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The map label for this gene is napA [H]

Identifier: 46445728

GI number: 46445728

Start: 155866

End: 157098

Strand: Direct

Name: napA [H]

Synonym: pc0094

Alternate gene names: 46445728

Gene position: 155866-157098 (Clockwise)

Preceding gene: 46445726

Following gene: 46445729

Centisome position: 6.46

GC content: 33.98

Gene sequence:

>1233_bases
GTGTTAATTCAAAATTTTTTTCTGCAATTAGTGATCATTCTGTTTGCAGCTCGTTTCTTAGGTGAAATTGCTTCGAGGTG
TAATATTCCTTCTGTCATAGGGGAACTTTTTGCAGGTATTTTGATAGGGCCAAGTTTATTTGGATTGATTGCTCCCACAG
ACACCATTAAACTTTTGTCAGAAATTGGTTTAATTTTATTGCTTTTTGAAGTTGGCTTAGAAACTGACTTATCAAGATTA
GCTAAAACTGGTTTTAAACCTTTTCTTGTAGCATTAGGAGGGATTATTTTTCCTTTTGCCGCGGGATTTATGATTAGCTA
CAATATATTTTATTTGAATTTACTCACTTCTTTATTCATTGCCAGTACGTTAACTGCAACAAGTATTGGGATCACTATTA
GAGTATTAACAGATCTTAAGAAGCATGCGAGTGATGAAGCTCAAATCGTTTTAGGAGCAGCTGTTGTTGATGATATATTA
GGGATTATTATTCTTTCTATGCTTTATGAATTTTCTGTAAGTGGGGAAATAGATCTGTTAAATGTTAGTAAAATCATTAT
ATTAGTTTTCTTATTTTTATTCCTTGCACCGATTGCTGCTAAGTTGATATCGCAAATCGTTAAATATTATGACGTTAAAA
GTGCAACTCCTGGATTAATTCCCACCATTATCATTTCATTGATTTTATTCTTTGCTTGGCTTGCTCATCAAATGGGCGCA
CCGGCATTACTGGGTGGGTTTGCAGCGGGTTTGGCCCTTTCAAGACAATTTTTTATTCCATTTCTTTCTATGCAGCAAAA
CATTCATTTTGCTCATCGTGTAGAAGAACAAATGAAACCAATTGTTCACCTTTTTACCCCTATTTTTTTTGTAACGATTG
GATTATCCTTAAATTTGCGAGCCATTGATTGGAGCTCATTCTTTATTTGGTCTTTATCATTAGCGATTTTAGCAGCGGCA
ATTTTAGGAAAATTTGCGTCAGGATTTTTATTATTTAAAGATTCTAAATGGGTGAAATGGGCTGTCGGATTAGCGATGAT
ACCACGGGGTGAGGTGGGGTTAATTTTTGCGGAAGTTGGAAAGAATGTGAAAATTTTTAACGATGATATTTACGCCTCAA
TGGTTATTGTCATTACCATCACAACAATTATTGCTCCCATATTGCTGAGAATGTTTTACTCTTATAAAGAGAAGAATTTT
GTTAAACTTTTAAGTAAAGACAAAGCAAAGTAA

Upstream 100 bases:

>100_bases
TAAATTATTCTGATGAATGGTATAGGAAGAAAAAGCATAAGACGCAAATTGCTTAAAAGCAAGAATTATACTAATTTTTG
GAGAAACAATAGGAGGAAAG

Downstream 100 bases:

>100_bases
AAATTGAGTATGACGTTGCGCTTGCTTAAAACCCATTTTTCAATTAATTTTTGTTTTTTAATCGAATTTTAAGGATGAAT
GAAATTCATGAGCCATATAA

Product: putative Na(+)/H(+) antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MLIQNFFLQLVIILFAARFLGEIASRCNIPSVIGELFAGILIGPSLFGLIAPTDTIKLLSEIGLILLLFEVGLETDLSRL
AKTGFKPFLVALGGIIFPFAAGFMISYNIFYLNLLTSLFIASTLTATSIGITIRVLTDLKKHASDEAQIVLGAAVVDDIL
GIIILSMLYEFSVSGEIDLLNVSKIIILVFLFLFLAPIAAKLISQIVKYYDVKSATPGLIPTIIISLILFFAWLAHQMGA
PALLGGFAAGLALSRQFFIPFLSMQQNIHFAHRVEEQMKPIVHLFTPIFFVTIGLSLNLRAIDWSSFFIWSLSLAILAAA
ILGKFASGFLLFKDSKWVKWAVGLAMIPRGEVGLIFAEVGKNVKIFNDDIYASMVIVITITTIIAPILLRMFYSYKEKNF
VKLLSKDKAK

Sequences:

>Translated_410_residues
MLIQNFFLQLVIILFAARFLGEIASRCNIPSVIGELFAGILIGPSLFGLIAPTDTIKLLSEIGLILLLFEVGLETDLSRL
AKTGFKPFLVALGGIIFPFAAGFMISYNIFYLNLLTSLFIASTLTATSIGITIRVLTDLKKHASDEAQIVLGAAVVDDIL
GIIILSMLYEFSVSGEIDLLNVSKIIILVFLFLFLAPIAAKLISQIVKYYDVKSATPGLIPTIIISLILFFAWLAHQMGA
PALLGGFAAGLALSRQFFIPFLSMQQNIHFAHRVEEQMKPIVHLFTPIFFVTIGLSLNLRAIDWSSFFIWSLSLAILAAA
ILGKFASGFLLFKDSKWVKWAVGLAMIPRGEVGLIFAEVGKNVKIFNDDIYASMVIVITITTIIAPILLRMFYSYKEKNF
VKLLSKDKAK
>Mature_410_residues
MLIQNFFLQLVIILFAARFLGEIASRCNIPSVIGELFAGILIGPSLFGLIAPTDTIKLLSEIGLILLLFEVGLETDLSRL
AKTGFKPFLVALGGIIFPFAAGFMISYNIFYLNLLTSLFIASTLTATSIGITIRVLTDLKKHASDEAQIVLGAAVVDDIL
GIIILSMLYEFSVSGEIDLLNVSKIIILVFLFLFLAPIAAKLISQIVKYYDVKSATPGLIPTIIISLILFFAWLAHQMGA
PALLGGFAAGLALSRQFFIPFLSMQQNIHFAHRVEEQMKPIVHLFTPIFFVTIGLSLNLRAIDWSSFFIWSLSLAILAAA
ILGKFASGFLLFKDSKWVKWAVGLAMIPRGEVGLIFAEVGKNVKIFNDDIYASMVIVITITTIIAPILLRMFYSYKEKNF
VKLLSKDKAK

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=308, Percent_Identity=22.7272727272727, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789749, Length=407, Percent_Identity=22.3587223587224, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322367, Length=423, Percent_Identity=25.531914893617, Blast_Score=111, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 45126; Mature: 45126

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure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CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]