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The map label for this gene is hemB [H]

Identifier: 46445726

GI number: 46445726

Start: 152383

End: 153417

Strand: Direct

Name: hemB [H]

Synonym: pc0092

Alternate gene names: 46445726

Gene position: 152383-153417 (Clockwise)

Preceding gene: 46445724

Following gene: 46445728

Centisome position: 6.31

GC content: 37.0

Gene sequence:

>1035_bases
TTGATGGAAAATAAAACTTTTTCTTCATTCCCTCCTGTTTTTTTACAATCCAATATCATTAAAAGGCCAAGAAGAAATAG
ACGTACAGCCGCTATAAGGGGTCTTGTTCAAGAAAATCATTTACATCCAAGTCAACTAATAGCTCCACTTTTTGTTTTAG
AAGGTAAACAACAACAAATAGCCATTAAAAGCATGCCAGGCATTTTTCGTTATTCGATCGACGAAATGTTAAAAGAAGTA
AAGTCCCTTTATCAATTAGGTATCCGCGCTGTAGATCTATTTTGTTACATTGAGGGCGACAAAAAAGATTCTTTTGCTTC
AGAAGCTGTTAGGTCAGGAAATTTATTTTGTCGAGCAATTCAAACTTTAAAAGAAAATTTTCCCGATCTTTGTGTGATGA
TGGATGTGGCTTTAGATCCTTTTACAAGTCATGGACATGATGGAATAACCAATGAAAAAGGGGAAATTGATAATGATCTA
ACTTTACCTATTTTAGCTCAAATGTCTATCTTGGCAGCAGAAGCTGGAGCAGATGTTGTAGCTCCGAGTGATATGATGGA
TGGGCGAATTGGCTATATTCGACACGCTCTTGATCAAGAAGGTTATCAGCAAGTAGGTATTTTGTCTTATGCAGCCAAAT
ATGCCTCAGCATTTTACGCTCCATTTAGAGAAGCTCTTCACTCTGTTCTTCAATTTGGAGATAAAAAAACCTATCAGATG
AACCCCGCAAATTCAAGAGAAGCAATGCTAGAATGCCAACTGGATGAACAGGAAGGGGCCGATCTCATTTTGATCAAACC
AGCTTTGGCTTATTTAGATATTATAGCAAAAATTAAAGAGCAAACGCATTTACCTGTTGGTGCTTATCATGTCAGTGGAG
AATATGCTATGGTAATGGCTGCAGCATTAAATGGTTGGTTAGACGCTGATAAAGTATTTGAAGAATCACTTCTTTCCATA
AAAAGAGCTGGAGCGGATTTTATCTTAACTTACGCAGCTCGTCGAGTAGCTGAAAATCTTCAAAAGCAATTTTGA

Upstream 100 bases:

>100_bases
AGATGGTATGATCCCTAAAACCATCTCTATTTAAATTATGAAAATATATGAACTGTTGCTTTGCATGAAATTATTAATAC
GTTTTTATCTATAGGTTTTT

Downstream 100 bases:

>100_bases
ACTAAAATCAAATTAGATGATTCGAGCAATCTTATATCTATTATCTCTACTGGCGATTTTGATTGATCATAAGATATAAC
TCTGTTCCGGTATAAGCTCT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MMENKTFSSFPPVFLQSNIIKRPRRNRRTAAIRGLVQENHLHPSQLIAPLFVLEGKQQQIAIKSMPGIFRYSIDEMLKEV
KSLYQLGIRAVDLFCYIEGDKKDSFASEAVRSGNLFCRAIQTLKENFPDLCVMMDVALDPFTSHGHDGITNEKGEIDNDL
TLPILAQMSILAAEAGADVVAPSDMMDGRIGYIRHALDQEGYQQVGILSYAAKYASAFYAPFREALHSVLQFGDKKTYQM
NPANSREAMLECQLDEQEGADLILIKPALAYLDIIAKIKEQTHLPVGAYHVSGEYAMVMAAALNGWLDADKVFEESLLSI
KRAGADFILTYAARRVAENLQKQF

Sequences:

>Translated_344_residues
MMENKTFSSFPPVFLQSNIIKRPRRNRRTAAIRGLVQENHLHPSQLIAPLFVLEGKQQQIAIKSMPGIFRYSIDEMLKEV
KSLYQLGIRAVDLFCYIEGDKKDSFASEAVRSGNLFCRAIQTLKENFPDLCVMMDVALDPFTSHGHDGITNEKGEIDNDL
TLPILAQMSILAAEAGADVVAPSDMMDGRIGYIRHALDQEGYQQVGILSYAAKYASAFYAPFREALHSVLQFGDKKTYQM
NPANSREAMLECQLDEQEGADLILIKPALAYLDIIAKIKEQTHLPVGAYHVSGEYAMVMAAALNGWLDADKVFEESLLSI
KRAGADFILTYAARRVAENLQKQF
>Mature_344_residues
MMENKTFSSFPPVFLQSNIIKRPRRNRRTAAIRGLVQENHLHPSQLIAPLFVLEGKQQQIAIKSMPGIFRYSIDEMLKEV
KSLYQLGIRAVDLFCYIEGDKKDSFASEAVRSGNLFCRAIQTLKENFPDLCVMMDVALDPFTSHGHDGITNEKGEIDNDL
TLPILAQMSILAAEAGADVVAPSDMMDGRIGYIRHALDQEGYQQVGILSYAAKYASAFYAPFREALHSVLQFGDKKTYQM
NPANSREAMLECQLDEQEGADLILIKPALAYLDIIAKIKEQTHLPVGAYHVSGEYAMVMAAALNGWLDADKVFEESLLSI
KRAGADFILTYAARRVAENLQKQF

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=305, Percent_Identity=38.3606557377049, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI87081728, Length=323, Percent_Identity=45.8204334365325, Blast_Score=274, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6321398, Length=316, Percent_Identity=37.9746835443038, Blast_Score=190, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21358291, Length=291, Percent_Identity=39.5189003436426, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 38447; Mature: 38447

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMENKTFSSFPPVFLQSNIIKRPRRNRRTAAIRGLVQENHLHPSQLIAPLFVLEGKQQQI
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEE
AIKSMPGIFRYSIDEMLKEVKSLYQLGIRAVDLFCYIEGDKKDSFASEAVRSGNLFCRAI
EHHCCCCHHHHHHHHHHHHHHHHHHHCHHEEEEEEEEECCCCHHHHHHHHHCCCHHHHHH
QTLKENFPDLCVMMDVALDPFTSHGHDGITNEKGEIDNDLTLPILAQMSILAAEAGADVV
HHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
APSDMMDGRIGYIRHALDQEGYQQVGILSYAAKYASAFYAPFREALHSVLQFGDKKTYQM
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NPANSREAMLECQLDEQEGADLILIKPALAYLDIIAKIKEQTHLPVGAYHVSGEYAMVMA
CCCCCCCHHEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
AALNGWLDADKVFEESLLSIKRAGADFILTYAARRVAENLQKQF
HHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMENKTFSSFPPVFLQSNIIKRPRRNRRTAAIRGLVQENHLHPSQLIAPLFVLEGKQQQI
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEE
AIKSMPGIFRYSIDEMLKEVKSLYQLGIRAVDLFCYIEGDKKDSFASEAVRSGNLFCRAI
EHHCCCCHHHHHHHHHHHHHHHHHHHCHHEEEEEEEEECCCCHHHHHHHHHCCCHHHHHH
QTLKENFPDLCVMMDVALDPFTSHGHDGITNEKGEIDNDLTLPILAQMSILAAEAGADVV
HHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
APSDMMDGRIGYIRHALDQEGYQQVGILSYAAKYASAFYAPFREALHSVLQFGDKKTYQM
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NPANSREAMLECQLDEQEGADLILIKPALAYLDIIAKIKEQTHLPVGAYHVSGEYAMVMA
CCCCCCCHHEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
AALNGWLDADKVFEESLLSIKRAGADFILTYAARRVAENLQKQF
HHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9784136 [H]