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The map label for this gene is dtd

Identifier: 46445990

GI number: 46445990

Start: 482872

End: 483327

Strand: Direct

Name: dtd

Synonym: pc0356

Alternate gene names: 46445990

Gene position: 482872-483327 (Clockwise)

Preceding gene: 46445989

Following gene: 46445991

Centisome position: 20.0

GC content: 35.53

Gene sequence:

>456_bases
ATGAAGTTAGTTATTCAACGTGTGTTACAAGCGCAAGTTTATATTGATGATAACCTGTTTAGTGCAATTGGCCCTGGCTT
AATGTTATTGCTAGGAATTCACCATCAAGATAACTTAGAGCAGATTTTATGGTCTGTGGATAAGCTAGTTCATTTACGCA
TTTTTAACGATGAAAATGGAAAGATGAATAGAAATGTAAAAGAATGTGAAGGAGAAATATTAGTAGTCAGTCAATTTACT
TTATACGGAAATTGTTTAAATGGTCGAAGACCCGACTTTATCCAAGCTGCTTCTCCTCCAATAGCTCTTTCTCTTTACAG
ACAATTTATTGATGAATTAAAAAAAGAAGCTCCCCATGTCAAAACAGGACAGTTTGGGGCTCAGATGCAAGTTTCATTAA
CAAACGATGGTCCTGTTACTTTTATCCTAGAGTCATTGGATCGACGGAAAGCATAA

Upstream 100 bases:

>100_bases
TTTTGTACTCCACCTCCTCCGGAAATGGTTCGATTGATTAAAAAAATAGACCCTAAATCTCCATATATTCGAGATGTTGA
ATAGGAGAGATAGATATGAG

Downstream 100 bases:

>100_bases
TTTAAAAATTTTTTGCTTTTTATCTACCATTTCACTTGTTTAACAAGTGAATAAATGCTTATAAAATATTTTATATAGAG
AAAGTAAAATAAAAAAAAAC

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MKLVIQRVLQAQVYIDDNLFSAIGPGLMLLLGIHHQDNLEQILWSVDKLVHLRIFNDENGKMNRNVKECEGEILVVSQFT
LYGNCLNGRRPDFIQAASPPIALSLYRQFIDELKKEAPHVKTGQFGAQMQVSLTNDGPVTFILESLDRRKA

Sequences:

>Translated_151_residues
MKLVIQRVLQAQVYIDDNLFSAIGPGLMLLLGIHHQDNLEQILWSVDKLVHLRIFNDENGKMNRNVKECEGEILVVSQFT
LYGNCLNGRRPDFIQAASPPIALSLYRQFIDELKKEAPHVKTGQFGAQMQVSLTNDGPVTFILESLDRRKA
>Mature_151_residues
MKLVIQRVLQAQVYIDDNLFSAIGPGLMLLLGIHHQDNLEQILWSVDKLVHLRIFNDENGKMNRNVKECEGEILVVSQFT
LYGNCLNGRRPDFIQAASPPIALSLYRQFIDELKKEAPHVKTGQFGAQMQVSLTNDGPVTFILESLDRRKA

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=149, Percent_Identity=44.9664429530201, Blast_Score=109, Evalue=9e-25,
Organism=Escherichia coli, GI1790320, Length=144, Percent_Identity=43.0555555555556, Blast_Score=127, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI115533292, Length=151, Percent_Identity=37.7483443708609, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=45.945945945946, Blast_Score=123, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281361569, Length=151, Percent_Identity=44.3708609271523, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_PARUW (Q6MEB9)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007355.1
- ProteinModelPortal:   Q6MEB9
- SMR:   Q6MEB9
- STRING:   Q6MEB9
- GeneID:   2780697
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0356
- NMPDR:   fig|264201.1.peg.356
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q6MEB9
- ProtClustDB:   PRK05273
- BioCyc:   CPRO264201:PC0356-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 17118; Mature: 17118

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVIQRVLQAQVYIDDNLFSAIGPGLMLLLGIHHQDNLEQILWSVDKLVHLRIFNDENG
CHHHHHHHHHHHEEECCCHHHHHCHHHEEHEECCCCCCHHHHHHHHHHEEEEEEEECCCC
KMNRNVKECEGEILVVSQFTLYGNCLNGRRPDFIQAASPPIALSLYRQFIDELKKEAPHV
CCCCCHHHCCCCEEEEEEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCC
KTGQFGAQMQVSLTNDGPVTFILESLDRRKA
CCCCCCCEEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKLVIQRVLQAQVYIDDNLFSAIGPGLMLLLGIHHQDNLEQILWSVDKLVHLRIFNDENG
CHHHHHHHHHHHEEECCCHHHHHCHHHEEHEECCCCCCHHHHHHHHHHEEEEEEEECCCC
KMNRNVKECEGEILVVSQFTLYGNCLNGRRPDFIQAASPPIALSLYRQFIDELKKEAPHV
CCCCCHHHCCCCEEEEEEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCC
KTGQFGAQMQVSLTNDGPVTFILESLDRRKA
CCCCCCCEEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA