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The map label for this gene is adk

Identifier: 45658682

GI number: 45658682

Start: 3458298

End: 3458861

Strand: Reverse

Name: adk

Synonym: LIC12852

Alternate gene names: 45658682

Gene position: 3458861-3458298 (Counterclockwise)

Preceding gene: 45658683

Following gene: 45658681

Centisome position: 80.87

GC content: 41.31

Gene sequence:

>564_bases
GTGAAGAATATTATCTTCATGGGGCCTCCTGGGGCTGGAAAAGGTACACAAGCAAAGATTCTTTGTGAGCGCCTTTCTAT
TCCTCAGATTTCTACAGGAGATATTTTACGCGAGGCAGTAAAGAATCAAACTGCGATGGGAATAGAAGCAAAACGTTATA
TGGATGCGGGAGACTTGGTTCCAGATTCCGTAGTGATTGGAATCATAAAAGATCGCATTCGAGAAGCGGATTGTAAAAAT
GGATTTTTGTTGGATGGATTTCCGAGAACCGTGGAACAAGCGGAAGCTTTAGATACACTTTTAAAAAATGAAGGCAAGTC
TATTGATAAAGCGATTAATCTTCAGGTTCCGGATGCGGAACTCTTAAAGAGATTACTCGGCCGTGCAGAAATAGAAGGTC
GCGCGGACGATAACGAAGTGACGATTAAAAATCGTCTCGATAATTATAATAAGAAGACCTTACCTCTTCTAGATTTTTAC
GCCACCCGTAAGAAACTTTCTCAAGTGAACGGCGTTGGAAGTCTCGAAGAAGTTACTTCTTTGATTCAAAAGGAGCTTGC
GTAA

Upstream 100 bases:

>100_bases
GCACTCGAGACTTTAAAACAAATTGAGTCTCAACTTTTAATGAGAAATTATGAAGGCTTCATGAAGAAGTCTAAAATTAA
GGGACGGTCTTAATTTTTCC

Downstream 100 bases:

>100_bases
GAGTGGCAAAAGAAGAAGCGATTACAGTTGACGGCACCGTTTTGGAGCCTTTGCCAAACGCAATGTTTCGAGTAGAACTG
GAAAACGGCCATAAGGTTTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MKNIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKN
GFLLDGFPRTVEQAEALDTLLKNEGKSIDKAINLQVPDAELLKRLLGRAEIEGRADDNEVTIKNRLDNYNKKTLPLLDFY
ATRKKLSQVNGVGSLEEVTSLIQKELA

Sequences:

>Translated_187_residues
MKNIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKN
GFLLDGFPRTVEQAEALDTLLKNEGKSIDKAINLQVPDAELLKRLLGRAEIEGRADDNEVTIKNRLDNYNKKTLPLLDFY
ATRKKLSQVNGVGSLEEVTSLIQKELA
>Mature_187_residues
MKNIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKN
GFLLDGFPRTVEQAEALDTLLKNEGKSIDKAINLQVPDAELLKRLLGRAEIEGRADDNEVTIKNRLDNYNKKTLPLLDFY
ATRKKLSQVNGVGSLEEVTSLIQKELA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=194, Percent_Identity=38.659793814433, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI4502013, Length=194, Percent_Identity=38.659793814433, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI4502011, Length=189, Percent_Identity=37.037037037037, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI28144897, Length=182, Percent_Identity=32.4175824175824, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI28144899, Length=182, Percent_Identity=32.4175824175824, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI19923437, Length=195, Percent_Identity=31.2820512820513, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI310110345, Length=195, Percent_Identity=31.2820512820513, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI53832003, Length=195, Percent_Identity=31.2820512820513, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI8051579, Length=195, Percent_Identity=31.2820512820513, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI53832001, Length=195, Percent_Identity=31.2820512820513, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI7706497, Length=181, Percent_Identity=29.8342541436464, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI22749187, Length=126, Percent_Identity=30.1587301587302, Blast_Score=74, Evalue=6e-14,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=40.7407407407407, Blast_Score=156, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17552384, Length=210, Percent_Identity=34.7619047619048, Blast_Score=132, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=35.6756756756757, Blast_Score=123, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17533833, Length=163, Percent_Identity=30.6748466257669, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=191, Percent_Identity=29.3193717277487, Blast_Score=90, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=219, Percent_Identity=25.5707762557078, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=185, Percent_Identity=41.6216216216216, Blast_Score=144, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=35.0253807106599, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=32.2404371584699, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI22026816, Length=207, Percent_Identity=39.1304347826087, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17737899, Length=194, Percent_Identity=30.4123711340206, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24645822, Length=194, Percent_Identity=30.4123711340206, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221459597, Length=187, Percent_Identity=31.0160427807487, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21356893, Length=187, Percent_Identity=31.0160427807487, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24663208, Length=160, Percent_Identity=31.25, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17647141, Length=160, Percent_Identity=31.25, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20594; Mature: 20594

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLV
CCCEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCC
PDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQAEALDTLLKNEGKSIDKAINLQVPDAE
CHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCHH
LLKRLLGRAEIEGRADDNEVTIKNRLDNYNKKTLPLLDFYATRKKLSQVNGVGSLEEVTS
HHHHHHHHHCCCCCCCCCCEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
LIQKELA
HHHHHCC
>Mature Secondary Structure
MKNIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLV
CCCEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCC
PDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQAEALDTLLKNEGKSIDKAINLQVPDAE
CHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCHH
LLKRLLGRAEIEGRADDNEVTIKNRLDNYNKKTLPLLDFYATRKKLSQVNGVGSLEEVTS
HHHHHHHHHCCCCCCCCCCEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
LIQKELA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA