| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
Click here to switch to the map view.
The map label for this gene is mrcA [H]
Identifier: 45658483
GI number: 45658483
Start: 3206079
End: 3208835
Strand: Reverse
Name: mrcA [H]
Synonym: LIC12646
Alternate gene names: 45658483
Gene position: 3208835-3206079 (Counterclockwise)
Preceding gene: 45658484
Following gene: 45658482
Centisome position: 75.02
GC content: 39.43
Gene sequence:
>2757_bases ATGAAGATGATGGAGACTGGGATTCAGACTCTAAAAACGACTCGATTTTTATGTCCTGAATGTGGAACTACTTCTAGGCT TCCGGAAGGAGTTCCTACCGGTTCTGTTTTTAGACTTACTTGCTATCAATGTGGGCACAAGGTTTTGGTGAGAGCGGATA TTCCAAAAGTTCCGGCTCCAGTTCAGCCATCCGACAAAATTTTGCGTCATCCGGAATTACCTAAAAATGTAGGAACTCCT AAATTGCAGTCTGCTCCACAGTTTCAGCCTGAGCCGACAATTCCCCAAACATCCGGGCCCGGAATTTTTGAAAAACTTTC CGAGATTCAGAATAGACTGCGACAGAAATTGTGGGAACTCACACAAAAATTTAGGGAAATAAAAAAGAATCGAGTTGAAT CCGATACCGTTCTATCGAGTTCGCATTCACTTCTTAGAAAAGAAAAGATTACATTCGAAAAAAAACCGTTTTTAACCGTT AGACGAGAAATTGGGGCAAATGGCCAACATACAGTCAAAACACTTGCTGAAAGACTCAGAGAACAAATAGGCAATCGTAA TATCCGACTTCCGAATGTGATTTTACTTTCTTTGGGAGCGGTTATTTCTCTACTTCTTTTGGGAATGATCCTTTTTTGGG TGGGAGTTATTACTCGAGAGTCGGAACTCAAAGAGATGATTTCTTTATTCTATAATCATCAACCTTCTGTGATCTACGAT CGGGATGGAAAAAAGGTCTCTGAAATTTTTGCAAAAAAAACGAGTAATCTGGAATGGGACGCTTATCCTGAAAACCTGAA AAAGATCGTGCTGTTGGTAGAAGATCGTAAATTTTTTTCCCACGGCGGAATCAATTATATGTCTTTACTCCGTGCGATTT TTGTAAACATTACAAGTTTTCGATTTAAACAAGGGGCTTCCACCATCACACAACAGCTCGCAAGGATCTTGTTAGACGAT AGGGAAAAAAGTCTCGTCCGAAAGATCAAAGAGGCGCAGCTTGCTTTTGCTTTAGAATATTCATATGAAAAAAAGCAAAT ATTCTTATATTATTTAAATAATGTATATTTAGGACACGGGGCGTTTGGATTTGCGAGCGCAGCAGAATTTTATTTCAAAA AAACTCCTTCTGAACTCAATACGGAAGAAATGATTGTACTTGCTTCCTTGGCTTCTGCCCCAAATCGTTTTTCACCTTTG AAAAATCCTGATCTTTCTAGACAAAGGGTCAACGCGATCATTCACTCTTTTAGGGAGGATCAAATCCTAAAGGAAAATCC CAAGGCAAAGCTCGATGAAATTTATCTTTCTTTTCACATGAGATCTCCCGGAGAAACCGTATTTGGAAATCGAAAGGATC ATTCTCCTTATGTAACCGAACACGTACGTAAATTTTTGAATTCTTTATACCCAGATTCCAATATCTACGAAACTGGAGGA TTTTCTATTTATACTACTGTTTCTGAGCCAGTTCAAGCGGAACTTCCAAAAATCGTAAAGAACTATGTAGATAACGTGCA GAAAAACGGGTTGGTCCGGAAAACAAGACTTACAGATAATAAAAATTCTAGCGAAACCGCTGTTTTTAGAAGATATATAC AAGATCTTTCGCCAGCGTTAGAATTATTTATCGATACGGATTCTTTTGGTGGTCAAAACGAATCTGGATTGCAAGTAGCG TTAGTCGCCGTTGATCCTTCAACTGGAGAGATTCTATTGATGCACGGTGGTTCCGAATTTAAAGCGGATAATCAATTGGA CAGAACTACTGCTATGAAACGTCAAACCGGATCTTCTATCAAACCGATTTTATATTCCGCAGCGATAGAGACCGGACTGA TCAACGCTTCTTCTCGAATTTTAGACGCACCGTTAATTTATAGAAATCAAACCGGAAACTGGATGCCTGAAAATATTGGA AATCAATACGACGGAGATATTAGCGTTAGGCTTGCTTTAGCAAAATCTAAAAATACCGCAGCGGTTCAAATTGCTGAGAA GTTAGGAATATCAAAGATTCAAGATTTTTTTCAAAAATATTTTTTCCCTGATTTGAAAGTATTATCTTCTAGATTTAGAG GAGATCTTTCCTTAGCTTTAGGTTCTTTAGAAATTTCGCCATTGGAAATGGCTCTTGCTTATTCTGCGTTTGCAAATGAC GGAGTGATCAAACGTCCTTATCTAATTCAAAAGATCACGGATCGATCTGGAAAGATTGTATTTGAAAGAAAATCTACGGA TGAGTTCGGTTTAAAAGTTCCGGAAGAAAGAAAGGTAGTATCTTCTCAGGTCGCAGAGATAATGATCGACCTACTTCATG GGAGCGCAAATTCTGCAGGAGTAAGAAGTACTGGATATAGAGGAGAAGTTGCAGGTAAAACTGGAACCACAAACGACAAC AGAGATAACTGGTTTGTGGGAGTAAAACCCGGAATGTCAATGGCGATTTGGTTAGGATACGATGATCCTAGTTACGGACT CGGCTCATCCGCGTTAGGTGGAACTGTCGCGGCTCCTCTTTGGGGAACCGTTGCTAAAATTTTCGAAGCGGCGGAAGGTT CGGACGAAAGAAGAAAATATTCCATTAGTGAACATGCAATTAGCACAACCGTCTGTGAAGAATCAGGTAAACTTCCCGGT CCTTCTTGTAAACATCCTAGAAAGGAACTTTTTAAGAACGGAACTGTACCTTCTGAAGTTTGTCCCCTAAATCACGGAAC GGATGTAAAGCGAGAAGTCCTTCGTAATGTATTTTAA
Upstream 100 bases:
>100_bases GACCGAAATACTCAAGGGTTGTGATTTTACAGTGATTACGGAAAGGAGAGAAAAAGAGAATTAAATTGCTTGTCTGGAAT TCGTACATTTTCCGACAATT
Downstream 100 bases:
>100_bases AATTTATTATTTTATTATTATATTCTTAATTTTTATCTATAGCCTACATTCTGTTTCTTATGAAGAAGCGTATGCGATGG AAAAAGAAGATCCGTTGTTT
Product: membrane carboxypeptidase
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 918; Mature: 918
Protein sequence:
>918_residues MKMMETGIQTLKTTRFLCPECGTTSRLPEGVPTGSVFRLTCYQCGHKVLVRADIPKVPAPVQPSDKILRHPELPKNVGTP KLQSAPQFQPEPTIPQTSGPGIFEKLSEIQNRLRQKLWELTQKFREIKKNRVESDTVLSSSHSLLRKEKITFEKKPFLTV RREIGANGQHTVKTLAERLREQIGNRNIRLPNVILLSLGAVISLLLLGMILFWVGVITRESELKEMISLFYNHQPSVIYD RDGKKVSEIFAKKTSNLEWDAYPENLKKIVLLVEDRKFFSHGGINYMSLLRAIFVNITSFRFKQGASTITQQLARILLDD REKSLVRKIKEAQLAFALEYSYEKKQIFLYYLNNVYLGHGAFGFASAAEFYFKKTPSELNTEEMIVLASLASAPNRFSPL KNPDLSRQRVNAIIHSFREDQILKENPKAKLDEIYLSFHMRSPGETVFGNRKDHSPYVTEHVRKFLNSLYPDSNIYETGG FSIYTTVSEPVQAELPKIVKNYVDNVQKNGLVRKTRLTDNKNSSETAVFRRYIQDLSPALELFIDTDSFGGQNESGLQVA LVAVDPSTGEILLMHGGSEFKADNQLDRTTAMKRQTGSSIKPILYSAAIETGLINASSRILDAPLIYRNQTGNWMPENIG NQYDGDISVRLALAKSKNTAAVQIAEKLGISKIQDFFQKYFFPDLKVLSSRFRGDLSLALGSLEISPLEMALAYSAFAND GVIKRPYLIQKITDRSGKIVFERKSTDEFGLKVPEERKVVSSQVAEIMIDLLHGSANSAGVRSTGYRGEVAGKTGTTNDN RDNWFVGVKPGMSMAIWLGYDDPSYGLGSSALGGTVAAPLWGTVAKIFEAAEGSDERRKYSISEHAISTTVCEESGKLPG PSCKHPRKELFKNGTVPSEVCPLNHGTDVKREVLRNVF
Sequences:
>Translated_918_residues MKMMETGIQTLKTTRFLCPECGTTSRLPEGVPTGSVFRLTCYQCGHKVLVRADIPKVPAPVQPSDKILRHPELPKNVGTP KLQSAPQFQPEPTIPQTSGPGIFEKLSEIQNRLRQKLWELTQKFREIKKNRVESDTVLSSSHSLLRKEKITFEKKPFLTV RREIGANGQHTVKTLAERLREQIGNRNIRLPNVILLSLGAVISLLLLGMILFWVGVITRESELKEMISLFYNHQPSVIYD RDGKKVSEIFAKKTSNLEWDAYPENLKKIVLLVEDRKFFSHGGINYMSLLRAIFVNITSFRFKQGASTITQQLARILLDD REKSLVRKIKEAQLAFALEYSYEKKQIFLYYLNNVYLGHGAFGFASAAEFYFKKTPSELNTEEMIVLASLASAPNRFSPL KNPDLSRQRVNAIIHSFREDQILKENPKAKLDEIYLSFHMRSPGETVFGNRKDHSPYVTEHVRKFLNSLYPDSNIYETGG FSIYTTVSEPVQAELPKIVKNYVDNVQKNGLVRKTRLTDNKNSSETAVFRRYIQDLSPALELFIDTDSFGGQNESGLQVA LVAVDPSTGEILLMHGGSEFKADNQLDRTTAMKRQTGSSIKPILYSAAIETGLINASSRILDAPLIYRNQTGNWMPENIG NQYDGDISVRLALAKSKNTAAVQIAEKLGISKIQDFFQKYFFPDLKVLSSRFRGDLSLALGSLEISPLEMALAYSAFAND GVIKRPYLIQKITDRSGKIVFERKSTDEFGLKVPEERKVVSSQVAEIMIDLLHGSANSAGVRSTGYRGEVAGKTGTTNDN RDNWFVGVKPGMSMAIWLGYDDPSYGLGSSALGGTVAAPLWGTVAKIFEAAEGSDERRKYSISEHAISTTVCEESGKLPG PSCKHPRKELFKNGTVPSEVCPLNHGTDVKREVLRNVF >Mature_918_residues MKMMETGIQTLKTTRFLCPECGTTSRLPEGVPTGSVFRLTCYQCGHKVLVRADIPKVPAPVQPSDKILRHPELPKNVGTP KLQSAPQFQPEPTIPQTSGPGIFEKLSEIQNRLRQKLWELTQKFREIKKNRVESDTVLSSSHSLLRKEKITFEKKPFLTV RREIGANGQHTVKTLAERLREQIGNRNIRLPNVILLSLGAVISLLLLGMILFWVGVITRESELKEMISLFYNHQPSVIYD RDGKKVSEIFAKKTSNLEWDAYPENLKKIVLLVEDRKFFSHGGINYMSLLRAIFVNITSFRFKQGASTITQQLARILLDD REKSLVRKIKEAQLAFALEYSYEKKQIFLYYLNNVYLGHGAFGFASAAEFYFKKTPSELNTEEMIVLASLASAPNRFSPL KNPDLSRQRVNAIIHSFREDQILKENPKAKLDEIYLSFHMRSPGETVFGNRKDHSPYVTEHVRKFLNSLYPDSNIYETGG FSIYTTVSEPVQAELPKIVKNYVDNVQKNGLVRKTRLTDNKNSSETAVFRRYIQDLSPALELFIDTDSFGGQNESGLQVA LVAVDPSTGEILLMHGGSEFKADNQLDRTTAMKRQTGSSIKPILYSAAIETGLINASSRILDAPLIYRNQTGNWMPENIG NQYDGDISVRLALAKSKNTAAVQIAEKLGISKIQDFFQKYFFPDLKVLSSRFRGDLSLALGSLEISPLEMALAYSAFAND GVIKRPYLIQKITDRSGKIVFERKSTDEFGLKVPEERKVVSSQVAEIMIDLLHGSANSAGVRSTGYRGEVAGKTGTTNDN RDNWFVGVKPGMSMAIWLGYDDPSYGLGSSALGGTVAAPLWGTVAKIFEAAEGSDERRKYSISEHAISTTVCEESGKLPG PSCKHPRKELFKNGTVPSEVCPLNHGTDVKREVLRNVF
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786343, Length=575, Percent_Identity=26.2608695652174, Blast_Score=183, Evalue=5e-47, Organism=Escherichia coli, GI87082258, Length=271, Percent_Identity=34.6863468634686, Blast_Score=150, Evalue=3e-37, Organism=Escherichia coli, GI1788867, Length=156, Percent_Identity=34.6153846153846, Blast_Score=96, Evalue=1e-20, Organism=Escherichia coli, GI1789601, Length=128, Percent_Identity=39.0625, Blast_Score=79, Evalue=2e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 3.4.-.-
Molecular weight: Translated: 102809; Mature: 102809
Theoretical pI: Translated: 9.72; Mature: 9.72
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKMMETGIQTLKTTRFLCPECGTTSRLPEGVPTGSVFRLTCYQCGHKVLVRADIPKVPAP CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCEEEEEECCCCCCCC VQPSDKILRHPELPKNVGTPKLQSAPQFQPEPTIPQTSGPGIFEKLSEIQNRLRQKLWEL CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH TQKFREIKKNRVESDTVLSSSHSLLRKEKITFEKKPFLTVRREIGANGQHTVKTLAERLR HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH EQIGNRNIRLPNVILLSLGAVISLLLLGMILFWVGVITRESELKEMISLFYNHQPSVIYD HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEC RDGKKVSEIFAKKTSNLEWDAYPENLKKIVLLVEDRKFFSHGGINYMSLLRAIFVNITSF CCCHHHHHHHHHHCCCCCCCCCHHCCEEEEEEEECCHHHHCCCCHHHHHHHHHHHHHHHH RFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFALEYSYEKKQIFLYYLNNVYLGHG HHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCEEECCC AFGFASAAEFYFKKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIIHSFRED CHHHHHHHHHHHHCCCCCCCHHHEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHC QILKENPKAKLDEIYLSFHMRSPGETVFGNRKDHSPYVTEHVRKFLNSLYPDSNIYETGG HHHHCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCC FSIYTTVSEPVQAELPKIVKNYVDNVQKNGLVRKTRLTDNKNSSETAVFRRYIQDLSPAL EEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH ELFIDTDSFGGQNESGLQVALVAVDPSTGEILLMHGGSEFKADNQLDRTTAMKRQTGSSI EEEECCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCC KPILYSAAIETGLINASSRILDAPLIYRNQTGNWMPENIGNQYDGDISVRLALAKSKNTA CHHHHHHHHHHHCCCCCHHHCCCCEEEECCCCCCCCHHCCCCCCCCEEEEEEEECCCCCH AVQIAEKLGISKIQDFFQKYFFPDLKVLSSRFRGDLSLALGSLEISPLEMALAYSAFAND HHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCC GVIKRPYLIQKITDRSGKIVFERKSTDEFGLKVPEERKVVSSQVAEIMIDLLHGSANSAG CCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC VRSTGYRGEVAGKTGTTNDNRDNWFVGVKPGMSMAIWLGYDDPSYGLGSSALGGTVAAPL CCCCCCCCEECCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHH WGTVAKIFEAAEGSDERRKYSISEHAISTTVCEESGKLPGPSCKHPRKELFKNGTVPSEV HHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCHHC CPLNHGTDVKREVLRNVF CCCCCCCHHHHHHHHHCC >Mature Secondary Structure MKMMETGIQTLKTTRFLCPECGTTSRLPEGVPTGSVFRLTCYQCGHKVLVRADIPKVPAP CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCEEEEEECCCCCCCC VQPSDKILRHPELPKNVGTPKLQSAPQFQPEPTIPQTSGPGIFEKLSEIQNRLRQKLWEL CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH TQKFREIKKNRVESDTVLSSSHSLLRKEKITFEKKPFLTVRREIGANGQHTVKTLAERLR HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH EQIGNRNIRLPNVILLSLGAVISLLLLGMILFWVGVITRESELKEMISLFYNHQPSVIYD HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEC RDGKKVSEIFAKKTSNLEWDAYPENLKKIVLLVEDRKFFSHGGINYMSLLRAIFVNITSF CCCHHHHHHHHHHCCCCCCCCCHHCCEEEEEEEECCHHHHCCCCHHHHHHHHHHHHHHHH RFKQGASTITQQLARILLDDREKSLVRKIKEAQLAFALEYSYEKKQIFLYYLNNVYLGHG HHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCEEECCC AFGFASAAEFYFKKTPSELNTEEMIVLASLASAPNRFSPLKNPDLSRQRVNAIIHSFRED CHHHHHHHHHHHHCCCCCCCHHHEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHC QILKENPKAKLDEIYLSFHMRSPGETVFGNRKDHSPYVTEHVRKFLNSLYPDSNIYETGG HHHHCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCC FSIYTTVSEPVQAELPKIVKNYVDNVQKNGLVRKTRLTDNKNSSETAVFRRYIQDLSPAL EEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH ELFIDTDSFGGQNESGLQVALVAVDPSTGEILLMHGGSEFKADNQLDRTTAMKRQTGSSI EEEECCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCC KPILYSAAIETGLINASSRILDAPLIYRNQTGNWMPENIGNQYDGDISVRLALAKSKNTA CHHHHHHHHHHHCCCCCHHHCCCCEEEECCCCCCCCHHCCCCCCCCEEEEEEEECCCCCH AVQIAEKLGISKIQDFFQKYFFPDLKVLSSRFRGDLSLALGSLEISPLEMALAYSAFAND HHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCC GVIKRPYLIQKITDRSGKIVFERKSTDEFGLKVPEERKVVSSQVAEIMIDLLHGSANSAG CCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC VRSTGYRGEVAGKTGTTNDNRDNWFVGVKPGMSMAIWLGYDDPSYGLGSSALGGTVAAPL CCCCCCCCEECCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHH WGTVAKIFEAAEGSDERRKYSISEHAISTTVCEESGKLPGPSCKHPRKELFKNGTVPSEV HHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCHHC CPLNHGTDVKREVLRNVF CCCCCCCHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA