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The map label for this gene is mutD [H]

Identifier: 46445668

GI number: 46445668

Start: 51894

End: 54179

Strand: Direct

Name: mutD [H]

Synonym: pc0034

Alternate gene names: 46445668

Gene position: 51894-54179 (Clockwise)

Preceding gene: 46445667

Following gene: 46445669

Centisome position: 2.15

GC content: 36.0

Gene sequence:

>2286_bases
TTGATTATCACAGGTATGGAAACCTTGCCGAGCGAGAAAAAGAATATAGACATCCATTACCCGGTCATAAAGGAAAAACC
TGTTTACCTTGTGGAGCTTGTTGTTGTGATGGATAATTTATTTAATTTAAATAAAGAGCAAAAAGATGCTGTGACAACCT
TAGAAGGTCCAGTATTAGTATTAGCGGGGGCGGGATCTGGAAAAACGCGTGTTGTTACCTCTAGAATTGTTAATTTGATA
GAAAACGGAATTTCTCCTTCTAATATTTTAGGAGTAACATTTACAAACAAAGCCGCTCAAGAAATGAGAGAACGCGTTTG
TAAGTTGACTCAACATCATGTTCTCATTTGTACATTTCATAGTTTAGGAGCAAAAATTTTACGGGAAAGCATTCATGTAT
TGGGATATCAACGTGATTTTACAATTTATGACGAAGAAGATGTTAATAAATTAGTCAAAGCCTGTTTAATGGAACTGAAT
TGGCAAGACAAAAAAGTAGATGCCAAGCCTTTTCGCCAAATGATCTCTCAAGCGAAAAATATGTTGCAACAACCTAATCC
ACACTATGATAAAGAGGTAACTTCCGATTTTGATGAAGCCTTTCCTCATGTCTATGCACTTTATCAAAAAAAGCTTCAAG
AGTATCAAGCAGTTGACTTTGATGATCTCCTTTTTTTAACAGCTAAAATTTGGCGTGAATATCCCTCTGTTCTTAATTAT
TACCAAGATCGCTGGCCCTTTGTTTTAATTGATGAATATCAAGATACTAATGCTGTTCAATATACCATGACGACCTTGCT
TGTAGAAAAAAGACGTAATCTATTCGTTGTCGGTGATCCTGATCAATCTATTTACTCTTGGAGAGGAGCAAATGTTCAGA
ATATTTTAAATTTTGAGCGAGATTATCCAGGTGCTAAAGTTATCCAATTAGAGCAAAACTATCGTAGCCGTACCAATATT
TTAAATGCTGCTAACGCTTTAATCAGTCATAATACGAATCGTTTTGAGAAAGAATTATGGAGTGAACTGGGTGCTGGTGA
GAAAGTTAAACTCTTTATTGGAGATGATGATCGAGCTGAAGCTGAATTTGTGGCTTCGCAGATTTCTTATCATCACAAAG
AACATCAGATCTCACTCAGTGAAATGGTAATTTTTTATCGAACGAATGCCCAATCAAGGGTTTTTGAAGACTACTTGCTT
TATCGTGGAATACCCTATGTCATTGTGGGGGGGATCTCTTTTTATCAAAGGCGTGAAATTAAAGATATTTTGGCATTTTT
GCGTTTTGCGCAATCTGGTGCAGATTTTGTAGCCTTTGCTCGAACAATTAATTTACCTAAAAGAGGCCTAGGAGAAACGA
CAATTGAAAAAATTCGGCAGAGCGCTAATGAAGAAAGAATGACGATTTACGCTTTTTGCGAGGCATTATTAAAAAATACT
CCCATGAAATCTATTGTTCGATTAACAGCCAAGCAGAGAGAAGGTTTAACTGAGTATTTAGCAATTGTCCAAGAACTACG
TACTTTAAGTAAAGCTGGGTCTGTACGAGAACTTGTTTTAGCAGCGATTGAAAAAACAAAATATTTGAACTATTTGATGG
AAGATAAAGAGTCCTACGAAGACCGTAGAGAGAACTTGGATGAATTGATTACTAAAGCTGTTGAATGGGAAATTTCTGCG
ACAGATCCTTCATTAGAGGCCTTTTTAGAAGAACTTTCTCTAAAATCAAGTTTAGATGAAGCTAATCAAGCTGTCGAACG
TTTAAGTTTGATGACTATCCACAATGGCAAAGGTCTTGAATTTACTACTACATTTTTAGTTGGGCTAGAAGAAGATTTAT
TTCCTCATGTGAATTCTAAAAATAACCGTGAAGATGTGGAAGAAGAACGGCGTCTTTGTTATGTGGGTATTACAAGAGCA
AAAGAATATCTTTACTTGAGCTTCTGTCATACCAGGTATTTATGGGGAAATCTTCGCTTTCAAAGGCCAAGTCGATTTCT
TAAAGAGCTGCCCTCAGAATATCTAGAAAAATGTCAACAATCCCAAATAATTTCTAAGCATGCTTTACAAAATCAGCAAA
AAGAACGTGTTACGTATGTGGAAAAACCGCTTCCTAGCGGCGAAATTTTTGCTCCCAGCGATACAATTTTTCATAAAGAT
TTTGGAATTGGGCAAATCAAGGAGGCTTATGAAGGCTCGATGGGGTTAACATATAAAATTTTTTTTACAAAAGACAATAG
TGTCAAAACTCTCGTGGCAAAATATGCCGTTTTAAACAGAGTATAA

Upstream 100 bases:

>100_bases
AATACTTTAGCGAATGCAGCTTGTCATTTAAATAGAGGGGAAGTAATGGCCAATGGACGATTAGAACTTCTTCATTTTTT
AAGAGAAGTAAGTTTAAGTT

Downstream 100 bases:

>100_bases
CTATTAAGCTGTTACAAACAGAGGAATTATTGTTAGGGGAATGGAGTTAAAAACAAAACAGCTTATTTTGAGGCAATTTA
CAATTGATCTCCACATTTTT

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 761; Mature: 761

Protein sequence:

>761_residues
MIITGMETLPSEKKNIDIHYPVIKEKPVYLVELVVVMDNLFNLNKEQKDAVTTLEGPVLVLAGAGSGKTRVVTSRIVNLI
ENGISPSNILGVTFTNKAAQEMRERVCKLTQHHVLICTFHSLGAKILRESIHVLGYQRDFTIYDEEDVNKLVKACLMELN
WQDKKVDAKPFRQMISQAKNMLQQPNPHYDKEVTSDFDEAFPHVYALYQKKLQEYQAVDFDDLLFLTAKIWREYPSVLNY
YQDRWPFVLIDEYQDTNAVQYTMTTLLVEKRRNLFVVGDPDQSIYSWRGANVQNILNFERDYPGAKVIQLEQNYRSRTNI
LNAANALISHNTNRFEKELWSELGAGEKVKLFIGDDDRAEAEFVASQISYHHKEHQISLSEMVIFYRTNAQSRVFEDYLL
YRGIPYVIVGGISFYQRREIKDILAFLRFAQSGADFVAFARTINLPKRGLGETTIEKIRQSANEERMTIYAFCEALLKNT
PMKSIVRLTAKQREGLTEYLAIVQELRTLSKAGSVRELVLAAIEKTKYLNYLMEDKESYEDRRENLDELITKAVEWEISA
TDPSLEAFLEELSLKSSLDEANQAVERLSLMTIHNGKGLEFTTTFLVGLEEDLFPHVNSKNNREDVEEERRLCYVGITRA
KEYLYLSFCHTRYLWGNLRFQRPSRFLKELPSEYLEKCQQSQIISKHALQNQQKERVTYVEKPLPSGEIFAPSDTIFHKD
FGIGQIKEAYEGSMGLTYKIFFTKDNSVKTLVAKYAVLNRV

Sequences:

>Translated_761_residues
MIITGMETLPSEKKNIDIHYPVIKEKPVYLVELVVVMDNLFNLNKEQKDAVTTLEGPVLVLAGAGSGKTRVVTSRIVNLI
ENGISPSNILGVTFTNKAAQEMRERVCKLTQHHVLICTFHSLGAKILRESIHVLGYQRDFTIYDEEDVNKLVKACLMELN
WQDKKVDAKPFRQMISQAKNMLQQPNPHYDKEVTSDFDEAFPHVYALYQKKLQEYQAVDFDDLLFLTAKIWREYPSVLNY
YQDRWPFVLIDEYQDTNAVQYTMTTLLVEKRRNLFVVGDPDQSIYSWRGANVQNILNFERDYPGAKVIQLEQNYRSRTNI
LNAANALISHNTNRFEKELWSELGAGEKVKLFIGDDDRAEAEFVASQISYHHKEHQISLSEMVIFYRTNAQSRVFEDYLL
YRGIPYVIVGGISFYQRREIKDILAFLRFAQSGADFVAFARTINLPKRGLGETTIEKIRQSANEERMTIYAFCEALLKNT
PMKSIVRLTAKQREGLTEYLAIVQELRTLSKAGSVRELVLAAIEKTKYLNYLMEDKESYEDRRENLDELITKAVEWEISA
TDPSLEAFLEELSLKSSLDEANQAVERLSLMTIHNGKGLEFTTTFLVGLEEDLFPHVNSKNNREDVEEERRLCYVGITRA
KEYLYLSFCHTRYLWGNLRFQRPSRFLKELPSEYLEKCQQSQIISKHALQNQQKERVTYVEKPLPSGEIFAPSDTIFHKD
FGIGQIKEAYEGSMGLTYKIFFTKDNSVKTLVAKYAVLNRV
>Mature_761_residues
MIITGMETLPSEKKNIDIHYPVIKEKPVYLVELVVVMDNLFNLNKEQKDAVTTLEGPVLVLAGAGSGKTRVVTSRIVNLI
ENGISPSNILGVTFTNKAAQEMRERVCKLTQHHVLICTFHSLGAKILRESIHVLGYQRDFTIYDEEDVNKLVKACLMELN
WQDKKVDAKPFRQMISQAKNMLQQPNPHYDKEVTSDFDEAFPHVYALYQKKLQEYQAVDFDDLLFLTAKIWREYPSVLNY
YQDRWPFVLIDEYQDTNAVQYTMTTLLVEKRRNLFVVGDPDQSIYSWRGANVQNILNFERDYPGAKVIQLEQNYRSRTNI
LNAANALISHNTNRFEKELWSELGAGEKVKLFIGDDDRAEAEFVASQISYHHKEHQISLSEMVIFYRTNAQSRVFEDYLL
YRGIPYVIVGGISFYQRREIKDILAFLRFAQSGADFVAFARTINLPKRGLGETTIEKIRQSANEERMTIYAFCEALLKNT
PMKSIVRLTAKQREGLTEYLAIVQELRTLSKAGSVRELVLAAIEKTKYLNYLMEDKESYEDRRENLDELITKAVEWEISA
TDPSLEAFLEELSLKSSLDEANQAVERLSLMTIHNGKGLEFTTTFLVGLEEDLFPHVNSKNNREDVEEERRLCYVGITRA
KEYLYLSFCHTRYLWGNLRFQRPSRFLKELPSEYLEKCQQSQIISKHALQNQQKERVTYVEKPLPSGEIFAPSDTIFHKD
FGIGQIKEAYEGSMGLTYKIFFTKDNSVKTLVAKYAVLNRV

Specific function: DNA helicase used for plasmid rolling-circle replication and also involved in UV repair [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=731, Percent_Identity=37.0725034199726, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI48994965, Length=658, Percent_Identity=39.0577507598784, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6322369, Length=713, Percent_Identity=27.3492286115007, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324477, Length=675, Percent_Identity=22.962962962963, Blast_Score=94, Evalue=6e-20,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 88011; Mature: 88011

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITGMETLPSEKKNIDIHYPVIKEKPVYLVELVVVMDNLFNLNKEQKDAVTTLEGPVLV
CEEECCHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEE
LAGAGSGKTRVVTSRIVNLIENGISPSNILGVTFTNKAAQEMRERVCKLTQHHVLICTFH
EEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEHH
SLGAKILRESIHVLGYQRDFTIYDEEDVNKLVKACLMELNWQDKKVDAKPFRQMISQAKN
HHHHHHHHHHHHHHEECCCEEEECHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
MLQQPNPHYDKEVTSDFDEAFPHVYALYQKKLQEYQAVDFDDLLFLTAKIWREYPSVLNY
HHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YQDRWPFVLIDEYQDTNAVQYTMTTLLVEKRRNLFVVGDPDQSIYSWRGANVQNILNFER
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCCCCHHHHHHHHC
DYPGAKVIQLEQNYRSRTNILNAANALISHNTNRFEKELWSELGAGEKVKLFIGDDDRAE
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCHH
AEFVASQISYHHKEHQISLSEMVIFYRTNAQSRVFEDYLLYRGIPYVIVGGISFYQRREI
HHHHHHHHHHHHHHHCEEHHHEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
KDILAFLRFAQSGADFVAFARTINLPKRGLGETTIEKIRQSANEERMTIYAFCEALLKNT
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
PMKSIVRLTAKQREGLTEYLAIVQELRTLSKAGSVRELVLAAIEKTKYLNYLMEDKESYE
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DRRENLDELITKAVEWEISATDPSLEAFLEELSLKSSLDEANQAVERLSLMTIHNGKGLE
HHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCE
FTTTFLVGLEEDLFPHVNSKNNREDVEEERRLCYVGITRAKEYLYLSFCHTRYLWGNLRF
EEHHEEEECCHHHCCCCCCCCCHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHCCCEE
QRPSRFLKELPSEYLEKCQQSQIISKHALQNQQKERVTYVEKPLPSGEIFAPSDTIFHKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEECCCCCEEECC
FGIGQIKEAYEGSMGLTYKIFFTKDNSVKTLVAKYAVLNRV
CCCHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIITGMETLPSEKKNIDIHYPVIKEKPVYLVELVVVMDNLFNLNKEQKDAVTTLEGPVLV
CEEECCHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEE
LAGAGSGKTRVVTSRIVNLIENGISPSNILGVTFTNKAAQEMRERVCKLTQHHVLICTFH
EEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEHH
SLGAKILRESIHVLGYQRDFTIYDEEDVNKLVKACLMELNWQDKKVDAKPFRQMISQAKN
HHHHHHHHHHHHHHEECCCEEEECHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
MLQQPNPHYDKEVTSDFDEAFPHVYALYQKKLQEYQAVDFDDLLFLTAKIWREYPSVLNY
HHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YQDRWPFVLIDEYQDTNAVQYTMTTLLVEKRRNLFVVGDPDQSIYSWRGANVQNILNFER
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHCCCCCHHHHHHHHC
DYPGAKVIQLEQNYRSRTNILNAANALISHNTNRFEKELWSELGAGEKVKLFIGDDDRAE
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCHH
AEFVASQISYHHKEHQISLSEMVIFYRTNAQSRVFEDYLLYRGIPYVIVGGISFYQRREI
HHHHHHHHHHHHHHHCEEHHHEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
KDILAFLRFAQSGADFVAFARTINLPKRGLGETTIEKIRQSANEERMTIYAFCEALLKNT
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
PMKSIVRLTAKQREGLTEYLAIVQELRTLSKAGSVRELVLAAIEKTKYLNYLMEDKESYE
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DRRENLDELITKAVEWEISATDPSLEAFLEELSLKSSLDEANQAVERLSLMTIHNGKGLE
HHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCE
FTTTFLVGLEEDLFPHVNSKNNREDVEEERRLCYVGITRAKEYLYLSFCHTRYLWGNLRF
EEHHEEEECCHHHCCCCCCCCCHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHCCCEE
QRPSRFLKELPSEYLEKCQQSQIISKHALQNQQKERVTYVEKPLPSGEIFAPSDTIFHKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEECCCCCEEECC
FGIGQIKEAYEGSMGLTYKIFFTKDNSVKTLVAKYAVLNRV
CCCHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9701819; 9384377 [H]