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The map label for this gene is folK

Identifier: 45658986

GI number: 45658986

Start: 3874007

End: 3874456

Strand: Reverse

Name: folK

Synonym: LIC13164

Alternate gene names: 45658986

Gene position: 3874456-3874007 (Counterclockwise)

Preceding gene: 45658987

Following gene: 45658985

Centisome position: 90.58

GC content: 33.78

Gene sequence:

>450_bases
ATGAAACAAGCCTTCCTTTCTCTGGGTTCCAATTTAGGAAATAGAGCTGAGTTTTTAAAAATTGCAGTTCGTAAATTGAA
AAATACGATAGGTATCGAAATTCTTAAAGAATCGACACCGTTGAACACGACTCCTTTGGAAGTTATCGATCAACCTGAAT
TCCTAAATCAAATTATAAAAATTGAAACTAGTTTAAATCCAGAAGAATTGTTAGAAGTTGTTCTTAGAATTGAAAAAGAA
ATGGGTCGTATTCGTAAGGTAGACAAAGGGCCAAGGGAAATCGACATAGACATTCTTTCTTATGAAAAAGTTAAGATAAA
TACTCAGGGATTAACTCTTCCTCATCATTCCCTTTTTACTCGTCCTTTTATCAGAGAGATTTTAGAATCGATCGGCGAAC
AGTCATTATACGAGCATTTTACGGGAGGCAAATATGAAAAACATACATAA

Upstream 100 bases:

>100_bases
CAGAAGGAAGAATTTATTCCAGACTTAAAGAAATGACCCAAGAAATCCATTTAGAATGTGCTGATTATCGTTTGAAACTT
TCCGAATCGGGAGAAAGAAA

Downstream 100 bases:

>100_bases
AATTTTTTCTCCTGAAAAGAAAGGGAAAGAAAAAATTTCCGTAGTTACATGTTACGATTTTAGTTTTGCTAGGATTTTAA
ACGAAACTGAAATCGATTCT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MKQAFLSLGSNLGNRAEFLKIAVRKLKNTIGIEILKESTPLNTTPLEVIDQPEFLNQIIKIETSLNPEELLEVVLRIEKE
MGRIRKVDKGPREIDIDILSYEKVKINTQGLTLPHHSLFTRPFIREILESIGEQSLYEHFTGGKYEKHT

Sequences:

>Translated_149_residues
MKQAFLSLGSNLGNRAEFLKIAVRKLKNTIGIEILKESTPLNTTPLEVIDQPEFLNQIIKIETSLNPEELLEVVLRIEKE
MGRIRKVDKGPREIDIDILSYEKVKINTQGLTLPHHSLFTRPFIREILESIGEQSLYEHFTGGKYEKHT
>Mature_149_residues
MKQAFLSLGSNLGNRAEFLKIAVRKLKNTIGIEILKESTPLNTTPLEVIDQPEFLNQIIKIETSLNPEELLEVVLRIEKE
MGRIRKVDKGPREIDIDILSYEKVKINTQGLTLPHHSLFTRPFIREILESIGEQSLYEHFTGGKYEKHT

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=38.4057971014493, Blast_Score=95, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324073, Length=134, Percent_Identity=33.5820895522388, Blast_Score=84, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17124; Mature: 17124

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQAFLSLGSNLGNRAEFLKIAVRKLKNTIGIEILKESTPLNTTPLEVIDQPEFLNQIIK
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHCCCHHHHHHHHH
IETSLNPEELLEVVLRIEKEMGRIRKVDKGPREIDIDILSYEKVKINTQGLTLPHHSLFT
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEECCCCCCCCCHHHHH
RPFIREILESIGEQSLYEHFTGGKYEKHT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKQAFLSLGSNLGNRAEFLKIAVRKLKNTIGIEILKESTPLNTTPLEVIDQPEFLNQIIK
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHCCCHHHHHHHHH
IETSLNPEELLEVVLRIEKEMGRIRKVDKGPREIDIDILSYEKVKINTQGLTLPHHSLFT
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEECCCCCCCCCHHHHH
RPFIREILESIGEQSLYEHFTGGKYEKHT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]