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The map label for this gene is pheA

Identifier: 45658294

GI number: 45658294

Start: 2969109

End: 2970215

Strand: Reverse

Name: pheA

Synonym: LIC12451

Alternate gene names: 45658294

Gene position: 2970215-2969109 (Counterclockwise)

Preceding gene: 45658295

Following gene: 45658293

Centisome position: 69.44

GC content: 40.83

Gene sequence:

>1107_bases
ATGATCTACTCGAAGATGAGTGATTTAGATCAGCAATTAAAAATCTTTAGAGATCAGATCGATTCTTTGGATCGAGAAAT
CGTAAAGTCTATCCAGACTCGTGCAGAGTTTGCGTCTAAGATCGGAGAGATTAAAAGAGAAAGAAACGAGCCGGTCTTCC
GACCAGATAGAGAAAAGGAAGTTTACGAAAAGATAAAGTCTTTTAGCCCCGGTCCACTTCCAGACAAAGTGTTGCTTGCA
ATTTACCGTGAAATCATGTCCGGTTCTATTTCCGTAGAAAAAGGATTAGAGATTGGTTATTTAGGACCGGCAGGTTCTTT
TTCCAATCAGGCGGTTCGTTCTCGTTTTGGAGCTTCGATCAACGCTTTAGAGTTCAATTCGATTCCAGACGTTTTTCGCG
CCGTAGAAACCGATAAAATCGATTACGGAGTTGTGCCTGTGGAAAATTCCAGCGAAGGTTTGGTCAACTCCACCTTAGAC
CAATTTTTAGTTTCCGATCTTCTGATTTACTCGGAACACTATTTAAGAATCAATATCAGCCTACTTGGATTGGAACATGA
TCTTTCTAAGATTAAAACGTTATACGGAATCAAAATCGCCAATTCTCAGTGTAAAAATTGGATCGCCGCCAATCTTCCTC
ACGTAGAAATCGTAGAAACTTCTTCTACTGCCAAAGCGGCTCAAATCGTAGCGGAAAAAAAAGACGCCTGTGCCGCAGTT
GCTTCTTCCATCGCTGCGGAAATCTATGGGCTCAGTCTGATTCGCGAATCTATCGAAGATCTTCCTGATAATACTACCCG
CTTTTTGATCATAGGAAAAAATCAATGTCCTCCTACGGGGAATGATAAAACTTCGATCGTTTTTTCCTGCCCCGATAAAC
CGGGTGCACTTTATCGTGTACTAAAACCTTTTTTTGATTATCAACTCAATTTGAGCAAAATAGAATCCAGACCCACAAGA
AGAAACTCCTGGGAATATAACTTTTTTATAGACTTTCACGGTCATCAAAAGGATCCATCGATCCAAAACGTTCTCGCCGG
TCTGAAAGAAAATACTATTTTTTTGAGAGTACTCGGTTCTTATCCGATGTCTCCGCAAAACCTGTGA

Upstream 100 bases:

>100_bases
TATGGAACTACGAAAGAGTTCTTGATTCATTTTGGATTGAATAAACTATCGGATCTTCCTGCTCCTGTGGAAGTAAAAGA
ATTGAAATTCGAAAATTTGG

Downstream 100 bases:

>100_bases
AATTAGAATTTTCTAATATTTTAATTTACGGATTGGGGCTGATGGGCGCTTCGCTTTCTTTGGCGCTTAAACAAAAGGGG
ATTTCAGCATCTATCACTGG

Product: chorismate mutase and prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MIYSKMSDLDQQLKIFRDQIDSLDREIVKSIQTRAEFASKIGEIKRERNEPVFRPDREKEVYEKIKSFSPGPLPDKVLLA
IYREIMSGSISVEKGLEIGYLGPAGSFSNQAVRSRFGASINALEFNSIPDVFRAVETDKIDYGVVPVENSSEGLVNSTLD
QFLVSDLLIYSEHYLRINISLLGLEHDLSKIKTLYGIKIANSQCKNWIAANLPHVEIVETSSTAKAAQIVAEKKDACAAV
ASSIAAEIYGLSLIRESIEDLPDNTTRFLIIGKNQCPPTGNDKTSIVFSCPDKPGALYRVLKPFFDYQLNLSKIESRPTR
RNSWEYNFFIDFHGHQKDPSIQNVLAGLKENTIFLRVLGSYPMSPQNL

Sequences:

>Translated_368_residues
MIYSKMSDLDQQLKIFRDQIDSLDREIVKSIQTRAEFASKIGEIKRERNEPVFRPDREKEVYEKIKSFSPGPLPDKVLLA
IYREIMSGSISVEKGLEIGYLGPAGSFSNQAVRSRFGASINALEFNSIPDVFRAVETDKIDYGVVPVENSSEGLVNSTLD
QFLVSDLLIYSEHYLRINISLLGLEHDLSKIKTLYGIKIANSQCKNWIAANLPHVEIVETSSTAKAAQIVAEKKDACAAV
ASSIAAEIYGLSLIRESIEDLPDNTTRFLIIGKNQCPPTGNDKTSIVFSCPDKPGALYRVLKPFFDYQLNLSKIESRPTR
RNSWEYNFFIDFHGHQKDPSIQNVLAGLKENTIFLRVLGSYPMSPQNL
>Mature_368_residues
MIYSKMSDLDQQLKIFRDQIDSLDREIVKSIQTRAEFASKIGEIKRERNEPVFRPDREKEVYEKIKSFSPGPLPDKVLLA
IYREIMSGSISVEKGLEIGYLGPAGSFSNQAVRSRFGASINALEFNSIPDVFRAVETDKIDYGVVPVENSSEGLVNSTLD
QFLVSDLLIYSEHYLRINISLLGLEHDLSKIKTLYGIKIANSQCKNWIAANLPHVEIVETSSTAKAAQIVAEKKDACAAV
ASSIAAEIYGLSLIRESIEDLPDNTTRFLIIGKNQCPPTGNDKTSIVFSCPDKPGALYRVLKPFFDYQLNLSKIESRPTR
RNSWEYNFFIDFHGHQKDPSIQNVLAGLKENTIFLRVLGSYPMSPQNL

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=375, Percent_Identity=29.0666666666667, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324013, Length=305, Percent_Identity=28.5245901639344, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 41306; Mature: 41306

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYSKMSDLDQQLKIFRDQIDSLDREIVKSIQTRAEFASKIGEIKRERNEPVFRPDREKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
VYEKIKSFSPGPLPDKVLLAIYREIMSGSISVEKGLEIGYLGPAGSFSNQAVRSRFGASI
HHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHCCCEEEECCCCCCCCHHHHHHHHCCCC
NALEFNSIPDVFRAVETDKIDYGVVPVENSSEGLVNSTLDQFLVSDLLIYSEHYLRINIS
CEEECCCCHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEE
LLGLEHDLSKIKTLYGIKIANSQCKNWIAANLPHVEIVETSSTAKAAQIVAEKKDACAAV
EEECHHHHHHHHHHHCEEECCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
ASSIAAEIYGLSLIRESIEDLPDNTTRFLIIGKNQCPPTGNDKTSIVFSCPDKPGALYRV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHH
LKPFFDYQLNLSKIESRPTRRNSWEYNFFIDFHGHQKDPSIQNVLAGLKENTIFLRVLGS
HHHHHCCCCCHHHHHCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECC
YPMSPQNL
CCCCCCCC
>Mature Secondary Structure
MIYSKMSDLDQQLKIFRDQIDSLDREIVKSIQTRAEFASKIGEIKRERNEPVFRPDREKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
VYEKIKSFSPGPLPDKVLLAIYREIMSGSISVEKGLEIGYLGPAGSFSNQAVRSRFGASI
HHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHCCCEEEECCCCCCCCHHHHHHHHCCCC
NALEFNSIPDVFRAVETDKIDYGVVPVENSSEGLVNSTLDQFLVSDLLIYSEHYLRINIS
CEEECCCCHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEE
LLGLEHDLSKIKTLYGIKIANSQCKNWIAANLPHVEIVETSSTAKAAQIVAEKKDACAAV
EEECHHHHHHHHHHHCEEECCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
ASSIAAEIYGLSLIRESIEDLPDNTTRFLIIGKNQCPPTGNDKTSIVFSCPDKPGALYRV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHH
LKPFFDYQLNLSKIESRPTRRNSWEYNFFIDFHGHQKDPSIQNVLAGLKENTIFLRVLGS
HHHHHCCCCCHHHHHCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECC
YPMSPQNL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]