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The map label for this gene is frlA [H]

Identifier: 45658863

GI number: 45658863

Start: 3708144

End: 3709625

Strand: Reverse

Name: frlA [H]

Synonym: LIC13037

Alternate gene names: 45658863

Gene position: 3709625-3708144 (Counterclockwise)

Preceding gene: 45658864

Following gene: 45658862

Centisome position: 86.73

GC content: 34.21

Gene sequence:

>1482_bases
TTGTTCATGGTGACGGAACTATCATACTGTCAGAAAATGACGCAGCTCAAGAGATCCCTCAATTTATTCGATTCTATATC
ACTTATGTTTAGTTCCATGGTAGGACCGGGGATCTTTATCACAACTGGATATATTCTTCATCAGGTTCCAAATCCTAATA
TCGTTTTACTCGCTTGGATCTTAGGAGGATTTCTTGCAGTAGCGGGAGCAATGTCTTATGCAAAATCTGCTTCACTTTTT
CCTTATGCTGGAGGAGATTATGTTTATCTAAAAGAAGCCTATTCGCCGATTGTCGCATTTGCAAGTGGATGGCTTTCTCT
TTCTATCAATTTTTCGGCTTCGATTTCTCTATCTGCATTAGCATTTTCTAAATCGTTTTTTTCATTAATTAATCCTTCTT
GGGATATTTATTTTTTTGAAATTCCGTTTTTAGGATTAACGATTTCGATTGGAACTGCACAGATTTTGGCGATGAGCGCA
ATTCTTGTATTTACGATCGTCAATTTTTTTGGAATTTCCACTGCATCTAGAATTCAAAATTTATTCACAAGCGTAAAAAT
TTTAGGTTTGGTATCTTTTGTAATTTTGGGATTTGTCATTGGAAATTATGATATTTCTCGATTTAAATCATTCTCTTTGT
TTCCTTCTGATTTAAAAGGATTTGAACTTTTGTTTGCGGGAGTGATTCCCGTGACATATTCTTATCTTGGGTGGAATATG
ATAACTTATGTTGCAGAAGAAGTCAAAGATCCGGATAAGAATATTTATAAAGCGGTTTTATATTCCTGTGCGTTAGTTAC
TATTCTTTATATTCTAATGAACTTCCTTTTTTTGAGTTCCGGAACTCTTTCAGAATTATCGGGGGATAAAATAGGAATTA
CAGCGTCATCTGCTTTGTTTGGTCCTAAAGCAACTGTTTTCATCACTGTTTTTATTTGTTGGGCTTTTTTAGCTTCAATC
TCAGCTTATATCATAGGAGGTTCAAGAATTTATTTTGCTATGGCAAGAGACGGATTCTTTTTTCAGAATATGGCAAAGTT
GCATTCTAAACATAAAAGTCCTTATATGTCACTTCTCTTTCAATGTGGTTATGCTTGTTTATTTTGTTTTGTAAAGGAGA
TAGAAAGTCTTCTTTACCTAATTACTTGTTCTACATTACTTCTCGCTACGATTACAGCGTATACGCCGATTCTTTTTGAA
AAAAGAAATTACAAATTGAAATTTAGAATTCCAGGATATCCTTATACAACTTATTTATATATCGCCTCCAATTTTGGTAT
TATTGCGACATTACTTTGGAATAAACCGACGGAGGCCTTTTGGGGAGTTGGCTTCACATTTCTTTCTATACCAATGTATT
ACTATTTTAAAATAATGCAAAATACTTTATCAAAAAATTCTACTCCTCTTGAAACCCCAGAGGTTTTGGCAACGAGTCTA
CTTCCAGAAAATGAACCGGTTCCAATTGCCAGTGGAGAATAG

Upstream 100 bases:

>100_bases
ATCATAAGCTTCTAATAGACATGGATAGTGCAACCAAAACAATTCTAATACTATTAGCTACCTTTCTAAATTTAAAAAAA
AACTATAAAAGGAAAAATCC

Downstream 100 bases:

>100_bases
TAATAATTGAAATTAATTTTACTTTGAAGACAAAATGTAGATTCAAGCTTCATTCCATTTTGGGAATTGTTTCTATCTTA
CTTTTAAGTTGTAAAAATTT

Product: amino acid transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MFMVTELSYCQKMTQLKRSLNLFDSISLMFSSMVGPGIFITTGYILHQVPNPNIVLLAWILGGFLAVAGAMSYAKSASLF
PYAGGDYVYLKEAYSPIVAFASGWLSLSINFSASISLSALAFSKSFFSLINPSWDIYFFEIPFLGLTISIGTAQILAMSA
ILVFTIVNFFGISTASRIQNLFTSVKILGLVSFVILGFVIGNYDISRFKSFSLFPSDLKGFELLFAGVIPVTYSYLGWNM
ITYVAEEVKDPDKNIYKAVLYSCALVTILYILMNFLFLSSGTLSELSGDKIGITASSALFGPKATVFITVFICWAFLASI
SAYIIGGSRIYFAMARDGFFFQNMAKLHSKHKSPYMSLLFQCGYACLFCFVKEIESLLYLITCSTLLLATITAYTPILFE
KRNYKLKFRIPGYPYTTYLYIASNFGIIATLLWNKPTEAFWGVGFTFLSIPMYYYFKIMQNTLSKNSTPLETPEVLATSL
LPENEPVPIASGE

Sequences:

>Translated_493_residues
MFMVTELSYCQKMTQLKRSLNLFDSISLMFSSMVGPGIFITTGYILHQVPNPNIVLLAWILGGFLAVAGAMSYAKSASLF
PYAGGDYVYLKEAYSPIVAFASGWLSLSINFSASISLSALAFSKSFFSLINPSWDIYFFEIPFLGLTISIGTAQILAMSA
ILVFTIVNFFGISTASRIQNLFTSVKILGLVSFVILGFVIGNYDISRFKSFSLFPSDLKGFELLFAGVIPVTYSYLGWNM
ITYVAEEVKDPDKNIYKAVLYSCALVTILYILMNFLFLSSGTLSELSGDKIGITASSALFGPKATVFITVFICWAFLASI
SAYIIGGSRIYFAMARDGFFFQNMAKLHSKHKSPYMSLLFQCGYACLFCFVKEIESLLYLITCSTLLLATITAYTPILFE
KRNYKLKFRIPGYPYTTYLYIASNFGIIATLLWNKPTEAFWGVGFTFLSIPMYYYFKIMQNTLSKNSTPLETPEVLATSL
LPENEPVPIASGE
>Mature_493_residues
MFMVTELSYCQKMTQLKRSLNLFDSISLMFSSMVGPGIFITTGYILHQVPNPNIVLLAWILGGFLAVAGAMSYAKSASLF
PYAGGDYVYLKEAYSPIVAFASGWLSLSINFSASISLSALAFSKSFFSLINPSWDIYFFEIPFLGLTISIGTAQILAMSA
ILVFTIVNFFGISTASRIQNLFTSVKILGLVSFVILGFVIGNYDISRFKSFSLFPSDLKGFELLFAGVIPVTYSYLGWNM
ITYVAEEVKDPDKNIYKAVLYSCALVTILYILMNFLFLSSGTLSELSGDKIGITASSALFGPKATVFITVFICWAFLASI
SAYIIGGSRIYFAMARDGFFFQNMAKLHSKHKSPYMSLLFQCGYACLFCFVKEIESLLYLITCSTLLLATITAYTPILFE
KRNYKLKFRIPGYPYTTYLYIASNFGIIATLLWNKPTEAFWGVGFTFLSIPMYYYFKIMQNTLSKNSTPLETPEVLATSL
LPENEPVPIASGE

Specific function: May be involved in fructoselysine transport [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=470, Percent_Identity=25.3191489361702, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI115648022, Length=470, Percent_Identity=25.3191489361702, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI71979932, Length=448, Percent_Identity=26.5625, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI33286428, Length=459, Percent_Identity=25.9259259259259, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI186910308, Length=378, Percent_Identity=25.9259259259259, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI186910306, Length=378, Percent_Identity=25.9259259259259, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI186910304, Length=378, Percent_Identity=25.9259259259259, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI187423910, Length=488, Percent_Identity=24.5901639344262, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI7657591, Length=488, Percent_Identity=24.5901639344262, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI7657683, Length=477, Percent_Identity=24.3186582809224, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI9790235, Length=374, Percent_Identity=26.2032085561497, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI258614003, Length=412, Percent_Identity=24.7572815533981, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI258614005, Length=412, Percent_Identity=24.7572815533981, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI258645169, Length=412, Percent_Identity=25, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI4507047, Length=416, Percent_Identity=23.0769230769231, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI114326544, Length=410, Percent_Identity=23.1707317073171, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI114326550, Length=410, Percent_Identity=23.1707317073171, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI33286430, Length=237, Percent_Identity=25.7383966244726, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI71999149, Length=353, Percent_Identity=24.3626062322946, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI110347453, Length=370, Percent_Identity=24.5945945945946, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082250, Length=429, Percent_Identity=28.6713286713287, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081869, Length=368, Percent_Identity=24.7282608695652, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=350, Percent_Identity=24.8571428571429, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32566699, Length=373, Percent_Identity=25.7372654155496, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17568033, Length=347, Percent_Identity=26.5129682997118, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71995388, Length=397, Percent_Identity=24.9370277078086, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71995382, Length=397, Percent_Identity=24.9370277078086, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71993915, Length=356, Percent_Identity=25.561797752809, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17532491, Length=450, Percent_Identity=25.3333333333333, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71982608, Length=367, Percent_Identity=24.2506811989101, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71982612, Length=367, Percent_Identity=24.2506811989101, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI193208714, Length=369, Percent_Identity=23.3062330623306, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32566695, Length=369, Percent_Identity=23.3062330623306, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71990446, Length=476, Percent_Identity=22.4789915966387, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17533459, Length=408, Percent_Identity=22.7941176470588, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71982623, Length=274, Percent_Identity=25.1824817518248, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=389, Percent_Identity=24.4215938303342, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24651635, Length=456, Percent_Identity=26.3157894736842, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24651633, Length=456, Percent_Identity=26.3157894736842, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI221331183, Length=384, Percent_Identity=27.6041666666667, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI17647653, Length=384, Percent_Identity=27.6041666666667, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24664379, Length=384, Percent_Identity=27.6041666666667, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45550968, Length=461, Percent_Identity=23.8611713665944, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI19921172, Length=461, Percent_Identity=23.8611713665944, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21357367, Length=462, Percent_Identity=25.974025974026, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24641993, Length=389, Percent_Identity=22.879177377892, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24641995, Length=389, Percent_Identity=22.879177377892, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24668806, Length=410, Percent_Identity=22.1951219512195, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356285, Length=410, Percent_Identity=22.1951219512195, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24668802, Length=410, Percent_Identity=22.1951219512195, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667468, Length=415, Percent_Identity=26.9879518072289, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI281366235, Length=428, Percent_Identity=23.1308411214953, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI116007820, Length=428, Percent_Identity=23.1308411214953, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI161077963, Length=389, Percent_Identity=22.6221079691517, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI116007818, Length=425, Percent_Identity=23.2941176470588, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI85725152, Length=425, Percent_Identity=23.2941176470588, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221512776, Length=397, Percent_Identity=21.6624685138539, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24666159, Length=397, Percent_Identity=21.6624685138539, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54823; Mature: 54823

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMVTELSYCQKMTQLKRSLNLFDSISLMFSSMVGPGIFITTGYILHQVPNPNIVLLAWI
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHEEECCCCCEEEEHHH
LGGFLAVAGAMSYAKSASLFPYAGGDYVYLKEAYSPIVAFASGWLSLSINFSASISLSAL
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCEEEEEEEEECCEEHHHH
AFSKSFFSLINPSWDIYFFEIPFLGLTISIGTAQILAMSAILVFTIVNFFGISTASRIQN
HHHHHHHHHHCCCCEEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LFTSVKILGLVSFVILGFVIGNYDISRFKSFSLFPSDLKGFELLFAGVIPVTYSYLGWNM
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ITYVAEEVKDPDKNIYKAVLYSCALVTILYILMNFLFLSSGTLSELSGDKIGITASSALF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCCC
GPKATVFITVFICWAFLASISAYIIGGSRIYFAMARDGFFFQNMAKLHSKHKSPYMSLLF
CCCHHHHHHHHHHHHHHHHHHHEEECCCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHH
QCGYACLFCFVKEIESLLYLITCSTLLLATITAYTPILFEKRNYKLKFRIPGYPYTTYLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCEEEEE
IASNFGIIATLLWNKPTEAFWGVGFTFLSIPMYYYFKIMQNTLSKNSTPLETPEVLATSL
EECCCCEEEEEECCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
LPENEPVPIASGE
CCCCCCCCCCCCC
>Mature Secondary Structure
MFMVTELSYCQKMTQLKRSLNLFDSISLMFSSMVGPGIFITTGYILHQVPNPNIVLLAWI
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHEEECCCCCEEEEHHH
LGGFLAVAGAMSYAKSASLFPYAGGDYVYLKEAYSPIVAFASGWLSLSINFSASISLSAL
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCEEEEEEEEECCEEHHHH
AFSKSFFSLINPSWDIYFFEIPFLGLTISIGTAQILAMSAILVFTIVNFFGISTASRIQN
HHHHHHHHHHCCCCEEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LFTSVKILGLVSFVILGFVIGNYDISRFKSFSLFPSDLKGFELLFAGVIPVTYSYLGWNM
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ITYVAEEVKDPDKNIYKAVLYSCALVTILYILMNFLFLSSGTLSELSGDKIGITASSALF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCCC
GPKATVFITVFICWAFLASISAYIIGGSRIYFAMARDGFFFQNMAKLHSKHKSPYMSLLF
CCCHHHHHHHHHHHHHHHHHHHEEECCCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHH
QCGYACLFCFVKEIESLLYLITCSTLLLATITAYTPILFEKRNYKLKFRIPGYPYTTYLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCEEEEE
IASNFGIIATLLWNKPTEAFWGVGFTFLSIPMYYYFKIMQNTLSKNSTPLETPEVLATSL
EECCCCEEEEEECCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
LPENEPVPIASGE
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]