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The map label for this gene is cobB

Identifier: 45657550

GI number: 45657550

Start: 2046831

End: 2047571

Strand: Reverse

Name: cobB

Synonym: LIC11684

Alternate gene names: 45657550

Gene position: 2047571-2046831 (Counterclockwise)

Preceding gene: 45657551

Following gene: 45657549

Centisome position: 47.87

GC content: 37.65

Gene sequence:

>741_bases
ATGAAAGAATTTATAACAAAACACAGAGATAAATTTCAAAAAATTAGCGCAATTTCCGGAGCAGGTATTTCTGCCGAAAG
TGGAATTCCTACGTTTCGTGGAAGTGAAGGTCTATGGAAAAATTTTAGAGCGGAAGATCTTGCAACTCCTCAAGCTTTTT
CCAAAAACCCTAAACTAGTCTGGGAATGGTATCTTTGGAGAAGAAATATCATCGAGACCAAACGTCCCAACCCTGGACAT
TTTGCTCTTGTAGAATTAGAAAGAATACATCCTGATTTTTTTCTAATCACCCAAAATGTGGATGGGCTCCATTCTCAAGC
AGGTTCTAAAAAGTTAACCGAAATTCATGGAAATATTTTTATCAATCGATGTATTTCTTGCGGACAAGAATCTAAGGAAA
CGATATCTGAAAACACAACTCCTCTTCCCCCACAATGCCAGAATTGTAATTCTTTTTTAAGACCAGGAGTCGTTTGGTTC
GGAGAAAGTTATGATGATTTTAAATTGAATTTTTCTATCCAAAGAATGAAACATACAGATCTATTACTCGTTCTTGGAAC
TTCGGGTTCTGTCAGTATGCCCGTTTATCTAGCGCAGATCGCAAAGGACTCTGGTGCGCTTCTTGTAGAAATCAACCCGG
AACGTTCTTCCTTTTCTTCTTCCGTTGATTTATTTCTACAAGGCAAGACGGGTGAGGTTTTACCAGAATTAATACGAGAA
ATTTTAGACAATCCATCCTAA

Upstream 100 bases:

>100_bases
TAGGCCCTGGTTCCGCATTTGAATTTGCTTTAGAACTCGTTAAAATTCTATCTGGAGAAGAATCCATGTTAAAAGTAAAA
TCAGCCCTTCAACTGGCTTC

Downstream 100 bases:

>100_bases
CGTCTCATTTGACTTATGTTAACTTGAGTACGTCGTAATAAAATCGAGACGATCCAGCTTGCCTATAACAAGCCAGACTA
GTAGGCTCTTTAACTCTGGT

Product: Sir2 transcriptional regulator

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKEFITKHRDKFQKISAISGAGISAESGIPTFRGSEGLWKNFRAEDLATPQAFSKNPKLVWEWYLWRRNIIETKRPNPGH
FALVELERIHPDFFLITQNVDGLHSQAGSKKLTEIHGNIFINRCISCGQESKETISENTTPLPPQCQNCNSFLRPGVVWF
GESYDDFKLNFSIQRMKHTDLLLVLGTSGSVSMPVYLAQIAKDSGALLVEINPERSSFSSSVDLFLQGKTGEVLPELIRE
ILDNPS

Sequences:

>Translated_246_residues
MKEFITKHRDKFQKISAISGAGISAESGIPTFRGSEGLWKNFRAEDLATPQAFSKNPKLVWEWYLWRRNIIETKRPNPGH
FALVELERIHPDFFLITQNVDGLHSQAGSKKLTEIHGNIFINRCISCGQESKETISENTTPLPPQCQNCNSFLRPGVVWF
GESYDDFKLNFSIQRMKHTDLLLVLGTSGSVSMPVYLAQIAKDSGALLVEINPERSSFSSSVDLFLQGKTGEVLPELIRE
ILDNPS
>Mature_246_residues
MKEFITKHRDKFQKISAISGAGISAESGIPTFRGSEGLWKNFRAEDLATPQAFSKNPKLVWEWYLWRRNIIETKRPNPGH
FALVELERIHPDFFLITQNVDGLHSQAGSKKLTEIHGNIFINRCISCGQESKETISENTTPLPPQCQNCNSFLRPGVVWF
GESYDDFKLNFSIQRMKHTDLLLVLGTSGSVSMPVYLAQIAKDSGALLVEINPERSSFSSSVDLFLQGKTGEVLPELIRE
ILDNPS

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI300795542, Length=240, Percent_Identity=42.0833333333333, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI6912664, Length=253, Percent_Identity=39.9209486166008, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI13787215, Length=229, Percent_Identity=41.4847161572052, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI6912662, Length=272, Percent_Identity=29.7794117647059, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI300797577, Length=236, Percent_Identity=30.9322033898305, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI300797597, Length=225, Percent_Identity=30.6666666666667, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI6912660, Length=206, Percent_Identity=31.0679611650485, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI300797705, Length=195, Percent_Identity=31.2820512820513, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI13775602, Length=198, Percent_Identity=31.3131313131313, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI63054862, Length=201, Percent_Identity=31.3432835820896, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI13775600, Length=198, Percent_Identity=31.3131313131313, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI308199517, Length=237, Percent_Identity=37.1308016877637, Blast_Score=146, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71990482, Length=264, Percent_Identity=31.0606060606061, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17567771, Length=264, Percent_Identity=30.3030303030303, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71990487, Length=266, Percent_Identity=30.8270676691729, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17541892, Length=237, Percent_Identity=29.957805907173, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17505510, Length=235, Percent_Identity=28.0851063829787, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325242, Length=168, Percent_Identity=30.3571428571429, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24648389, Length=197, Percent_Identity=31.9796954314721, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571445, Length=257, Percent_Identity=28.0155642023346, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137536, Length=270, Percent_Identity=27.037037037037, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24650933, Length=237, Percent_Identity=26.5822784810127, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24645650, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD_LEPIC (Q72RR0)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001636.1
- ProteinModelPortal:   Q72RR0
- SMR:   Q72RR0
- GeneID:   2771862
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11684
- NMPDR:   fig|267671.1.peg.1636
- HOGENOM:   HBG641281
- OMA:   AQHESEF
- ProtClustDB:   CLSK574303
- BioCyc:   LINT267671:LIC_11684-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27683; Mature: 27683

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEFITKHRDKFQKISAISGAGISAESGIPTFRGSEGLWKNFRAEDLATPQAFSKNPKLV
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCHHHCCCCHHHCCCCCEE
WEWYLWRRNIIETKRPNPGHFALVELERIHPDFFLITQNVDGLHSQAGSKKLTEIHGNIF
EEEEHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEECCCCCHHHHCCCCHHHHHHHHHH
INRCISCGQESKETISENTTPLPPQCQNCNSFLRPGVVWFGESYDDFKLNFSIQRMKHTD
HHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHCCCEEEECCCCCCEEEEEEEEEECCCC
LLLVLGTSGSVSMPVYLAQIAKDSGALLVEINPERSSFSSSVDLFLQGKTGEVLPELIRE
EEEEEECCCCCCHHHHHEEHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHH
ILDNPS
HHCCCC
>Mature Secondary Structure
MKEFITKHRDKFQKISAISGAGISAESGIPTFRGSEGLWKNFRAEDLATPQAFSKNPKLV
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCHHHCCCCHHHCCCCCEE
WEWYLWRRNIIETKRPNPGHFALVELERIHPDFFLITQNVDGLHSQAGSKKLTEIHGNIF
EEEEHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEEECCCCCHHHHCCCCHHHHHHHHHH
INRCISCGQESKETISENTTPLPPQCQNCNSFLRPGVVWFGESYDDFKLNFSIQRMKHTD
HHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHCCCEEEECCCCCCEEEEEEEEEECCCC
LLLVLGTSGSVSMPVYLAQIAKDSGALLVEINPERSSFSSSVDLFLQGKTGEVLPELIRE
EEEEEECCCCCCHHHHHEEHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHH
ILDNPS
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA