Click here to switch to the map view.

The map label for this gene is ribA

Identifier: 45658376

GI number: 45658376

Start: 3070930

End: 3072135

Strand: Reverse

Name: ribA

Synonym: LIC12534

Alternate gene names: 45658376

Gene position: 3072135-3070930 (Counterclockwise)

Preceding gene: 45658377

Following gene: 45658375

Centisome position: 71.83

GC content: 40.22

Gene sequence:

>1206_bases
ATGATTCAACCCATTGAAAATGCAATCGAAGAAATTAAGTCCGGTAAAATGATTATACTTGTGGATTCGGAAGACCGGGA
AAACGAAGGAGACCTTGTAGTTGCGGCCGAATTTGCGGATAAAGAAAAAATCAACTTTATGGCTGCTTTTGGGCGTGGTC
TGATTTGTATACCTATGGAAGTAGAACGTCTTAAAAAATTAGGACTGAATCGGATGGTAGACGATTATTCCCTAGGAGAC
AAACACGGAACTGCGTTTACTGTTTCAGTGGACGCCAAACACGGAACTTCGACCGGAATTTCTGCACAGGATAGGGCGGT
TACGGTCCAAGTCCTTTTAGATGATAAAACCGTTTCTGCCGATTTGATGCGTCCTGGTCATTTATTTCCTCTACAAGCGG
TACCCGGTGGAGTTTTAAGAAGGGCTGGGCATACCGAAGCTGCTGTAGATCTGTCAAAACTTGCTGGTTTGTATCCGGCG
GGTGTAATTTGCGAAATTATGAACGACGATGGGACTATGGCCCGTTTGCCCGATTTAGAAAAATTTGCAGAGAAACACGG
ACTGAATATTTATACGATCGAAGATTTGATCCGTTATCGAAGAGCCAAAGAAAATTTAATTCGTTTAGAAGTAGAATCTA
AACTACCGACTGAATACGGAGAGTTTACCATCCGAGCGTATTCTACTCTGATAGACGATAAGATTCATATCGCCTTGATC
AAAGGAGATATTAAAAAAGAAGAAACTATAATGGTTCGGGTGCATAGCGAATGTTTGACTGGAGATATTTTTTCGAGTAA
TCGTTGTGATTGTGGACCACAGCTTCATGCCGCTTTGGAAATGATTTCTAAAGAAGGGAGGGGGGTTCTTCTTTATATGA
GACAGGAAGGAAGAGGAATTGGTCTGATCAATAAATTAAAAGCTTATAATATTCAAGATAAGGGATATGATACGGTCGAA
GCCAATGAAAAATTAGGCTTTGCACCGGATCTTAGAGATTATGGAATTGGAGCCCAAATTTTGAGAGAAATAGGTGTAGG
TAAAATGAAGATTTTAACGAATAATCCTCGTAAGATCGTAGGTTTAGATGGTTACGGTTTAGAAGTGGTAGAAAGAGTTC
CGATCGAAATTCAACCCGGTTCCGACAACCATGATTATTTGATGACTAAAAAATTAAAGCTTGGTCATATGTTAGGTCTT
GGTTGA

Upstream 100 bases:

>100_bases
CTAAACGTTATATTGTTTTTGAGAAGTAAATGGTAAACTTAATATTTAAGTTTCTGTAGCCAAATTTTAGTCCAATAGAA
GAGATGGTAAGAATAGATCT

Downstream 100 bases:

>100_bases
ATCTCGTTTTTAGTTCGTTCTTTTTTAAAAGATTATTATATTACCTTTTGTTTTAATAGTTTATTTTGTACTTATTTACT
TGATGTGAGCAGGACGTAAT

Product: GTP cyclohydrolase 2

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MIQPIENAIEEIKSGKMIILVDSEDRENEGDLVVAAEFADKEKINFMAAFGRGLICIPMEVERLKKLGLNRMVDDYSLGD
KHGTAFTVSVDAKHGTSTGISAQDRAVTVQVLLDDKTVSADLMRPGHLFPLQAVPGGVLRRAGHTEAAVDLSKLAGLYPA
GVICEIMNDDGTMARLPDLEKFAEKHGLNIYTIEDLIRYRRAKENLIRLEVESKLPTEYGEFTIRAYSTLIDDKIHIALI
KGDIKKEETIMVRVHSECLTGDIFSSNRCDCGPQLHAALEMISKEGRGVLLYMRQEGRGIGLINKLKAYNIQDKGYDTVE
ANEKLGFAPDLRDYGIGAQILREIGVGKMKILTNNPRKIVGLDGYGLEVVERVPIEIQPGSDNHDYLMTKKLKLGHMLGL
G

Sequences:

>Translated_401_residues
MIQPIENAIEEIKSGKMIILVDSEDRENEGDLVVAAEFADKEKINFMAAFGRGLICIPMEVERLKKLGLNRMVDDYSLGD
KHGTAFTVSVDAKHGTSTGISAQDRAVTVQVLLDDKTVSADLMRPGHLFPLQAVPGGVLRRAGHTEAAVDLSKLAGLYPA
GVICEIMNDDGTMARLPDLEKFAEKHGLNIYTIEDLIRYRRAKENLIRLEVESKLPTEYGEFTIRAYSTLIDDKIHIALI
KGDIKKEETIMVRVHSECLTGDIFSSNRCDCGPQLHAALEMISKEGRGVLLYMRQEGRGIGLINKLKAYNIQDKGYDTVE
ANEKLGFAPDLRDYGIGAQILREIGVGKMKILTNNPRKIVGLDGYGLEVVERVPIEIQPGSDNHDYLMTKKLKLGHMLGL
G
>Mature_401_residues
MIQPIENAIEEIKSGKMIILVDSEDRENEGDLVVAAEFADKEKINFMAAFGRGLICIPMEVERLKKLGLNRMVDDYSLGD
KHGTAFTVSVDAKHGTSTGISAQDRAVTVQVLLDDKTVSADLMRPGHLFPLQAVPGGVLRRAGHTEAAVDLSKLAGLYPA
GVICEIMNDDGTMARLPDLEKFAEKHGLNIYTIEDLIRYRRAKENLIRLEVESKLPTEYGEFTIRAYSTLIDDKIHIALI
KGDIKKEETIMVRVHSECLTGDIFSSNRCDCGPQLHAALEMISKEGRGVLLYMRQEGRGIGLINKLKAYNIQDKGYDTVE
ANEKLGFAPDLRDYGIGAQILREIGVGKMKILTNNPRKIVGLDGYGLEVVERVPIEIQPGSDNHDYLMTKKLKLGHMLGL
G

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=187, Percent_Identity=51.8716577540107, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=47, Blast_Score=198, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6320695, Length=205, Percent_Identity=45.8536585365854, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6319438, Length=169, Percent_Identity=45.5621301775148, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44362; Mature: 44362

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQPIENAIEEIKSGKMIILVDSEDRENEGDLVVAAEFADKEKINFMAAFGRGLICIPME
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCHHEEEEECCCCEEEECCC
VERLKKLGLNRMVDDYSLGDKHGTAFTVSVDAKHGTSTGISAQDRAVTVQVLLDDKTVSA
HHHHHHCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCH
DLMRPGHLFPLQAVPGGVLRRAGHTEAAVDLSKLAGLYPAGVICEIMNDDGTMARLPDLE
HHCCCCCEEEHHCCCCHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCHH
KFAEKHGLNIYTIEDLIRYRRAKENLIRLEVESKLPTEYGEFTIRAYSTLIDDKIHIALI
HHHHHHCCEEEEHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEHHHHHCCCEEEEEE
KGDIKKEETIMVRVHSECLTGDIFSSNRCDCGPQLHAALEMISKEGRGVLLYMRQEGRGI
ECCCCCCCEEEEEEECCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCC
GLINKLKAYNIQDKGYDTVEANEKLGFAPDLRDYGIGAQILREIGVGKMKILTNNPRKIV
CEEHHHEEECCCCCCCCCEECCCCCCCCCCHHHCCCHHHHHHHCCCCEEEEEECCCCEEE
GLDGYGLEVVERVPIEIQPGSDNHDYLMTKKLKLGHMLGLG
EECCCCHHHHEECCEEEECCCCCCCEEEEEEEHHHHHCCCC
>Mature Secondary Structure
MIQPIENAIEEIKSGKMIILVDSEDRENEGDLVVAAEFADKEKINFMAAFGRGLICIPME
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCHHEEEEECCCCEEEECCC
VERLKKLGLNRMVDDYSLGDKHGTAFTVSVDAKHGTSTGISAQDRAVTVQVLLDDKTVSA
HHHHHHCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCH
DLMRPGHLFPLQAVPGGVLRRAGHTEAAVDLSKLAGLYPAGVICEIMNDDGTMARLPDLE
HHCCCCCEEEHHCCCCHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCHH
KFAEKHGLNIYTIEDLIRYRRAKENLIRLEVESKLPTEYGEFTIRAYSTLIDDKIHIALI
HHHHHHCCEEEEHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEHHHHHCCCEEEEEE
KGDIKKEETIMVRVHSECLTGDIFSSNRCDCGPQLHAALEMISKEGRGVLLYMRQEGRGI
ECCCCCCCEEEEEEECCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCC
GLINKLKAYNIQDKGYDTVEANEKLGFAPDLRDYGIGAQILREIGVGKMKILTNNPRKIV
CEEHHHEEECCCCCCCCCEECCCCCCCCCCHHHCCCHHHHHHHCCCCEEEEEECCCCEEE
GLDGYGLEVVERVPIEIQPGSDNHDYLMTKKLKLGHMLGLG
EECCCCHHHHEECCEEEECCCCCCCEEEEEEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA