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The map label for this gene is yuxL [H]

Identifier: 46445859

GI number: 46445859

Start: 319680

End: 321629

Strand: Direct

Name: yuxL [H]

Synonym: pc0225

Alternate gene names: 46445859

Gene position: 319680-321629 (Clockwise)

Preceding gene: 46445853

Following gene: 46445860

Centisome position: 13.24

GC content: 38.1

Gene sequence:

>1950_bases
ATGAGAGTTTGGAAATTAATTATTTTAGTGGGTTTGTTTGGTTGGAGTATGACAAATGCAACAATTTCATCTCAGGAGTC
GACCACTTTAATTCCAAGACATCTTCTATTTGGAAATCCTGAGAAAACAAATCCTCGATTATCTCCAAATGGTCAATATT
TGGCTTATCTAGCGCCTGATGCACAAAACGTTTTAAATGTTTGGCTAAAAAATTTAAAAACAGCAGAAAAAGACAGACAA
GTTACGACAGATAAAAAAAGAGGAATCCGCTCATTTTTATGGCAATTTGACGGGGACCATATTTTGTACGAGCAAGATAA
AGATGGGGATGAAAATTGGCATCTTTATCAAACGCATATTCAATCTAATCTTACAAGAGATTTGACTCCATACGAAGGCG
TGAAAGCTGAAATTGTGCAATACGATCCTAAATTCCCCCAAGATTTGTTAGTACAATTGAACCTGCGCAATCCTCAACTC
TTTGACGTATATCGTCTCGATTTGCAAACGAGAAATTTACAGCTTGATACGGAAAATCAGGCAAATGTCATTAGATGGGT
GGCAGATCACAATCTTTGTATTCGGATTGCTCAATCCTATAATGATGATGGATCAATGCTAATTAGAACAAGAGAGGGTA
AAGATCAATCTTGGAAAGAATTTTTGAAACTTGATGCTAGTGAAATTAACGGGGAAGTTTACGGTTTTACAGCTGATAAT
CAATCAATTTATTTAATCTCTAGTTTGCAGGGAAATACGGCAGGTCTTTTATTAGTTGATCTGACGACAGGAAAACAAAA
TTTAATTGTGGATGATCCCGTATACGATTTATCCACTTTGATGACTCACCCAACAACTTATGCTCTTGAAGCAGTAGGAT
TTGATAAGGAAAAGTTTGAATGGAAAGCTTTAGACAATGCCGTCAAAATTGATTTTTCTTTATTATCAACGAAATTAAAT
ACTCCTTTCAAGATTATTAACTCAGATCTAGCCAATCAAAAGTGGGTTGTTGCTTCTTTGTCTGATCAGCGCCCTGTTCG
TTATTATCTATATGAAAGGCAATCTAAATTTTTAACCTTTCTTTTTAGTGCTCAAAGTTCCTTGGAGAATTTCACTCTAA
GTGCCATGTCACCTATCTCCTTATCGGCAAGAGATGGAATGAAGCTTTACGGTTACCTGACTTTACCGTCTGGAAAAGAA
CCTAGAAACTTGCCAATGATTTTACTTGTTCATGGAGGTCCTTGGGCAAGGGATTCTTGGGGATTAAATCCAACTGTTCA
GTGGTTAACTAATCGCGGTTATGCTGTCGTGCAATTGAATTACAGAGGCTCAAGTGGATACGGCAAACATTATTTGAATG
CGGGAAATCGAGAGTGGTCTAAAAAAATGCACACTGATCTACTGGATGCAAAGCAATGGATGATTGACCAAGGATATGTT
GATCCTCATAAAGTAGCTATTTATGGAGGTAGTTATGGTGGGTATGCTACGCTGGTAGGGCTGGCATTTACTCCTGATGA
ATTTTGTTGTGGGGTTGATATCGTCGGCCCTTCTAACCTCGTAACTCTTTTGCAAACACTCCCTCCCTATTGGGCTCCTT
TAAAAGCAAAAATGGAGCTTCGTTTAGGGAATTTAGATACAGACGCCGAATTTTTAAAAGCATGTTCCCCTCTTTTTAAA
GTTGACCAAATTAAAAAACCTCTCTTAATCGCGCAAGGTGCCAATGATCCTCGGGTAAAGCAGTCAGAGAGTGATCAAAT
TGTTAAAGCGATGCGAGAGAAAAACTTACCTGTTGAATATTTATTATTTCCTGACGAAGGCCATGGTTTTGCAAGGCCGG
AAAATCGATTGAAATTTGCAGCTGCGGCAGAAGATTTTCTGGTGAAGTATTTAGGTGGAAGAAGTGAGCCCGCCTCTTCA
GCCGAAGATTGGAAAACTCTTAGAAAATAA

Upstream 100 bases:

>100_bases
AGATATCAAATTTCGTACTATTTTTCTTGCTTGTCAATTAGTTGAGTATAATCAAGCAAGGCAGTAGAATATTTCTCTGA
TGCAAAAAAGTAGGTTTTTT

Downstream 100 bases:

>100_bases
AGGATTTTATGAATTATTCTACATATAATAAACAAAATCCTTTTTTAGCTACGATTAGAAATCGATACCAACTATCAAAA
TCTGGATCTCAAAAAAATAC

Product: hypothetical protein

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MRVWKLIILVGLFGWSMTNATISSQESTTLIPRHLLFGNPEKTNPRLSPNGQYLAYLAPDAQNVLNVWLKNLKTAEKDRQ
VTTDKKRGIRSFLWQFDGDHILYEQDKDGDENWHLYQTHIQSNLTRDLTPYEGVKAEIVQYDPKFPQDLLVQLNLRNPQL
FDVYRLDLQTRNLQLDTENQANVIRWVADHNLCIRIAQSYNDDGSMLIRTREGKDQSWKEFLKLDASEINGEVYGFTADN
QSIYLISSLQGNTAGLLLVDLTTGKQNLIVDDPVYDLSTLMTHPTTYALEAVGFDKEKFEWKALDNAVKIDFSLLSTKLN
TPFKIINSDLANQKWVVASLSDQRPVRYYLYERQSKFLTFLFSAQSSLENFTLSAMSPISLSARDGMKLYGYLTLPSGKE
PRNLPMILLVHGGPWARDSWGLNPTVQWLTNRGYAVVQLNYRGSSGYGKHYLNAGNREWSKKMHTDLLDAKQWMIDQGYV
DPHKVAIYGGSYGGYATLVGLAFTPDEFCCGVDIVGPSNLVTLLQTLPPYWAPLKAKMELRLGNLDTDAEFLKACSPLFK
VDQIKKPLLIAQGANDPRVKQSESDQIVKAMREKNLPVEYLLFPDEGHGFARPENRLKFAAAAEDFLVKYLGGRSEPASS
AEDWKTLRK

Sequences:

>Translated_649_residues
MRVWKLIILVGLFGWSMTNATISSQESTTLIPRHLLFGNPEKTNPRLSPNGQYLAYLAPDAQNVLNVWLKNLKTAEKDRQ
VTTDKKRGIRSFLWQFDGDHILYEQDKDGDENWHLYQTHIQSNLTRDLTPYEGVKAEIVQYDPKFPQDLLVQLNLRNPQL
FDVYRLDLQTRNLQLDTENQANVIRWVADHNLCIRIAQSYNDDGSMLIRTREGKDQSWKEFLKLDASEINGEVYGFTADN
QSIYLISSLQGNTAGLLLVDLTTGKQNLIVDDPVYDLSTLMTHPTTYALEAVGFDKEKFEWKALDNAVKIDFSLLSTKLN
TPFKIINSDLANQKWVVASLSDQRPVRYYLYERQSKFLTFLFSAQSSLENFTLSAMSPISLSARDGMKLYGYLTLPSGKE
PRNLPMILLVHGGPWARDSWGLNPTVQWLTNRGYAVVQLNYRGSSGYGKHYLNAGNREWSKKMHTDLLDAKQWMIDQGYV
DPHKVAIYGGSYGGYATLVGLAFTPDEFCCGVDIVGPSNLVTLLQTLPPYWAPLKAKMELRLGNLDTDAEFLKACSPLFK
VDQIKKPLLIAQGANDPRVKQSESDQIVKAMREKNLPVEYLLFPDEGHGFARPENRLKFAAAAEDFLVKYLGGRSEPASS
AEDWKTLRK
>Mature_649_residues
MRVWKLIILVGLFGWSMTNATISSQESTTLIPRHLLFGNPEKTNPRLSPNGQYLAYLAPDAQNVLNVWLKNLKTAEKDRQ
VTTDKKRGIRSFLWQFDGDHILYEQDKDGDENWHLYQTHIQSNLTRDLTPYEGVKAEIVQYDPKFPQDLLVQLNLRNPQL
FDVYRLDLQTRNLQLDTENQANVIRWVADHNLCIRIAQSYNDDGSMLIRTREGKDQSWKEFLKLDASEINGEVYGFTADN
QSIYLISSLQGNTAGLLLVDLTTGKQNLIVDDPVYDLSTLMTHPTTYALEAVGFDKEKFEWKALDNAVKIDFSLLSTKLN
TPFKIINSDLANQKWVVASLSDQRPVRYYLYERQSKFLTFLFSAQSSLENFTLSAMSPISLSARDGMKLYGYLTLPSGKE
PRNLPMILLVHGGPWARDSWGLNPTVQWLTNRGYAVVQLNYRGSSGYGKHYLNAGNREWSKKMHTDLLDAKQWMIDQGYV
DPHKVAIYGGSYGGYATLVGLAFTPDEFCCGVDIVGPSNLVTLLQTLPPYWAPLKAKMELRLGNLDTDAEFLKACSPLFK
VDQIKKPLLIAQGANDPRVKQSESDQIVKAMREKNLPVEYLLFPDEGHGFARPENRLKFAAAAEDFLVKYLGGRSEPASS
AEDWKTLRK

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=218, Percent_Identity=28.8990825688073, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI16933540, Length=251, Percent_Identity=22.7091633466135, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI18765694, Length=220, Percent_Identity=23.6363636363636, Blast_Score=69, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144537, Length=650, Percent_Identity=36.3076923076923, Blast_Score=390, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI25144540, Length=386, Percent_Identity=42.2279792746114, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI25144543, Length=553, Percent_Identity=33.996383363472, Blast_Score=294, Evalue=9e-80,
Organism=Caenorhabditis elegans, GI17552908, Length=238, Percent_Identity=29.8319327731092, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25149159, Length=233, Percent_Identity=27.0386266094421, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24582257, Length=301, Percent_Identity=23.2558139534884, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 73707; Mature: 73707

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVWKLIILVGLFGWSMTNATISSQESTTLIPRHLLFGNPEKTNPRLSPNGQYLAYLAPD
CHHHHHHHHHHHHCCCCCCCEECCCCCCEECCHHHHCCCCCCCCCCCCCCCCEEEEECCC
AQNVLNVWLKNLKTAEKDRQVTTDKKRGIRSFLWQFDGDHILYEQDKDGDENWHLYQTHI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEH
QSNLTRDLTPYEGVKAEIVQYDPKFPQDLLVQLNLRNPQLFDVYRLDLQTRNLQLDTENQ
HHCCCCCCCCCCCCEEEEEECCCCCCHHHEEEEECCCCCEEEEEEEEEEECEEEECCCCC
ANVIRWVADHNLCIRIAQSYNDDGSMLIRTREGKDQSWKEFLKLDASEINGEVYGFTADN
CCEEEEEECCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHCCHHHCCCEEEEEECCC
QSIYLISSLQGNTAGLLLVDLTTGKQNLIVDDPVYDLSTLMTHPTTYALEAVGFDKEKFE
CEEEEEEECCCCCCEEEEEEEECCCCCEEECCCCHHHHHHHCCCCCEEEEECCCCHHHCC
WKALDNAVKIDFSLLSTKLNTPFKIINSDLANQKWVVASLSDQRPVRYYLYERQSKFLTF
HHHCCCEEEEEHHHHHHCCCCCHHHHHHCCCCCCEEEEECCCCCCEEEEEEHHCCCEEEE
LFSAQSSLENFTLSAMSPISLSARDGMKLYGYLTLPSGKEPRNLPMILLVHGGPWARDSW
EHHHHHHHHHEEEECCCCCEEECCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCC
GLNPTVQWLTNRGYAVVQLNYRGSSGYGKHYLNAGNREWSKKMHTDLLDAKQWMIDQGYV
CCCCHHHHCCCCCEEEEEEEECCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DPHKVAIYGGSYGGYATLVGLAFTPDEFCCGVDIVGPSNLVTLLQTLPPYWAPLKAKMEL
CCCEEEEEECCCCCCEEEEEEEECCCHHHCCEEEECCHHHHHHHHHCCCCCCCCEEEEEE
RLGNLDTDAEFLKACSPLFKVDQIKKPLLIAQGANDPRVKQSESDQIVKAMREKNLPVEY
EECCCCCHHHHHHHCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEE
LLFPDEGHGFARPENRLKFAAAAEDFLVKYLGGRSEPASSAEDWKTLRK
EEECCCCCCCCCCHHHEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MRVWKLIILVGLFGWSMTNATISSQESTTLIPRHLLFGNPEKTNPRLSPNGQYLAYLAPD
CHHHHHHHHHHHHCCCCCCCEECCCCCCEECCHHHHCCCCCCCCCCCCCCCCEEEEECCC
AQNVLNVWLKNLKTAEKDRQVTTDKKRGIRSFLWQFDGDHILYEQDKDGDENWHLYQTHI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEH
QSNLTRDLTPYEGVKAEIVQYDPKFPQDLLVQLNLRNPQLFDVYRLDLQTRNLQLDTENQ
HHCCCCCCCCCCCCEEEEEECCCCCCHHHEEEEECCCCCEEEEEEEEEEECEEEECCCCC
ANVIRWVADHNLCIRIAQSYNDDGSMLIRTREGKDQSWKEFLKLDASEINGEVYGFTADN
CCEEEEEECCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHCCHHHCCCEEEEEECCC
QSIYLISSLQGNTAGLLLVDLTTGKQNLIVDDPVYDLSTLMTHPTTYALEAVGFDKEKFE
CEEEEEEECCCCCCEEEEEEEECCCCCEEECCCCHHHHHHHCCCCCEEEEECCCCHHHCC
WKALDNAVKIDFSLLSTKLNTPFKIINSDLANQKWVVASLSDQRPVRYYLYERQSKFLTF
HHHCCCEEEEEHHHHHHCCCCCHHHHHHCCCCCCEEEEECCCCCCEEEEEEHHCCCEEEE
LFSAQSSLENFTLSAMSPISLSARDGMKLYGYLTLPSGKEPRNLPMILLVHGGPWARDSW
EHHHHHHHHHEEEECCCCCEEECCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCC
GLNPTVQWLTNRGYAVVQLNYRGSSGYGKHYLNAGNREWSKKMHTDLLDAKQWMIDQGYV
CCCCHHHHCCCCCEEEEEEEECCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DPHKVAIYGGSYGGYATLVGLAFTPDEFCCGVDIVGPSNLVTLLQTLPPYWAPLKAKMEL
CCCEEEEEECCCCCCEEEEEEEECCCHHHCCEEEECCHHHHHHHHHCCCCCCCCEEEEEE
RLGNLDTDAEFLKACSPLFKVDQIKKPLLIAQGANDPRVKQSESDQIVKAMREKNLPVEY
EECCCCCHHHHHHHCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEE
LLFPDEGHGFARPENRLKFAAAAEDFLVKYLGGRSEPASSAEDWKTLRK
EEECCCCCCCCCCHHHEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.6 {N-benzoyl-Arg} 0.92 {benzoyl-Lys} 0.23 {tosyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.47 {tosyl-Lys-methyl} 80 {acetyl-tyrosine} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]