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The map label for this gene is hldE [H]

Identifier: 45658049

GI number: 45658049

Start: 2653232

End: 2654761

Strand: Reverse

Name: hldE [H]

Synonym: LIC12200

Alternate gene names: 45658049

Gene position: 2654761-2653232 (Counterclockwise)

Preceding gene: 45658050

Following gene: 45658048

Centisome position: 62.07

GC content: 37.06

Gene sequence:

>1530_bases
ATGATTCCCAATTCTCATAAGATCATATCTGTCGGGGATGTTTCACAACTTAGTGAAAGTCCATTAGAAGAATCTTTAGT
TCTTTGTTATGGACATTTTAACGTTATACATCCAGGACATATTCGATTTTTACAATATGCTAAAAGTCTTGGAAAAAAAC
TAAAAGTAGCGGTTCTAGGAGATCAAAGTATTGCGGAATCCCAAAGAAGTAAGTACTTTCATCAAATGGAAAGAGCGGAA
GGCGTAGCCTCTTTACATTTTGTAGATTTAGTTTATGTTTTGGATAAAATTTCCCTTGAGGACTTATCGGTCCATATCAA
ACCTTCTGTTTTAGTTTTAGGAAAAGAGTTAGAAAATACACATCGTGAAGACATTAAGGCTGCGGTTTATAGTATTGAGA
AACAAAACGGGAAAGTGATTTTTCATGCAGGTGAAGTTCATTATGCAAGCGCTGATTTACTTCATGGTAGCCAACAAGAT
CTTGAATCGGAAAGAAAACATTTATTTCTTCAGGCAAACAAACGACAAGGGATCGATCTTGCAAAGCTTGTAGCTTACAT
TGGAAAGTTTACCAATTCTAAGATCCTTGTTATAGGAGATACCATCGTAGATCAATATGTAGCTTGCGATGCTATTGGAA
TTAGTGCTGAAGCTCCGGTTCTTGTAGTTAAGGAATTAGAAACTAGAGAATTTGTGGGCGGGGCAGGTGTAGTTGCCGCA
CACGTAAAAGCTTTAGGTGCAGATTGTACTTTTTTATCCGTTGTAGGCGAAGATGAAAACGCAAATTTAGTAGGTAAGAA
CTTACAAGAACAAGGTATCGACGTACAATTGGTTGGTGATAGCAGTCGTCCTACTACATTCAAAATTCGTTATATGGTTG
AAAATCAAAAACTATTTCGGGTCAGTCGTCTTAAGGAACACTCTCTCTCAAAAAAAATTGAAGATCAACTCATTGAAAAA
TTAAGAAAAATTGCGAAAAATTACGACGGAATTCTCGTTTGTGATTTTGTATATGGAGTAATAACGAACAGAGTTCTTGC
TGAAATTAGATCGATAGCAAAGGAAAACAACATTTTACTCTTTGGAGATTTACAGTGTAGTAGCCAAGTTGGCAATGTTG
CTAAATTTGAGGACTTTGATTTGTTATGTCCGACAGAAAGGGAGGCAAGAATTGCTCTCAGCAATCATGAAGACGGAGTA
GAATGGATTGCAAATACTCTTTTGGAAAAAACACGTTCCAAAAATTTATTAGTTAAATTAGGCGCCGAAGGATTTATCGC
GTATTCGAACGATATTCCCGGTAATTTTAAGAAAAGAGAACATTTTCCTGCTTTGGTTTCCAACCCAGTAGACGTAGCCG
GAGCAGGTGATTCCTTATTGGCAGCTATTTCTGTTAGTATGTGTTCCGGTGCAAATTTAATGGAAGCCTCTGCGATTGGT
GCTTGTATGGCGGCGCTTGCCGTTCAAACAATTGGAAATATACCCGTTTCTCATCAGAAACTTGAAAGCTATATTAAGAA
TTTGAGGTAA

Upstream 100 bases:

>100_bases
AGGCTCAAAAGGAAGTTACTTTCCCAGAAAACAATAATTTAGATGAATGGGAAACAGAATTTTTGTCGAACTCGATTCAT
CAGTCAATTCAGTCAATATT

Downstream 100 bases:

>100_bases
ATATGAATCCAGATATTAAAAGTATCTATATAACAGGCGGGGCCGGTTACGTTGGGGCCATGCTTGTGCCCCGCCTTCTT
TCGGAGGGTTATAAAGTAAC

Product: ADP-heptose synthetase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MIPNSHKIISVGDVSQLSESPLEESLVLCYGHFNVIHPGHIRFLQYAKSLGKKLKVAVLGDQSIAESQRSKYFHQMERAE
GVASLHFVDLVYVLDKISLEDLSVHIKPSVLVLGKELENTHREDIKAAVYSIEKQNGKVIFHAGEVHYASADLLHGSQQD
LESERKHLFLQANKRQGIDLAKLVAYIGKFTNSKILVIGDTIVDQYVACDAIGISAEAPVLVVKELETREFVGGAGVVAA
HVKALGADCTFLSVVGEDENANLVGKNLQEQGIDVQLVGDSSRPTTFKIRYMVENQKLFRVSRLKEHSLSKKIEDQLIEK
LRKIAKNYDGILVCDFVYGVITNRVLAEIRSIAKENNILLFGDLQCSSQVGNVAKFEDFDLLCPTEREARIALSNHEDGV
EWIANTLLEKTRSKNLLVKLGAEGFIAYSNDIPGNFKKREHFPALVSNPVDVAGAGDSLLAAISVSMCSGANLMEASAIG
ACMAALAVQTIGNIPVSHQKLESYIKNLR

Sequences:

>Translated_509_residues
MIPNSHKIISVGDVSQLSESPLEESLVLCYGHFNVIHPGHIRFLQYAKSLGKKLKVAVLGDQSIAESQRSKYFHQMERAE
GVASLHFVDLVYVLDKISLEDLSVHIKPSVLVLGKELENTHREDIKAAVYSIEKQNGKVIFHAGEVHYASADLLHGSQQD
LESERKHLFLQANKRQGIDLAKLVAYIGKFTNSKILVIGDTIVDQYVACDAIGISAEAPVLVVKELETREFVGGAGVVAA
HVKALGADCTFLSVVGEDENANLVGKNLQEQGIDVQLVGDSSRPTTFKIRYMVENQKLFRVSRLKEHSLSKKIEDQLIEK
LRKIAKNYDGILVCDFVYGVITNRVLAEIRSIAKENNILLFGDLQCSSQVGNVAKFEDFDLLCPTEREARIALSNHEDGV
EWIANTLLEKTRSKNLLVKLGAEGFIAYSNDIPGNFKKREHFPALVSNPVDVAGAGDSLLAAISVSMCSGANLMEASAIG
ACMAALAVQTIGNIPVSHQKLESYIKNLR
>Mature_509_residues
MIPNSHKIISVGDVSQLSESPLEESLVLCYGHFNVIHPGHIRFLQYAKSLGKKLKVAVLGDQSIAESQRSKYFHQMERAE
GVASLHFVDLVYVLDKISLEDLSVHIKPSVLVLGKELENTHREDIKAAVYSIEKQNGKVIFHAGEVHYASADLLHGSQQD
LESERKHLFLQANKRQGIDLAKLVAYIGKFTNSKILVIGDTIVDQYVACDAIGISAEAPVLVVKELETREFVGGAGVVAA
HVKALGADCTFLSVVGEDENANLVGKNLQEQGIDVQLVGDSSRPTTFKIRYMVENQKLFRVSRLKEHSLSKKIEDQLIEK
LRKIAKNYDGILVCDFVYGVITNRVLAEIRSIAKENNILLFGDLQCSSQVGNVAKFEDFDLLCPTEREARIALSNHEDGV
EWIANTLLEKTRSKNLLVKLGAEGFIAYSNDIPGNFKKREHFPALVSNPVDVAGAGDSLLAAISVSMCSGANLMEASAIG
ACMAALAVQTIGNIPVSHQKLESYIKNLR

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=320, Percent_Identity=24.6875, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 55871; Mature: 55871

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNSHKIISVGDVSQLSESPLEESLVLCYGHFNVIHPGHIRFLQYAKSLGKKLKVAVLG
CCCCCCCEEEECCHHHHHCCCCCCCEEEEEECCEEECCCHHHHHHHHHHHCCEEEEEEEC
DQSIAESQRSKYFHQMERAEGVASLHFVDLVYVLDKISLEDLSVHIKPSVLVLGKELENT
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEECHHHHH
HREDIKAAVYSIEKQNGKVIFHAGEVHYASADLLHGSQQDLESERKHLFLQANKRQGIDL
HHHHHHHHHHHHCCCCCEEEEEECCEEECCHHHHCCCHHHHHHHHHEEEEEECCCCCCCH
AKLVAYIGKFTNSKILVIGDTIVDQYVACDAIGISAEAPVLVVKELETREFVGGAGVVAA
HHHHHHHHHCCCCEEEEEEHHHHHHHHHHCEECCCCCCCEEEEEECCHHHHCCCCHHHHH
HVKALGADCTFLSVVGEDENANLVGKNLQEQGIDVQLVGDSSRPTTFKIRYMVENQKLFR
HHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCEEEEECCCCCCEEEEEEEEECCCHHHH
VSRLKEHSLSKKIEDQLIEKLRKIAKNYDGILVCDFVYGVITNRVLAEIRSIAKENNILL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEE
FGDLQCSSQVGNVAKFEDFDLLCPTEREARIALSNHEDGVEWIANTLLEKTRSKNLLVKL
EECCCCCHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEE
GAEGFIAYSNDIPGNFKKREHFPALVSNPVDVAGAGDSLLAAISVSMCSGANLMEASAIG
CCCEEEEECCCCCCCCCHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
ACMAALAVQTIGNIPVSHQKLESYIKNLR
HHHHHHHHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MIPNSHKIISVGDVSQLSESPLEESLVLCYGHFNVIHPGHIRFLQYAKSLGKKLKVAVLG
CCCCCCCEEEECCHHHHHCCCCCCCEEEEEECCEEECCCHHHHHHHHHHHCCEEEEEEEC
DQSIAESQRSKYFHQMERAEGVASLHFVDLVYVLDKISLEDLSVHIKPSVLVLGKELENT
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEECHHHHH
HREDIKAAVYSIEKQNGKVIFHAGEVHYASADLLHGSQQDLESERKHLFLQANKRQGIDL
HHHHHHHHHHHHCCCCCEEEEEECCEEECCHHHHCCCHHHHHHHHHEEEEEECCCCCCCH
AKLVAYIGKFTNSKILVIGDTIVDQYVACDAIGISAEAPVLVVKELETREFVGGAGVVAA
HHHHHHHHHCCCCEEEEEEHHHHHHHHHHCEECCCCCCCEEEEEECCHHHHCCCCHHHHH
HVKALGADCTFLSVVGEDENANLVGKNLQEQGIDVQLVGDSSRPTTFKIRYMVENQKLFR
HHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCEEEEECCCCCCEEEEEEEEECCCHHHH
VSRLKEHSLSKKIEDQLIEKLRKIAKNYDGILVCDFVYGVITNRVLAEIRSIAKENNILL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEE
FGDLQCSSQVGNVAKFEDFDLLCPTEREARIALSNHEDGVEWIANTLLEKTRSKNLLVKL
EECCCCCHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEE
GAEGFIAYSNDIPGNFKKREHFPALVSNPVDVAGAGDSLLAAISVSMCSGANLMEASAIG
CCCEEEEECCCCCCCCCHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
ACMAALAVQTIGNIPVSHQKLESYIKNLR
HHHHHHHHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA