Click here to switch to the map view.

The map label for this gene is fus

Identifier: 45658706

GI number: 45658706

Start: 3470720

End: 3472585

Strand: Reverse

Name: fus

Synonym: LIC12876

Alternate gene names: 45658706

Gene position: 3472585-3470720 (Counterclockwise)

Preceding gene: 45658707

Following gene: 45658705

Centisome position: 81.19

GC content: 40.35

Gene sequence:

>1866_bases
ATGCAGATCTTAAACGTAGGAATCTTTGCCCACATAGACGCAGGAAAAACGACACTTTTAGAAAGGATTCTTTACGAAAC
CGGAAAAATTCGAAGGCCGGGAACGATAGAAGAAGGGACAACCGAGTCCGATTATTTACAAGAAGAAATTGAACGAGGAA
TATCGATTCAATCTACGTTGGCTCGAGTCTTTTGGCCGAACGAGAAAGAGTCTAGGATGCTGTTTCAATTTTTAGACAAT
CCGGGGCATCTCGATTTTCAAAGTCAAACCAGCGCTTCTTTAATCGTAGCAGATTTAGGAATTGTTCTTATAGATGCGTT
TGAAGGTCTCAAGTCTCAAACGTTACAAAACGTAGAATGGCTTCGAAAAAGAAAGATTCCAATTTTATTTTTCCTAAATA
AACTCGATCGAACTGGAATTGATATTACAGATTCGCTTGTAGATTTAGAAGCGGTCTTAGGAAAAGAACCGATTCTACTT
TGGAAAGAAGGAGAAACTTGTTCTCTTTTAAAAGAGGGTAGTTCTGACCAAGAACTCTTACCACTTTTAGAGTGGGACGA
AAAACTTTCCGAACGATATTTGAAACATCCGGATTCTTTATCGGAATTAGCTCGGGAAGGATTTGCAGAAGGGTTTTGGA
AGAATCAATTTTTTCCGGTTTTTGGAGGAGCCGCTTTACATGGAGATGGGGTGCGTGAACTTCTTGCCGTTTTAGAACTT
CTATCCAAAACGTTTCGGCCGGAGTTACGACCTAAAGAGGAATTAGGAATTGTATTTAAACGAGAGTTACATCCAGATCT
AGGTAAAATCGTTTATATTCAACCGATGCAGGAGTTCCCACAAAATTCTCATTTTTATTCCGCAGCTGGCAAGGCACAAT
TTGGATCTTTTTATCAACTTTCCATGCGAGAGTTTGAAGAAACCTCACGGACTCAACCTAGAGAGATCGTTGTTACTACC
GGACTAGAATTTCTCAAGCCAGGTGAAATACTCTATTCGACTCCGCAAAATAATTATAAGTCGGAACTTCTCCCTGTTCG
AAAACAATTTCAAATCATACTCGAGCCGGAAGTTGCAGAACATAGAGATTCCCTTTGGAATTCGCTTCAGACACTGGTTT
GGTTGGATGAAGGATTGGAAACTAAAATACTTTCTGAAACGGGACAGATTCAACTTTCCGGATTGGGGGAATTACATTTA
GAAGTTTCTCTATCACGACTCAAAGAATTCTTTCCTAATACATTCAACGTAAGTAGTATTAAAGTTGCAAGGTTTGAGCT
CTGGAAAAAAATGGCCCGACAGGGTGAATTTCAGCATACCGCGTTTGATCAAAAAATCTCAAGCGGACTGGTGCACGCCT
CTTTGGTCAGCTCTAACAGTTTTGCCAGAGAAGTGCGGTTTGAAACTAAGATTACTGAAACTCTAAAAGAAGCCATTACA
TCAGCATTTTATGAAGTAGTGGTAAAGGGAACCAAGGGAGAAGAAATTCTCGGCTTGGATTTGATCGTTCATCGTTACGA
TCCTCCGGATATATCTATAGATGTTTCTTCCCTTGTAAAAGTAGCCGTCATCAAGGGCTTAAAGGACATAATTCCGGGAA
ACACGGAATTAGTTGGTCCTATTTCACATTTGGAGATCTTGATATCAGATTCGTCGTTAGGCGATGTGCTTGGTTCTCTT
TCTAAGAGAAGTGCAAAGATTCAGGAAGTAAATCCAATCGGTGATGGCAAGTCGCTTGTACGTGCAAGTGCTTCTACGGA
AAACTTGCTTGGCTTTGCAGGCGTTCTTAGAAATATGACACAGGGAAGGGGTGTTCTGTCTTTAGATTCCCTCTTTGACC
CTGAACACTATTACGTAATTACATAA

Upstream 100 bases:

>100_bases
GAGAGCAAAAAACTTGCGAAAACTTTAAAAATTGAGAATCGATTTTGTTTGAAAATGGATTCTTTGAAAAAAAAGTAGGA
ACTTCTCCAGGGCAAAAAAC

Downstream 100 bases:

>100_bases
GTCGATTCCCGTTAGGGTTCGTTCAAAAGTAAGGAGATTAAAAAGTCACTATGGCTAAAGAAAAGTTTGATAGGTCTAAA
CCTCACTTAAACGTTGGAAC

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G 2 [H]

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MQILNVGIFAHIDAGKTTLLERILYETGKIRRPGTIEEGTTESDYLQEEIERGISIQSTLARVFWPNEKESRMLFQFLDN
PGHLDFQSQTSASLIVADLGIVLIDAFEGLKSQTLQNVEWLRKRKIPILFFLNKLDRTGIDITDSLVDLEAVLGKEPILL
WKEGETCSLLKEGSSDQELLPLLEWDEKLSERYLKHPDSLSELAREGFAEGFWKNQFFPVFGGAALHGDGVRELLAVLEL
LSKTFRPELRPKEELGIVFKRELHPDLGKIVYIQPMQEFPQNSHFYSAAGKAQFGSFYQLSMREFEETSRTQPREIVVTT
GLEFLKPGEILYSTPQNNYKSELLPVRKQFQIILEPEVAEHRDSLWNSLQTLVWLDEGLETKILSETGQIQLSGLGELHL
EVSLSRLKEFFPNTFNVSSIKVARFELWKKMARQGEFQHTAFDQKISSGLVHASLVSSNSFAREVRFETKITETLKEAIT
SAFYEVVVKGTKGEEILGLDLIVHRYDPPDISIDVSSLVKVAVIKGLKDIIPGNTELVGPISHLEILISDSSLGDVLGSL
SKRSAKIQEVNPIGDGKSLVRASASTENLLGFAGVLRNMTQGRGVLSLDSLFDPEHYYVIT

Sequences:

>Translated_621_residues
MQILNVGIFAHIDAGKTTLLERILYETGKIRRPGTIEEGTTESDYLQEEIERGISIQSTLARVFWPNEKESRMLFQFLDN
PGHLDFQSQTSASLIVADLGIVLIDAFEGLKSQTLQNVEWLRKRKIPILFFLNKLDRTGIDITDSLVDLEAVLGKEPILL
WKEGETCSLLKEGSSDQELLPLLEWDEKLSERYLKHPDSLSELAREGFAEGFWKNQFFPVFGGAALHGDGVRELLAVLEL
LSKTFRPELRPKEELGIVFKRELHPDLGKIVYIQPMQEFPQNSHFYSAAGKAQFGSFYQLSMREFEETSRTQPREIVVTT
GLEFLKPGEILYSTPQNNYKSELLPVRKQFQIILEPEVAEHRDSLWNSLQTLVWLDEGLETKILSETGQIQLSGLGELHL
EVSLSRLKEFFPNTFNVSSIKVARFELWKKMARQGEFQHTAFDQKISSGLVHASLVSSNSFAREVRFETKITETLKEAIT
SAFYEVVVKGTKGEEILGLDLIVHRYDPPDISIDVSSLVKVAVIKGLKDIIPGNTELVGPISHLEILISDSSLGDVLGSL
SKRSAKIQEVNPIGDGKSLVRASASTENLLGFAGVLRNMTQGRGVLSLDSLFDPEHYYVIT
>Mature_621_residues
MQILNVGIFAHIDAGKTTLLERILYETGKIRRPGTIEEGTTESDYLQEEIERGISIQSTLARVFWPNEKESRMLFQFLDN
PGHLDFQSQTSASLIVADLGIVLIDAFEGLKSQTLQNVEWLRKRKIPILFFLNKLDRTGIDITDSLVDLEAVLGKEPILL
WKEGETCSLLKEGSSDQELLPLLEWDEKLSERYLKHPDSLSELAREGFAEGFWKNQFFPVFGGAALHGDGVRELLAVLEL
LSKTFRPELRPKEELGIVFKRELHPDLGKIVYIQPMQEFPQNSHFYSAAGKAQFGSFYQLSMREFEETSRTQPREIVVTT
GLEFLKPGEILYSTPQNNYKSELLPVRKQFQIILEPEVAEHRDSLWNSLQTLVWLDEGLETKILSETGQIQLSGLGELHL
EVSLSRLKEFFPNTFNVSSIKVARFELWKKMARQGEFQHTAFDQKISSGLVHASLVSSNSFAREVRFETKITETLKEAIT
SAFYEVVVKGTKGEEILGLDLIVHRYDPPDISIDVSSLVKVAVIKGLKDIIPGNTELVGPISHLEILISDSSLGDVLGSL
SKRSAKIQEVNPIGDGKSLVRASASTENLLGFAGVLRNMTQGRGVLSLDSLFDPEHYYVIT

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923640, Length=713, Percent_Identity=25.6661991584853, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI18390331, Length=695, Percent_Identity=23.5971223021583, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI25306287, Length=284, Percent_Identity=30.2816901408451, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI25306283, Length=284, Percent_Identity=30.2816901408451, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI157426893, Length=140, Percent_Identity=33.5714285714286, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI217272892, Length=233, Percent_Identity=25.7510729613734, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI217272894, Length=233, Percent_Identity=25.7510729613734, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4503483, Length=149, Percent_Identity=31.5436241610738, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI94966754, Length=139, Percent_Identity=33.0935251798561, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789738, Length=696, Percent_Identity=23.7068965517241, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1790835, Length=176, Percent_Identity=35.7954545454545, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788922, Length=188, Percent_Identity=29.2553191489362, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994988, Length=151, Percent_Identity=27.8145695364238, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17533571, Length=701, Percent_Identity=24.5363766048502, Blast_Score=142, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17556745, Length=159, Percent_Identity=35.8490566037736, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17557151, Length=141, Percent_Identity=36.1702127659575, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17506493, Length=160, Percent_Identity=29.375, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71988819, Length=144, Percent_Identity=28.4722222222222, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71988811, Length=144, Percent_Identity=28.4722222222222, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323098, Length=694, Percent_Identity=23.1988472622478, Blast_Score=158, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322359, Length=721, Percent_Identity=23.8557558945908, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6322675, Length=148, Percent_Identity=33.1081081081081, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324707, Length=159, Percent_Identity=30.188679245283, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320593, Length=159, Percent_Identity=30.188679245283, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323320, Length=139, Percent_Identity=30.9352517985612, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221458488, Length=706, Percent_Identity=23.371104815864, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24582462, Length=690, Percent_Identity=25.3623188405797, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI78706572, Length=156, Percent_Identity=35.2564102564103, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24585711, Length=152, Percent_Identity=30.2631578947368, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585713, Length=152, Percent_Identity=30.2631578947368, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585709, Length=152, Percent_Identity=30.2631578947368, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574573, Length=142, Percent_Identity=33.0985915492958, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 69897; Mature: 69897

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQILNVGIFAHIDAGKTTLLERILYETGKIRRPGTIEEGTTESDYLQEEIERGISIQSTL
CEEEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHH
ARVFWPNEKESRMLFQFLDNPGHLDFQSQTSASLIVADLGIVLIDAFEGLKSQTLQNVEW
HHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRKRKIPILFFLNKLDRTGIDITDSLVDLEAVLGKEPILLWKEGETCSLLKEGSSDQELL
HHHCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCCHHH
PLLEWDEKLSERYLKHPDSLSELAREGFAEGFWKNQFFPVFGGAALHGDGVRELLAVLEL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEECCCCCEECCCCHHHHHHHHHH
LSKTFRPELRPKEELGIVFKRELHPDLGKIVYIQPMQEFPQNSHFYSAAGKAQFGSFYQL
HHHHCCCCCCCHHHHCHHEEHHCCCCCCCEEEEECHHHCCCCCCEECCCCCCCCCCHHHH
SMREFEETSRTQPREIVVTTGLEFLKPGEILYSTPQNNYKSELLPVRKQFQIILEPEVAE
HHHHHHHHCCCCCCEEEEECCHHHCCCCCEEEECCCCCCHHHHHHHHHHEEEEECCCHHH
HRDSLWNSLQTLVWLDEGLETKILSETGQIQLSGLGELHLEVSLSRLKEFFPNTFNVSSI
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEECCCEEEHHHHHHHHHHHCCCCCCCCHH
KVARFELWKKMARQGEFQHTAFDQKISSGLVHASLVSSNSFAREVRFETKITETLKEAIT
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHH
SAFYEVVVKGTKGEEILGLDLIVHRYDPPDISIDVSSLVKVAVIKGLKDIIPGNTELVGP
HHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCCCCEEECC
ISHLEILISDSSLGDVLGSLSKRSAKIQEVNPIGDGKSLVRASASTENLLGFAGVLRNMT
HHHEEEEEECCHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHH
QGRGVLSLDSLFDPEHYYVIT
CCCCEEEHHHCCCCCCEEEEC
>Mature Secondary Structure
MQILNVGIFAHIDAGKTTLLERILYETGKIRRPGTIEEGTTESDYLQEEIERGISIQSTL
CEEEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHH
ARVFWPNEKESRMLFQFLDNPGHLDFQSQTSASLIVADLGIVLIDAFEGLKSQTLQNVEW
HHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRKRKIPILFFLNKLDRTGIDITDSLVDLEAVLGKEPILLWKEGETCSLLKEGSSDQELL
HHHCCCCCEEEEHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCCHHH
PLLEWDEKLSERYLKHPDSLSELAREGFAEGFWKNQFFPVFGGAALHGDGVRELLAVLEL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEECCCCCEECCCCHHHHHHHHHH
LSKTFRPELRPKEELGIVFKRELHPDLGKIVYIQPMQEFPQNSHFYSAAGKAQFGSFYQL
HHHHCCCCCCCHHHHCHHEEHHCCCCCCCEEEEECHHHCCCCCCEECCCCCCCCCCHHHH
SMREFEETSRTQPREIVVTTGLEFLKPGEILYSTPQNNYKSELLPVRKQFQIILEPEVAE
HHHHHHHHCCCCCCEEEEECCHHHCCCCCEEEECCCCCCHHHHHHHHHHEEEEECCCHHH
HRDSLWNSLQTLVWLDEGLETKILSETGQIQLSGLGELHLEVSLSRLKEFFPNTFNVSSI
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEECCCEEEHHHHHHHHHHHCCCCCCCCHH
KVARFELWKKMARQGEFQHTAFDQKISSGLVHASLVSSNSFAREVRFETKITETLKEAIT
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHH
SAFYEVVVKGTKGEEILGLDLIVHRYDPPDISIDVSSLVKVAVIKGLKDIIPGNTELVGP
HHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCCCCEEECC
ISHLEILISDSSLGDVLGSLSKRSAKIQEVNPIGDGKSLVRASASTENLLGFAGVLRNMT
HHHEEEEEECCHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHH
QGRGVLSLDSLFDPEHYYVIT
CCCCEEEHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA