Click here to switch to the map view.

The map label for this gene is dut

Identifier: 46445902

GI number: 46445902

Start: 380512

End: 380964

Strand: Reverse

Name: dut

Synonym: pc0268

Alternate gene names: 46445902

Gene position: 380964-380512 (Counterclockwise)

Preceding gene: 46445903

Following gene: 46445901

Centisome position: 15.78

GC content: 39.29

Gene sequence:

>453_bases
ATGACCCAATCTTATTCAAATACGTTGACTATTCCTACTCTAATTGAAAATGAAGAGCTACTTCCCTTCTATATGACTCC
CGAAGCAGCAGGAGCTGATGTTAAAGCCTATTTGAAAGAGTCGCTAGAGATTCCTCCTGGACAGTCTGCGTTAATTCCCA
CAGGCATGCGATTGGCTATTCCTGAAGGTTATGAAATTCAAGTTCGCCCGAGAAGTGGTTTAGCATTGAAACATCAAGTG
ACAGTTTTAAATACTCCCGGAACAATCGATGCAGACTATCGAGGAGAGATTAAAATTATTTTAATTAATCATGGAACTAA
CGCATTTATTGTTGAACCTGGAATGAGAATTGCTCAATTAGTTCTAGCTCAAGTCTTACGAGCAAATTTTGTTTTATCCG
AAGAATTAGAATCTACTCAACGAGGAGTGGGAGGATTTGGCCATACCGGTTAA

Upstream 100 bases:

>100_bases
TTTTAAAAGGAAATTTTTCTGAAGAAAATGAGCCTTCCCCCCCTCCTAAAAATTTAATTAAAAAAACTTCTCCTTTAAAA
GATAAAAATTAAGTATTTTC

Downstream 100 bases:

>100_bases
GCCTTCTGAGATTGAACATGAAAAAAAAGCCTATTTCTAACTATCTCGATTCTAATTTGGTCGTTTTTTTAAACACTCCT
ACACGCAATGAAGCTTTAAG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MTQSYSNTLTIPTLIENEELLPFYMTPEAAGADVKAYLKESLEIPPGQSALIPTGMRLAIPEGYEIQVRPRSGLALKHQV
TVLNTPGTIDADYRGEIKIILINHGTNAFIVEPGMRIAQLVLAQVLRANFVLSEELESTQRGVGGFGHTG

Sequences:

>Translated_150_residues
MTQSYSNTLTIPTLIENEELLPFYMTPEAAGADVKAYLKESLEIPPGQSALIPTGMRLAIPEGYEIQVRPRSGLALKHQV
TVLNTPGTIDADYRGEIKIILINHGTNAFIVEPGMRIAQLVLAQVLRANFVLSEELESTQRGVGGFGHTG
>Mature_149_residues
TQSYSNTLTIPTLIENEELLPFYMTPEAAGADVKAYLKESLEIPPGQSALIPTGMRLAIPEGYEIQVRPRSGLALKHQVT
VLNTPGTIDADYRGEIKIILINHGTNAFIVEPGMRIAQLVLAQVLRANFVLSEELESTQRGVGGFGHTG

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI70906444, Length=129, Percent_Identity=40.3100775193798, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI4503423, Length=129, Percent_Identity=40.3100775193798, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI70906441, Length=129, Percent_Identity=40.3100775193798, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1790071, Length=131, Percent_Identity=41.9847328244275, Blast_Score=117, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71988561, Length=149, Percent_Identity=44.9664429530201, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319729, Length=151, Percent_Identity=34.4370860927152, Blast_Score=92, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583610, Length=142, Percent_Identity=36.6197183098592, Blast_Score=93, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19921126, Length=142, Percent_Identity=36.6197183098592, Blast_Score=93, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_PARUW (Q6MEK7)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007267.1
- ProteinModelPortal:   Q6MEK7
- SMR:   Q6MEK7
- STRING:   Q6MEK7
- GeneID:   2779452
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0268
- NMPDR:   fig|264201.1.peg.268
- eggNOG:   COG0756
- HOGENOM:   HBG436079
- OMA:   HGIALVN
- PhylomeDB:   Q6MEK7
- ProtClustDB:   CLSK2762114
- BioCyc:   CPRO264201:PC0268-MONOMER
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 16303; Mature: 16172

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: BINDING 84-84 BINDING 98-98

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSYSNTLTIPTLIENEELLPFYMTPEAAGADVKAYLKESLEIPPGQSALIPTGMRLAI
CCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCEECCCCEEEEC
PEGYEIQVRPRSGLALKHQVTVLNTPGTIDADYRGEIKIILINHGTNAFIVEPGMRIAQL
CCCCEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCEEEECCCHHHHHH
VLAQVLRANFVLSEELESTQRGVGGFGHTG
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TQSYSNTLTIPTLIENEELLPFYMTPEAAGADVKAYLKESLEIPPGQSALIPTGMRLAI
CCCCCCEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCEECCCCEEEEC
PEGYEIQVRPRSGLALKHQVTVLNTPGTIDADYRGEIKIILINHGTNAFIVEPGMRIAQL
CCCCEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCEEEEEEECCCCEEEECCCHHHHHH
VLAQVLRANFVLSEELESTQRGVGGFGHTG
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA