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The map label for this gene is pa5518

Identifier: 45659256

GI number: 45659256

Start: 4215862

End: 4217634

Strand: Direct

Name: pa5518

Synonym: LIC13439

Alternate gene names: 45659256

Gene position: 4215862-4217634 (Clockwise)

Preceding gene: 45659255

Following gene: 45659257

Centisome position: 98.57

GC content: 36.89

Gene sequence:

>1773_bases
ATGGAGCATCATTCACTCTCCCTTCTAAATGATATTGCGTTAAGTATCATCTTCGCTACATTCTTTTCGCATATCGCCAG
AATTACAAAACAACCATTAATTCTAGGTTATGTGGCGGGCGGGCTTTTACTCGGACCAAATTTGGGTTTGAGTCTTGTGA
TCAACGAAGAAAGTATCGAATTGATTTCTGAAATCGGATTGATTCTTCTTTTATTCATCATCGGTCTTGAAATCGATTTA
AAAGAATTAGCGCGTATGGGAAAGTCCATGTTCGTTTTAGGAATTGTTCAGTTTGTATTTTGTGTATTATTTGGATTTTT
CTTTTTTAAATGGATTCTCGCCAATTCAACAGGTAGGTTTGATCTTTTATACTTTGCCATTGCACTCGCCATTAGTTCCA
CCATGATCGTAGTCAAACTTTTACACGATAAATTTGAAGTGAGTACGATCGCGGGACGTCTTACAATTGGAGTTTTAGTT
CTTCAAGATATTTGGGCGATCATTTTTATGGGAGTTCAACCTAATTTACAAAACCCTCAAATTCTAAAAATTGCAGGTTC
GTTAGGAATCGGCTTAGTTTTAATATGTGTTTCTTTTTTGATTAGTAGATTCTTTTTATCTAAATTGTTTAACGCTGCGG
CTTCCAAACCCGAATTGATTTTAATCACTTCAATCGCTTGGTGTTTTTTACTTTGTGGTTTTGCAGAAAAAGCAGGACTT
TCCAAAGAAATGGGAGCCTTAATCGCCGGAGTAAGCATCGCAGCATTTCCGTATGGCGCAGACGTAATTGCAAAACTTTC
AGGAATTAGAGATTTTTTCATCACTCTTTTTTTTGTCGCTCTCGGAATGAAAATTCCGATTCCTTCCATTCAAATCCTCA
GTATTTCTTTGATCGCAGTTGTGTTCGTCATTTTTAGCAGAGTGATCACGGTTGCGACCCCGGTTTATCTTTCCGGAAAA
GGTTTAAGAGCTGGAATCGTCACCGGTTTAAATTTAGCTCAGATCAGCGAATTTTCTCTCGTGATTTTATCTTTGGGAAT
GGGTTATGGCCATATTAGTAAAGAGTTAGAATCCACCGTTTTGACTTCTATGATTTTAGCATCTGTAGTTTCGACTTATA
TCATTCTATTTAACGATCCGATTTCAAGATTTATTTTAAAAATATTGAATATGATTGGCCTAAAAGAAAAAGAAGATGAA
GAAGATCAAACCGAATCTTATATCACTGGCCAATCTAAAAGAGACATCGTAATTTTAGGTTATTTTAGAATCGCGCAAGG
TCTTTTAGAGGGAATCGAACGCGAAAAACCGGAATGGCTCAATCGAATTTTAATCGTAGATTTTAATCCGGTTTTTCGCC
AATCTTTAGAAGCAAAAGGAATCCGTTGGGCCTATGGCGATTTGGCAAACCCAGAAACGTTACATCATCTCGGAATCGAA
GAAGCAAAATATGTGATCTGTACAATTTCCGATATGATTCTTAAAGGAACCACCAGCCGTAGATTATTAGAATCTCTTAA
AGTTATTTGCCATCGCACCCAACCTTCCATCATTCTTACCACGGACGATGTTCAAGAAGCCGAAATTCTTGTAAAAAGTG
GAGCCGCACATGTCATTGTTCCAGGTAGAATCAGCGGTATGTCTCTTTTTAAAGAAATGAAAACAATCGTAGATCATTCT
AAACGATCGTTGGAGAGCCAAACCAGCAGTGTGAAGAAGAAAAAAACGATGAAAAAAAAAGTATCTTCCACATCTAAAAT
TAAGGTTAAGTAA

Upstream 100 bases:

>100_bases
TCTTTCATACCTTAGCATGCAAAGCGATTACAGTCCGCCACAAACCCGAGTTCTTTCTTGTGAAAAACCAAAAACTGTAA
TCGTTGTAGGACAATCATAA

Downstream 100 bases:

>100_bases
ATAAATTGGTTCGTTCTCCTTGTAATAAAATTTGTTCCATGAACTTTGAATCTGGTTTATGTAAAGGATGCTTTAGAACA
TTAGAAGAAATCTGTAACTG

Product: putative potassium efflux transporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MEHHSLSLLNDIALSIIFATFFSHIARITKQPLILGYVAGGLLLGPNLGLSLVINEESIELISEIGLILLLFIIGLEIDL
KELARMGKSMFVLGIVQFVFCVLFGFFFFKWILANSTGRFDLLYFAIALAISSTMIVVKLLHDKFEVSTIAGRLTIGVLV
LQDIWAIIFMGVQPNLQNPQILKIAGSLGIGLVLICVSFLISRFFLSKLFNAAASKPELILITSIAWCFLLCGFAEKAGL
SKEMGALIAGVSIAAFPYGADVIAKLSGIRDFFITLFFVALGMKIPIPSIQILSISLIAVVFVIFSRVITVATPVYLSGK
GLRAGIVTGLNLAQISEFSLVILSLGMGYGHISKELESTVLTSMILASVVSTYIILFNDPISRFILKILNMIGLKEKEDE
EDQTESYITGQSKRDIVILGYFRIAQGLLEGIEREKPEWLNRILIVDFNPVFRQSLEAKGIRWAYGDLANPETLHHLGIE
EAKYVICTISDMILKGTTSRRLLESLKVICHRTQPSIILTTDDVQEAEILVKSGAAHVIVPGRISGMSLFKEMKTIVDHS
KRSLESQTSSVKKKKTMKKKVSSTSKIKVK

Sequences:

>Translated_590_residues
MEHHSLSLLNDIALSIIFATFFSHIARITKQPLILGYVAGGLLLGPNLGLSLVINEESIELISEIGLILLLFIIGLEIDL
KELARMGKSMFVLGIVQFVFCVLFGFFFFKWILANSTGRFDLLYFAIALAISSTMIVVKLLHDKFEVSTIAGRLTIGVLV
LQDIWAIIFMGVQPNLQNPQILKIAGSLGIGLVLICVSFLISRFFLSKLFNAAASKPELILITSIAWCFLLCGFAEKAGL
SKEMGALIAGVSIAAFPYGADVIAKLSGIRDFFITLFFVALGMKIPIPSIQILSISLIAVVFVIFSRVITVATPVYLSGK
GLRAGIVTGLNLAQISEFSLVILSLGMGYGHISKELESTVLTSMILASVVSTYIILFNDPISRFILKILNMIGLKEKEDE
EDQTESYITGQSKRDIVILGYFRIAQGLLEGIEREKPEWLNRILIVDFNPVFRQSLEAKGIRWAYGDLANPETLHHLGIE
EAKYVICTISDMILKGTTSRRLLESLKVICHRTQPSIILTTDDVQEAEILVKSGAAHVIVPGRISGMSLFKEMKTIVDHS
KRSLESQTSSVKKKKTMKKKVSSTSKIKVK
>Mature_590_residues
MEHHSLSLLNDIALSIIFATFFSHIARITKQPLILGYVAGGLLLGPNLGLSLVINEESIELISEIGLILLLFIIGLEIDL
KELARMGKSMFVLGIVQFVFCVLFGFFFFKWILANSTGRFDLLYFAIALAISSTMIVVKLLHDKFEVSTIAGRLTIGVLV
LQDIWAIIFMGVQPNLQNPQILKIAGSLGIGLVLICVSFLISRFFLSKLFNAAASKPELILITSIAWCFLLCGFAEKAGL
SKEMGALIAGVSIAAFPYGADVIAKLSGIRDFFITLFFVALGMKIPIPSIQILSISLIAVVFVIFSRVITVATPVYLSGK
GLRAGIVTGLNLAQISEFSLVILSLGMGYGHISKELESTVLTSMILASVVSTYIILFNDPISRFILKILNMIGLKEKEDE
EDQTESYITGQSKRDIVILGYFRIAQGLLEGIEREKPEWLNRILIVDFNPVFRQSLEAKGIRWAYGDLANPETLHHLGIE
EAKYVICTISDMILKGTTSRRLLESLKVICHRTQPSIILTTDDVQEAEILVKSGAAHVIVPGRISGMSLFKEMKTIVDHS
KRSLESQTSSVKKKKTMKKKVSSTSKIKVK

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=358, Percent_Identity=25.4189944134078, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1786232, Length=532, Percent_Identity=28.1954887218045, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI1786685, Length=510, Percent_Identity=23.1372549019608, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789749, Length=529, Percent_Identity=22.6843100189036, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 64981; Mature: 64981

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHHSLSLLNDIALSIIFATFFSHIARITKQPLILGYVAGGLLLGPNLGLSLVINEESIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHCCEEECCCCCEEEEECHHHHH
LISEIGLILLLFIIGLEIDLKELARMGKSMFVLGIVQFVFCVLFGFFFFKWILANSTGRF
HHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DLLYFAIALAISSTMIVVKLLHDKFEVSTIAGRLTIGVLVLQDIWAIIFMGVQPNLQNPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ILKIAGSLGIGLVLICVSFLISRFFLSKLFNAAASKPELILITSIAWCFLLCGFAEKAGL
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCC
SKEMGALIAGVSIAAFPYGADVIAKLSGIRDFFITLFFVALGMKIPIPSIQILSISLIAV
CHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
VFVIFSRVITVATPVYLSGKGLRAGIVTGLNLAQISEFSLVILSLGMGYGHISKELESTV
HHHHHHHHHHHHCCCEECCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LTSMILASVVSTYIILFNDPISRFILKILNMIGLKEKEDEEDQTESYITGQSKRDIVILG
HHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEEE
YFRIAQGLLEGIEREKPEWLNRILIVDFNPVFRQSLEAKGIRWAYGDLANPETLHHLGIE
HHHHHHHHHHHHHCCCHHHHCEEEEEECCHHHHHHHHCCCCEEECCCCCCCHHHHHCCCC
EAKYVICTISDMILKGTTSRRLLESLKVICHRTQPSIILTTDDVQEAEILVKSGAAHVIV
CCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCEEEE
PGRISGMSLFKEMKTIVDHSKRSLESQTSSVKKKKTMKKKVSSTSKIKVK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
>Mature Secondary Structure
MEHHSLSLLNDIALSIIFATFFSHIARITKQPLILGYVAGGLLLGPNLGLSLVINEESIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHCCEEECCCCCEEEEECHHHHH
LISEIGLILLLFIIGLEIDLKELARMGKSMFVLGIVQFVFCVLFGFFFFKWILANSTGRF
HHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DLLYFAIALAISSTMIVVKLLHDKFEVSTIAGRLTIGVLVLQDIWAIIFMGVQPNLQNPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ILKIAGSLGIGLVLICVSFLISRFFLSKLFNAAASKPELILITSIAWCFLLCGFAEKAGL
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCC
SKEMGALIAGVSIAAFPYGADVIAKLSGIRDFFITLFFVALGMKIPIPSIQILSISLIAV
CHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
VFVIFSRVITVATPVYLSGKGLRAGIVTGLNLAQISEFSLVILSLGMGYGHISKELESTV
HHHHHHHHHHHHCCCEECCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LTSMILASVVSTYIILFNDPISRFILKILNMIGLKEKEDEEDQTESYITGQSKRDIVILG
HHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEEE
YFRIAQGLLEGIEREKPEWLNRILIVDFNPVFRQSLEAKGIRWAYGDLANPETLHHLGIE
HHHHHHHHHHHHHCCCHHHHCEEEEEECCHHHHHHHHCCCCEEECCCCCCCHHHHHCCCC
EAKYVICTISDMILKGTTSRRLLESLKVICHRTQPSIILTTDDVQEAEILVKSGAAHVIV
CCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCEEEE
PGRISGMSLFKEMKTIVDHSKRSLESQTSSVKKKKTMKKKVSSTSKIKVK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA