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The map label for this gene is kdsA

Identifier: 46445996

GI number: 46445996

Start: 488378

End: 489205

Strand: Direct

Name: kdsA

Synonym: pc0362

Alternate gene names: 46445996

Gene position: 488378-489205 (Clockwise)

Preceding gene: 46445995

Following gene: 46445997

Centisome position: 20.23

GC content: 37.68

Gene sequence:

>828_bases
ATGCGTCGAATTGTTGTTAAAGATTTTGCGATAGGTCCTAAAGAACCTCTCGTTATCATGTCTGGTCCTTGTGTAATCGA
AAGCGAAACGCACTGCTTAAAAGCTGCAGAAACGCTGAAAAATATGTTTGAAAAATATAACGTTTCTCTAATTTTTAAAT
CTAGCTACGATAAGGCTAATCGATCTGCGTATGATTCTTTTAGAGGACCCGGTCTAGAAGAAGGTCTTCGTATTTTAGAA
CGTATACAAAAAGAGTTCGGTTTAGCAGTCGTTACAGATGTTCATTCCCCTCAAGAAGCAACTACTGCTGGTTCAGTTTG
TGAAATAATTCAAATTCCAGCTTTTTTGTGTAGACAAACAGATCTTATTTTAGCTGCAGCCCAAACAGGAGCGATTGTTA
GTATTAAAAAAGGGCAATTTTTAGCTCCTTGGGATATGGAAAATGTCATCAGAAAAATGGAATCCGGTGGAAATTCTAAT
ATTATCTTAGTCGATCGCGGAACAACTTTTGGTTATAATAATCTTATCAGTGATATGCGAGGGATTCCAATTATGCAAGA
ATTGGGTTATCCTGTGTGCTTTGATGCTACGCATTCAGTGCAAAAACCTGGAGGTTTAGGTTCTAAGTCTGGTGGGGATC
GAGAATTTATTCCGATTCTAGCAAAAGCAGCATTGGCTGCGGGAGCCAATTGTTTATTTATTGAATCTCATCCAAATCCT
TCTGAGGCTAAAAGTGATGCTGCTTCTGTAATGGATTTCAAAGATCTAGATCAATTATTGCCTCAATTTAAAGAACTCTA
TGAACTTATTCAGAAGCAAGGCAAGTAG

Upstream 100 bases:

>100_bases
GAGTAATGATACAAAATCTCACATTTGATACCTCAGATTGGGTAATTCCATTAAACGATTCTAATACTTAAAGATTTTTT
ATCTCTATTAAAGGTTGAAT

Downstream 100 bases:

>100_bases
GTTAAAGCAATGTTTAAAAAAAGAAAAATTGCTCTAATAGGCATTCTAATAAATTTGATTTTAGGGGGAATTTGGTTTTA
TAGCACTCCTTCTGCGGATG

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MRRIVVKDFAIGPKEPLVIMSGPCVIESETHCLKAAETLKNMFEKYNVSLIFKSSYDKANRSAYDSFRGPGLEEGLRILE
RIQKEFGLAVVTDVHSPQEATTAGSVCEIIQIPAFLCRQTDLILAAAQTGAIVSIKKGQFLAPWDMENVIRKMESGGNSN
IILVDRGTTFGYNNLISDMRGIPIMQELGYPVCFDATHSVQKPGGLGSKSGGDREFIPILAKAALAAGANCLFIESHPNP
SEAKSDAASVMDFKDLDQLLPQFKELYELIQKQGK

Sequences:

>Translated_275_residues
MRRIVVKDFAIGPKEPLVIMSGPCVIESETHCLKAAETLKNMFEKYNVSLIFKSSYDKANRSAYDSFRGPGLEEGLRILE
RIQKEFGLAVVTDVHSPQEATTAGSVCEIIQIPAFLCRQTDLILAAAQTGAIVSIKKGQFLAPWDMENVIRKMESGGNSN
IILVDRGTTFGYNNLISDMRGIPIMQELGYPVCFDATHSVQKPGGLGSKSGGDREFIPILAKAALAAGANCLFIESHPNP
SEAKSDAASVMDFKDLDQLLPQFKELYELIQKQGK
>Mature_275_residues
MRRIVVKDFAIGPKEPLVIMSGPCVIESETHCLKAAETLKNMFEKYNVSLIFKSSYDKANRSAYDSFRGPGLEEGLRILE
RIQKEFGLAVVTDVHSPQEATTAGSVCEIIQIPAFLCRQTDLILAAAQTGAIVSIKKGQFLAPWDMENVIRKMESGGNSN
IILVDRGTTFGYNNLISDMRGIPIMQELGYPVCFDATHSVQKPGGLGSKSGGDREFIPILAKAALAAGANCLFIESHPNP
SEAKSDAASVMDFKDLDQLLPQFKELYELIQKQGK

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=272, Percent_Identity=41.1764705882353, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_PARUW (Q6MEB3)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007361.1
- ProteinModelPortal:   Q6MEB3
- SMR:   Q6MEB3
- STRING:   Q6MEB3
- GeneID:   2780542
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0362
- NMPDR:   fig|264201.1.peg.362
- eggNOG:   COG2877
- HOGENOM:   HBG575990
- OMA:   YEAAQKN
- PhylomeDB:   Q6MEB3
- ProtClustDB:   PRK05198
- BioCyc:   CPRO264201:PC0362-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 30089; Mature: 30089

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIVVKDFAIGPKEPLVIMSGPCVIESETHCLKAAETLKNMFEKYNVSLIFKSSYDKAN
CCEEEEECCCCCCCCCEEEEECCEEECCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCH
RSAYDSFRGPGLEEGLRILERIQKEFGLAVVTDVHSPQEATTAGSVCEIIQIPAFLCRQT
HHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
DLILAAAQTGAIVSIKKGQFLAPWDMENVIRKMESGGNSNIILVDRGTTFGYNNLISDMR
HHEEEEECCCCEEEECCCCEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHC
GIPIMQELGYPVCFDATHSVQKPGGLGSKSGGDREFIPILAKAALAAGANCLFIESHPNP
CCCHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCH
SEAKSDAASVMDFKDLDQLLPQFKELYELIQKQGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRIVVKDFAIGPKEPLVIMSGPCVIESETHCLKAAETLKNMFEKYNVSLIFKSSYDKAN
CCEEEEECCCCCCCCCEEEEECCEEECCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCH
RSAYDSFRGPGLEEGLRILERIQKEFGLAVVTDVHSPQEATTAGSVCEIIQIPAFLCRQT
HHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
DLILAAAQTGAIVSIKKGQFLAPWDMENVIRKMESGGNSNIILVDRGTTFGYNNLISDMR
HHEEEEECCCCEEEECCCCEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHC
GIPIMQELGYPVCFDATHSVQKPGGLGSKSGGDREFIPILAKAALAAGANCLFIESHPNP
CCCHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCH
SEAKSDAASVMDFKDLDQLLPQFKELYELIQKQGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA