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The map label for this gene is uvrB

Identifier: 46445808

GI number: 46445808

Start: 260950

End: 262971

Strand: Direct

Name: uvrB

Synonym: pc0174

Alternate gene names: 46445808

Gene position: 260950-262971 (Clockwise)

Preceding gene: 46445807

Following gene: 46445812

Centisome position: 10.81

GC content: 39.12

Gene sequence:

>2022_bases
ATGAATCCAAGCCAACTTTTTCAATTACACACAGAATTTGAACCATGCGGAGATCAACCAGAAGCCATTAATCAACTAGT
GGCAAGCATTTTGCAAAACAAACGTTCGCAAGTTCTTTTGGGAATTACAGGGTCTGGAAAAACGTTTACAATGGCGAATG
TGATTGCCAAGGTACAACGTCCAACATTAATTTTGGCTCATAATAAAACTTTAGCAGCTCAACTTTATCAAGAATTTAAG
GCTTTTTTTCCTCACAATGCGGTAGAGTATTTTGTTTCTTATTATGACTATTATCAACCGGAAGCTTACGTTCCTCGGAC
AGATACCTATATAGAAAAAGACATGTCGATTAATGACAAGATAGACAAAATGCGTTTAAGTGCGACACGCTCGCTCCTTG
AGCGTTCCGACGTAATTATTGTTTCTTCAGTTTCATGCATTTATGGCTTGGGCTCTCCAGAGTATTATCGAGGAATGAAT
TTGACACTTTCTCAAGGACAAATGCGACGACGAGATGATATTTTGCTCCATTTAGTAGAAATGCAATATAAAAGAAATGA
CTTCGAATTTATTCGATCAACGTTTCGTGTGAGAGGTGATGTACTAGATATTTTTCCAGCTTATGAAGAAGATTTAGCCA
TTCGAGTTGAAATGTTTGGGGATGAGATTGAGCAGATCAGCGAAATTGACCCCTTAACAGGTAAAGTTAAACGACGCATC
GCTTCTATTACTATTTATCCAAGTTCTCACCACGTTACGCCTGAAGAAATTCGGTTAAAAGCGATGGAAACTATTCGAGC
AGAACTTGATGAGCGAAGGCAATTTTATGAAACGGAAAAAAAATATTTAGAGTTAGAGCGAATTCAGCAACGGACAATGT
ACGATCTAGAAATGTTAAAAGAAGTGGGAACTTGTAAAGGAATCGAAAATTATTCTCGTCATTTTAGCATGCGTCAGCCA
GGTGCGCCACCCCCGTGTTTATTAGATTATTTTCCTTCAGATTATTTACTTGTTATTGATGAATCTCACCAAACACTTCC
TCAGGTCCATGCGATGTTTAATGGAGATCGCGCACGGAAGCAAACTTTGGTCGATTTTGGATTTCGGTTACCTTCTGCTT
TTGATAATCGACCTTTGCGCTTTGAAGAGGTTTACGGACGGATTCATCAAGTTGTTTATGTTTCTGCAACACCCGGTGCT
TGGGAAGTTCAAGAAGCTGGAGGGGAGATCGTCGAACAATTAATTCGACCGACAGGTCTTTTAGATCCCATCATTGAAAT
ACGTCCTGCATCTGGTCAGGTAGACGATTGTTTAGCAGAAATCCGTTCCCATGTCAGTAAAGGAGGGCGTGTTTTACTCA
CCACACTCACAAAGAAGCTTTCGGAAGAATTGACGACTTATCTCAATGATTTAAACGTGAAAGCTAAATATCTTCATTCG
GATATTGATACAATTGAACGTGTACAAATTATTCGAGATTTGCGTTTAGGGGTATTCGATGTTTTAGTAGGAATCAATCT
TTTAAGAGAAGGATTGGATATTCCTGAAGTTTCTCTTGTGGCTATTTTAGATGCCGATAAAGAGGGATTTTTGCGCAGTG
AAACTTCTTTAATTCAAACTTGCGGTCGAGCGGCGCGAAATGCAGAAGGTCGGGTGATTATGTATGCTGACAAAATCACT
AAATCTATTAAACGAACTCTAGAAATCACAGAATCTAGGCGTGCTCTACAAATGCGTTATAATGAGCAGCATGGCATTAC
ACCCCGAACGGTGAAACGGGAAATTTCTGTATTAATGGAATCTGAAGAAGATCAAGTCACTCATCCAACCAAACTGGAAG
AAGAAATTTTTAAAGCAGCAGAAGAGGCGCATCATTATTTAACCTTGGATGAAGTGCGTTTAAAAATTAAAGAATGCGAA
AAAGAAATGAAAAAAGCGGCCAAAGAATTTCGATTTGAAGAAGCCGCAGATTGGCGAGATCAGATGCGGCGTTATCAACA
AATCGAATTAACATTGGCCTGA

Upstream 100 bases:

>100_bases
TCAAGAGAGTATAGAAATATCGAAATAGATATTTTCACTTATTTTAGAAATATCTCTAATTTTTTAGAGAAGGGCCCAAG
CATAGGTATTTAAGGAAATT

Downstream 100 bases:

>100_bases
TTGGCTCAAAGATTAAGCAAGCATTTGGTTAATACTATTTGCTAAATATTGAAGCTCAGTTAGTTCTTCATTGTGCGATT
CAGGGACACCAATAATACGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 673; Mature: 673

Protein sequence:

>673_residues
MNPSQLFQLHTEFEPCGDQPEAINQLVASILQNKRSQVLLGITGSGKTFTMANVIAKVQRPTLILAHNKTLAAQLYQEFK
AFFPHNAVEYFVSYYDYYQPEAYVPRTDTYIEKDMSINDKIDKMRLSATRSLLERSDVIIVSSVSCIYGLGSPEYYRGMN
LTLSQGQMRRRDDILLHLVEMQYKRNDFEFIRSTFRVRGDVLDIFPAYEEDLAIRVEMFGDEIEQISEIDPLTGKVKRRI
ASITIYPSSHHVTPEEIRLKAMETIRAELDERRQFYETEKKYLELERIQQRTMYDLEMLKEVGTCKGIENYSRHFSMRQP
GAPPPCLLDYFPSDYLLVIDESHQTLPQVHAMFNGDRARKQTLVDFGFRLPSAFDNRPLRFEEVYGRIHQVVYVSATPGA
WEVQEAGGEIVEQLIRPTGLLDPIIEIRPASGQVDDCLAEIRSHVSKGGRVLLTTLTKKLSEELTTYLNDLNVKAKYLHS
DIDTIERVQIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSETSLIQTCGRAARNAEGRVIMYADKIT
KSIKRTLEITESRRALQMRYNEQHGITPRTVKREISVLMESEEDQVTHPTKLEEEIFKAAEEAHHYLTLDEVRLKIKECE
KEMKKAAKEFRFEEAADWRDQMRRYQQIELTLA

Sequences:

>Translated_673_residues
MNPSQLFQLHTEFEPCGDQPEAINQLVASILQNKRSQVLLGITGSGKTFTMANVIAKVQRPTLILAHNKTLAAQLYQEFK
AFFPHNAVEYFVSYYDYYQPEAYVPRTDTYIEKDMSINDKIDKMRLSATRSLLERSDVIIVSSVSCIYGLGSPEYYRGMN
LTLSQGQMRRRDDILLHLVEMQYKRNDFEFIRSTFRVRGDVLDIFPAYEEDLAIRVEMFGDEIEQISEIDPLTGKVKRRI
ASITIYPSSHHVTPEEIRLKAMETIRAELDERRQFYETEKKYLELERIQQRTMYDLEMLKEVGTCKGIENYSRHFSMRQP
GAPPPCLLDYFPSDYLLVIDESHQTLPQVHAMFNGDRARKQTLVDFGFRLPSAFDNRPLRFEEVYGRIHQVVYVSATPGA
WEVQEAGGEIVEQLIRPTGLLDPIIEIRPASGQVDDCLAEIRSHVSKGGRVLLTTLTKKLSEELTTYLNDLNVKAKYLHS
DIDTIERVQIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSETSLIQTCGRAARNAEGRVIMYADKIT
KSIKRTLEITESRRALQMRYNEQHGITPRTVKREISVLMESEEDQVTHPTKLEEEIFKAAEEAHHYLTLDEVRLKIKECE
KEMKKAAKEFRFEEAADWRDQMRRYQQIELTLA
>Mature_673_residues
MNPSQLFQLHTEFEPCGDQPEAINQLVASILQNKRSQVLLGITGSGKTFTMANVIAKVQRPTLILAHNKTLAAQLYQEFK
AFFPHNAVEYFVSYYDYYQPEAYVPRTDTYIEKDMSINDKIDKMRLSATRSLLERSDVIIVSSVSCIYGLGSPEYYRGMN
LTLSQGQMRRRDDILLHLVEMQYKRNDFEFIRSTFRVRGDVLDIFPAYEEDLAIRVEMFGDEIEQISEIDPLTGKVKRRI
ASITIYPSSHHVTPEEIRLKAMETIRAELDERRQFYETEKKYLELERIQQRTMYDLEMLKEVGTCKGIENYSRHFSMRQP
GAPPPCLLDYFPSDYLLVIDESHQTLPQVHAMFNGDRARKQTLVDFGFRLPSAFDNRPLRFEEVYGRIHQVVYVSATPGA
WEVQEAGGEIVEQLIRPTGLLDPIIEIRPASGQVDDCLAEIRSHVSKGGRVLLTTLTKKLSEELTTYLNDLNVKAKYLHS
DIDTIERVQIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSETSLIQTCGRAARNAEGRVIMYADKIT
KSIKRTLEITESRRALQMRYNEQHGITPRTVKREISVLMESEEDQVTHPTKLEEEIFKAAEEAHHYLTLDEVRLKIKECE
KEMKKAAKEFRFEEAADWRDQMRRYQQIELTLA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=667, Percent_Identity=56.5217391304348, Blast_Score=755, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_PARUW (Q6MEV1)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007173.1
- ProteinModelPortal:   Q6MEV1
- STRING:   Q6MEV1
- GeneID:   2780840
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0174
- NMPDR:   fig|264201.1.peg.174
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- PhylomeDB:   Q6MEV1
- ProtClustDB:   PRK05298
- BioCyc:   CPRO264201:PC0174-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 77790; Mature: 77790

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSQLFQLHTEFEPCGDQPEAINQLVASILQNKRSQVLLGITGSGKTFTMANVIAKVQR
CCHHHHEEHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEHHHHHHHHHCC
PTLILAHNKTLAAQLYQEFKAFFPHNAVEYFVSYYDYYQPEAYVPRTDTYIEKDMSINDK
CEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCHH
IDKMRLSATRSLLERSDVIIVSSVSCIYGLGSPEYYRGMNLTLSQGQMRRRDDILLHLVE
HHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHCCCCEEECCCHHHHHHHHHHHHHH
MQYKRNDFEFIRSTFRVRGDVLDIFPAYEEDLAIRVEMFGDEIEQISEIDPLTGKVKRRI
HHHCCCHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHH
ASITIYPSSHHVTPEEIRLKAMETIRAELDERRQFYETEKKYLELERIQQRTMYDLEMLK
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVGTCKGIENYSRHFSMRQPGAPPPCLLDYFPSDYLLVIDESHQTLPQVHAMFNGDRARK
HHHCCCCHHHHHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCHHHH
QTLVDFGFRLPSAFDNRPLRFEEVYGRIHQVVYVSATPGAWEVQEAGGEIVEQLIRPTGL
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
LDPIIEIRPASGQVDDCLAEIRSHVSKGGRVLLTTLTKKLSEELTTYLNDLNVKAKYLHS
CCCHHEEECCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DIDTIERVQIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSETSLIQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
CGRAARNAEGRVIMYADKITKSIKRTLEITESRRALQMRYNEQHGITPRTVKREISVLME
HHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
SEEDQVTHPTKLEEEIFKAAEEAHHYLTLDEVRLKIKECEKEMKKAAKEFRFEEAADWRD
CCCCCCCCCCHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QMRRYQQIELTLA
HHHHHHHHEEEEC
>Mature Secondary Structure
MNPSQLFQLHTEFEPCGDQPEAINQLVASILQNKRSQVLLGITGSGKTFTMANVIAKVQR
CCHHHHEEHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCEEHHHHHHHHHCC
PTLILAHNKTLAAQLYQEFKAFFPHNAVEYFVSYYDYYQPEAYVPRTDTYIEKDMSINDK
CEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCHH
IDKMRLSATRSLLERSDVIIVSSVSCIYGLGSPEYYRGMNLTLSQGQMRRRDDILLHLVE
HHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHCCCCEEECCCHHHHHHHHHHHHHH
MQYKRNDFEFIRSTFRVRGDVLDIFPAYEEDLAIRVEMFGDEIEQISEIDPLTGKVKRRI
HHHCCCHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHH
ASITIYPSSHHVTPEEIRLKAMETIRAELDERRQFYETEKKYLELERIQQRTMYDLEMLK
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVGTCKGIENYSRHFSMRQPGAPPPCLLDYFPSDYLLVIDESHQTLPQVHAMFNGDRARK
HHHCCCCHHHHHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCHHHH
QTLVDFGFRLPSAFDNRPLRFEEVYGRIHQVVYVSATPGAWEVQEAGGEIVEQLIRPTGL
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
LDPIIEIRPASGQVDDCLAEIRSHVSKGGRVLLTTLTKKLSEELTTYLNDLNVKAKYLHS
CCCHHEEECCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DIDTIERVQIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSETSLIQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
CGRAARNAEGRVIMYADKITKSIKRTLEITESRRALQMRYNEQHGITPRTVKREISVLME
HHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
SEEDQVTHPTKLEEEIFKAAEEAHHYLTLDEVRLKIKECEKEMKKAAKEFRFEEAADWRD
CCCCCCCCCCHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QMRRYQQIELTLA
HHHHHHHHEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA