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The map label for this gene is gltA

Identifier: 45658659

GI number: 45658659

Start: 3432810

End: 3434099

Strand: Direct

Name: gltA

Synonym: LIC12829

Alternate gene names: 45658659

Gene position: 3432810-3434099 (Clockwise)

Preceding gene: 45658658

Following gene: 45658660

Centisome position: 80.26

GC content: 40.23

Gene sequence:

>1290_bases
ATGGCAGAGGTAGCAATTCTGAAAATCGATGGGAAAGAATACGAACTCCCGATCGTAATAGGCACCGAAAAAGAAAAAGC
AATCGATATTTCTAAACTCCGTCAACAGACCGGATATGTAACCTTGGACAACGGATATTTAAATACTGGAGCCTGCACAA
GCGCGGTGACTTTTTTAGACGGAGAACTAGGTATTTTAAGATACAGAGGAATTCCGATCGAACAACTCGCCGAAAATTCC
ACATTTACTGAAGTCGCCTATTTACTGATATACGGAAAAATTCCTTCAGACTCAGAATTGAAAAAATGGAACGACGAACT
TACGATGCACACGTTGATCCACGAGGATCTTAAACGTCTTTATAATGGATTTCCAAAAGACGGTCACCCAATGGCGATCA
TGTCTTCTATGATCGGATCTCTTTCCACTTATTATCAAGATTCTTACGATCCGGAAAATGCAGAACACAGACATATTTCT
ATGATTCGTCTTCTCGCTAAGTTTCCTACAATCGCCGCATTCGCTTATAAGAAATCCATTGGACAACCTACAATTCATCC
TTTGAACAGTTTGGATTATTGCGCAAACTTTATGAACATGATGTTCTCCGTTCCAAGCGAGGATTATAAAATTGATCCAG
AAATCGTAAAAGCGTTGAACTTATTATTGATTCTTCATGCGGACCACGAACAAAACTGTTCTACGTCTACGGTGCGTTTG
GTGGGATCTTCTCTCGCAAACTTATACGGCGCGATCTCTGCTGGAATTTGTGCTCTTTGGGGACCTAGACACGGAGGAGC
CAATCAAGAAGTATTAGAAATGTTGCAAGAGATTCAGGCAAGCGGTTTGCCCGTAAAAAAAATCGTAGAAAAAGCAAAAG
ATAAAAATGACTCTTTCCGTCTTTCCGGATTCGGTCACAGGGTCTATAAAAATTTTGATCCACGTGCAAAGATCATCAAA
AAGGCGTGCGACTCCGTATTAAAAAGATTAGGCGTTCAAGATTCTTTATTAGATATTGCTAAAGAACTAGAAGAAACAGC
TCTTCATGATCCTTACTTTGTGGAAAGAAAACTCTATCCAAACGTAGACTTTTATTCCGGAATTATCTACCGAGCCCTCG
GAATTCCAGTAAATATGTTTACGGTAATGTTTGCTATGGGACGTCTTCCAGGTTGGATCGCTCAGTGGAAAGAAATGATA
GAATCTCCGGATATGAAAATTGGTCGTCCAAGACAAATCTACACCGGTTCTACAGAAACTTCCTACAAAGAAGCCAAGAA
AAAAGCCTGA

Upstream 100 bases:

>100_bases
TGTCTCTCTGATAGAAAGAATAGGATAGGAATCTGAAACAATTGAAGCGCAATTTTTGAACGCCACCGCAAAAACGACAA
ACATTTATTAGGAGAATAAC

Downstream 100 bases:

>100_bases
ACTCTCATTCTACAAACTTCCGGTTTCATAGATACCAATTGAACCGGAAGAGCGAAATTTCCATTCGACGCGGACATCCC
TGGATCTTTGGCGGCAATCT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MAEVAILKIDGKEYELPIVIGTEKEKAIDISKLRQQTGYVTLDNGYLNTGACTSAVTFLDGELGILRYRGIPIEQLAENS
TFTEVAYLLIYGKIPSDSELKKWNDELTMHTLIHEDLKRLYNGFPKDGHPMAIMSSMIGSLSTYYQDSYDPENAEHRHIS
MIRLLAKFPTIAAFAYKKSIGQPTIHPLNSLDYCANFMNMMFSVPSEDYKIDPEIVKALNLLLILHADHEQNCSTSTVRL
VGSSLANLYGAISAGICALWGPRHGGANQEVLEMLQEIQASGLPVKKIVEKAKDKNDSFRLSGFGHRVYKNFDPRAKIIK
KACDSVLKRLGVQDSLLDIAKELEETALHDPYFVERKLYPNVDFYSGIIYRALGIPVNMFTVMFAMGRLPGWIAQWKEMI
ESPDMKIGRPRQIYTGSTETSYKEAKKKA

Sequences:

>Translated_429_residues
MAEVAILKIDGKEYELPIVIGTEKEKAIDISKLRQQTGYVTLDNGYLNTGACTSAVTFLDGELGILRYRGIPIEQLAENS
TFTEVAYLLIYGKIPSDSELKKWNDELTMHTLIHEDLKRLYNGFPKDGHPMAIMSSMIGSLSTYYQDSYDPENAEHRHIS
MIRLLAKFPTIAAFAYKKSIGQPTIHPLNSLDYCANFMNMMFSVPSEDYKIDPEIVKALNLLLILHADHEQNCSTSTVRL
VGSSLANLYGAISAGICALWGPRHGGANQEVLEMLQEIQASGLPVKKIVEKAKDKNDSFRLSGFGHRVYKNFDPRAKIIK
KACDSVLKRLGVQDSLLDIAKELEETALHDPYFVERKLYPNVDFYSGIIYRALGIPVNMFTVMFAMGRLPGWIAQWKEMI
ESPDMKIGRPRQIYTGSTETSYKEAKKKA
>Mature_428_residues
AEVAILKIDGKEYELPIVIGTEKEKAIDISKLRQQTGYVTLDNGYLNTGACTSAVTFLDGELGILRYRGIPIEQLAENST
FTEVAYLLIYGKIPSDSELKKWNDELTMHTLIHEDLKRLYNGFPKDGHPMAIMSSMIGSLSTYYQDSYDPENAEHRHISM
IRLLAKFPTIAAFAYKKSIGQPTIHPLNSLDYCANFMNMMFSVPSEDYKIDPEIVKALNLLLILHADHEQNCSTSTVRLV
GSSLANLYGAISAGICALWGPRHGGANQEVLEMLQEIQASGLPVKKIVEKAKDKNDSFRLSGFGHRVYKNFDPRAKIIKK
ACDSVLKRLGVQDSLLDIAKELEETALHDPYFVERKLYPNVDFYSGIIYRALGIPVNMFTVMFAMGRLPGWIAQWKEMIE
SPDMKIGRPRQIYTGSTETSYKEAKKKA

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=438, Percent_Identity=27.8538812785388, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786939, Length=414, Percent_Identity=53.3816425120773, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI1786527, Length=388, Percent_Identity=30.4123711340206, Blast_Score=165, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17555174, Length=415, Percent_Identity=27.4698795180723, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6324328, Length=436, Percent_Identity=29.1284403669725, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319850, Length=367, Percent_Identity=28.6103542234332, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6325257, Length=408, Percent_Identity=26.2254901960784, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24640126, Length=453, Percent_Identity=27.5938189845475, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24640124, Length=453, Percent_Identity=27.5938189845475, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356863, Length=367, Percent_Identity=25.8855585831063, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48238; Mature: 48107

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVAILKIDGKEYELPIVIGTEKEKAIDISKLRQQTGYVTLDNGYLNTGACTSAVTFLD
CCCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCC
GELGILRYRGIPIEQLAENSTFTEVAYLLIYGKIPSDSELKKWNDELTMHTLIHEDLKRL
CCCCEEEECCCCHHHHHCCCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YNGFPKDGHPMAIMSSMIGSLSTYYQDSYDPENAEHRHISMIRLLAKFPTIAAFAYKKSI
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHC
GQPTIHPLNSLDYCANFMNMMFSVPSEDYKIDPEIVKALNLLLILHADHEQNCSTSTVRL
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCCHHHHHH
VGSSLANLYGAISAGICALWGPRHGGANQEVLEMLQEIQASGLPVKKIVEKAKDKNDSFR
HHHHHHHHHHHHHHCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEE
LSGFGHRVYKNFDPRAKIIKKACDSVLKRLGVQDSLLDIAKELEETALHDPYFVERKLYP
EECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEHHCCCC
NVDFYSGIIYRALGIPVNMFTVMFAMGRLPGWIAQWKEMIESPDMKIGRPRQIYTGSTET
CCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCH
SYKEAKKKA
HHHHHHCCC
>Mature Secondary Structure 
AEVAILKIDGKEYELPIVIGTEKEKAIDISKLRQQTGYVTLDNGYLNTGACTSAVTFLD
CCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCC
GELGILRYRGIPIEQLAENSTFTEVAYLLIYGKIPSDSELKKWNDELTMHTLIHEDLKRL
CCCCEEEECCCCHHHHHCCCHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YNGFPKDGHPMAIMSSMIGSLSTYYQDSYDPENAEHRHISMIRLLAKFPTIAAFAYKKSI
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHC
GQPTIHPLNSLDYCANFMNMMFSVPSEDYKIDPEIVKALNLLLILHADHEQNCSTSTVRL
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCCHHHHHH
VGSSLANLYGAISAGICALWGPRHGGANQEVLEMLQEIQASGLPVKKIVEKAKDKNDSFR
HHHHHHHHHHHHHHCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEE
LSGFGHRVYKNFDPRAKIIKKACDSVLKRLGVQDSLLDIAKELEETALHDPYFVERKLYP
EECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEHHCCCC
NVDFYSGIIYRALGIPVNMFTVMFAMGRLPGWIAQWKEMIESPDMKIGRPRQIYTGSTET
CCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCH
SYKEAKKKA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]