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The map label for this gene is manC

Identifier: 45658092

GI number: 45658092

Start: 2707221

End: 2708282

Strand: Reverse

Name: manC

Synonym: LIC12243

Alternate gene names: 45658092

Gene position: 2708282-2707221 (Counterclockwise)

Preceding gene: 45658093

Following gene: 45658090

Centisome position: 63.32

GC content: 36.25

Gene sequence:

>1062_bases
ATGAACCAAGACAAACCGGTAGTTTTGATTATGGCGGGTGGAAAGGGAGAGCGTTTTTGGCCTCGTTCTAGAATTTCCAC
ACCGAAACAACTTCAGAAAGTATATTCTAATAAAACACTTTTACGAGAAACTTTAGAACGAGCTCTTACAATTACTACGA
TAGATCGTATTTATATCGGAACTAACGCGAGCCTGAAAAAATCAATTTTAATTCAGGAAAAAAATTTCCCCGAAAAAAAT
TTTATCATAGAGCCCGAAGGAAAAAATACGGCTCCTATCATCGCACTTGCTTCTTTATATTTTCAGGAAAGATATGGCGA
CCCACTACAGGTAGTGTTGTCTGCGGACGCTTGGATTCATCCAGTAAAAGAATTTACAAAGACGATTTCTAAGGCTTTAG
AATATACAAAGGAGCATCTGGTTTTACTAGGAATCAAACCCAATCGTCCTGAAATAGGATATGGTTATATAGAAGCAGGA
AAATCAACTGACGCCTGTTTTGCGGTAAAATCTTTTTATGAAAAACCAGATGTAAAAACTGCACTCAAATATATTAAAAA
GAAAAACTTCTATTGGAATCCGGGGATTTTTTTATGGAGAACTTCTATAATATTAGAGGAATTTAAAACATATTCTCCTA
AAATTTTAGATCCTCTTAAAGAGCGATTTCCTTTTAAAAAAGCGGGAGAACTTGCTGCGGCTTTTAAAATAATCCCTTCT
GAACCTGTGGACATAACGATTATGGAAAAAAGTTCTCGTATCAAAATGGTTGAGGCTAGTTTTGGCTGGGATGACGTAGG
ATCTTGGACTTCATTAGAAAGGGTGATGCCCGGAGACGAGTTGGGAAACAGACATATGGGAAAAACGATTTTGTTCCACA
AGTCTTCCGGAAATATCACTCAGACTCGTAAAGAGTTCACAGCCGTTTTAGGTGTAAACGATTTGATTGTTGTAGAAGAG
GAAGACGTTTTATTTATCAGTACAAAATCAGGAATAGGTGATATTAAAAACCTAGTCTCAGAACTTCGTAAAAATAAAAC
TTTACAAAAGTACACGGAATAG

Upstream 100 bases:

>100_bases
CCGACAACGTAGAAGTGATTTTACTTCCTTCGGAGATGATCTTAGGAGAAGTTCCGTCCTCTAAAAAGAAAAAGAATTCT
AAAAGACCCAAAGAGGTAGA

Downstream 100 bases:

>100_bases
TTTTTTGACAGGAAGGAAAATCTAAGGAGTTCTTTAATGCCTTCAGGTAAAAAAAGAAAGCGCAGAAAGATCGCTACTCA
TAAAAGAAAGAAAAAGAGAA

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MNQDKPVVLIMAGGKGERFWPRSRISTPKQLQKVYSNKTLLRETLERALTITTIDRIYIGTNASLKKSILIQEKNFPEKN
FIIEPEGKNTAPIIALASLYFQERYGDPLQVVLSADAWIHPVKEFTKTISKALEYTKEHLVLLGIKPNRPEIGYGYIEAG
KSTDACFAVKSFYEKPDVKTALKYIKKKNFYWNPGIFLWRTSIILEEFKTYSPKILDPLKERFPFKKAGELAAAFKIIPS
EPVDITIMEKSSRIKMVEASFGWDDVGSWTSLERVMPGDELGNRHMGKTILFHKSSGNITQTRKEFTAVLGVNDLIVVEE
EDVLFISTKSGIGDIKNLVSELRKNKTLQKYTE

Sequences:

>Translated_353_residues
MNQDKPVVLIMAGGKGERFWPRSRISTPKQLQKVYSNKTLLRETLERALTITTIDRIYIGTNASLKKSILIQEKNFPEKN
FIIEPEGKNTAPIIALASLYFQERYGDPLQVVLSADAWIHPVKEFTKTISKALEYTKEHLVLLGIKPNRPEIGYGYIEAG
KSTDACFAVKSFYEKPDVKTALKYIKKKNFYWNPGIFLWRTSIILEEFKTYSPKILDPLKERFPFKKAGELAAAFKIIPS
EPVDITIMEKSSRIKMVEASFGWDDVGSWTSLERVMPGDELGNRHMGKTILFHKSSGNITQTRKEFTAVLGVNDLIVVEE
EDVLFISTKSGIGDIKNLVSELRKNKTLQKYTE
>Mature_353_residues
MNQDKPVVLIMAGGKGERFWPRSRISTPKQLQKVYSNKTLLRETLERALTITTIDRIYIGTNASLKKSILIQEKNFPEKN
FIIEPEGKNTAPIIALASLYFQERYGDPLQVVLSADAWIHPVKEFTKTISKALEYTKEHLVLLGIKPNRPEIGYGYIEAG
KSTDACFAVKSFYEKPDVKTALKYIKKKNFYWNPGIFLWRTSIILEEFKTYSPKILDPLKERFPFKKAGELAAAFKIIPS
EPVDITIMEKSSRIKMVEASFGWDDVGSWTSLERVMPGDELGNRHMGKTILFHKSSGNITQTRKEFTAVLGVNDLIVVEE
EDVLFISTKSGIGDIKNLVSELRKNKTLQKYTE

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group B O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=364, Percent_Identity=33.7912087912088, Blast_Score=189, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 40206; Mature: 40206

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQDKPVVLIMAGGKGERFWPRSRISTPKQLQKVYSNKTLLRETLERALTITTIDRIYIG
CCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHHHHCCHHHHHHHHHHHEEEEEEEEEEEC
TNASLKKSILIQEKNFPEKNFIIEPEGKNTAPIIALASLYFQERYGDPLQVVLSADAWIH
CCCCCCCEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHH
PVKEFTKTISKALEYTKEHLVLLGIKPNRPEIGYGYIEAGKSTDACFAVKSFYEKPDVKT
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCHHH
ALKYIKKKNFYWNPGIFLWRTSIILEEFKTYSPKILDPLKERFPFKKAGELAAAFKIIPS
HHHHHHHCCCEECCCEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHCCHHEEEEECCC
EPVDITIMEKSSRIKMVEASFGWDDVGSWTSLERVMPGDELGNRHMGKTILFHKSSGNIT
CCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHCCCCHHHCCCCCCCEEEEECCCCCCH
QTRKEFTAVLGVNDLIVVEEEDVLFISTKSGIGDIKNLVSELRKNKTLQKYTE
HHHHHHHHHCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MNQDKPVVLIMAGGKGERFWPRSRISTPKQLQKVYSNKTLLRETLERALTITTIDRIYIG
CCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHHHHCCHHHHHHHHHHHEEEEEEEEEEEC
TNASLKKSILIQEKNFPEKNFIIEPEGKNTAPIIALASLYFQERYGDPLQVVLSADAWIH
CCCCCCCEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHH
PVKEFTKTISKALEYTKEHLVLLGIKPNRPEIGYGYIEAGKSTDACFAVKSFYEKPDVKT
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCHHH
ALKYIKKKNFYWNPGIFLWRTSIILEEFKTYSPKILDPLKERFPFKKAGELAAAFKIIPS
HHHHHHHCCCEECCCEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHCCHHEEEEECCC
EPVDITIMEKSSRIKMVEASFGWDDVGSWTSLERVMPGDELGNRHMGKTILFHKSSGNIT
CCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHCCCCHHHCCCCCCCEEEEECCCCCCH
QTRKEFTAVLGVNDLIVVEEEDVLFISTKSGIGDIKNLVSELRKNKTLQKYTE
HHHHHHHHHCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]