| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is folC
Identifier: 45658778
GI number: 45658778
Start: 3581020
End: 3582312
Strand: Direct
Name: folC
Synonym: LIC12950
Alternate gene names: 45658778
Gene position: 3581020-3582312 (Clockwise)
Preceding gene: 45658777
Following gene: 45658786
Centisome position: 83.72
GC content: 32.64
Gene sequence:
>1293_bases ATGAATTCAGATTCCGACTTTTTAGAATTTGCAAACGGACTTTCTAATTTAGAAAAAAGCAGAAACTTCAATGTTTTTGC CGGTTATTCCTTGGAACCATTTACCAAAACCTTAAAAAAGTTTAATTTTGATCAGAGAAATGAATCCACTTTTTGTAGAA TCTCAGTGGTAGGAACAAACGCAAAAGGTTCTATCACTCATTTTTTAGGAGAATACTTTCGAATCTATGGTTTCAAAACG GGACTTTACACTTCACCTCATTTAATTAGTCCTTTAGAAAGAATTCGGATCGGGAGCCAATCTCAAAATTTTAGAAACAT TCTCACAAAAGAATTAGATCAATTGTTAAGCGAATGGAAATCTCTCAAAGCCATAGAGGACTTAAAATCTTTTTCTTTTT TTGAACTTTTCACTTGTGCCTCATTTTCTTTTTTCGAAAAAGAATCTGCGGAAGTCCAAATTTACGAGGCAGGACTTGGA GGCAGACTAGACGCAACTAAACTTTGCAATCCGGACGTAGTCGTTTTAGGAGTGATAGGTTTAGATCATAAAGAAATATT AGGAAATACGAAAGAAGAAATTTTAGAAGAAAAACTTGGAATTTGTACTTCCAACACAAAAGCACTTTTTGCGATCGAAC AGAACGAACCACAATTGAACGAAAAAATTTCATCCTGGTGTTCTCAAAACGGAATTCACTGCAATATCATTACCCAAACC CAATCTAAAGATACATATCTAACAAGAAATCAGATCTTCTGTTATCAAGTATTTCAAAATATTCTAAAATTTGATTTCTT TTTAAAATCTACCAACAAAAAAATCGATCTAGGATTTTCTAAGCATGAAAACGTTTCTTTAATTTTAAATGAACTTAGTT TTGAAATTTTCGAAAAATATATGACTCCTCCTCTGGGTAGATTAAGCGTTTTACGACATTCTCCACTGCTCGTTTTTGAT CCTGCACACAATCCAGATGCTTTTACAGAAACTCTACAAAGTTTATCCTTTCTTTTTCCATATTATAAATTTCGGATTTA TGCGGGTTTGTTAAAAGATAAGGATGGAAACGGTGTTTTGGAAATTTTAAGAAAGGCCCGTAACAAATCGGATATTCTAA ATTTTCAATTTTTAAAGGAAGATGAATTTGTTATTCCAACCAATTGCCATGCAAAAGAAACAATCTCCACCTCTGAATTC AGATCCGTATTACAACGTTTAGACGATTCTTTCGAACCGATTTTAATTTTAGGTAGTTTTCGTTTATTTCCGATTGTTGT TGATCTATTGTGA
Upstream 100 bases:
>100_bases ATCAAGCAATGAAACAGTTCGAACTTTTTACAGAAATTTCGCCTAACGCAGAAGATATAATCAAAACCAGGGAACGTTTG TCTAAAGCATTAGAAAATCG
Downstream 100 bases:
>100_bases CAAGACTAAAAAAATGAACGTGGTCTTTCTATAGCCAAGTATAAAAGTGAATTTTTGTGGAAACGTCATAGTTCCCACAA ATTGAGTTTCTTTTTGCGAT
Product: dihydrofolate synthase
Products: NA
Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]
Number of amino acids: Translated: 430; Mature: 430
Protein sequence:
>430_residues MNSDSDFLEFANGLSNLEKSRNFNVFAGYSLEPFTKTLKKFNFDQRNESTFCRISVVGTNAKGSITHFLGEYFRIYGFKT GLYTSPHLISPLERIRIGSQSQNFRNILTKELDQLLSEWKSLKAIEDLKSFSFFELFTCASFSFFEKESAEVQIYEAGLG GRLDATKLCNPDVVVLGVIGLDHKEILGNTKEEILEEKLGICTSNTKALFAIEQNEPQLNEKISSWCSQNGIHCNIITQT QSKDTYLTRNQIFCYQVFQNILKFDFFLKSTNKKIDLGFSKHENVSLILNELSFEIFEKYMTPPLGRLSVLRHSPLLVFD PAHNPDAFTETLQSLSFLFPYYKFRIYAGLLKDKDGNGVLEILRKARNKSDILNFQFLKEDEFVIPTNCHAKETISTSEF RSVLQRLDDSFEPILILGSFRLFPIVVDLL
Sequences:
>Translated_430_residues MNSDSDFLEFANGLSNLEKSRNFNVFAGYSLEPFTKTLKKFNFDQRNESTFCRISVVGTNAKGSITHFLGEYFRIYGFKT GLYTSPHLISPLERIRIGSQSQNFRNILTKELDQLLSEWKSLKAIEDLKSFSFFELFTCASFSFFEKESAEVQIYEAGLG GRLDATKLCNPDVVVLGVIGLDHKEILGNTKEEILEEKLGICTSNTKALFAIEQNEPQLNEKISSWCSQNGIHCNIITQT QSKDTYLTRNQIFCYQVFQNILKFDFFLKSTNKKIDLGFSKHENVSLILNELSFEIFEKYMTPPLGRLSVLRHSPLLVFD PAHNPDAFTETLQSLSFLFPYYKFRIYAGLLKDKDGNGVLEILRKARNKSDILNFQFLKEDEFVIPTNCHAKETISTSEF RSVLQRLDDSFEPILILGSFRLFPIVVDLL >Mature_430_residues MNSDSDFLEFANGLSNLEKSRNFNVFAGYSLEPFTKTLKKFNFDQRNESTFCRISVVGTNAKGSITHFLGEYFRIYGFKT GLYTSPHLISPLERIRIGSQSQNFRNILTKELDQLLSEWKSLKAIEDLKSFSFFELFTCASFSFFEKESAEVQIYEAGLG GRLDATKLCNPDVVVLGVIGLDHKEILGNTKEEILEEKLGICTSNTKALFAIEQNEPQLNEKISSWCSQNGIHCNIITQT QSKDTYLTRNQIFCYQVFQNILKFDFFLKSTNKKIDLGFSKHENVSLILNELSFEIFEKYMTPPLGRLSVLRHSPLLVFD PAHNPDAFTETLQSLSFLFPYYKFRIYAGLLKDKDGNGVLEILRKARNKSDILNFQFLKEDEFVIPTNCHAKETISTSEF RSVLQRLDDSFEPILILGSFRLFPIVVDLL
Specific function: Conversion of folates to polyglutamate derivatives [H]
COG id: COG0285
COG function: function code H; Folylpolyglutamate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the folylpolyglutamate synthase family [H]
Homologues:
Organism=Homo sapiens, GI66932990, Length=165, Percent_Identity=32.7272727272727, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI66932984, Length=165, Percent_Identity=32.7272727272727, Blast_Score=87, Evalue=2e-17, Organism=Escherichia coli, GI1788654, Length=399, Percent_Identity=27.0676691729323, Blast_Score=113, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17553148, Length=189, Percent_Identity=29.1005291005291, Blast_Score=80, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17553150, Length=189, Percent_Identity=29.1005291005291, Blast_Score=80, Evalue=2e-15, Organism=Caenorhabditis elegans, GI71984923, Length=189, Percent_Identity=29.1005291005291, Blast_Score=80, Evalue=2e-15, Organism=Saccharomyces cerevisiae, GI6323760, Length=400, Percent_Identity=24.5, Blast_Score=96, Evalue=9e-21, Organism=Saccharomyces cerevisiae, GI6324815, Length=176, Percent_Identity=36.3636363636364, Blast_Score=86, Evalue=9e-18, Organism=Drosophila melanogaster, GI24641571, Length=219, Percent_Identity=28.7671232876712, Blast_Score=86, Evalue=4e-17,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR018109 - InterPro: IPR001645 - InterPro: IPR004101 - InterPro: IPR013221 [H]
Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.17; =6.3.2.12 [H]
Molecular weight: Translated: 49300; Mature: 49300
Theoretical pI: Translated: 6.33; Mature: 6.33
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.9 %Cys (Translated Protein) 0.5 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 1.9 %Cys (Mature Protein) 0.5 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNSDSDFLEFANGLSNLEKSRNFNVFAGYSLEPFTKTLKKFNFDQRNESTFCRISVVGTN CCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCCCCCCCCCEEEEEEEECC AKGSITHFLGEYFRIYGFKTGLYTSPHLISPLERIRIGSQSQNFRNILTKELDQLLSEWK CCCHHHHHHHHHHHHHEECCCCCCCCHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH SLKAIEDLKSFSFFELFTCASFSFFEKESAEVQIYEAGLGGRLDATKLCNPDVVVLGVIG HHHHHHHHHHHHHHHHHHHHCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEC LDHKEILGNTKEEILEEKLGICTSNTKALFAIEQNEPQLNEKISSWCSQNGIHCNIITQT CCHHHHHCCCHHHHHHHHHCCEECCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEC QSKDTYLTRNQIFCYQVFQNILKFDFFLKSTNKKIDLGFSKHENVSLILNELSFEIFEKY CCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHH MTPPLGRLSVLRHSPLLVFDPAHNPDAFTETLQSLSFLFPYYKFRIYAGLLKDKDGNGVL HCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH EILRKARNKSDILNFQFLKEDEFVIPTNCHAKETISTSEFRSVLQRLDDSFEPILILGSF HHHHHHCCCCCCCEEEEECCCCEEECCCCCCHHCCCHHHHHHHHHHHCCCCCCEEEEECH RLFPIVVDLL HHHHHHHHCC >Mature Secondary Structure MNSDSDFLEFANGLSNLEKSRNFNVFAGYSLEPFTKTLKKFNFDQRNESTFCRISVVGTN CCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCCCCCCCCCEEEEEEEECC AKGSITHFLGEYFRIYGFKTGLYTSPHLISPLERIRIGSQSQNFRNILTKELDQLLSEWK CCCHHHHHHHHHHHHHEECCCCCCCCHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH SLKAIEDLKSFSFFELFTCASFSFFEKESAEVQIYEAGLGGRLDATKLCNPDVVVLGVIG HHHHHHHHHHHHHHHHHHHHCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEC LDHKEILGNTKEEILEEKLGICTSNTKALFAIEQNEPQLNEKISSWCSQNGIHCNIITQT CCHHHHHCCCHHHHHHHHHCCEECCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEC QSKDTYLTRNQIFCYQVFQNILKFDFFLKSTNKKIDLGFSKHENVSLILNELSFEIFEKY CCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHH MTPPLGRLSVLRHSPLLVFDPAHNPDAFTETLQSLSFLFPYYKFRIYAGLLKDKDGNGVL HCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH EILRKARNKSDILNFQFLKEDEFVIPTNCHAKETISTSEFRSVLQRLDDSFEPILILGSF HHHHHHCCCCCCCEEEEECCCCEEECCCCCCHHCCCHHHHHHHHHHHCCCCCCEEEEECH RLFPIVVDLL HHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]