKLNPLFKEEL
EHHHEEEEECCCCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
QIFLGHSDFTEPGKLADFAVALTTASREELQDVLETFDIRKRIDKALILLKKELDISILQ
HHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HNINQKIEATINKSQKDFFLREQLKTIKKELGIERDDKSLDREKFEARLKERVVPSDVMK
HHHCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
VITEELEKLSVLDMQSAEYSVVRGYLDWLTTIPWGIYSQENHNLEEAEKILAHDHYGLED
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
IKQRILEFIGVGKLAKGVRGSIICLVGPPGVGKTSIGKSIARALNRKFYRFSVGGMRDEA
HHHHHHHHHCCHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHH
EIKGHRRTYVGAMPGKMIQALKYCQTMNPVIMLDEVDKMGKSFQGDPASALLEVLDPEQN
HHCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCCC
AEFLDHYLDVRCNLSEVLFIVTANVLDTIPEPLKDRMDILRLSGYIMQEKLEIAKKYLIP
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RNRKEMGLKALEVSFTQEALRSIINGYARESGVRNLENLLKKILRKLAVNIVREQEEHDK
CCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQAKKKKSSRSKKPIAFVPTKHSITPSNLKDFLGKPVFTSDRFYERTPVGVCMGLAWTAM
HHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHC
GGATLYIESIKVAGEKTVMKLTGQAGDVMKESAEIAWSYVHSSIHKYAPGYTFFEKSQVH
CCCEEEEEEHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEE
IHIPEGATPKDGPSAGITMVTSLLSLILDTPVLDNLGMTGELTLTGRVLPIGGVKEKLVA
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCEEEEEEEEEEECCCHHHHHHH
ARRSGLKVLIFPKDNLRDYEELPEYIRKGITVHFVDHYDQVFKISFPNKHQMKLC
HHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA