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The map label for this gene is nuoD2

Identifier: 45658578

GI number: 45658578

Start: 3340013

End: 3341230

Strand: Direct

Name: nuoD2

Synonym: LIC12744

Alternate gene names: 45658578

Gene position: 3340013-3341230 (Clockwise)

Preceding gene: 45658577

Following gene: 45658579

Centisome position: 78.09

GC content: 43.02

Gene sequence:

>1218_bases
ATGATGTACGAAAAAACCGCAGAACACTTCGAACAAAAATATAAAAATCTTCCCGAAGGTCATCTACTCGTAAACTTGGG
ACCGTCCCATCCGGCCACACACGGAATTCTACAAAACGTGATCCAAATCGACGGAGAAAGAATCGTAGAAGCGGAATCGG
TGATCGGATACGTACACCGTTGTTTTGAAAAATTAGGAGAACGTTATACTTACAATCAATTCTTAGTTTGCACCGATCGG
ATGAACTATGTTTCCACTCCACTCAATAATATTGGCTGGATTTTGGCCGTGGAAAAAATGATGCAGATAGAAGTTCCGGA
TCGTGTAACGTATGTTAGAATGATCATCTCCGAACTTTCCAGGATCATAGATCATATCATCTGCACCGGAATTTTAGGTG
TGGATTTAGGCGCATTCTCGGGGATGTTACATCTATTTCATCATAGAGAAAACATCTATCAAATCATCGAAAAACTAACA
GGCGCTAGACTCACCACTACGTTTTGTAGAATCGGAGGTCTTGAAAAAGATATTTATCCAGACTTTGTAAAAGAGGTCAA
ACTGGTCTGTAAAGGACTCAAACCTGCAATTGAAGAATTCAACAGTCTTCTTTTAAAAAATAAAATTTTTCTGGGACGCA
CGGAAGGGATTGGAGGAATTTCCGCAGAAAACGCAATCGCCTATGGTTATACCGGACCCAACCTCAGAGCGGCTGGGGTG
GACTGGGACGTTCGTAAAGACGAACCGTATCTATTTTACGACAAAGTCGATTTTGACATTCCAATTGGAGAAGACGGAAG
CGTTCTTCACAGAAGTTTAGTGAGAATGGAAGAAATGCGTCAGTCGATCCGGATCATCGAACAGCTCGTAGACGGAATTC
CAAGCGGACCTTGGCACGCAGATCTTCCTCACGCCTATCTTCCCGAAAAACACAAAGTCTACAACAACATGGAAGAATTG
ATCTATCATTTTAAGATCATTATGCACGGCGTAAAAGTACCTCCGGGAGAATACTACATGGCAACGGAAGCAGCCAACGG
AGAGTTAGGATTTTACATCGTATCCGAAGGGGAAAAATCACCTTGGAGAGTACACGTTAGACGCCCTTGTTTTTGGTATT
ATCAATCTTTTGCAGAACTGGTCCGTGGCGGACTTTTAGCGGATTCGGTCGCGACCATGAGTTCCTTAAATGTGATCGCA
GGGGAGTTGGATTGCTGA

Upstream 100 bases:

>100_bases
GACTTTCCTTTGGAAGGTTTTGGTCAAGATTATCTGATCGAAGACCTTTTACACATTCACGTAAACGAAGACATTACAAA
AGAAGGAGGGAAGAAATAGT

Downstream 100 bases:

>100_bases
TGGGTTATAAGTTCAGCGAAACTTCCGAAAAAAGATTTCAAAAAATGCTGGAAGCGTTTCCGGACAAACGTTCCCTGATT
CTTCCTTGTTTGTATATTCT

Product: NADH dehydrogenase subunit I D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHRCFEKLGERYTYNQFLVCTDR
MNYVSTPLNNIGWILAVEKMMQIEVPDRVTYVRMIISELSRIIDHIICTGILGVDLGAFSGMLHLFHHRENIYQIIEKLT
GARLTTTFCRIGGLEKDIYPDFVKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGYTGPNLRAAGV
DWDVRKDEPYLFYDKVDFDIPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGPWHADLPHAYLPEKHKVYNNMEEL
IYHFKIIMHGVKVPPGEYYMATEAANGELGFYIVSEGEKSPWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIA
GELDC

Sequences:

>Translated_405_residues
MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHRCFEKLGERYTYNQFLVCTDR
MNYVSTPLNNIGWILAVEKMMQIEVPDRVTYVRMIISELSRIIDHIICTGILGVDLGAFSGMLHLFHHRENIYQIIEKLT
GARLTTTFCRIGGLEKDIYPDFVKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGYTGPNLRAAGV
DWDVRKDEPYLFYDKVDFDIPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGPWHADLPHAYLPEKHKVYNNMEEL
IYHFKIIMHGVKVPPGEYYMATEAANGELGFYIVSEGEKSPWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIA
GELDC
>Mature_405_residues
MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHRCFEKLGERYTYNQFLVCTDR
MNYVSTPLNNIGWILAVEKMMQIEVPDRVTYVRMIISELSRIIDHIICTGILGVDLGAFSGMLHLFHHRENIYQIIEKLT
GARLTTTFCRIGGLEKDIYPDFVKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGYTGPNLRAAGV
DWDVRKDEPYLFYDKVDFDIPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGPWHADLPHAYLPEKHKVYNNMEEL
IYHFKIIMHGVKVPPGEYYMATEAANGELGFYIVSEGEKSPWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIA
GELDC

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=384, Percent_Identity=37.7604166666667, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI260898743, Length=379, Percent_Identity=37.467018469657, Blast_Score=289, Evalue=4e-78,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=35.6589147286822, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1789076, Length=289, Percent_Identity=29.4117647058824, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1788832, Length=289, Percent_Identity=27.3356401384083, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17568379, Length=394, Percent_Identity=37.3096446700508, Blast_Score=296, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI17555284, Length=398, Percent_Identity=36.1809045226131, Blast_Score=293, Evalue=9e-80,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=40.0523560209424, Blast_Score=314, Evalue=6e-86,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=39.0625, Blast_Score=314, Evalue=7e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46118; Mature: 46118

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHR
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
CFEKLGERYTYNQFLVCTDRMNYVSTPLNNIGWILAVEKMMQIEVPDRVTYVRMIISELS
HHHHHCCCCCCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RIIDHIICTGILGVDLGAFSGMLHLFHHRENIYQIIEKLTGARLTTTFCRIGGLEKDIYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCH
DFVKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGYTGPNLRAAGV
HHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEECCCCCCEECCC
DWDVRKDEPYLFYDKVDFDIPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGPWHA
CCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DLPHAYLPEKHKVYNNMEELIYHFKIIMHGVKVPPGEYYMATEAANGELGFYIVSEGEKS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCC
PWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIAGELDC
CEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHR
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
CFEKLGERYTYNQFLVCTDRMNYVSTPLNNIGWILAVEKMMQIEVPDRVTYVRMIISELS
HHHHHCCCCCCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RIIDHIICTGILGVDLGAFSGMLHLFHHRENIYQIIEKLTGARLTTTFCRIGGLEKDIYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCH
DFVKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGYTGPNLRAAGV
HHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEECCCCCCEECCC
DWDVRKDEPYLFYDKVDFDIPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGPWHA
CCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DLPHAYLPEKHKVYNNMEELIYHFKIIMHGVKVPPGEYYMATEAANGELGFYIVSEGEKS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCC
PWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIAGELDC
CEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA