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The map label for this gene is pyrD

Identifier: 45659250

GI number: 45659250

Start: 4209987

End: 4211135

Strand: Direct

Name: pyrD

Synonym: LIC13433

Alternate gene names: 45659250

Gene position: 4209987-4211135 (Clockwise)

Preceding gene: 45659249

Following gene: 45659251

Centisome position: 98.43

GC content: 35.42

Gene sequence:

>1149_bases
TTGATCAATAGAAATAAAATAGTTTTAGAGATGTTTTTACCTCACTTAAGACAAAGTGCATATTCGGTTTTTCTAAAGCC
GTTTTTTCTCTCCTTAGATCCCGAAACGGCACACGAACTTGCAAAGAATTTTCTTGGTATCGGTCAAAAATTTCCTGGAT
TTTTAACATTAATGGAATCGATGACTTCTTATCAAAGCGATCGTTTAAAAACAAAAATCGCTGGAATCGAGTTTGAAAAT
CCTTTGGGAATGGGAGCGGGTTTCGATAAAACGGGAGAACTATATCCCTTTCTTTCGAGAATGGGTTTCGGTCATATCGA
AGTAGGAACAATCACAGGACAGAAACAATCCGGAAATCCGAAACCTAGAGTATTTCGTTATCCACAAGATCAAGCTTTAG
TCAATCGTATGGGTTTTAATAACCCAGGAGCAGACTCCGCAAAAAAAATTATTTCCTCCCAAAAAAAAACAAAGATCCGA
GGTATCAACGCAGGAAAAACGAAGATCGTTCCAGAGGAAAAAGCGGTCGAGGATTACGTTTACACTCTCAAAAAACTTTC
ACCTTATGCAGATTATGCGGTCATCAACATAAGCTCTCCAAATACTCCTGGATTAAGAAATTTTCAAAAGCAAGAAAACT
TTGTATCTTTGATTCAAGGAATTAGAAAAGACTTAGGCAAAAATTTTAAAATTCCTTTATTCGTAAAATTTGCCCCCGAT
ATGGAAACAAAAGAACTCGAAGCCTTACTCGAAACTTCTTTGAGTTTAAAAATCAACGGAGTCGTTTTAACCAATACAAC
TATTGACAAATCTTGTCTAAAAAACTACCCTAACGTAGAAAAAGAAGGAGGGCTTTCTGGGACTCCTTTAAAAAACCGTT
CTACAGAATTTGTTCGAATTGCCTATCGAATTTTAAAACGAAGAATTCCGATCATAGGAGTGGGTGGAATTGACTCTGAA
AAAACCGCTTTAGAAAAAATTCTTGCAGGAGCTGATTTAATCCAAATTTATACCGGTTATATCTATCAGGGTCCTTTTTT
ACCTATGAGAATTTTAAAGTTTTTGGATCGGTTCTTAGAAAAGCAAGATCTAAAAACCGTATCAGATCTAGTAGGAAAAG
AAAAGGAAATTAGATTAGATCAAAAATAG

Upstream 100 bases:

>100_bases
TTGAAGGCGTGGAGTTAAGTTCGGTAATTCCTACTTTGATTTCGTTGTTTTTATATGGAATTGTCTTTCTTTTTATAGGA
AATAAAATTTTTCGCTGGTC

Downstream 100 bases:

>100_bases
TTTAAAATTGTCTTTCAAAAATATATCTAATTTTACAAATAAGCGAAATTATCTACTTTAAAATATTAAAATTTTATTAA
ATATGAATTAGGAATTCAAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MINRNKIVLEMFLPHLRQSAYSVFLKPFFLSLDPETAHELAKNFLGIGQKFPGFLTLMESMTSYQSDRLKTKIAGIEFEN
PLGMGAGFDKTGELYPFLSRMGFGHIEVGTITGQKQSGNPKPRVFRYPQDQALVNRMGFNNPGADSAKKIISSQKKTKIR
GINAGKTKIVPEEKAVEDYVYTLKKLSPYADYAVINISSPNTPGLRNFQKQENFVSLIQGIRKDLGKNFKIPLFVKFAPD
METKELEALLETSLSLKINGVVLTNTTIDKSCLKNYPNVEKEGGLSGTPLKNRSTEFVRIAYRILKRRIPIIGVGGIDSE
KTALEKILAGADLIQIYTGYIYQGPFLPMRILKFLDRFLEKQDLKTVSDLVGKEKEIRLDQK

Sequences:

>Translated_382_residues
MINRNKIVLEMFLPHLRQSAYSVFLKPFFLSLDPETAHELAKNFLGIGQKFPGFLTLMESMTSYQSDRLKTKIAGIEFEN
PLGMGAGFDKTGELYPFLSRMGFGHIEVGTITGQKQSGNPKPRVFRYPQDQALVNRMGFNNPGADSAKKIISSQKKTKIR
GINAGKTKIVPEEKAVEDYVYTLKKLSPYADYAVINISSPNTPGLRNFQKQENFVSLIQGIRKDLGKNFKIPLFVKFAPD
METKELEALLETSLSLKINGVVLTNTTIDKSCLKNYPNVEKEGGLSGTPLKNRSTEFVRIAYRILKRRIPIIGVGGIDSE
KTALEKILAGADLIQIYTGYIYQGPFLPMRILKFLDRFLEKQDLKTVSDLVGKEKEIRLDQK
>Mature_382_residues
MINRNKIVLEMFLPHLRQSAYSVFLKPFFLSLDPETAHELAKNFLGIGQKFPGFLTLMESMTSYQSDRLKTKIAGIEFEN
PLGMGAGFDKTGELYPFLSRMGFGHIEVGTITGQKQSGNPKPRVFRYPQDQALVNRMGFNNPGADSAKKIISSQKKTKIR
GINAGKTKIVPEEKAVEDYVYTLKKLSPYADYAVINISSPNTPGLRNFQKQENFVSLIQGIRKDLGKNFKIPLFVKFAPD
METKELEALLETSLSLKINGVVLTNTTIDKSCLKNYPNVEKEGGLSGTPLKNRSTEFVRIAYRILKRRIPIIGVGGIDSE
KTALEKILAGADLIQIYTGYIYQGPFLPMRILKFLDRFLEKQDLKTVSDLVGKEKEIRLDQK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=366, Percent_Identity=38.2513661202186, Blast_Score=251, Evalue=9e-67,
Organism=Escherichia coli, GI1787177, Length=340, Percent_Identity=42.0588235294118, Blast_Score=255, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17509475, Length=318, Percent_Identity=38.3647798742138, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322633, Length=322, Percent_Identity=25.776397515528, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281361352, Length=369, Percent_Identity=35.7723577235772, Blast_Score=227, Evalue=8e-60,
Organism=Drosophila melanogaster, GI17137316, Length=369, Percent_Identity=35.7723577235772, Blast_Score=227, Evalue=8e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 42972; Mature: 42972

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINRNKIVLEMFLPHLRQSAYSVFLKPFFLSLDPETAHELAKNFLGIGQKFPGFLTLMES
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCCCCHHHHHHHH
MTSYQSDRLKTKIAGIEFENPLGMGAGFDKTGELYPFLSRMGFGHIEVGTITGQKQSGNP
HHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCC
KPRVFRYPQDQALVNRMGFNNPGADSAKKIISSQKKTKIRGINAGKTKIVPEEKAVEDYV
CCCEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
YTLKKLSPYADYAVINISSPNTPGLRNFQKQENFVSLIQGIRKDLGKNFKIPLFVKFAPD
HHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
METKELEALLETSLSLKINGVVLTNTTIDKSCLKNYPNVEKEGGLSGTPLKNRSTEFVRI
CCHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHH
AYRILKRRIPIIGVGGIDSEKTALEKILAGADLIQIYTGYIYQGPFLPMRILKFLDRFLE
HHHHHHHCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KQDLKTVSDLVGKEKEIRLDQK
HHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MINRNKIVLEMFLPHLRQSAYSVFLKPFFLSLDPETAHELAKNFLGIGQKFPGFLTLMES
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCCCCHHHHHHHH
MTSYQSDRLKTKIAGIEFENPLGMGAGFDKTGELYPFLSRMGFGHIEVGTITGQKQSGNP
HHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCC
KPRVFRYPQDQALVNRMGFNNPGADSAKKIISSQKKTKIRGINAGKTKIVPEEKAVEDYV
CCCEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
YTLKKLSPYADYAVINISSPNTPGLRNFQKQENFVSLIQGIRKDLGKNFKIPLFVKFAPD
HHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
METKELEALLETSLSLKINGVVLTNTTIDKSCLKNYPNVEKEGGLSGTPLKNRSTEFVRI
CCHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHH
AYRILKRRIPIIGVGGIDSEKTALEKILAGADLIQIYTGYIYQGPFLPMRILKFLDRFLE
HHHHHHHCCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KQDLKTVSDLVGKEKEIRLDQK
HHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]