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The map label for this gene is pbp2 [H]

Identifier: 46445947

GI number: 46445947

Start: 429696

End: 431726

Strand: Direct

Name: pbp2 [H]

Synonym: pc0313

Alternate gene names: 46445947

Gene position: 429696-431726 (Clockwise)

Preceding gene: 46445946

Following gene: 46445948

Centisome position: 17.8

GC content: 37.08

Gene sequence:

>2031_bases
ATGACTTTAAAAAAAATTCCCAACTCTTCTGAAAAAAGGCGCCTTCTTTATGTGGCGCTATTTATTTTTATTTTGTTTTC
TTTTCTAATTATTCAATTTTACCATATTCAAATTTTAGAAGGAAAAAAGTGGGCTATTCAGGCTCAAAAGCAGCATTTTT
TTATTGTTAAAGAACCTTTTATTAGAGGAAGTTTTTATTCTAATCCCTTTATTAAAAAAAATCATCCCGCTATTCCACAA
CCCTTTGTGATCGATGTTCCAAAATTTCATTTATATGCTGATCCAGAATCAATTCCGATTCCGCTAAAAGAGGAAATCGC
CGACCATTTAATGGCTTTTCTTGATATTTCAATTTCTGAAAAATTCCATTTACAAAAGCAGTTAGACAAATCAAGTCGGA
GTCGAAAATTGGCTATGTGGCTCGATAAAGAAACGCATCAAAATTTGCTTAAATGGTGGCAAGGATACGCTAAAATACAT
AAAATTCCTCGGAATGCTCTTTTTTTCATTAAAGATTATCAACGTTCGTATCCTTATGGGAAAGTTTTAGGTAATGTTTT
ACATACTATCCAAAACCAAAAAGATGAAAAAACTCGCCAAGCGCTTCCAACAGGAGGTTTAGAACTTTTTTTTAATTCCT
ATCTGCAGGGAAAACAAGGAAAAAGACGTTTAATGCGCTCTCCTCGAAATTCTTTAGAAACAGGGGAAGTTATTGATTAT
CCGGAACACGGTGCGGATATTTACTTAACAATTAATTCTTGCTTACAAGCTATTGCAGAAGAAGAAGTGGAAAAAGGTGT
CAAAAGATGTAAAGCCAAAGGGGGCTGGGCTGCGATGATGGATCCTCGCACCGGGGAAATTCTTGCTTTAGCTCAATATC
CGTTTTTTAATCCTCCTGATTACCAACAGTTTTTTAATGATCCTCAACTCATTGAACATACGAAAGTGAAAGCTGTAACA
GATGCAAATGAGCCTGGATCAATCTTCAAACCTTTTACAATCGCTTTAGCTTTAAAAGCCAATCAAGTATTAAGACAAAA
AGGAGAAAAAGAGCTTTTTTTTCCCGAAGAAAAAATAGCAACCAGTAACGGTCGTTTTCCTGGGCGATCTAAGCCTATTT
CAGACACGCGAGTACATTACTTTTTGAATATGGATATGGGAATGCAAAAATCGTCAAACATCTATATGGGTCGATTAGCA
GAAAAGATCGTGGGTAGACTTGGCAATGAGTGGTACCGCAGACAACTTCAACAATTATTTGGATTTGGTCAAAAAACTTT
TATCGAGCTACCTGCGGAAAGTCCTGGGATTTTACCTACACCGGGGAAGTATCATCCAAGTGGAGCTTTGGAATGGTCTT
TACCTACTCCTTTTTCATTAGCAATAGGGCATAATATTCAAGTCAATAGCATTCAAATTCTTCGAGCTTATTCTGTGTTG
GCAAATGGGGGATTTCTAGTCAAACCTACGATCATTCGACAAATTGTTAAAAAAGATCGTAATGCTCAAACGCAAATTTT
AGTCGATCACACAAAGAAAGAACGAATTGCACAATTTCCGCGAGTATTAGAAGAGGATATTGTTAAACGAGTTGTCCAAT
CTATGCGTTATGTGACAAAGCCTGGAGGGACAGCTATCAAAGCAGATGTGCCTGGTTATACGGAAGTATGTAAAACTAGT
ACTGCCAAGAAAATCATTGATGGTGTTTATTCGGAGCGTTTATATTGCCCTACTCTTGCTGGTTTTACTCCTGCTGTACA
CCCTGCTTTTGTTTTAGTTGTGACGATGGATGAGCCAGAATATGGTTACATTCCAGGAGTGGGAAAAAATCATAATGGAG
GTAATTGCACAGCAAATGTTTTCCGAGAAATTGCAACGCGTTCTCTTGCTTATCTTGGAATTCCTCCAGATGATCCTTAC
GGCTATCCTTATGGAGATCCAAGAAGCAATCCGGAAAAGGCCAGTTGGATGAATGAAACGAGAAGATTGCAAGAAATATA
TAAGAAATGGAATAACATCTCCGAAAATTAG

Upstream 100 bases:

>100_bases
GAGTTGGCCAATAAACCGGAATTTGGACATCTGAAATACCCTCCCTTAACCGATGTTCTATTGATCCCTGAAGAAAGTAT
TATAGAAATTCATTAATAAC

Downstream 100 bases:

>100_bases
GGCATAGCGTTTAAAATGAAGTTAAAAGAATTGTTTAGAAACATTGAATCCTGCCAGTTTAAAGGCTCCCAAGAAGTGTT
GTTGACTGGATTGACAGCTA

Product: putative penicillin-binding protein 2 (transglycolase/transpeptidase)

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MTLKKIPNSSEKRRLLYVALFIFILFSFLIIQFYHIQILEGKKWAIQAQKQHFFIVKEPFIRGSFYSNPFIKKNHPAIPQ
PFVIDVPKFHLYADPESIPIPLKEEIADHLMAFLDISISEKFHLQKQLDKSSRSRKLAMWLDKETHQNLLKWWQGYAKIH
KIPRNALFFIKDYQRSYPYGKVLGNVLHTIQNQKDEKTRQALPTGGLELFFNSYLQGKQGKRRLMRSPRNSLETGEVIDY
PEHGADIYLTINSCLQAIAEEEVEKGVKRCKAKGGWAAMMDPRTGEILALAQYPFFNPPDYQQFFNDPQLIEHTKVKAVT
DANEPGSIFKPFTIALALKANQVLRQKGEKELFFPEEKIATSNGRFPGRSKPISDTRVHYFLNMDMGMQKSSNIYMGRLA
EKIVGRLGNEWYRRQLQQLFGFGQKTFIELPAESPGILPTPGKYHPSGALEWSLPTPFSLAIGHNIQVNSIQILRAYSVL
ANGGFLVKPTIIRQIVKKDRNAQTQILVDHTKKERIAQFPRVLEEDIVKRVVQSMRYVTKPGGTAIKADVPGYTEVCKTS
TAKKIIDGVYSERLYCPTLAGFTPAVHPAFVLVVTMDEPEYGYIPGVGKNHNGGNCTANVFREIATRSLAYLGIPPDDPY
GYPYGDPRSNPEKASWMNETRRLQEIYKKWNNISEN

Sequences:

>Translated_676_residues
MTLKKIPNSSEKRRLLYVALFIFILFSFLIIQFYHIQILEGKKWAIQAQKQHFFIVKEPFIRGSFYSNPFIKKNHPAIPQ
PFVIDVPKFHLYADPESIPIPLKEEIADHLMAFLDISISEKFHLQKQLDKSSRSRKLAMWLDKETHQNLLKWWQGYAKIH
KIPRNALFFIKDYQRSYPYGKVLGNVLHTIQNQKDEKTRQALPTGGLELFFNSYLQGKQGKRRLMRSPRNSLETGEVIDY
PEHGADIYLTINSCLQAIAEEEVEKGVKRCKAKGGWAAMMDPRTGEILALAQYPFFNPPDYQQFFNDPQLIEHTKVKAVT
DANEPGSIFKPFTIALALKANQVLRQKGEKELFFPEEKIATSNGRFPGRSKPISDTRVHYFLNMDMGMQKSSNIYMGRLA
EKIVGRLGNEWYRRQLQQLFGFGQKTFIELPAESPGILPTPGKYHPSGALEWSLPTPFSLAIGHNIQVNSIQILRAYSVL
ANGGFLVKPTIIRQIVKKDRNAQTQILVDHTKKERIAQFPRVLEEDIVKRVVQSMRYVTKPGGTAIKADVPGYTEVCKTS
TAKKIIDGVYSERLYCPTLAGFTPAVHPAFVLVVTMDEPEYGYIPGVGKNHNGGNCTANVFREIATRSLAYLGIPPDDPY
GYPYGDPRSNPEKASWMNETRRLQEIYKKWNNISEN
>Mature_675_residues
TLKKIPNSSEKRRLLYVALFIFILFSFLIIQFYHIQILEGKKWAIQAQKQHFFIVKEPFIRGSFYSNPFIKKNHPAIPQP
FVIDVPKFHLYADPESIPIPLKEEIADHLMAFLDISISEKFHLQKQLDKSSRSRKLAMWLDKETHQNLLKWWQGYAKIHK
IPRNALFFIKDYQRSYPYGKVLGNVLHTIQNQKDEKTRQALPTGGLELFFNSYLQGKQGKRRLMRSPRNSLETGEVIDYP
EHGADIYLTINSCLQAIAEEEVEKGVKRCKAKGGWAAMMDPRTGEILALAQYPFFNPPDYQQFFNDPQLIEHTKVKAVTD
ANEPGSIFKPFTIALALKANQVLRQKGEKELFFPEEKIATSNGRFPGRSKPISDTRVHYFLNMDMGMQKSSNIYMGRLAE
KIVGRLGNEWYRRQLQQLFGFGQKTFIELPAESPGILPTPGKYHPSGALEWSLPTPFSLAIGHNIQVNSIQILRAYSVLA
NGGFLVKPTIIRQIVKKDRNAQTQILVDHTKKERIAQFPRVLEEDIVKRVVQSMRYVTKPGGTAIKADVPGYTEVCKTST
AKKIIDGVYSERLYCPTLAGFTPAVHPAFVLVVTMDEPEYGYIPGVGKNHNGGNCTANVFREIATRSLAYLGIPPDDPYG
YPYGDPRSNPEKASWMNETRRLQEIYKKWNNISEN

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=562, Percent_Identity=26.5124555160142, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1786854, Length=519, Percent_Identity=23.3140655105973, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 77321; Mature: 77190

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKKIPNSSEKRRLLYVALFIFILFSFLIIQFYHIQILEGKKWAIQAQKQHFFIVKEPF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCEEEEEECCC
IRGSFYSNPFIKKNHPAIPQPFVIDVPKFHLYADPESIPIPLKEEIADHLMAFLDISISE
CCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCH
KFHLQKQLDKSSRSRKLAMWLDKETHQNLLKWWQGYAKIHKIPRNALFFIKDYQRSYPYG
HHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCHH
KVLGNVLHTIQNQKDEKTRQALPTGGLELFFNSYLQGKQGKRRLMRSPRNSLETGEVIDY
HHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEECC
PEHGADIYLTINSCLQAIAEEEVEKGVKRCKAKGGWAAMMDPRTGEILALAQYPFFNPPD
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCCC
YQQFFNDPQLIEHTKVKAVTDANEPGSIFKPFTIALALKANQVLRQKGEKELFFPEEKIA
HHHHCCCCHHHHHHHEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCHHHHC
TSNGRFPGRSKPISDTRVHYFLNMDMGMQKSSNIYMGRLAEKIVGRLGNEWYRRQLQQLF
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHH
GFGQKTFIELPAESPGILPTPGKYHPSGALEWSLPTPFSLAIGHNIQVNSIQILRAYSVL
CCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCEEECHHHHHHHHHHH
ANGGFLVKPTIIRQIVKKDRNAQTQILVDHTKKERIAQFPRVLEEDIVKRVVQSMRYVTK
HCCCEEECHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGGTAIKADVPGYTEVCKTSTAKKIIDGVYSERLYCPTLAGFTPAVHPAFVLVVTMDEPE
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEECCHHCCCCCCCCCEEEEEEEECCCC
YGYIPGVGKNHNGGNCTANVFREIATRSLAYLGIPPDDPYGYPYGDPRSNPEKASWMNET
CCCCCCCCCCCCCCCHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
RRLQEIYKKWNNISEN
HHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLKKIPNSSEKRRLLYVALFIFILFSFLIIQFYHIQILEGKKWAIQAQKQHFFIVKEPF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEECCCEEEEEECCC
IRGSFYSNPFIKKNHPAIPQPFVIDVPKFHLYADPESIPIPLKEEIADHLMAFLDISISE
CCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCH
KFHLQKQLDKSSRSRKLAMWLDKETHQNLLKWWQGYAKIHKIPRNALFFIKDYQRSYPYG
HHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCHH
KVLGNVLHTIQNQKDEKTRQALPTGGLELFFNSYLQGKQGKRRLMRSPRNSLETGEVIDY
HHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEECC
PEHGADIYLTINSCLQAIAEEEVEKGVKRCKAKGGWAAMMDPRTGEILALAQYPFFNPPD
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCCC
YQQFFNDPQLIEHTKVKAVTDANEPGSIFKPFTIALALKANQVLRQKGEKELFFPEEKIA
HHHHCCCCHHHHHHHEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCHHHHC
TSNGRFPGRSKPISDTRVHYFLNMDMGMQKSSNIYMGRLAEKIVGRLGNEWYRRQLQQLF
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHH
GFGQKTFIELPAESPGILPTPGKYHPSGALEWSLPTPFSLAIGHNIQVNSIQILRAYSVL
CCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCEEECHHHHHHHHHHH
ANGGFLVKPTIIRQIVKKDRNAQTQILVDHTKKERIAQFPRVLEEDIVKRVVQSMRYVTK
HCCCEEECHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGGTAIKADVPGYTEVCKTSTAKKIIDGVYSERLYCPTLAGFTPAVHPAFVLVVTMDEPE
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEECCHHCCCCCCCCCEEEEEEEECCCC
YGYIPGVGKNHNGGNCTANVFREIATRSLAYLGIPPDDPYGYPYGDPRSNPEKASWMNET
CCCCCCCCCCCCCCCHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
RRLQEIYKKWNNISEN
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]