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The map label for this gene is erg3 [H]

Identifier: 45658182

GI number: 45658182

Start: 2821205

End: 2822533

Strand: Direct

Name: erg3 [H]

Synonym: LIC12336

Alternate gene names: 45658182

Gene position: 2821205-2822533 (Clockwise)

Preceding gene: 45658181

Following gene: 45658187

Centisome position: 65.96

GC content: 37.62

Gene sequence:

>1329_bases
ATGGAAATCAATCTTGTCACGATCGCAATTCCGTTTTTCTTTTTACTAATCTTTCTAGAAATTGGATTTTCCGCATATCA
TAAACGCAAACTCTATCGTTTAAACGATTCCATCAACGATTTGTCTACAGGAACTGCGAGTCAAGTCGTAGGAGTTTTTT
CTAAAGTTGTTACTTTAGCAGCTTATATTTATATCTATCAAAATTTTAGGATTTTCAATCTTCCTTCTTGGCCAAGTGAA
GCGCTTTCCATTTTTCCAAACGGAATATTAGGACTCAGCTCTTATACTTGGGCTTGGATTTTTGTAGTAGCAGTTTGGAT
TTTTTGTTTTATTGGTTACGACCTAGCCTATTACTGGGTTCATCGTCTGAGCCATGAGATTAACTTTCTTTGGGCGGGAC
ACGTTGTACATCATCAAAGCGAAGAATACAATCTCACAGTCGCCCTCAGACAAGCAAGTTTTCACGGTCTTTTTACTTGG
GTTTTCTATCTTCCTTTAGCTTTGATCGGTTTTTCTCCGGTCGTGATGATTCTAAACGGACAACTCAATCTTATTTATCA
ATTCTGGATTCATACGAAGGCGATCAATAAATTTCCTCGTTGGTTCGAAGCAATTTTTAATACCCCTTCTCATCATAGAG
TTCATCACGGAATCAATCCCCAATATATCGATAAAAACCACGGAGGAACTCTGATCGTTTTTGACAAATGGTTCGGAACC
TTTGAACCGGAATTAGAAGAACCTGTTTATGGAACCGTTAAACCTCTACGTAGTTTCAATCCGATTTGGGCCAATCTTCA
CTATTGGTGGGAAATGATCGAGCTCGCTCGAAATTGCTCCCGCTGGTCAGATAAGTTTAAAGTTTTTTTTGCAGTTCCTG
GTTGGAGACCCAAAGAACTCGGAGGTCAATATCCAATTCCCGAAGTTTCTACAAAAACATTCCATAAATTTGATATAGAT
CTTCCTAAAGGTTTAAGTTTATATTCTCTAGTTTGGTTTATCATTTCCGTAGTACTTACATTTGGAATGCTCGTTAAAGT
TCAGTCCCTTCCTTGGTTCAATATAGGTGTCATTAGTTTTGTCTCTTTGATTTCTCTTTTGACAATTGGTGGAATCTTAG
AAAAAAAACGTTGGGCTCTTTTTGTAGAACCGATCCGCTTAGTCATTTTAGTCGGTGCCGCTTATGTTCTTTCAGCGGAA
ATGAGTATTACGTTAGGTACTATTGCTCTAAGTGTAATTTCTACAATTTGGTTTTTTACCTACAGAACTTATTTCGTTTT
GTCCCAGGAAATCAATCCGGTAGGTGAAATTCTTAGAAGAACCGCTTAA

Upstream 100 bases:

>100_bases
GATCGTGATATTAAAACGATCCTTCCTAAACAATGTTTTTGAATTGACCTCGAACGAATTAGAAGAATAAACTTAAAGTA
GAACTTACTGGGATGGCTTT

Downstream 100 bases:

>100_bases
CGTTTCTAAAAAAATAATCAGAAGTTAAATAGAAATAAGAGTTTGTCCCAAAACCTCAAAAAATTTTACGCGATAACTCT
TTAGAAATTTTTAATAAAAT

Product: sterol desaturase-related protein

Products: NA

Alternate protein names: Sterol-C5-desaturase [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MEINLVTIAIPFFFLLIFLEIGFSAYHKRKLYRLNDSINDLSTGTASQVVGVFSKVVTLAAYIYIYQNFRIFNLPSWPSE
ALSIFPNGILGLSSYTWAWIFVVAVWIFCFIGYDLAYYWVHRLSHEINFLWAGHVVHHQSEEYNLTVALRQASFHGLFTW
VFYLPLALIGFSPVVMILNGQLNLIYQFWIHTKAINKFPRWFEAIFNTPSHHRVHHGINPQYIDKNHGGTLIVFDKWFGT
FEPELEEPVYGTVKPLRSFNPIWANLHYWWEMIELARNCSRWSDKFKVFFAVPGWRPKELGGQYPIPEVSTKTFHKFDID
LPKGLSLYSLVWFIISVVLTFGMLVKVQSLPWFNIGVISFVSLISLLTIGGILEKKRWALFVEPIRLVILVGAAYVLSAE
MSITLGTIALSVISTIWFFTYRTYFVLSQEINPVGEILRRTA

Sequences:

>Translated_442_residues
MEINLVTIAIPFFFLLIFLEIGFSAYHKRKLYRLNDSINDLSTGTASQVVGVFSKVVTLAAYIYIYQNFRIFNLPSWPSE
ALSIFPNGILGLSSYTWAWIFVVAVWIFCFIGYDLAYYWVHRLSHEINFLWAGHVVHHQSEEYNLTVALRQASFHGLFTW
VFYLPLALIGFSPVVMILNGQLNLIYQFWIHTKAINKFPRWFEAIFNTPSHHRVHHGINPQYIDKNHGGTLIVFDKWFGT
FEPELEEPVYGTVKPLRSFNPIWANLHYWWEMIELARNCSRWSDKFKVFFAVPGWRPKELGGQYPIPEVSTKTFHKFDID
LPKGLSLYSLVWFIISVVLTFGMLVKVQSLPWFNIGVISFVSLISLLTIGGILEKKRWALFVEPIRLVILVGAAYVLSAE
MSITLGTIALSVISTIWFFTYRTYFVLSQEINPVGEILRRTA
>Mature_442_residues
MEINLVTIAIPFFFLLIFLEIGFSAYHKRKLYRLNDSINDLSTGTASQVVGVFSKVVTLAAYIYIYQNFRIFNLPSWPSE
ALSIFPNGILGLSSYTWAWIFVVAVWIFCFIGYDLAYYWVHRLSHEINFLWAGHVVHHQSEEYNLTVALRQASFHGLFTW
VFYLPLALIGFSPVVMILNGQLNLIYQFWIHTKAINKFPRWFEAIFNTPSHHRVHHGINPQYIDKNHGGTLIVFDKWFGT
FEPELEEPVYGTVKPLRSFNPIWANLHYWWEMIELARNCSRWSDKFKVFFAVPGWRPKELGGQYPIPEVSTKTFHKFDID
LPKGLSLYSLVWFIISVVLTFGMLVKVQSLPWFNIGVISFVSLISLLTIGGILEKKRWALFVEPIRLVILVGAAYVLSAE
MSITLGTIALSVISTIWFFTYRTYFVLSQEINPVGEILRRTA

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family [H]

Homologues:

Organism=Homo sapiens, GI51972212, Length=391, Percent_Identity=37.3401534526854, Blast_Score=240, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI25144659, Length=271, Percent_Identity=35.0553505535055, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006694 [H]

Pfam domain/function: PF04116 FA_hydroxylase [H]

EC number: NA

Molecular weight: Translated: 51193; Mature: 51193

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEINLVTIAIPFFFLLIFLEIGFSAYHKRKLYRLNDSINDLSTGTASQVVGVFSKVVTLA
CCEEEEEHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
AYIYIYQNFRIFNLPSWPSEALSIFPNGILGLSSYTWAWIFVVAVWIFCFIGYDLAYYWV
HHHHHHCCCEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLSHEINFLWAGHVVHHQSEEYNLTVALRQASFHGLFTWVFYLPLALIGFSPVVMILNG
HHHHHHCEEEEECCEEECCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECC
QLNLIYQFWIHTKAINKFPRWFEAIFNTPSHHRVHHGINPQYIDKNHGGTLIVFDKWFGT
CCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEECCCCCEEEEEECCCCC
FEPELEEPVYGTVKPLRSFNPIWANLHYWWEMIELARNCSRWSDKFKVFFAVPGWRPKEL
CCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHC
GGQYPIPEVSTKTFHKFDIDLPKGLSLYSLVWFIISVVLTFGMLVKVQSLPWFNIGVISF
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VSLISLLTIGGILEKKRWALFVEPIRLVILVGAAYVLSAEMSITLGTIALSVISTIWFFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRTYFVLSQEINPVGEILRRTA
HHHHHEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MEINLVTIAIPFFFLLIFLEIGFSAYHKRKLYRLNDSINDLSTGTASQVVGVFSKVVTLA
CCEEEEEHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
AYIYIYQNFRIFNLPSWPSEALSIFPNGILGLSSYTWAWIFVVAVWIFCFIGYDLAYYWV
HHHHHHCCCEEEECCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLSHEINFLWAGHVVHHQSEEYNLTVALRQASFHGLFTWVFYLPLALIGFSPVVMILNG
HHHHHHCEEEEECCEEECCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECC
QLNLIYQFWIHTKAINKFPRWFEAIFNTPSHHRVHHGINPQYIDKNHGGTLIVFDKWFGT
CCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEECCCCCEEEEEECCCCC
FEPELEEPVYGTVKPLRSFNPIWANLHYWWEMIELARNCSRWSDKFKVFFAVPGWRPKEL
CCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHC
GGQYPIPEVSTKTFHKFDIDLPKGLSLYSLVWFIISVVLTFGMLVKVQSLPWFNIGVISF
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VSLISLLTIGGILEKKRWALFVEPIRLVILVGAAYVLSAEMSITLGTIALSVISTIWFFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRTYFVLSQEINPVGEILRRTA
HHHHHEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]