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The map label for this gene is pgd [H]

Identifier: 46445951

GI number: 46445951

Start: 435659

End: 437113

Strand: Direct

Name: pgd [H]

Synonym: pc0317

Alternate gene names: 46445951

Gene position: 435659-437113 (Clockwise)

Preceding gene: 46445950

Following gene: 46445957

Centisome position: 18.04

GC content: 38.56

Gene sequence:

>1455_bases
ATGCACATGACACAAGCAGATATTGGTTTAATCGGTCTAGCCGTAATGGGACAAAATCTCGTTCTTAATATGAACGATCA
TGGATACACGGTTGCTGTTTATAATAGGACAACTTCCAAGGTAGATGAATTTTTAGATGGGCCAGCAAAAGGCACAAAAG
TCATTGGGGCTCATTCATTAAAAGATTTGATTAGTCAGTTGAAACGGCCACGCCGTGTGATGCTAATGGTTAAAGCAGGT
GAACCTGTCGATAATTTTATTGAGCAATGTCTTCCTTATCTTGAAAAAGGTGACATACTTATCGATGGAGGAAATAGCTT
ATTTACAGACACAAATCGCCGTTGTAATAGTTTGAAAGAAAAAGGAATTATTTTTATTGGAACGGGAATTTCTGGAGGAG
AGGAGGGAGCTCGTCATGGTCCTTCTATTATGCCTGGAGGAAATCCTGAGGGATGGCCACATATTAAAGAAATTTTTCAA
TCCATCAGTGCTAAAGTTGAAGGGGAACCTTGTTGTGATTGGGTAGGCGATCAAGGAGCTGGGCATTACGTTAAAATGGT
TCATAATGGGATCGAATATGGCGACATGCAGCTGATTTCAGAAGCTTATTATTTGTTGAAAGAAGCTCTTCATCTTAATC
AAAACGAATTATATCAGGTGTTTGCAGATTGGAATAAAGGAGATTTGGATAGCTATTTAATCGAAATCACTTCGAAAATA
TTTAAAGTGAATGATGAAGACGGAAAACCACTTGTAGATAAAATTTTAGACGTTGCAGGTCAAAAAGGCACAGGAAAATG
GACAGTGATTAATGCATTGGATTTAGGAATGCCTTTAACATTAATTGGAGAGGCAGTTTTTGCAAGATGTTTGTCTGCTT
TAAAAGATGAACGGGTAGCTGCAAGCGAGTTATTGAAAGGGCCTGATGCCAAATTTGAAGGAAATAGGGAAGAGTTTATT
CAAGCAATTCGAGAAGCTCTTTATTCCTCAAAAATCATTAGTTATACTCAAGGTTTTATGTTAATGCAACAAGCGGCAGC
AGAATATAAATGGCAGCTTAATTATGGGGCAATTGCCTTAATGTGGCGTGGTGGATGTATTATCCGCAGTCAATTTTTGG
GCAAAATTAAAGAAGCATTTAAACTAAATCCAAACCTCAAGAGTTTACTTCTTGATGAATACTTTCTTCAAGAAATTCAA
AAGCGGCAAAAAGGGTGGAGAAAAGTCGTTTCTAAATCAGTTGAGCTTGGAATTGCCACTCCTTGTTTTAATACTGCCTT
GGTGTTTTACGATGGTTATCGCACAGCAAAATTACCTGCCAATCTCTTACAAGCTCAAAGAGATTTCTTTGGGGCTCATA
CCTATGAACGAGGAGATCGGGCTCGAGGACAATATTTTCATACAGATTGGTCAGGCACCGGTGGAAAGGTGAGTTCAGGT
TCGTACAACGCTTAA

Upstream 100 bases:

>100_bases
CCTCTATCACTTTTATTAAATAGAATTGGATGGCAAAAAACATTATCTTTTTAATCTTTTATTATTCAAAATCCGCATTA
ATAACCTCTTAACGAAGGAC

Downstream 100 bases:

>100_bases
TCCTATGAATTTTAGCTAGGAATGTTTCCTATACAGCCATTGTCAGACCATTGTTTGAGAGCTTCAATTTTGTGTCTGAC
GACTGTTGTCAATTCTTGGC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MHMTQADIGLIGLAVMGQNLVLNMNDHGYTVAVYNRTTSKVDEFLDGPAKGTKVIGAHSLKDLISQLKRPRRVMLMVKAG
EPVDNFIEQCLPYLEKGDILIDGGNSLFTDTNRRCNSLKEKGIIFIGTGISGGEEGARHGPSIMPGGNPEGWPHIKEIFQ
SISAKVEGEPCCDWVGDQGAGHYVKMVHNGIEYGDMQLISEAYYLLKEALHLNQNELYQVFADWNKGDLDSYLIEITSKI
FKVNDEDGKPLVDKILDVAGQKGTGKWTVINALDLGMPLTLIGEAVFARCLSALKDERVAASELLKGPDAKFEGNREEFI
QAIREALYSSKIISYTQGFMLMQQAAAEYKWQLNYGAIALMWRGGCIIRSQFLGKIKEAFKLNPNLKSLLLDEYFLQEIQ
KRQKGWRKVVSKSVELGIATPCFNTALVFYDGYRTAKLPANLLQAQRDFFGAHTYERGDRARGQYFHTDWSGTGGKVSSG
SYNA

Sequences:

>Translated_484_residues
MHMTQADIGLIGLAVMGQNLVLNMNDHGYTVAVYNRTTSKVDEFLDGPAKGTKVIGAHSLKDLISQLKRPRRVMLMVKAG
EPVDNFIEQCLPYLEKGDILIDGGNSLFTDTNRRCNSLKEKGIIFIGTGISGGEEGARHGPSIMPGGNPEGWPHIKEIFQ
SISAKVEGEPCCDWVGDQGAGHYVKMVHNGIEYGDMQLISEAYYLLKEALHLNQNELYQVFADWNKGDLDSYLIEITSKI
FKVNDEDGKPLVDKILDVAGQKGTGKWTVINALDLGMPLTLIGEAVFARCLSALKDERVAASELLKGPDAKFEGNREEFI
QAIREALYSSKIISYTQGFMLMQQAAAEYKWQLNYGAIALMWRGGCIIRSQFLGKIKEAFKLNPNLKSLLLDEYFLQEIQ
KRQKGWRKVVSKSVELGIATPCFNTALVFYDGYRTAKLPANLLQAQRDFFGAHTYERGDRARGQYFHTDWSGTGGKVSSG
SYNA
>Mature_484_residues
MHMTQADIGLIGLAVMGQNLVLNMNDHGYTVAVYNRTTSKVDEFLDGPAKGTKVIGAHSLKDLISQLKRPRRVMLMVKAG
EPVDNFIEQCLPYLEKGDILIDGGNSLFTDTNRRCNSLKEKGIIFIGTGISGGEEGARHGPSIMPGGNPEGWPHIKEIFQ
SISAKVEGEPCCDWVGDQGAGHYVKMVHNGIEYGDMQLISEAYYLLKEALHLNQNELYQVFADWNKGDLDSYLIEITSKI
FKVNDEDGKPLVDKILDVAGQKGTGKWTVINALDLGMPLTLIGEAVFARCLSALKDERVAASELLKGPDAKFEGNREEFI
QAIREALYSSKIISYTQGFMLMQQAAAEYKWQLNYGAIALMWRGGCIIRSQFLGKIKEAFKLNPNLKSLLLDEYFLQEIQ
KRQKGWRKVVSKSVELGIATPCFNTALVFYDGYRTAKLPANLLQAQRDFFGAHTYERGDRARGQYFHTDWSGTGGKVSSG
SYNA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=484, Percent_Identity=66.5289256198347, Blast_Score=667, Evalue=0.0,
Organism=Escherichia coli, GI1788341, Length=469, Percent_Identity=54.5842217484009, Blast_Score=525, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17542558, Length=485, Percent_Identity=61.8556701030928, Blast_Score=652, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321695, Length=492, Percent_Identity=59.9593495934959, Blast_Score=635, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321977, Length=488, Percent_Identity=63.1147540983607, Blast_Score=625, Evalue=1e-180,
Organism=Drosophila melanogaster, GI24639279, Length=481, Percent_Identity=61.954261954262, Blast_Score=605, Evalue=1e-173,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53791; Mature: 53791

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHMTQADIGLIGLAVMGQNLVLNMNDHGYTVAVYNRTTSKVDEFLDGPAKGTKVIGAHSL
CCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHCCCCCCCEEECHHHH
KDLISQLKRPRRVMLMVKAGEPVDNFIEQCLPYLEKGDILIDGGNSLFTDTNRRCNSLKE
HHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHH
KGIIFIGTGISGGEEGARHGPSIMPGGNPEGWPHIKEIFQSISAKVEGEPCCDWVGDQGA
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GHYVKMVHNGIEYGDMQLISEAYYLLKEALHLNQNELYQVFADWNKGDLDSYLIEITSKI
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
FKVNDEDGKPLVDKILDVAGQKGTGKWTVINALDLGMPLTLIGEAVFARCLSALKDERVA
HCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ASELLKGPDAKFEGNREEFIQAIREALYSSKIISYTQGFMLMQQAAAEYKWQLNYGAIAL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEE
MWRGGCIIRSQFLGKIKEAFKLNPNLKSLLLDEYFLQEIQKRQKGWRKVVSKSVELGIAT
EECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEC
PCFNTALVFYDGYRTAKLPANLLQAQRDFFGAHTYERGDRARGQYFHTDWSGTGGKVSSG
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
SYNA
CCCC
>Mature Secondary Structure
MHMTQADIGLIGLAVMGQNLVLNMNDHGYTVAVYNRTTSKVDEFLDGPAKGTKVIGAHSL
CCCCCHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHCCCCCCCEEECHHHH
KDLISQLKRPRRVMLMVKAGEPVDNFIEQCLPYLEKGDILIDGGNSLFTDTNRRCNSLKE
HHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHH
KGIIFIGTGISGGEEGARHGPSIMPGGNPEGWPHIKEIFQSISAKVEGEPCCDWVGDQGA
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GHYVKMVHNGIEYGDMQLISEAYYLLKEALHLNQNELYQVFADWNKGDLDSYLIEITSKI
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
FKVNDEDGKPLVDKILDVAGQKGTGKWTVINALDLGMPLTLIGEAVFARCLSALKDERVA
HCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ASELLKGPDAKFEGNREEFIQAIREALYSSKIISYTQGFMLMQQAAAEYKWQLNYGAIAL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEE
MWRGGCIIRSQFLGKIKEAFKLNPNLKSLLLDEYFLQEIQKRQKGWRKVVSKSVELGIAT
EECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEC
PCFNTALVFYDGYRTAKLPANLLQAQRDFFGAHTYERGDRARGQYFHTDWSGTGGKVSSG
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
SYNA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]