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The map label for this gene is acoA

Identifier: 45657760

GI number: 45657760

Start: 2294415

End: 2295398

Strand: Direct

Name: acoA

Synonym: LIC11897

Alternate gene names: 45657760

Gene position: 2294415-2295398 (Clockwise)

Preceding gene: 45657750

Following gene: 45657761

Centisome position: 53.64

GC content: 42.68

Gene sequence:

>984_bases
ATGATGAACCATCCTAAAACCAAACAAGAAACCCAAGACCTTTTCGAACTCTACAGACAAATGCTTCTCATTCGCCGTTT
TGAAGAAGGTGCCGCCAAATCTTATAGCACCGGAAAGATAGGCGGTTTTTGCCATCTTTATATCGGCCAAGAAGCGGTTG
GTGTCGGTTCGATCGCGGCCCTTAAAGAACAAGACTATATCGTTTCCACTTACAGAGATCACGGCCACGCACTCGCAAGA
GGTTTAGATCCAAAGGCATTGATGGCGGAACTTTTTGGTAAAAGAACGGGAATCTCCAGTGGCTACGGAGGTTCGATGCA
TTTCTTCGATAAGAACAAACGATTTATGGGAGGGCATGGAATCGTGGGAGGTCATATTTCTCTCGCTGCGGGGATCGCCT
ATGCTTCTAAATATAAAAACGAAAACTCGGTTACAATTTGTTTTTTCGGAGAAGGAGCTGCAAACATAGGTTCCTTTCAT
GAAGGAATGAATTTAGCAGCGATCTGGAAACTTCCTCTTGTAATGATCTGTGAAAACAATCACTACGCAATGGGAACCCC
AGAATATCGCTCGTTATCCGTAAAGGACGTTTCGGTTCGTGCAACCGCTTATGACATTGCAAGAGATCATATCGAAGGAG
ACGAGGTTCGTAAAGTGAGAGATCACGTAAGTGTCGCAGTCGAACGAGCTCGAAGAGGAGAAGGCCCCACTCTCATGGAA
ATTTCCACCTATCGTTTTAGAGGACATTCCATGTCCGATCCTGCAAAGTATAGAACCAAGGAAGAATTAGATCGTTATAA
AAAAAGTGATCCACTTTTAAAGGCAAAGGATGATCTTATTCATTCTGAATGGAAAGAAGAAGAACTAGAAAAACTTGATA
TAGATATACAAGCTCAAGTGGAAGATGCAATCGTATTTGCAGACAAAAGTGAAGAACCTCCTTTAGGTTGGTTGTATAAA
CACGTATATGCGGAGGATGTATAA

Upstream 100 bases:

>100_bases
CATCCAAAACTTTGGAATTTTTTTAAGTTAGAAACGAAATCGGTTTGCATAAGTCGCTTCTCGAAAGATACTTTGCGATT
GTTTTAACAACTTAAATTTT

Downstream 100 bases:

>100_bases
TGGCGGTTCTGACATATAGAGAGGCTCTGAATCGGGCAATGTGCGAAGAAATGGATAAGGATCCAAATATATTTCTCATG
GGAGAAGAAGTGGGTCACTA

Product: pyruvate dehydrogenase alpha2 subunit protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MMNHPKTKQETQDLFELYRQMLLIRRFEEGAAKSYSTGKIGGFCHLYIGQEAVGVGSIAALKEQDYIVSTYRDHGHALAR
GLDPKALMAELFGKRTGISSGYGGSMHFFDKNKRFMGGHGIVGGHISLAAGIAYASKYKNENSVTICFFGEGAANIGSFH
EGMNLAAIWKLPLVMICENNHYAMGTPEYRSLSVKDVSVRATAYDIARDHIEGDEVRKVRDHVSVAVERARRGEGPTLME
ISTYRFRGHSMSDPAKYRTKEELDRYKKSDPLLKAKDDLIHSEWKEEELEKLDIDIQAQVEDAIVFADKSEEPPLGWLYK
HVYAEDV

Sequences:

>Translated_327_residues
MMNHPKTKQETQDLFELYRQMLLIRRFEEGAAKSYSTGKIGGFCHLYIGQEAVGVGSIAALKEQDYIVSTYRDHGHALAR
GLDPKALMAELFGKRTGISSGYGGSMHFFDKNKRFMGGHGIVGGHISLAAGIAYASKYKNENSVTICFFGEGAANIGSFH
EGMNLAAIWKLPLVMICENNHYAMGTPEYRSLSVKDVSVRATAYDIARDHIEGDEVRKVRDHVSVAVERARRGEGPTLME
ISTYRFRGHSMSDPAKYRTKEELDRYKKSDPLLKAKDDLIHSEWKEEELEKLDIDIQAQVEDAIVFADKSEEPPLGWLYK
HVYAEDV
>Mature_327_residues
MMNHPKTKQETQDLFELYRQMLLIRRFEEGAAKSYSTGKIGGFCHLYIGQEAVGVGSIAALKEQDYIVSTYRDHGHALAR
GLDPKALMAELFGKRTGISSGYGGSMHFFDKNKRFMGGHGIVGGHISLAAGIAYASKYKNENSVTICFFGEGAANIGSFH
EGMNLAAIWKLPLVMICENNHYAMGTPEYRSLSVKDVSVRATAYDIARDHIEGDEVRKVRDHVSVAVERARRGEGPTLME
ISTYRFRGHSMSDPAKYRTKEELDRYKKSDPLLKAKDDLIHSEWKEEELEKLDIDIQAQVEDAIVFADKSEEPPLGWLYK
HVYAEDV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=315, Percent_Identity=42.5396825396825, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4505685, Length=318, Percent_Identity=42.7672955974843, Blast_Score=245, Evalue=3e-65,
Organism=Homo sapiens, GI291084742, Length=318, Percent_Identity=42.7672955974843, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI291084744, Length=325, Percent_Identity=41.8461538461538, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI291084757, Length=318, Percent_Identity=38.3647798742138, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI11386135, Length=317, Percent_Identity=31.2302839116719, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI258645172, Length=320, Percent_Identity=31.875, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=39.8773006134969, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=39.8773006134969, Blast_Score=234, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI86563355, Length=321, Percent_Identity=29.2834890965732, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI86563357, Length=321, Percent_Identity=29.2834890965732, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=332, Percent_Identity=38.2530120481928, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24639748, Length=319, Percent_Identity=41.0658307210031, Blast_Score=235, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24639744, Length=316, Percent_Identity=38.9240506329114, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI28571106, Length=316, Percent_Identity=38.9240506329114, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24639740, Length=316, Percent_Identity=38.9240506329114, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24639746, Length=310, Percent_Identity=39.0322580645161, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI21355903, Length=328, Percent_Identity=28.3536585365854, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36748; Mature: 36748

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNHPKTKQETQDLFELYRQMLLIRRFEEGAAKSYSTGKIGGFCHLYIGQEAVGVGSIAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHH
LKEQDYIVSTYRDHGHALARGLDPKALMAELFGKRTGISSGYGGSMHFFDKNKRFMGGHG
HCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEECCCC
IVGGHISLAAGIAYASKYKNENSVTICFFGEGAANIGSFHEGMNLAAIWKLPLVMICENN
EECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCCCEEEEECCCEEEEECCC
HYAMGTPEYRSLSVKDVSVRATAYDIARDHIEGDEVRKVRDHVSVAVERARRGEGPTLME
EEECCCCCCCEEEEEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
ISTYRFRGHSMSDPAKYRTKEELDRYKKSDPLLKAKDDLIHSEWKEEELEKLDIDIQAQV
EEEEEECCCCCCCCHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEE
EDAIVFADKSEEPPLGWLYKHVYAEDV
EEEEEEECCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MMNHPKTKQETQDLFELYRQMLLIRRFEEGAAKSYSTGKIGGFCHLYIGQEAVGVGSIAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHH
LKEQDYIVSTYRDHGHALARGLDPKALMAELFGKRTGISSGYGGSMHFFDKNKRFMGGHG
HCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEECCCC
IVGGHISLAAGIAYASKYKNENSVTICFFGEGAANIGSFHEGMNLAAIWKLPLVMICENN
EECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHCCCCEEEEECCCEEEEECCC
HYAMGTPEYRSLSVKDVSVRATAYDIARDHIEGDEVRKVRDHVSVAVERARRGEGPTLME
EEECCCCCCCEEEEEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
ISTYRFRGHSMSDPAKYRTKEELDRYKKSDPLLKAKDDLIHSEWKEEELEKLDIDIQAQV
EEEEEECCCCCCCCHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEE
EDAIVFADKSEEPPLGWLYKHVYAEDV
EEEEEEECCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]