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The map label for this gene is napA [H]

Identifier: 45658070

GI number: 45658070

Start: 2679159

End: 2681411

Strand: Direct

Name: napA [H]

Synonym: LIC12221

Alternate gene names: 45658070

Gene position: 2679159-2681411 (Clockwise)

Preceding gene: 45658069

Following gene: 45658071

Centisome position: 62.64

GC content: 36.48

Gene sequence:

>2253_bases
ATGACGAAACAGGAATTCGTTCCTACAATGCCTCCGAACATGAAAAAAATATCGCTATTTTATATTTTTCTAATTTTCTT
ATTCATTCTGTCCCTAGGTTTTATCCTACAGTCAGGAAAAAATCTGGAACTGGAAAAAGAAAATTTTCATTCTTCCCAGG
TTTTATTATCCAAGAAGTATCTAGATAACACACCCAATGAATCTTCAAAGATAAACTTTCCCAGACCAGGTTTTTTAGAT
TTAGAGGCAATAGTAAAAATTTTTTCCGGACATTTAAAACAACCAATTTCTAGACTTCTACTTCAGTTGATAGTGATCAT
ACTTGCCGCCAGATTTTGCGGTAAACTCGCTACTATTTTAGGACAACCTTCTGTAATCGGAGAAATACTCGCTGGAATCC
TTCTTGGACCGTCTCTACTTGGTTTGATTTTTCCGGAGGGGTTTCAACTTTTATTTCCTAAAGAATCTCTTTCCACTCTT
CAAATCCTAAGCCAGCTTGGTCTTTTACTTTTTATGTTCGTAGTAGGAATGGAGTTAGATCTAAAAATTCTACGAAACCA
AGCAGAGTCTGCAATTGTAATTTCTCACTCAAGCATTATGTTTCCGTTTCTTTTGGGCGCGGGACTCGCTTATTTGATCT
ATGTACCATTAGCTCCCGAAGGTGTGGATTTTATTGCATTTTGTCTTTTTATGGGAATCGGTATGAGTATCACTGCCTTT
CCAGTTCTCGCCAGAATCATTTTAGAAAAAGGTTTAACTAAAACCACGTTAGGCAGCCTTGCCCTCACTGCTGCTGCTGC
AGACGACGTGACTGCTTGGTGTGTATTAGCAATTGTAGTTACGATCGTCAACGCAGGTTCTTTTTCCTCCGGGATTTTGA
TGATCGTAATGTCTCTGACTTATATGTTCGTTATGTGGAAAGGAATTCTTCCTTTGATGAAAAGAGCCGGAAACTTATAC
ACCACCAAAGAATCCATGACAAAATCGATCACTGCGTTTTTCTTTTTATTCATTTTTATTTCTGCTTGGATTACGGAAGC
GATTGGAATCCACGCTCTTTTTGGTGCATTTTTAGCCGGAGTCGTAATGCCGGATAAAAAGGAACTCAGAAACAATCTGG
TGGAAAAAATTGAAGACTTTAGCCTTACCGTTTTACTTCCTCTTTTTTTCGCATTTACCGGACTGAGAACTAAATTCGGC
CTTTTGTCAAGTTCTGGATTATGGCCCGTTTTTTTCCTAATTCTTTTCGTAGCCGTCTTAGGAAAGTTAGGTGGAAGCGC
CATCGCTTCTCGTTTATCCGGTAAAAGTTGGATGGATTCTTTTTCGATTGGAATCCTTATGAATACCAGAGGCCTTATGG
AGTTGATTGTACTCAATATAGGTTACGATTTAGGAGTACTATCGGAAGAAATTTTTTCGATGATGGTACTTATGGCCCTT
ACTACAACGGTTATGACTGGTCCCGGACTTAAACTGATAGAGCTTTTTTTTACAAAACGAGATACTATTGTAAAACCAAC
TTTGAATTCAGGAATTCTAATCTCCTTTGCCCAACATACGAGAGGTTTAGAACTATTAAAGATTGCTTATGGACTTTTTC
CAGAAAAAAAGAAAGAAAGAAACGTTACAGCAGTTCATTTATCTCCTGATTCTAATATTTCTGAATCTCACGCGGAAAAA
TACGAATCCTTGAGTTTTACTCCTCTGAAAGAACTTTCAAAAGATTTAAATGTAAATCTGAGTACAATTTATAAAACTTC
TACGAATATTACTAAGGACATTGTTCGAATCGTAAACGAAGGAAATTATAAATTACTTTTGATTGGTGCAGCGCGTTCTT
TTTTTTCGGATGATATTTTAGGCGGAAAAATTAGAACTATACTAAATGAAACAAATTGTAATACTGGAATTTTATTCTCA
TCCCAATTGCAAGACATCAAAAATATACATATCTTATTTGGTAGAGAAAAAGATTTGGAACTTCTTCAAATCGCAAAAAG
ACTGGCGGCAAACTACAATTCTAGATTGTCGATCGTAGATTTGAACGGATCTACAAACCAACCTCAAATTAAGCAAAGTC
TCAAAAAAGAAAAAGTAAAAATCCTAACTCCAGTAGATTGGAAACAATTCGATTTGATTCTCTGTGATTTGGATATATGG
GAGAATCATTCCGAATTCAGAGTAGACGAACTTCCTCAAGGTGGAGGACTTCTTTTAATCCGTTCTACAGACGGTTTTAT
AATCGAAGCTTGA

Upstream 100 bases:

>100_bases
ATTTCGGGAGAAGTTACAAATCCTTTGAAAGCGGCGGAACTCACTTCTAAAATTCTCAAAGACGAATCCATCATTCCTTA
AACGATCCTAAAAAATCTGA

Downstream 100 bases:

>100_bases
TTTTAATTTTATCGGGGTATTTATTACAAATTTATAATTTGCCTAAGATTTAGTTTTTAATCTGAGTCGACTTCTAAAAA
CGTTTGAGTAGACATAAAAA

Product: cation:proton antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MTKQEFVPTMPPNMKKISLFYIFLIFLFILSLGFILQSGKNLELEKENFHSSQVLLSKKYLDNTPNESSKINFPRPGFLD
LEAIVKIFSGHLKQPISRLLLQLIVIILAARFCGKLATILGQPSVIGEILAGILLGPSLLGLIFPEGFQLLFPKESLSTL
QILSQLGLLLFMFVVGMELDLKILRNQAESAIVISHSSIMFPFLLGAGLAYLIYVPLAPEGVDFIAFCLFMGIGMSITAF
PVLARIILEKGLTKTTLGSLALTAAAADDVTAWCVLAIVVTIVNAGSFSSGILMIVMSLTYMFVMWKGILPLMKRAGNLY
TTKESMTKSITAFFFLFIFISAWITEAIGIHALFGAFLAGVVMPDKKELRNNLVEKIEDFSLTVLLPLFFAFTGLRTKFG
LLSSSGLWPVFFLILFVAVLGKLGGSAIASRLSGKSWMDSFSIGILMNTRGLMELIVLNIGYDLGVLSEEIFSMMVLMAL
TTTVMTGPGLKLIELFFTKRDTIVKPTLNSGILISFAQHTRGLELLKIAYGLFPEKKKERNVTAVHLSPDSNISESHAEK
YESLSFTPLKELSKDLNVNLSTIYKTSTNITKDIVRIVNEGNYKLLLIGAARSFFSDDILGGKIRTILNETNCNTGILFS
SQLQDIKNIHILFGREKDLELLQIAKRLAANYNSRLSIVDLNGSTNQPQIKQSLKKEKVKILTPVDWKQFDLILCDLDIW
ENHSEFRVDELPQGGGLLLIRSTDGFIIEA

Sequences:

>Translated_750_residues
MTKQEFVPTMPPNMKKISLFYIFLIFLFILSLGFILQSGKNLELEKENFHSSQVLLSKKYLDNTPNESSKINFPRPGFLD
LEAIVKIFSGHLKQPISRLLLQLIVIILAARFCGKLATILGQPSVIGEILAGILLGPSLLGLIFPEGFQLLFPKESLSTL
QILSQLGLLLFMFVVGMELDLKILRNQAESAIVISHSSIMFPFLLGAGLAYLIYVPLAPEGVDFIAFCLFMGIGMSITAF
PVLARIILEKGLTKTTLGSLALTAAAADDVTAWCVLAIVVTIVNAGSFSSGILMIVMSLTYMFVMWKGILPLMKRAGNLY
TTKESMTKSITAFFFLFIFISAWITEAIGIHALFGAFLAGVVMPDKKELRNNLVEKIEDFSLTVLLPLFFAFTGLRTKFG
LLSSSGLWPVFFLILFVAVLGKLGGSAIASRLSGKSWMDSFSIGILMNTRGLMELIVLNIGYDLGVLSEEIFSMMVLMAL
TTTVMTGPGLKLIELFFTKRDTIVKPTLNSGILISFAQHTRGLELLKIAYGLFPEKKKERNVTAVHLSPDSNISESHAEK
YESLSFTPLKELSKDLNVNLSTIYKTSTNITKDIVRIVNEGNYKLLLIGAARSFFSDDILGGKIRTILNETNCNTGILFS
SQLQDIKNIHILFGREKDLELLQIAKRLAANYNSRLSIVDLNGSTNQPQIKQSLKKEKVKILTPVDWKQFDLILCDLDIW
ENHSEFRVDELPQGGGLLLIRSTDGFIIEA
>Mature_749_residues
TKQEFVPTMPPNMKKISLFYIFLIFLFILSLGFILQSGKNLELEKENFHSSQVLLSKKYLDNTPNESSKINFPRPGFLDL
EAIVKIFSGHLKQPISRLLLQLIVIILAARFCGKLATILGQPSVIGEILAGILLGPSLLGLIFPEGFQLLFPKESLSTLQ
ILSQLGLLLFMFVVGMELDLKILRNQAESAIVISHSSIMFPFLLGAGLAYLIYVPLAPEGVDFIAFCLFMGIGMSITAFP
VLARIILEKGLTKTTLGSLALTAAAADDVTAWCVLAIVVTIVNAGSFSSGILMIVMSLTYMFVMWKGILPLMKRAGNLYT
TKESMTKSITAFFFLFIFISAWITEAIGIHALFGAFLAGVVMPDKKELRNNLVEKIEDFSLTVLLPLFFAFTGLRTKFGL
LSSSGLWPVFFLILFVAVLGKLGGSAIASRLSGKSWMDSFSIGILMNTRGLMELIVLNIGYDLGVLSEEIFSMMVLMALT
TTVMTGPGLKLIELFFTKRDTIVKPTLNSGILISFAQHTRGLELLKIAYGLFPEKKKERNVTAVHLSPDSNISESHAEKY
ESLSFTPLKELSKDLNVNLSTIYKTSTNITKDIVRIVNEGNYKLLLIGAARSFFSDDILGGKIRTILNETNCNTGILFSS
QLQDIKNIHILFGREKDLELLQIAKRLAANYNSRLSIVDLNGSTNQPQIKQSLKKEKVKILTPVDWKQFDLILCDLDIWE
NHSEFRVDELPQGGGLLLIRSTDGFIIEA

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=419, Percent_Identity=31.2649164677804, Blast_Score=226, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 83041; Mature: 82910

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQEFVPTMPPNMKKISLFYIFLIFLFILSLGFILQSGKNLELEKENFHSSQVLLSKKY
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
LDNTPNESSKINFPRPGFLDLEAIVKIFSGHLKQPISRLLLQLIVIILAARFCGKLATIL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQPSVIGEILAGILLGPSLLGLIFPEGFQLLFPKESLSTLQILSQLGLLLFMFVVGMELD
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHH
LKILRNQAESAIVISHSSIMFPFLLGAGLAYLIYVPLAPEGVDFIAFCLFMGIGMSITAF
HHHHHCCCCCEEEEECCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHH
PVLARIILEKGLTKTTLGSLALTAAAADDVTAWCVLAIVVTIVNAGSFSSGILMIVMSLT
HHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YMFVMWKGILPLMKRAGNLYTTKESMTKSITAFFFLFIFISAWITEAIGIHALFGAFLAG
HHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVMPDKKELRNNLVEKIEDFSLTVLLPLFFAFTGLRTKFGLLSSSGLWPVFFLILFVAVL
HCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GKLGGSAIASRLSGKSWMDSFSIGILMNTRGLMELIVLNIGYDLGVLSEEIFSMMVLMAL
HHCCHHHHHHHHCCHHHHHHHCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TTTVMTGPGLKLIELFFTKRDTIVKPTLNSGILISFAQHTRGLELLKIAYGLFPEKKKER
HHHHHCCCCHHHHHHHHHCCCCEECCCCCCCEEEEEHHHHCCHHHHHHHHHCCCCCHHCC
NVTAVHLSPDSNISESHAEKYESLSFTPLKELSKDLNVNLSTIYKTSTNITKDIVRIVNE
CEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCC
GNYKLLLIGAARSFFSDDILGGKIRTILNETNCNTGILFSSQLQDIKNIHILFGREKDLE
CCEEEEEEECCHHHHCCCCCCCHHHHHHHHCCCCCCEEEHHHHHHHCCEEEEECCCCCHH
LLQIAKRLAANYNSRLSIVDLNGSTNQPQIKQSLKKEKVKILTPVDWKQFDLILCDLDIW
HHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCEEEECCCCCCCEEEEEEEEHHH
ENHSEFRVDELPQGGGLLLIRSTDGFIIEA
CCCCCCCHHCCCCCCCEEEEEECCCCEEEC
>Mature Secondary Structure 
TKQEFVPTMPPNMKKISLFYIFLIFLFILSLGFILQSGKNLELEKENFHSSQVLLSKKY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
LDNTPNESSKINFPRPGFLDLEAIVKIFSGHLKQPISRLLLQLIVIILAARFCGKLATIL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQPSVIGEILAGILLGPSLLGLIFPEGFQLLFPKESLSTLQILSQLGLLLFMFVVGMELD
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHH
LKILRNQAESAIVISHSSIMFPFLLGAGLAYLIYVPLAPEGVDFIAFCLFMGIGMSITAF
HHHHHCCCCCEEEEECCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHH
PVLARIILEKGLTKTTLGSLALTAAAADDVTAWCVLAIVVTIVNAGSFSSGILMIVMSLT
HHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YMFVMWKGILPLMKRAGNLYTTKESMTKSITAFFFLFIFISAWITEAIGIHALFGAFLAG
HHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVMPDKKELRNNLVEKIEDFSLTVLLPLFFAFTGLRTKFGLLSSSGLWPVFFLILFVAVL
HCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GKLGGSAIASRLSGKSWMDSFSIGILMNTRGLMELIVLNIGYDLGVLSEEIFSMMVLMAL
HHCCHHHHHHHHCCHHHHHHHCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TTTVMTGPGLKLIELFFTKRDTIVKPTLNSGILISFAQHTRGLELLKIAYGLFPEKKKER
HHHHHCCCCHHHHHHHHHCCCCEECCCCCCCEEEEEHHHHCCHHHHHHHHHCCCCCHHCC
NVTAVHLSPDSNISESHAEKYESLSFTPLKELSKDLNVNLSTIYKTSTNITKDIVRIVNE
CEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCC
GNYKLLLIGAARSFFSDDILGGKIRTILNETNCNTGILFSSQLQDIKNIHILFGREKDLE
CCEEEEEEECCHHHHCCCCCCCHHHHHHHHCCCCCCEEEHHHHHHHCCEEEEECCCCCHH
LLQIAKRLAANYNSRLSIVDLNGSTNQPQIKQSLKKEKVKILTPVDWKQFDLILCDLDIW
HHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCEEEECCCCCCCEEEEEEEEHHH
ENHSEFRVDELPQGGGLLLIRSTDGFIIEA
CCCCCCCHHCCCCCCCEEEEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]