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The map label for this gene is htpG [H]

Identifier: 45658311

GI number: 45658311

Start: 2989495

End: 2991306

Strand: Direct

Name: htpG [H]

Synonym: LIC12469

Alternate gene names: 45658311

Gene position: 2989495-2991306 (Clockwise)

Preceding gene: 45658310

Following gene: 45658312

Centisome position: 69.89

GC content: 41.23

Gene sequence:

>1812_bases
GTGAGTCATAAGTTCCAAGTCAACTTACGTGGAATCATCAATCTACTTTCAGAACATCTTTACAGTGGGCCGCAAGTATT
CGTACGTGAACTTTTACAAAACGGAGTAGATGCAATCCAAGCCCGCTCCTATCTCGAACCAGAAAACGAAGGAGAGATCC
ATCTTGAAATCATTCCCGGAAAGGACGGAACACCTCCAACTCTTATCTTTACGGACAACGGAGTCGGATTGGTAGAATCG
GAAATCCACGAGTTCTTGGCAACCATAGGACAAAGTTCGAAACGAGGAGAATTTCAATCTCCGAAAGGATTTATCGGTCA
ATTTGGAGTGGGTTTACTCTCTTGTTTTATCGTAAGCGACGAAGTTGTAGTAGTCACTCGTTCCGTAAAAGACAAAACAC
AACCTGCTTTCGAATGGCGTGGAAAACAAGATGGAACTTACTCAATTAAAACCCTTGGAAGCGACTTGCCCTTTGGAACT
CAGGTCTATCTTCTTTGTAAACCTGGCTCTGAAGAATACTTTGAACGAGAAACTCTTTGTAATCTTGTAAAAAAATTCGG
TGGTCTGTTATCCGTTCCTCTTCAATTTTTAGAAGGAGAGTCCACCGAGCTTCTAAATCCGGAACCTGCACCTTGGAACC
GCACGTATCGAAGTAAAGCACAAGAAAGAAAGACATTTCTTGATTTCGGAAAAAAGTTATTTGAAACTTCATTTTTTGAC
GCAATCCCGCTGACTTCCGACATAGGCAAGGTACAGGGAATCGCTTTCGTTTTGCCTTATTCCCCCAGTCTTGCACAAAA
AAACATACATCGCATTTATCTCAAAAACATGCTTTTATCTGAGTCAGCCGCGTCCCTTCTACCAGATTGGGCGTTCTTTG
TCAAATGTGTAGTCAACTCTGACGAACTCAGACCCACTGCATCACGAGAAGATTTTTACGAAGATCAATCTCTCGAAAAA
GCGAGAGAAACATTGGGGCAATGTCTTAGAGATTATCTGATCGCACTTTCCGAAGACGAACCAGAACGTCTTCGTCATCT
GATCAACCTTCATCATCTATCCATGAAAGCGCTTGCGGTTCAGGACTCCGATTTTTTCCGTTTGATCATCGACTTTCTTC
CGTTTGAAACTACGTTCGGGAGAATGACCTTAAAAGAATTTCGGGAAAAAAATCCAGTAATCCGTTATGTATCCAGTCAT
GATCAATATCGACAGATTTCAGGAGTTGCAGCGGCGCAAGGAGAGGCTATTATCAACGGAGGTTACGTCTACGACAGCGA
ACTACTCGAACGTTTTAGCGAACTATATCCAGTAGAACAGGTGGACGCAGCTGGATTCGCTCAAACGTTCGAAGACATTA
CTCTCGAAGAACGAGATTCTGTATTCGATTTTTTGCAAGTAGCAGATCAGGTTTTGCGTCCTTTTCAGTGTGTGACCGAC
ATCAAAAAATTTCTTCCGATCGAAATGCCTATGTTGTATCACCTAAGTCAAGAAGGAGACTTTTTACGTTCTGTAGAACA
TTCTAAAGAAATTGCAAATAAGATGTGGTCTGACATATTAAACAATCTCTCTGATTCTTATTCAAAAGAAATCAACGCGT
ATCTTTTTTTCAATCTACGGAATCCTTTAATTCAAAAGCTCGTAAAACTAAAAGACGTCCAATTGATAGGCAGAGCCGTT
CAGATGCTTTATATACAAGCGCTTTTAATGGGACATCACCCACTTCATGTTAAAGAGTTGTCTCTTCTTACGGGTGGACT
TTCGGACTTAATCGAAGGATGTATAAACAATCAAATTAGGGAAAATCAATGA

Upstream 100 bases:

>100_bases
GACAAAAGTTTAATTCTATGCACGTGGAATCCGACTTGACCCAAACTTATCCTTACATTCTTACTATTTCTTTGAAATCT
AATGAAAAAAGAGCTATCTT

Downstream 100 bases:

>100_bases
TAGAGATAAATCCCAACACAGAAGATTTGTTTCCTGTCCTATGGGACGTGGAATCCATGAAAAACGATTTCTCAAAGTGT
CCGCTTTTAGAAGAAATCAT

Product: HSP90 family protein

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MSHKFQVNLRGIINLLSEHLYSGPQVFVRELLQNGVDAIQARSYLEPENEGEIHLEIIPGKDGTPPTLIFTDNGVGLVES
EIHEFLATIGQSSKRGEFQSPKGFIGQFGVGLLSCFIVSDEVVVVTRSVKDKTQPAFEWRGKQDGTYSIKTLGSDLPFGT
QVYLLCKPGSEEYFERETLCNLVKKFGGLLSVPLQFLEGESTELLNPEPAPWNRTYRSKAQERKTFLDFGKKLFETSFFD
AIPLTSDIGKVQGIAFVLPYSPSLAQKNIHRIYLKNMLLSESAASLLPDWAFFVKCVVNSDELRPTASREDFYEDQSLEK
ARETLGQCLRDYLIALSEDEPERLRHLINLHHLSMKALAVQDSDFFRLIIDFLPFETTFGRMTLKEFREKNPVIRYVSSH
DQYRQISGVAAAQGEAIINGGYVYDSELLERFSELYPVEQVDAAGFAQTFEDITLEERDSVFDFLQVADQVLRPFQCVTD
IKKFLPIEMPMLYHLSQEGDFLRSVEHSKEIANKMWSDILNNLSDSYSKEINAYLFFNLRNPLIQKLVKLKDVQLIGRAV
QMLYIQALLMGHHPLHVKELSLLTGGLSDLIEGCINNQIRENQ

Sequences:

>Translated_603_residues
MSHKFQVNLRGIINLLSEHLYSGPQVFVRELLQNGVDAIQARSYLEPENEGEIHLEIIPGKDGTPPTLIFTDNGVGLVES
EIHEFLATIGQSSKRGEFQSPKGFIGQFGVGLLSCFIVSDEVVVVTRSVKDKTQPAFEWRGKQDGTYSIKTLGSDLPFGT
QVYLLCKPGSEEYFERETLCNLVKKFGGLLSVPLQFLEGESTELLNPEPAPWNRTYRSKAQERKTFLDFGKKLFETSFFD
AIPLTSDIGKVQGIAFVLPYSPSLAQKNIHRIYLKNMLLSESAASLLPDWAFFVKCVVNSDELRPTASREDFYEDQSLEK
ARETLGQCLRDYLIALSEDEPERLRHLINLHHLSMKALAVQDSDFFRLIIDFLPFETTFGRMTLKEFREKNPVIRYVSSH
DQYRQISGVAAAQGEAIINGGYVYDSELLERFSELYPVEQVDAAGFAQTFEDITLEERDSVFDFLQVADQVLRPFQCVTD
IKKFLPIEMPMLYHLSQEGDFLRSVEHSKEIANKMWSDILNNLSDSYSKEINAYLFFNLRNPLIQKLVKLKDVQLIGRAV
QMLYIQALLMGHHPLHVKELSLLTGGLSDLIEGCINNQIRENQ
>Mature_602_residues
SHKFQVNLRGIINLLSEHLYSGPQVFVRELLQNGVDAIQARSYLEPENEGEIHLEIIPGKDGTPPTLIFTDNGVGLVESE
IHEFLATIGQSSKRGEFQSPKGFIGQFGVGLLSCFIVSDEVVVVTRSVKDKTQPAFEWRGKQDGTYSIKTLGSDLPFGTQ
VYLLCKPGSEEYFERETLCNLVKKFGGLLSVPLQFLEGESTELLNPEPAPWNRTYRSKAQERKTFLDFGKKLFETSFFDA
IPLTSDIGKVQGIAFVLPYSPSLAQKNIHRIYLKNMLLSESAASLLPDWAFFVKCVVNSDELRPTASREDFYEDQSLEKA
RETLGQCLRDYLIALSEDEPERLRHLINLHHLSMKALAVQDSDFFRLIIDFLPFETTFGRMTLKEFREKNPVIRYVSSHD
QYRQISGVAAAQGEAIINGGYVYDSELLERFSELYPVEQVDAAGFAQTFEDITLEERDSVFDFLQVADQVLRPFQCVTDI
KKFLPIEMPMLYHLSQEGDFLRSVEHSKEIANKMWSDILNNLSDSYSKEINAYLFFNLRNPLIQKLVKLKDVQLIGRAVQ
MLYIQALLMGHHPLHVKELSLLTGGLSDLIEGCINNQIRENQ

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI155722983, Length=362, Percent_Identity=25.414364640884, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI154146191, Length=209, Percent_Identity=29.1866028708134, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI153792590, Length=209, Percent_Identity=29.1866028708134, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI20149594, Length=209, Percent_Identity=28.7081339712919, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI4507677, Length=207, Percent_Identity=30.9178743961353, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1786679, Length=405, Percent_Identity=26.1728395061728, Blast_Score=130, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI115535205, Length=383, Percent_Identity=28.1984334203655, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI115535167, Length=383, Percent_Identity=28.1984334203655, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17559162, Length=469, Percent_Identity=22.3880597014925, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17542208, Length=375, Percent_Identity=25.0666666666667, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6325016, Length=221, Percent_Identity=26.2443438914027, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323840, Length=221, Percent_Identity=25.7918552036199, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24586016, Length=426, Percent_Identity=26.9953051643192, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17647529, Length=205, Percent_Identity=27.8048780487805, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357739, Length=518, Percent_Identity=22.972972972973, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 68554; Mature: 68423

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHKFQVNLRGIINLLSEHLYSGPQVFVRELLQNGVDAIQARSYLEPENEGEIHLEIIPG
CCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
KDGTPPTLIFTDNGVGLVESEIHEFLATIGQSSKRGEFQSPKGFIGQFGVGLLSCFIVSD
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
EVVVVTRSVKDKTQPAFEWRGKQDGTYSIKTLGSDLPFGTQVYLLCKPGSEEYFERETLC
CEEEEEECCCCCCCCHHHCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHH
NLVKKFGGLLSVPLQFLEGESTELLNPEPAPWNRTYRSKAQERKTFLDFGKKLFETSFFD
HHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
AIPLTSDIGKVQGIAFVLPYSPSLAQKNIHRIYLKNMLLSESAASLLPDWAFFVKCVVNS
CCCCCHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
DELRPTASREDFYEDQSLEKARETLGQCLRDYLIALSEDEPERLRHLINLHHLSMKALAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEE
QDSDFFRLIIDFLPFETTFGRMTLKEFREKNPVIRYVSSHDQYRQISGVAAAQGEAIING
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHHCHHHCCCCEEEEC
GYVYDSELLERFSELYPVEQVDAAGFAQTFEDITLEERDSVFDFLQVADQVLRPFQCVTD
CEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IKKFLPIEMPMLYHLSQEGDFLRSVEHSKEIANKMWSDILNNLSDSYSKEINAYLFFNLR
HHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
NPLIQKLVKLKDVQLIGRAVQMLYIQALLMGHHPLHVKELSLLTGGLSDLIEGCINNQIR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHCCCCC
ENQ
CCC
>Mature Secondary Structure 
SHKFQVNLRGIINLLSEHLYSGPQVFVRELLQNGVDAIQARSYLEPENEGEIHLEIIPG
CCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
KDGTPPTLIFTDNGVGLVESEIHEFLATIGQSSKRGEFQSPKGFIGQFGVGLLSCFIVSD
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
EVVVVTRSVKDKTQPAFEWRGKQDGTYSIKTLGSDLPFGTQVYLLCKPGSEEYFERETLC
CEEEEEECCCCCCCCHHHCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHH
NLVKKFGGLLSVPLQFLEGESTELLNPEPAPWNRTYRSKAQERKTFLDFGKKLFETSFFD
HHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
AIPLTSDIGKVQGIAFVLPYSPSLAQKNIHRIYLKNMLLSESAASLLPDWAFFVKCVVNS
CCCCCHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
DELRPTASREDFYEDQSLEKARETLGQCLRDYLIALSEDEPERLRHLINLHHLSMKALAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEE
QDSDFFRLIIDFLPFETTFGRMTLKEFREKNPVIRYVSSHDQYRQISGVAAAQGEAIING
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEHHCCHHHHHHHCHHHCCCCEEEEC
GYVYDSELLERFSELYPVEQVDAAGFAQTFEDITLEERDSVFDFLQVADQVLRPFQCVTD
CEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IKKFLPIEMPMLYHLSQEGDFLRSVEHSKEIANKMWSDILNNLSDSYSKEINAYLFFNLR
HHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
NPLIQKLVKLKDVQLIGRAVQMLYIQALLMGHHPLHVKELSLLTGGLSDLIEGCINNQIR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHCCCCC
ENQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA