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The map label for this gene is folK [H]

Identifier: 46445995

GI number: 46445995

Start: 487833

End: 488348

Strand: Direct

Name: folK [H]

Synonym: pc0361

Alternate gene names: 46445995

Gene position: 487833-488348 (Clockwise)

Preceding gene: 46445991

Following gene: 46445996

Centisome position: 20.2

GC content: 32.75

Gene sequence:

>516_bases
TTGTTGCAAATCGTTTATTTAGGAATTGGGGGCAATCAAGAGGAAACTTTAAAAGCCATAGAAAAAGCTCTTAATGAACT
TGCTCTATTTTCAGAAGAAGCCCTTGAAATTTCGAAATTATATAAAACCTCACCCGTTGGAGATAAAAATCAAAACAATT
TCACTAATTTAGTTTGCCGATTGCACACTTCATTTGATCCGAAGCTTTTACTAAAAAAAATTGAATTGCTTGAAAAGAAA
ATAGGTAAAACACCTAAACCGAAGTGGGCTTCCCGCCTCATTGATATCGATATCCTTTTTTATGGAAATATCATTTATTC
TGATGAAGCATTGCAAATTCCTCATCCACATTGGCAAGAAAGATTATTTGTTTTGATTCCTCTGCTGGATTTAACTCCAA
CAATTTCTATTCGTGAAGGTGAACAATCGAAAAATTACGATTTGAGAGTAATGATACAAAATCTCACATTTGATACCTCA
GATTGGGTAATTCCATTAAACGATTCTAATACTTAA

Upstream 100 bases:

>100_bases
ACAATATTATGTGAATTGATTGACCTAAGTTTAATCCAGGAGATTTTAGTTGAGGGATATCAGCTAGAGAATAATTTGAA
ACTTAGAAAAGCAGGGACTA

Downstream 100 bases:

>100_bases
AGATTTTTTATCTCTATTAAAGGTTGAATATGCGTCGAATTGTTGTTAAAGATTTTGCGATAGGTCCTAAAGAACCTCTC
GTTATCATGTCTGGTCCTTG

Product: putative multifunctional folic acid synthesis protein

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MLQIVYLGIGGNQEETLKAIEKALNELALFSEEALEISKLYKTSPVGDKNQNNFTNLVCRLHTSFDPKLLLKKIELLEKK
IGKTPKPKWASRLIDIDILFYGNIIYSDEALQIPHPHWQERLFVLIPLLDLTPTISIREGEQSKNYDLRVMIQNLTFDTS
DWVIPLNDSNT

Sequences:

>Translated_171_residues
MLQIVYLGIGGNQEETLKAIEKALNELALFSEEALEISKLYKTSPVGDKNQNNFTNLVCRLHTSFDPKLLLKKIELLEKK
IGKTPKPKWASRLIDIDILFYGNIIYSDEALQIPHPHWQERLFVLIPLLDLTPTISIREGEQSKNYDLRVMIQNLTFDTS
DWVIPLNDSNT
>Mature_171_residues
MLQIVYLGIGGNQEETLKAIEKALNELALFSEEALEISKLYKTSPVGDKNQNNFTNLVCRLHTSFDPKLLLKKIELLEKK
IGKTPKPKWASRLIDIDILFYGNIIYSDEALQIPHPHWQERLFVLIPLLDLTPTISIREGEQSKNYDLRVMIQNLTFDTS
DWVIPLNDSNT

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=159, Percent_Identity=30.8176100628931, Blast_Score=89, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19652; Mature: 19652

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQIVYLGIGGNQEETLKAIEKALNELALFSEEALEISKLYKTSPVGDKNQNNFTNLVCR
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
LHTSFDPKLLLKKIELLEKKIGKTPKPKWASRLIDIDILFYGNIIYSDEALQIPHPHWQE
EECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEEEEECCEEECCCEEECCCCCHHC
RLFVLIPLLDLTPTISIREGEQSKNYDLRVMIQNLTFDTSDWVIPLNDSNT
CEEEEEECCCCCCCEEEECCCCCCCCEEEEEEEECEECCCCCEEECCCCCC
>Mature Secondary Structure
MLQIVYLGIGGNQEETLKAIEKALNELALFSEEALEISKLYKTSPVGDKNQNNFTNLVCR
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
LHTSFDPKLLLKKIELLEKKIGKTPKPKWASRLIDIDILFYGNIIYSDEALQIPHPHWQE
EECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEEEEECCEEECCCEEECCCCCHHC
RLFVLIPLLDLTPTISIREGEQSKNYDLRVMIQNLTFDTSDWVIPLNDSNT
CEEEEEECCCCCCCEEEECCCCCCCCEEEEEEEECEECCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]