Click here to switch to the map view.

The map label for this gene is obgE

Identifier: 46445853

GI number: 46445853

Start: 311300

End: 312313

Strand: Direct

Name: obgE

Synonym: pc0219

Alternate gene names: 46445853

Gene position: 311300-312313 (Clockwise)

Preceding gene: 46445852

Following gene: 46445859

Centisome position: 12.89

GC content: 37.57

Gene sequence:

>1014_bases
ATGTTTGTTGATCGTGTAATCATTGAATTGATAGCTGGCAAAGGCGGAAATGGTGTTGTGGCATGGCGTAGAGAAAAATA
TATTCCTAAAGGTGGTCCGGCTGGAGGAAATGGGGGGCGGGGAGGTTCTGTTATTTTAGAAGCAGATACTCAAATTTCAT
CTTTGGATTGGTTTCGCCATCGTCGCATATTAAAAGCTCAGAGTGGGGGAGATGGAGGAGGGAATTGCCGCCAGGGAAAA
AATGGAACAGATTTGATTTTGAAAGTTCCTTGCGGTACTCTCCTTAAAGATGCCAAATCAGGTAAAGTCATACATGACTT
TGTAGAAGATAAAGAAAGATTTGTGCTCTGCAAAGGTGGGAGAGGAGGAAGAGGCAATGACAGCTTTAAGACTCCTACTC
ATCAAGCTCCTAATATTTGTACAGAGGGAACACTTGGTGAAATTCATCACATAGAGCTGGAGCTAAAGCTAATTGCAGAT
GTAGGATTGGTTGGTTTTCCAAATGCAGGTAAATCAACTTTGATTTCCTCATTAGCAGGATTAAGAGTGAAAGTAGCAGC
CTATCCTTTTACTACACTACAACCTAACTTGGGATTTATTGAACTAGATAATTATAAACGCATTTATATTGCTGATATTC
CAGGAATTATTGAAGGAGCTAGCCATAATCGAGGTTTGGGATTAGAGTTTCTAAGGCATATTGAAAGGACTAAACTTCTT
ATTTTTATTTTAGATGCATCAGGCATTGATGGAAGAACCCCTTCTCATGATTTTCGAATTCTCCGTGAAGAAATTGGAGC
TTATAATCCTGAATTATTAGAAAGGCCTTATCTAGTGGTATTAAATAAAATAGATACAGAAGATTCGCCTTCTCATATTC
AAGAATTTGAAAAAAACTTCTCTATTTCATCCGATATGCTTTTTAAAATTTCAGCTGTTTATGGCGAAGGTTTACAAGAG
TTAATTGAAAAAATGACACAACGTCTTTCTCAGAAAAAAGAAATCGAGTATTAG

Upstream 100 bases:

>100_bases
GATTTGAAACCTAGCTTAACTAGGTTTCAAACTTTCTTTGTTTTTTCTTCTTTATCTGTCAAATTTATATTAATTACTTA
TTGTTACTCCTAGAGGGATC

Downstream 100 bases:

>100_bases
TCCAGTTTTAGTTCTTGCTTGGTAAAAGCACAATACGAAATATTAATCTTTGCTAATTCAATAAATGGTGAAGTTTGTTT
TAAAATAAATTTTTTTTAAA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MFVDRVIIELIAGKGGNGVVAWRREKYIPKGGPAGGNGGRGGSVILEADTQISSLDWFRHRRILKAQSGGDGGGNCRQGK
NGTDLILKVPCGTLLKDAKSGKVIHDFVEDKERFVLCKGGRGGRGNDSFKTPTHQAPNICTEGTLGEIHHIELELKLIAD
VGLVGFPNAGKSTLISSLAGLRVKVAAYPFTTLQPNLGFIELDNYKRIYIADIPGIIEGASHNRGLGLEFLRHIERTKLL
IFILDASGIDGRTPSHDFRILREEIGAYNPELLERPYLVVLNKIDTEDSPSHIQEFEKNFSISSDMLFKISAVYGEGLQE
LIEKMTQRLSQKKEIEY

Sequences:

>Translated_337_residues
MFVDRVIIELIAGKGGNGVVAWRREKYIPKGGPAGGNGGRGGSVILEADTQISSLDWFRHRRILKAQSGGDGGGNCRQGK
NGTDLILKVPCGTLLKDAKSGKVIHDFVEDKERFVLCKGGRGGRGNDSFKTPTHQAPNICTEGTLGEIHHIELELKLIAD
VGLVGFPNAGKSTLISSLAGLRVKVAAYPFTTLQPNLGFIELDNYKRIYIADIPGIIEGASHNRGLGLEFLRHIERTKLL
IFILDASGIDGRTPSHDFRILREEIGAYNPELLERPYLVVLNKIDTEDSPSHIQEFEKNFSISSDMLFKISAVYGEGLQE
LIEKMTQRLSQKKEIEY
>Mature_337_residues
MFVDRVIIELIAGKGGNGVVAWRREKYIPKGGPAGGNGGRGGSVILEADTQISSLDWFRHRRILKAQSGGDGGGNCRQGK
NGTDLILKVPCGTLLKDAKSGKVIHDFVEDKERFVLCKGGRGGRGNDSFKTPTHQAPNICTEGTLGEIHHIELELKLIAD
VGLVGFPNAGKSTLISSLAGLRVKVAAYPFTTLQPNLGFIELDNYKRIYIADIPGIIEGASHNRGLGLEFLRHIERTKLL
IFILDASGIDGRTPSHDFRILREEIGAYNPELLERPYLVVLNKIDTEDSPSHIQEFEKNFSISSDMLFKISAVYGEGLQE
LIEKMTQRLSQKKEIEY

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=321, Percent_Identity=39.5638629283489, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI111955139, Length=300, Percent_Identity=35.6666666666667, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI111955063, Length=256, Percent_Identity=33.59375, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI4758796, Length=88, Percent_Identity=45.4545454545455, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789574, Length=325, Percent_Identity=43.0769230769231, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1790615, Length=175, Percent_Identity=32, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787454, Length=137, Percent_Identity=29.1970802919708, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=335, Percent_Identity=35.5223880597015, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17552324, Length=305, Percent_Identity=30.1639344262295, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=37.2881355932203, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=37.2881355932203, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=167, Percent_Identity=40.7185628742515, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=38.0952380952381, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321649, Length=138, Percent_Identity=32.6086956521739, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129375, Length=334, Percent_Identity=37.4251497005988, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24585318, Length=293, Percent_Identity=38.9078498293515, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI17981711, Length=118, Percent_Identity=41.5254237288136, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356473, Length=89, Percent_Identity=40.4494382022472, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_PARUW (Q6MEQ6)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007218.1
- HSSP:   P44681
- ProteinModelPortal:   Q6MEQ6
- SMR:   Q6MEQ6
- STRING:   Q6MEQ6
- GeneID:   2779577
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0219
- NMPDR:   fig|264201.1.peg.219
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   KFMLLEE
- ProtClustDB:   PRK12299
- BioCyc:   CPRO264201:PC0219-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 37066; Mature: 37066

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDRVIIELIAGKGGNGVVAWRREKYIPKGGPAGGNGGRGGSVILEADTQISSLDWFRH
CCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHH
RRILKAQSGGDGGGNCRQGKNGTDLILKVPCGTLLKDAKSGKVIHDFVEDKERFVLCKGG
HHHHEECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCHHHHHCCCCEEEEEECC
RGGRGNDSFKTPTHQAPNICTEGTLGEIHHIELELKLIADVGLVGFPNAGKSTLISSLAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCEEECCCCCHHHHHHHHHC
LRVKVAAYPFTTLQPNLGFIELDNYKRIYIADIPGIIEGASHNRGLGLEFLRHIERTKLL
CEEEEEECCCEECCCCCCEEEECCCCEEEEECCCCCEECCCCCCCCCHHHHHHHHHCEEE
IFILDASGIDGRTPSHDFRILREEIGAYNPELLERPYLVVLNKIDTEDSPSHIQEFEKNF
EEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHCC
SISSDMLFKISAVYGEGLQELIEKMTQRLSQKKEIEY
CCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFVDRVIIELIAGKGGNGVVAWRREKYIPKGGPAGGNGGRGGSVILEADTQISSLDWFRH
CCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHH
RRILKAQSGGDGGGNCRQGKNGTDLILKVPCGTLLKDAKSGKVIHDFVEDKERFVLCKGG
HHHHEECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCHHHHHCCCCEEEEEECC
RGGRGNDSFKTPTHQAPNICTEGTLGEIHHIELELKLIADVGLVGFPNAGKSTLISSLAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCEEECCCCCHHHHHHHHHC
LRVKVAAYPFTTLQPNLGFIELDNYKRIYIADIPGIIEGASHNRGLGLEFLRHIERTKLL
CEEEEEECCCEECCCCCCEEEECCCCEEEEECCCCCEECCCCCCCCCHHHHHHHHHCEEE
IFILDASGIDGRTPSHDFRILREEIGAYNPELLERPYLVVLNKIDTEDSPSHIQEFEKNF
EEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHCC
SISSDMLFKISAVYGEGLQELIEKMTQRLSQKKEIEY
CCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA