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The map label for this gene is truD [H]

Identifier: 45658864

GI number: 45658864

Start: 3710444

End: 3711577

Strand: Reverse

Name: truD [H]

Synonym: LIC13038

Alternate gene names: 45658864

Gene position: 3711577-3710444 (Counterclockwise)

Preceding gene: 45658870

Following gene: 45658863

Centisome position: 86.78

GC content: 33.51

Gene sequence:

>1134_bases
TTGATCCAAAAAACTGGGAAATGGATGATCTTTAGGCTTCAAAAATCTGGTTGGAATACGTTAGACGCGCTTCTGAGGAT
TTCTAAAGAGTCTAAAGTTTCTATTTTTGAAATCGGTTATGCCGGAAAAAAAGATCGTCACGCTTCTACTTCTCAATACA
TAAGTTGTCAAAAACCTTTGAGGGTTCCTAAAGAACTCACAAAGGTAATTCAATTGGATAAAATTGGTTTTAGTAAAAAA
TCGTTAAGTACAGAATTAAATGTTGGCAATCGATTTCAACTTGTTCTAAGAAATTTGCTCGAAAAAGAAATCGAATCGAT
TCGAAATAATTTCGAAAAGATTACTAAAAACGGTTTTATTAACTATTACGATTCACAACGATTTAGTCGCTTTCACTCGG
AGTTCCGGCTTCCTATTTTACCGTTTTTTAAAGGAGACGCGGAAACTTGTCTAAAGCTGATTCTGACAGATCCTTTTCCT
GGAGAAAAAAAACAGGCTCGGGACAGAAAAAAAATTCTTTATGACCTTTGGGGAAATTGGTCTCAGTGTGAAAAATGGTC
TAAGAGCAAATTGGAAAAAAATATTTTTTCCAATTTAAAAAAAGAAAAAAAACCGACACAAAAAACCTATTCCGATTTGA
TTCTTCGATTTCCGGAAGAAGAATTATTGATGTTAGTTTCTTCGTTTCAGTCTTTGATCTGGAACGAATTTGTATCCGAA
ATTTTCATTTCCGACAATTTTACTGGAGTTTGGATTAAAACAAAAACTGGCCCTTTGTTTTTTCCGGGAGAATCCTCTAT
TCAATCCGTTCCATTTTCCAAAAATCTTCCGGTTCCAGGTAATCCAGGAATTTATAAATTAGAATATTCTAAAAAAGAAA
TAGATACTTTAAAGAAAATACTAAATCAAAACGGATTGACCGAATCGGTTTTGGATAGTTCCCCTTTTCCAATTATTAAA
ATGAATTCTTTTGAACGAAAAGTGAGAATACTTCCAAATGATTTTCAAATTGGCGATTTTGAAGAAGACGATCAGCATCC
TGGAAAAAGGAAAGTTAAAATATCTTTTCGACTCCCTTCAGGAGTCTATGCAACTATGCTAATTAAGCGGTTAATGCTAA
GGTCGCGTATATAA

Upstream 100 bases:

>100_bases
CTATGTTTTGGAACTTGTGCAGCCATTTAGCGGTTTTTTAGTCTATGATTTGAAACAAACACCAGAAGATTTTCAGGTTG
AGGAGATTCTTCCTTCAGAT

Downstream 100 bases:

>100_bases
CATTCACTTTAGAATCTGAAAAAGAAGTTATAAGAATTGTCTTTGGATGGGTTTTTACCCAACTTGAAATATTTGACAAT
AGAGTTGTTGAAAAATTCCC

Product: hypothetical protein

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D; tRNA-uridine isomerase D [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MIQKTGKWMIFRLQKSGWNTLDALLRISKESKVSIFEIGYAGKKDRHASTSQYISCQKPLRVPKELTKVIQLDKIGFSKK
SLSTELNVGNRFQLVLRNLLEKEIESIRNNFEKITKNGFINYYDSQRFSRFHSEFRLPILPFFKGDAETCLKLILTDPFP
GEKKQARDRKKILYDLWGNWSQCEKWSKSKLEKNIFSNLKKEKKPTQKTYSDLILRFPEEELLMLVSSFQSLIWNEFVSE
IFISDNFTGVWIKTKTGPLFFPGESSIQSVPFSKNLPVPGNPGIYKLEYSKKEIDTLKKILNQNGLTESVLDSSPFPIIK
MNSFERKVRILPNDFQIGDFEEDDQHPGKRKVKISFRLPSGVYATMLIKRLMLRSRI

Sequences:

>Translated_377_residues
MIQKTGKWMIFRLQKSGWNTLDALLRISKESKVSIFEIGYAGKKDRHASTSQYISCQKPLRVPKELTKVIQLDKIGFSKK
SLSTELNVGNRFQLVLRNLLEKEIESIRNNFEKITKNGFINYYDSQRFSRFHSEFRLPILPFFKGDAETCLKLILTDPFP
GEKKQARDRKKILYDLWGNWSQCEKWSKSKLEKNIFSNLKKEKKPTQKTYSDLILRFPEEELLMLVSSFQSLIWNEFVSE
IFISDNFTGVWIKTKTGPLFFPGESSIQSVPFSKNLPVPGNPGIYKLEYSKKEIDTLKKILNQNGLTESVLDSSPFPIIK
MNSFERKVRILPNDFQIGDFEEDDQHPGKRKVKISFRLPSGVYATMLIKRLMLRSRI
>Mature_377_residues
MIQKTGKWMIFRLQKSGWNTLDALLRISKESKVSIFEIGYAGKKDRHASTSQYISCQKPLRVPKELTKVIQLDKIGFSKK
SLSTELNVGNRFQLVLRNLLEKEIESIRNNFEKITKNGFINYYDSQRFSRFHSEFRLPILPFFKGDAETCLKLILTDPFP
GEKKQARDRKKILYDLWGNWSQCEKWSKSKLEKNIFSNLKKEKKPTQKTYSDLILRFPEEELLMLVSSFQSLIWNEFVSE
IFISDNFTGVWIKTKTGPLFFPGESSIQSVPFSKNLPVPGNPGIYKLEYSKKEIDTLKKILNQNGLTESVLDSSPFPIIK
MNSFERKVRILPNDFQIGDFEEDDQHPGKRKVKISFRLPSGVYATMLIKRLMLRSRI

Specific function: Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs [H]

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17557232, Length=403, Percent_Identity=25.3101736972705, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324817, Length=254, Percent_Identity=29.5275590551181, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355799, Length=248, Percent_Identity=24.5967741935484, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR020119
- InterPro:   IPR011760 [H]

Pfam domain/function: PF01142 TruD [H]

EC number: NA

Molecular weight: Translated: 43949; Mature: 43949

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: PS50984 TRUD ; PS01268 UPF0024

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQKTGKWMIFRLQKSGWNTLDALLRISKESKVSIFEIGYAGKKDRHASTSQYISCQKPL
CCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCCC
RVPKELTKVIQLDKIGFSKKSLSTELNVGNRFQLVLRNLLEKEIESIRNNFEKITKNGFI
CCHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
NYYDSQRFSRFHSEFRLPILPFFKGDAETCLKLILTDPFPGEKKQARDRKKILYDLWGNW
EEHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCH
SQCEKWSKSKLEKNIFSNLKKEKKPTQKTYSDLILRFPEEELLMLVSSFQSLIWNEFVSE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IFISDNFTGVWIKTKTGPLFFPGESSIQSVPFSKNLPVPGNPGIYKLEYSKKEIDTLKKI
HHHCCCCEEEEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHH
LNQNGLTESVLDSSPFPIIKMNSFERKVRILPNDFQIGDFEEDDQHPGKRKVKISFRLPS
HCCCCCCHHHHCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCC
GVYATMLIKRLMLRSRI
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIQKTGKWMIFRLQKSGWNTLDALLRISKESKVSIFEIGYAGKKDRHASTSQYISCQKPL
CCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCCC
RVPKELTKVIQLDKIGFSKKSLSTELNVGNRFQLVLRNLLEKEIESIRNNFEKITKNGFI
CCHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
NYYDSQRFSRFHSEFRLPILPFFKGDAETCLKLILTDPFPGEKKQARDRKKILYDLWGNW
EEHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCH
SQCEKWSKSKLEKNIFSNLKKEKKPTQKTYSDLILRFPEEELLMLVSSFQSLIWNEFVSE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IFISDNFTGVWIKTKTGPLFFPGESSIQSVPFSKNLPVPGNPGIYKLEYSKKEIDTLKKI
HHHCCCCEEEEEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHH
LNQNGLTESVLDSSPFPIIKMNSFERKVRILPNDFQIGDFEEDDQHPGKRKVKISFRLPS
HCCCCCCHHHHCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCC
GVYATMLIKRLMLRSRI
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA