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The map label for this gene is hpt

Identifier: 45659255

GI number: 45659255

Start: 4215019

End: 4215570

Strand: Direct

Name: hpt

Synonym: LIC13438

Alternate gene names: 45659255

Gene position: 4215019-4215570 (Clockwise)

Preceding gene: 45659254

Following gene: 45659256

Centisome position: 98.55

GC content: 33.15

Gene sequence:

>552_bases
ATGAAAAAAATCAATTCAGATATTTTACACCCTCGTTTTAGTAGAGAAGACATTTCTCAAAAAGTAAAATCTCTTGCTTT
ACAAATATCAGAAGATTATAAAAAGCTAAATCCTATTTTTATTTGCGTGTTAAAAGGAGGCGTCTATTTTTTTACAGACC
TAACCAGAGAAATTCCTTTTTCGGTAGAGATTAATTTTGTTCAAGCAAGATCTTATTCCGGAACGGTGTCTACAGGAAAA
ATCGAACTGTTAAAAGACATAGACATTGATCTTTCGGATCGTCACGTAATTATAGTAGAAGACATTTTAGATACCGGATT
TACTCTTCAATATTTAGTAAGACACATTTTTACTCGTAATCCCGCAAGTCTGGAAATTGTAACCCTCCTTTTAAAAGAAA
GAAAAGACACTTTAGAATTTCCTGTAAAATATATAGGTTGGAGAATTCCTGACGAATTCTTGGTGGGTTACGGTTTGGAT
TTTGACGGGAGATATAGAAATTTACCGGATATACACGTTTTAGAACCTGGTGAACCTCAATTTCCGGTTTAA

Upstream 100 bases:

>100_bases
AGTTTCCAACATCCGGTTTTCTTAGTATACAAGTTAAAGCCGAGTCTTGGGAAGAGCTTGGAAAACTTCCGGGAAAAATA
ATTAGATTCTGGATACCATA

Downstream 100 bases:

>100_bases
TTTTTTATTATAAAGCGCAGTAGAACTATAATTTGTCACAATCCAGAATTAATTTCTGATCTTTTATATTAAACGGAAAT
CTGAGAATATTTATTTTTAC

Product: hypoxanthine-guanine-xanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MKKINSDILHPRFSREDISQKVKSLALQISEDYKKLNPIFICVLKGGVYFFTDLTREIPFSVEINFVQARSYSGTVSTGK
IELLKDIDIDLSDRHVIIVEDILDTGFTLQYLVRHIFTRNPASLEIVTLLLKERKDTLEFPVKYIGWRIPDEFLVGYGLD
FDGRYRNLPDIHVLEPGEPQFPV

Sequences:

>Translated_183_residues
MKKINSDILHPRFSREDISQKVKSLALQISEDYKKLNPIFICVLKGGVYFFTDLTREIPFSVEINFVQARSYSGTVSTGK
IELLKDIDIDLSDRHVIIVEDILDTGFTLQYLVRHIFTRNPASLEIVTLLLKERKDTLEFPVKYIGWRIPDEFLVGYGLD
FDGRYRNLPDIHVLEPGEPQFPV
>Mature_183_residues
MKKINSDILHPRFSREDISQKVKSLALQISEDYKKLNPIFICVLKGGVYFFTDLTREIPFSVEINFVQARSYSGTVSTGK
IELLKDIDIDLSDRHVIIVEDILDTGFTLQYLVRHIFTRNPASLEIVTLLLKERKDTLEFPVKYIGWRIPDEFLVGYGLD
FDGRYRNLPDIHVLEPGEPQFPV

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=177, Percent_Identity=32.7683615819209, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI9910262, Length=177, Percent_Identity=30.5084745762712, Blast_Score=90, Evalue=9e-19,
Organism=Escherichia coli, GI87081689, Length=156, Percent_Identity=42.3076923076923, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17510817, Length=168, Percent_Identity=32.1428571428571, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 21176; Mature: 21176

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKINSDILHPRFSREDISQKVKSLALQISEDYKKLNPIFICVLKGGVYFFTDLTREIPF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEEEHHHHCCC
SVEINFVQARSYSGTVSTGKIELLKDIDIDLSDRHVIIVEDILDTGFTLQYLVRHIFTRN
EEEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHCCC
PASLEIVTLLLKERKDTLEFPVKYIGWRIPDEFLVGYGLDFDGRYRNLPDIHVLEPGEPQ
CCCHHHHHHHHHHCCCHHHCCHHHCCCCCCHHHHEEECCCCCCCCCCCCCEEEECCCCCC
FPV
CCC
>Mature Secondary Structure
MKKINSDILHPRFSREDISQKVKSLALQISEDYKKLNPIFICVLKGGVYFFTDLTREIPF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEEEHHHHCCC
SVEINFVQARSYSGTVSTGKIELLKDIDIDLSDRHVIIVEDILDTGFTLQYLVRHIFTRN
EEEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHCCC
PASLEIVTLLLKERKDTLEFPVKYIGWRIPDEFLVGYGLDFDGRYRNLPDIHVLEPGEPQ
CCCHHHHHHHHHHCCCHHHCCHHHCCCCCCHHHHEEECCCCCCCCCCCCCEEEECCCCCC
FPV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]