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The map label for this gene is mucD

Identifier: 45658643

GI number: 45658643

Start: 3417232

End: 3418398

Strand: Reverse

Name: mucD

Synonym: LIC12812

Alternate gene names: 45658643

Gene position: 3418398-3417232 (Counterclockwise)

Preceding gene: 45658644

Following gene: 45658642

Centisome position: 79.92

GC content: 43.36

Gene sequence:

>1167_bases
ATGAAAAATACGGAAAAATTGAAGTATGTTGCAATCGTAAGCATTTCTCTTCTACTTGGAGCTTTTTTATCTCCTGTGAT
GTTTTGTGGAACCGGTCAGAATAGTCCTCTCTTTCTAAGTGCCAAAGGTGATAAGGAACCGAGCCCTGCAACTCGTCAGG
CAATTACAATTCAACAAGCATTTGAAGAAGTGTATCAAACCGCTTCTCCGAGCGTTGTTTCCATCGCTACGGAAAGAATT
CAAAACGTTCCAGCTCATCCCGGACCTTTCGGAGATCCGTTCTTTGATCAATTTTTTGGTAGAGGTCAAGGCGGTGGTGG
TAGGGTGATGAAACAAAAACAAACCGGTCTCGGCTCTGGAATCATCCTCAATACTCAAGGATATATTTTAACGAACGAAC
ACGTAGTTCGTTCTATGGATAAACTCACCGTTCGTCTAAAAACCGGTAAGACGTTTACTGCGGAGTTGATCGGTTCCGAT
CCTGTTATTGATTTGGCTCTTTTGAAAATCAAACCGGAAGGAGAAATCGTTCCGATTGAACTCGGTGATTCTTCTGCAGT
AAAAGTAGGGGATTGGGCGATTGCGATTGGTGCTCCTCTTGGTTATGAACAATCTTTAACCGCTGGGATTGTAAGTGCAG
TTGGTAGGACCGGAATCGATAATAGCGGGGTTCATTATCTTCAAACAGACGCTTCTATCAATCAAGGAAATTCAGGAGGT
CCTCTTTTAGATATCAACGGTCGTGTGATCGGTATCAATCGTATGATTGCTTCTCAAAGTGGTGGTTCGGTTGGAATCGG
ATTTGCGATTCCGATTAACGAGGCTAAGGCGATCATGGAAGAATTAAAAACCACCGGTAAAGTTAAACGTCCTGCACAGG
CCTGGCTTGGAGTTGGGGTAGATTATCTTCACGAAGATGATGCCAAGAAGTTAAATCTTTCAGGTGGTGCGGTTGTGGTT
CAAATTATGAATGATTCTCCCGCTGACCGTGCCGGGATTCAATTGATGGACGTGATCACTGAAATTTCCGGAACCAAAAT
CAATTCTCCCGAGGAAGTGGTCAGTACAGTCAAAAAAAATAAGGTAGGGGATAGAATTACGGTTACCGTTGTACGTCAAG
GGAACATTTCCAGAATCTCTATCCAACTTAAGGAAAGACCGAACTGA

Upstream 100 bases:

>100_bases
TCTGGGAAGACTCGCTTCTAAATCTAACTTGACAGTCACGGAAGCGAGTCGATCCTTTTAGTACCCAAGCGGATATTCAT
TTTCAGAGGGATCGAATTCA

Downstream 100 bases:

>100_bases
TTGGCAAAATCCCATACTCTGAATCCTGAAGAAGAATTTGAAGAAGAGTCGGGCCTTCGCCCTTCTCTTCTTTCCGAATT
TATAGGTCAAAAAGAAGTCC

Product: serine protease MucD precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKNTEKLKYVAIVSISLLLGAFLSPVMFCGTGQNSPLFLSAKGDKEPSPATRQAITIQQAFEEVYQTASPSVVSIATERI
QNVPAHPGPFGDPFFDQFFGRGQGGGGRVMKQKQTGLGSGIILNTQGYILTNEHVVRSMDKLTVRLKTGKTFTAELIGSD
PVIDLALLKIKPEGEIVPIELGDSSAVKVGDWAIAIGAPLGYEQSLTAGIVSAVGRTGIDNSGVHYLQTDASINQGNSGG
PLLDINGRVIGINRMIASQSGGSVGIGFAIPINEAKAIMEELKTTGKVKRPAQAWLGVGVDYLHEDDAKKLNLSGGAVVV
QIMNDSPADRAGIQLMDVITEISGTKINSPEEVVSTVKKNKVGDRITVTVVRQGNISRISIQLKERPN

Sequences:

>Translated_388_residues
MKNTEKLKYVAIVSISLLLGAFLSPVMFCGTGQNSPLFLSAKGDKEPSPATRQAITIQQAFEEVYQTASPSVVSIATERI
QNVPAHPGPFGDPFFDQFFGRGQGGGGRVMKQKQTGLGSGIILNTQGYILTNEHVVRSMDKLTVRLKTGKTFTAELIGSD
PVIDLALLKIKPEGEIVPIELGDSSAVKVGDWAIAIGAPLGYEQSLTAGIVSAVGRTGIDNSGVHYLQTDASINQGNSGG
PLLDINGRVIGINRMIASQSGGSVGIGFAIPINEAKAIMEELKTTGKVKRPAQAWLGVGVDYLHEDDAKKLNLSGGAVVV
QIMNDSPADRAGIQLMDVITEISGTKINSPEEVVSTVKKNKVGDRITVTVVRQGNISRISIQLKERPN
>Mature_388_residues
MKNTEKLKYVAIVSISLLLGAFLSPVMFCGTGQNSPLFLSAKGDKEPSPATRQAITIQQAFEEVYQTASPSVVSIATERI
QNVPAHPGPFGDPFFDQFFGRGQGGGGRVMKQKQTGLGSGIILNTQGYILTNEHVVRSMDKLTVRLKTGKTFTAELIGSD
PVIDLALLKIKPEGEIVPIELGDSSAVKVGDWAIAIGAPLGYEQSLTAGIVSAVGRTGIDNSGVHYLQTDASINQGNSGG
PLLDINGRVIGINRMIASQSGGSVGIGFAIPINEAKAIMEELKTTGKVKRPAQAWLGVGVDYLHEDDAKKLNLSGGAVVV
QIMNDSPADRAGIQLMDVITEISGTKINSPEEVVSTVKKNKVGDRITVTVVRQGNISRISIQLKERPN

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=273, Percent_Identity=35.1648351648352, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=32.2463768115942, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI24308541, Length=270, Percent_Identity=32.2222222222222, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI7019477, Length=256, Percent_Identity=32.8125, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1789629, Length=323, Percent_Identity=39.3188854489164, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1786356, Length=357, Percent_Identity=38.0952380952381, Blast_Score=201, Evalue=5e-53,
Organism=Escherichia coli, GI1789630, Length=278, Percent_Identity=38.1294964028777, Blast_Score=163, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24646839, Length=282, Percent_Identity=34.7517730496454, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 41116; Mature: 41116

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTEKLKYVAIVSISLLLGAFLSPVMFCGTGQNSPLFLSAKGDKEPSPATRQAITIQQA
CCCCHHEEEEHHHHHHHHHHHHHHHHEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
FEEVYQTASPSVVSIATERIQNVPAHPGPFGDPFFDQFFGRGQGGGGRVMKQKQTGLGSG
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCCC
IILNTQGYILTNEHVVRSMDKLTVRLKTGKTFTAELIGSDPVIDLALLKIKPEGEIVPIE
EEEECCCEEEECHHHHHHHEEEEEEEECCCEEEEEECCCCCCEEEEEEEECCCCCEEEEE
LGDSSAVKVGDWAIAIGAPLGYEQSLTAGIVSAVGRTGIDNSGVHYLQTDASINQGNSGG
ECCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCC
PLLDINGRVIGINRMIASQSGGSVGIGFAIPINEAKAIMEELKTTGKVKRPAQAWLGVGV
CEEEECCEEEEEEEEEECCCCCCEEEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHCCH
DYLHEDDAKKLNLSGGAVVVQIMNDSPADRAGIQLMDVITEISGTKINSPEEVVSTVKKN
HHHCCCCCCEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
KVGDRITVTVVRQGNISRISIQLKERPN
CCCCEEEEEEEECCCEEEEEEEEECCCC
>Mature Secondary Structure
MKNTEKLKYVAIVSISLLLGAFLSPVMFCGTGQNSPLFLSAKGDKEPSPATRQAITIQQA
CCCCHHEEEEHHHHHHHHHHHHHHHHEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
FEEVYQTASPSVVSIATERIQNVPAHPGPFGDPFFDQFFGRGQGGGGRVMKQKQTGLGSG
HHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCCC
IILNTQGYILTNEHVVRSMDKLTVRLKTGKTFTAELIGSDPVIDLALLKIKPEGEIVPIE
EEEECCCEEEECHHHHHHHEEEEEEEECCCEEEEEECCCCCCEEEEEEEECCCCCEEEEE
LGDSSAVKVGDWAIAIGAPLGYEQSLTAGIVSAVGRTGIDNSGVHYLQTDASINQGNSGG
ECCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCC
PLLDINGRVIGINRMIASQSGGSVGIGFAIPINEAKAIMEELKTTGKVKRPAQAWLGVGV
CEEEECCEEEEEEEEEECCCCCCEEEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHCCH
DYLHEDDAKKLNLSGGAVVVQIMNDSPADRAGIQLMDVITEISGTKINSPEEVVSTVKKN
HHHCCCCCCEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
KVGDRITVTVVRQGNISRISIQLKERPN
CCCCEEEEEEEECCCEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]