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The map label for this gene is sas

Identifier: 45658018

GI number: 45658018

Start: 2620267

End: 2622528

Strand: Reverse

Name: sas

Synonym: LIC12169

Alternate gene names: NA

Gene position: 2622528-2620267 (Counterclockwise)

Preceding gene: 45658019

Following gene: 45658017

Centisome position: 61.31

GC content: 36.07

Gene sequence:

>2262_bases
ATGATCATTGATAAAAATATTTCTCAGTATGTCGTTTTTTGGGAGGATAGCATTAAAAACGCTCTCAAAAAAATTGAAGC
CAATAAATCTAAAACCATTTTTGCAGTTTCGGAAGGGAACAAGTTGATGGGAGTGATCACGGATGGAGATTTTCGTCGAT
GGATATTAAACGACGAAACATTGGATCGAAGTTTAGATCAAGAAGTGAAAAATATTATCAATACAAATTTCAAGTATTTA
TACGTCACCGAAAGTTCTAAAAGAATTCGAAGTACATTTAATAATAGAATTTCTATCATTCCGCTCATTAATGAGAATGG
GATTTTGGAGGCGATTGCAAAGGAAACTTCTGAAGAAATCTTGGTTGAAGGAATTTCTTTGAGTCAGAATTCGCCAGCTT
TTGTGATTGCAGAGATAGGAAACAATCATAATGGAAGTTTTGAATTGGCGAAAAAATTGGTTCGAGAGGCTAAACTTGCG
GGAGCTGATTGTGCTAAGTTTCAAATGCGGAATTTAGACGCTTTATACAGAAATTCCGGAAATGCGAATGATGCTGAAGA
AGATTTAGGTTCCCAGTACACTCTAGATTTATTAAATAAATTTCAACTTTCGGATGACGAACTATTTCGGATTTTTGATT
ACTGCCGTGAAGAATCTTTGATACCTTTATGTACTCCTTGGGATGAAGAAAGTTTTTTTAAATTAGAGAGTTATGGGATC
CCAGCATATAAGATTGCATCGGCGGATTTTACGAATCATGAACTGATTCGGTTGGTTGCGAAGTCGGGTAAGCCTGTGAT
TTGTTCTACCGGAATGTCGACCGAAGATGAAATTATGGATTCTATCCATGTCTTACAGGATTTAGGGGCTCAATACGTTT
TATTACATTGTAATTCCACTTATCCCGCGCCTTTTAAAGATATCAATCTCAGATATATCGAACATTTGAAGAAAAGCGGA
GGTTGTTTGGTCGGATATTCGGGACATGAACGGGGATATTTGGTTGCTTTAGCGGCAGTATCTTTAGGCGCTAAAGTGAT
TGAGAAACATTTCACGTTAGATAGAGAAATGGAAGGGAACGACCACAAGGTTAGTCTTTTGCCCGGTGAATTCCGAGAAA
TGGTGGATGGGATTCGACAAATAGAAGAATCTTTGGGTAATAAAAATTTCCGTCAGATAACTCAAGGAGAATTGATGAAC
CGTGAAACCTTGGGTAAGAGTCTATTAATCAATAGAGACTTAAAATTGGGAGAGATCATAACTTCTGATATGGTGGACAT
TAGAAGTCCGGGAAAAGGATTACCGCCTTATTTTAAGGAAAAATTAATCGGAAAATCCGCGAAGAGAGATTTTAAAAAGG
GGGATTTCTTTTATAAATCGGATATAGCGGACGATGTAATTGAGTTTAAAAAGAAATTTATTTTTTCGCGTCCTTGGGGA
TTACCGGTTCGATATCATGATTTGGAACAAATTCTATCTAAAGTTGAAATGGATTTAGTGGAATTTCATTTCAGTTATAA
GGATTTGAAAGTTGAGATATCGGAGTACATTAAAAAACCATTAAATACTGATTTTGTAGTTCATTGTCCAGAGCTTTTTG
AAAACGATCATTTATTGGATCTTTGCACGGAAGATGAGGATTATAGAAAAAGGTCTTTGATAGAAATTCAGAAAGTGATC
GATATTACCAGAAGATTAAAGGATTTTTTTCCGAATTCGAATAAGAAGCCTTTCATCGTTACAAATGTAGGTGGGTTTTC
TTTAAATAAACCTTTAGATACGACTATTCGTGAAAAATTATATAAAAATCTATCACGATCTTTGAATGATTTGGATTCCG
AAGGGGTAGAAATTATTCCGCAGACAATGCCTCCTTTTCCTTGGCTTTTTGGCGGACAAAGATATCATAATCTTTTTCTA
TCCGCCGAAGAAATTGTCGAATTTTGTAAGCGACACTCTATTCGAATTTGCCTCGATGTTTCTCATTCTAAATTGGCTTG
CAATCACTATCACTGGTCTTTTAGTAAATTTGTAGAACAAGTCTCCCCCTATGTCGCACATTTACATATCGTGGATGCGA
AAGGGGTGGATGGTGAAGGGCTCCAAATAGGAGAAGGAGAAATCGATTTTCATATGCTTTCTAACATACTTAGAGAAAAA
GCTCCCAAGGCGTCGTTTATACCTGAAATTTGGCAGGGACATAAAAATAACGGAGAAGGTTTTCTCATTTCTCTTACTCG
TTTGGAAAAGTTTCATTTATAG

Upstream 100 bases:

>100_bases
AATACGATCCGGAAAATTCTCAGTTTGTATCTTTGATGAAAGAGTTAGACGTTCCTTTGAAAAATAATTTATAACCATAA
TATTTGGTCCGGTTTCTTTT

Downstream 100 bases:

>100_bases
AAATAATTTTAGGGGTTTAAAGTGGATTTTAAAATTAAATGGTCAGGTAGATCGATTGATTATACCCAAGAAGAGATCGA
TACTGTTGTAGAAGTTATGA

Product: sialic acid synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 753; Mature: 753

Protein sequence:

>753_residues
MIIDKNISQYVVFWEDSIKNALKKIEANKSKTIFAVSEGNKLMGVITDGDFRRWILNDETLDRSLDQEVKNIINTNFKYL
YVTESSKRIRSTFNNRISIIPLINENGILEAIAKETSEEILVEGISLSQNSPAFVIAEIGNNHNGSFELAKKLVREAKLA
GADCAKFQMRNLDALYRNSGNANDAEEDLGSQYTLDLLNKFQLSDDELFRIFDYCREESLIPLCTPWDEESFFKLESYGI
PAYKIASADFTNHELIRLVAKSGKPVICSTGMSTEDEIMDSIHVLQDLGAQYVLLHCNSTYPAPFKDINLRYIEHLKKSG
GCLVGYSGHERGYLVALAAVSLGAKVIEKHFTLDREMEGNDHKVSLLPGEFREMVDGIRQIEESLGNKNFRQITQGELMN
RETLGKSLLINRDLKLGEIITSDMVDIRSPGKGLPPYFKEKLIGKSAKRDFKKGDFFYKSDIADDVIEFKKKFIFSRPWG
LPVRYHDLEQILSKVEMDLVEFHFSYKDLKVEISEYIKKPLNTDFVVHCPELFENDHLLDLCTEDEDYRKRSLIEIQKVI
DITRRLKDFFPNSNKKPFIVTNVGGFSLNKPLDTTIREKLYKNLSRSLNDLDSEGVEIIPQTMPPFPWLFGGQRYHNLFL
SAEEIVEFCKRHSIRICLDVSHSKLACNHYHWSFSKFVEQVSPYVAHLHIVDAKGVDGEGLQIGEGEIDFHMLSNILREK
APKASFIPEIWQGHKNNGEGFLISLTRLEKFHL

Sequences:

>Translated_753_residues
MIIDKNISQYVVFWEDSIKNALKKIEANKSKTIFAVSEGNKLMGVITDGDFRRWILNDETLDRSLDQEVKNIINTNFKYL
YVTESSKRIRSTFNNRISIIPLINENGILEAIAKETSEEILVEGISLSQNSPAFVIAEIGNNHNGSFELAKKLVREAKLA
GADCAKFQMRNLDALYRNSGNANDAEEDLGSQYTLDLLNKFQLSDDELFRIFDYCREESLIPLCTPWDEESFFKLESYGI
PAYKIASADFTNHELIRLVAKSGKPVICSTGMSTEDEIMDSIHVLQDLGAQYVLLHCNSTYPAPFKDINLRYIEHLKKSG
GCLVGYSGHERGYLVALAAVSLGAKVIEKHFTLDREMEGNDHKVSLLPGEFREMVDGIRQIEESLGNKNFRQITQGELMN
RETLGKSLLINRDLKLGEIITSDMVDIRSPGKGLPPYFKEKLIGKSAKRDFKKGDFFYKSDIADDVIEFKKKFIFSRPWG
LPVRYHDLEQILSKVEMDLVEFHFSYKDLKVEISEYIKKPLNTDFVVHCPELFENDHLLDLCTEDEDYRKRSLIEIQKVI
DITRRLKDFFPNSNKKPFIVTNVGGFSLNKPLDTTIREKLYKNLSRSLNDLDSEGVEIIPQTMPPFPWLFGGQRYHNLFL
SAEEIVEFCKRHSIRICLDVSHSKLACNHYHWSFSKFVEQVSPYVAHLHIVDAKGVDGEGLQIGEGEIDFHMLSNILREK
APKASFIPEIWQGHKNNGEGFLISLTRLEKFHL
>Mature_753_residues
MIIDKNISQYVVFWEDSIKNALKKIEANKSKTIFAVSEGNKLMGVITDGDFRRWILNDETLDRSLDQEVKNIINTNFKYL
YVTESSKRIRSTFNNRISIIPLINENGILEAIAKETSEEILVEGISLSQNSPAFVIAEIGNNHNGSFELAKKLVREAKLA
GADCAKFQMRNLDALYRNSGNANDAEEDLGSQYTLDLLNKFQLSDDELFRIFDYCREESLIPLCTPWDEESFFKLESYGI
PAYKIASADFTNHELIRLVAKSGKPVICSTGMSTEDEIMDSIHVLQDLGAQYVLLHCNSTYPAPFKDINLRYIEHLKKSG
GCLVGYSGHERGYLVALAAVSLGAKVIEKHFTLDREMEGNDHKVSLLPGEFREMVDGIRQIEESLGNKNFRQITQGELMN
RETLGKSLLINRDLKLGEIITSDMVDIRSPGKGLPPYFKEKLIGKSAKRDFKKGDFFYKSDIADDVIEFKKKFIFSRPWG
LPVRYHDLEQILSKVEMDLVEFHFSYKDLKVEISEYIKKPLNTDFVVHCPELFENDHLLDLCTEDEDYRKRSLIEIQKVI
DITRRLKDFFPNSNKKPFIVTNVGGFSLNKPLDTTIREKLYKNLSRSLNDLDSEGVEIIPQTMPPFPWLFGGQRYHNLFL
SAEEIVEFCKRHSIRICLDVSHSKLACNHYHWSFSKFVEQVSPYVAHLHIVDAKGVDGEGLQIGEGEIDFHMLSNILREK
APKASFIPEIWQGHKNNGEGFLISLTRLEKFHL

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=329, Percent_Identity=34.6504559270517, Blast_Score=199, Evalue=9e-51,
Organism=Drosophila melanogaster, GI21357081, Length=338, Percent_Identity=32.2485207100592, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 86207; Mature: 86207

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIDKNISQYVVFWEDSIKNALKKIEANKSKTIFAVSEGNKLMGVITDGDFRRWILNDET
CCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCEEEECCCHH
LDRSLDQEVKNIINTNFKYLYVTESSKRIRSTFNNRISIIPLINENGILEAIAKETSEEI
HHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
LVEGISLSQNSPAFVIAEIGNNHNGSFELAKKLVREAKLAGADCAKFQMRNLDALYRNSG
HHCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHCCC
NANDAEEDLGSQYTLDLLNKFQLSDDELFRIFDYCREESLIPLCTPWDEESFFKLESYGI
CCCCCHHHCCCCEEHHHHHHHCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEHHCCC
PAYKIASADFTNHELIRLVAKSGKPVICSTGMSTEDEIMDSIHVLQDLGAQYVLLHCNST
CEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCC
YPAPFKDINLRYIEHLKKSGGCLVGYSGHERGYLVALAAVSLGAKVIEKHFTLDREMEGN
CCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCC
DHKVSLLPGEFREMVDGIRQIEESLGNKNFRQITQGELMNRETLGKSLLINRDLKLGEII
CCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHCCHHEEECCCCHHHHH
TSDMVDIRSPGKGLPPYFKEKLIGKSAKRDFKKGDFFYKSDIADDVIEFKKKFIFSRPWG
HHHHHHHCCCCCCCCHHHHHHHHCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCC
LPVRYHDLEQILSKVEMDLVEFHFSYKDLKVEISEYIKKPLNTDFVVHCPELFENDHLLD
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCCEEEECHHHHCCCCEEE
LCTEDEDYRKRSLIEIQKVIDITRRLKDFFPNSNKKPFIVTNVGGFSLNKPLDTTIREKL
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHH
YKNLSRSLNDLDSEGVEIIPQTMPPFPWLFGGQRYHNLFLSAEEIVEFCKRHSIRICLDV
HHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCEEEEEEC
SHSKLACNHYHWSFSKFVEQVSPYVAHLHIVDAKGVDGEGLQIGEGEIDFHMLSNILREK
CCCEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHC
APKASFIPEIWQGHKNNGEGFLISLTRLEKFHL
CCCCCCCHHHHCCCCCCCCEEEEEEEHHHHHCC
>Mature Secondary Structure
MIIDKNISQYVVFWEDSIKNALKKIEANKSKTIFAVSEGNKLMGVITDGDFRRWILNDET
CCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCEEEECCCHH
LDRSLDQEVKNIINTNFKYLYVTESSKRIRSTFNNRISIIPLINENGILEAIAKETSEEI
HHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
LVEGISLSQNSPAFVIAEIGNNHNGSFELAKKLVREAKLAGADCAKFQMRNLDALYRNSG
HHCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHCCC
NANDAEEDLGSQYTLDLLNKFQLSDDELFRIFDYCREESLIPLCTPWDEESFFKLESYGI
CCCCCHHHCCCCEEHHHHHHHCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEHHCCC
PAYKIASADFTNHELIRLVAKSGKPVICSTGMSTEDEIMDSIHVLQDLGAQYVLLHCNST
CEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECCC
YPAPFKDINLRYIEHLKKSGGCLVGYSGHERGYLVALAAVSLGAKVIEKHFTLDREMEGN
CCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCC
DHKVSLLPGEFREMVDGIRQIEESLGNKNFRQITQGELMNRETLGKSLLINRDLKLGEII
CCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHCCHHEEECCCCHHHHH
TSDMVDIRSPGKGLPPYFKEKLIGKSAKRDFKKGDFFYKSDIADDVIEFKKKFIFSRPWG
HHHHHHHCCCCCCCCHHHHHHHHCCHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCC
LPVRYHDLEQILSKVEMDLVEFHFSYKDLKVEISEYIKKPLNTDFVVHCPELFENDHLLD
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCCCEEEECHHHHCCCCEEE
LCTEDEDYRKRSLIEIQKVIDITRRLKDFFPNSNKKPFIVTNVGGFSLNKPLDTTIREKL
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHH
YKNLSRSLNDLDSEGVEIIPQTMPPFPWLFGGQRYHNLFLSAEEIVEFCKRHSIRICLDV
HHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCEEEEEEC
SHSKLACNHYHWSFSKFVEQVSPYVAHLHIVDAKGVDGEGLQIGEGEIDFHMLSNILREK
CCCEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHC
APKASFIPEIWQGHKNNGEGFLISLTRLEKFHL
CCCCCCCHHHHCCCCCCCCEEEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]