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The map label for this gene is acoB

Identifier: 45657761

GI number: 45657761

Start: 2295398

End: 2296372

Strand: Direct

Name: acoB

Synonym: LIC11898

Alternate gene names: 45657761

Gene position: 2295398-2296372 (Clockwise)

Preceding gene: 45657760

Following gene: 304570494

Centisome position: 53.67

GC content: 43.08

Gene sequence:

>975_bases
ATGGCGGTTCTGACATATAGAGAGGCTCTGAATCGGGCAATGTGCGAAGAAATGGATAAGGATCCAAATATATTTCTCAT
GGGAGAAGAAGTGGGTCACTATGATGGAGCTTATAAGGTTTCCCAAGGAATGCTTTCTAAATACGGAGAAAAAAGAGTCA
TAGACACTCCCATTTCCGAAAACGGTTTTGCGGGAGTTGGGATCGGAGCCGCCATGGTGGGTCTTCGTCCTATCATAGAA
TTTATGACTTGGAATTTTTCTTTAGTCGCGATTGATCAGATCATCAACTCGGCGGCAAAAATGAATTATATGAGTGCGGG
TCAGTTTCCAATTCCGATTGTGTTTCGAGGCGCAGGAGGCGCTGGCGGAAGACTAGCCGCTCAACACTCTCAATCCTTTG
AAAGTTGGTACGCTCACATCCCAGGTTTAAAAGTAATCGCTCCTTATACTCCTTCTGACGCTTGTGGTCTTTTAAAAACC
GCGATCAGAGACAATAACCCCACGATTTTTATTGAAAGTGAAGTGTTATACGGAACCAGAGGAGAAGTTCCCGATCAGGA
ATATTCCATTCCATTTGGTAAAGCGGACATCAAACGAGAAGGTTCTGATATAACGATTGTTAGTTGGTCTAGAGCATTAA
TGTATGTTCTACCCGCCGCAGAAAAACTTTCCAAAGAAGGAATTTCAGTTGAAGTTTTAGATCTTCGTTCGATCCGACCT
TTGGACGAAGAAGCGATCTATACTTCAATTCGTAAAACGAACCGTGCATTGGTAGTAGAAGAAGGTTGGGAAGTCGCTGG
TTTTGGTTCCCAAATCGCTTATTTAATCCAGAAAAATTCTTTCGATGATCTAGACGCTCCCGTAGAAAGAATTACTCAGG
AAGACGTTCCTATGCCTTACGCCGCAAACTTAGAAAAGGCTTCCTTACCCAGCGAAGAAAAGATCATCTCCAAAGTTCGG
GAAATGCTGGAATAA

Upstream 100 bases:

>100_bases
ATATACAAGCTCAAGTGGAAGATGCAATCGTATTTGCAGACAAAAGTGAAGAACCTCCTTTAGGTTGGTTGTATAAACAC
GTATATGCGGAGGATGTATA

Downstream 100 bases:

>100_bases
CAAGAATAAGGAATATTCAAAATGGCTAAAATTGCAGAAATGACTCAACTCAGTCCTACAATGGCGGAAGGTAAAATAGT
CCGTTGGCTTAAACAAAAAG

Product: pyruvate dehydrogenase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MAVLTYREALNRAMCEEMDKDPNIFLMGEEVGHYDGAYKVSQGMLSKYGEKRVIDTPISENGFAGVGIGAAMVGLRPIIE
FMTWNFSLVAIDQIINSAAKMNYMSAGQFPIPIVFRGAGGAGGRLAAQHSQSFESWYAHIPGLKVIAPYTPSDACGLLKT
AIRDNNPTIFIESEVLYGTRGEVPDQEYSIPFGKADIKREGSDITIVSWSRALMYVLPAAEKLSKEGISVEVLDLRSIRP
LDEEAIYTSIRKTNRALVVEEGWEVAGFGSQIAYLIQKNSFDDLDAPVERITQEDVPMPYAANLEKASLPSEEKIISKVR
EMLE

Sequences:

>Translated_324_residues
MAVLTYREALNRAMCEEMDKDPNIFLMGEEVGHYDGAYKVSQGMLSKYGEKRVIDTPISENGFAGVGIGAAMVGLRPIIE
FMTWNFSLVAIDQIINSAAKMNYMSAGQFPIPIVFRGAGGAGGRLAAQHSQSFESWYAHIPGLKVIAPYTPSDACGLLKT
AIRDNNPTIFIESEVLYGTRGEVPDQEYSIPFGKADIKREGSDITIVSWSRALMYVLPAAEKLSKEGISVEVLDLRSIRP
LDEEAIYTSIRKTNRALVVEEGWEVAGFGSQIAYLIQKNSFDDLDAPVERITQEDVPMPYAANLEKASLPSEEKIISKVR
EMLE
>Mature_323_residues
AVLTYREALNRAMCEEMDKDPNIFLMGEEVGHYDGAYKVSQGMLSKYGEKRVIDTPISENGFAGVGIGAAMVGLRPIIEF
MTWNFSLVAIDQIINSAAKMNYMSAGQFPIPIVFRGAGGAGGRLAAQHSQSFESWYAHIPGLKVIAPYTPSDACGLLKTA
IRDNNPTIFIESEVLYGTRGEVPDQEYSIPFGKADIKREGSDITIVSWSRALMYVLPAAEKLSKEGISVEVLDLRSIRPL
DEEAIYTSIRKTNRALVVEEGWEVAGFGSQIAYLIQKNSFDDLDAPVERITQEDVPMPYAANLEKASLPSEEKIISKVRE
MLE

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=325, Percent_Identity=54.1538461538462, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI291084858, Length=325, Percent_Identity=51.0769230769231, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI4557353, Length=320, Percent_Identity=37.1875, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI34101272, Length=320, Percent_Identity=37.1875, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17538422, Length=327, Percent_Identity=55.3516819571865, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17506935, Length=318, Percent_Identity=38.3647798742138, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=51.6819571865443, Blast_Score=355, Evalue=8e-99,
Organism=Drosophila melanogaster, GI21358145, Length=325, Percent_Identity=53.8461538461538, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24650940, Length=325, Percent_Identity=53.8461538461538, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI160714832, Length=320, Percent_Identity=38.75, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI160714828, Length=320, Percent_Identity=38.75, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24650943, Length=112, Percent_Identity=56.25, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24650945, Length=112, Percent_Identity=56.25, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35745; Mature: 35614

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLTYREALNRAMCEEMDKDPNIFLMGEEVGHYDGAYKVSQGMLSKYGEKRVIDTPISE
CEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCC
NGFAGVGIGAAMVGLRPIIEFMTWNFSLVAIDQIINSAAKMNYMSAGQFPIPIVFRGAGG
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
AGGRLAAQHSQSFESWYAHIPGLKVIAPYTPSDACGLLKTAIRDNNPTIFIESEVLYGTR
CCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEECCEEECCC
GEVPDQEYSIPFGKADIKREGSDITIVSWSRALMYVLPAAEKLSKEGISVEVLDLRSIRP
CCCCCCCCCCCCCCCHHHCCCCCEEEEEHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCC
LDEEAIYTSIRKTNRALVVEEGWEVAGFGSQIAYLIQKNSFDDLDAPVERITQEDVPMPY
CCHHHHHHHHHHCCCEEEEECCCCEECCCHHEEEEEECCCCCCHHHHHHHHHHHCCCCCC
AANLEKASLPSEEKIISKVREMLE
CCCCHHHCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
AVLTYREALNRAMCEEMDKDPNIFLMGEEVGHYDGAYKVSQGMLSKYGEKRVIDTPISE
EEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCC
NGFAGVGIGAAMVGLRPIIEFMTWNFSLVAIDQIINSAAKMNYMSAGQFPIPIVFRGAGG
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
AGGRLAAQHSQSFESWYAHIPGLKVIAPYTPSDACGLLKTAIRDNNPTIFIESEVLYGTR
CCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEECCEEECCC
GEVPDQEYSIPFGKADIKREGSDITIVSWSRALMYVLPAAEKLSKEGISVEVLDLRSIRP
CCCCCCCCCCCCCCCHHHCCCCCEEEEEHHHHHHHHHCCHHHHHHCCCEEEEEECCCCCC
LDEEAIYTSIRKTNRALVVEEGWEVAGFGSQIAYLIQKNSFDDLDAPVERITQEDVPMPY
CCHHHHHHHHHHCCCEEEEECCCCEECCCHHEEEEEECCCCCCHHHHHHHHHHHCCCCCC
AANLEKASLPSEEKIISKVREMLE
CCCCHHHCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]