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The map label for this gene is yajL [H]

Identifier: 45657551

GI number: 45657551

Start: 2047568

End: 2048113

Strand: Reverse

Name: yajL [H]

Synonym: LIC11685

Alternate gene names: 45657551

Gene position: 2048113-2047568 (Counterclockwise)

Preceding gene: 45657554

Following gene: 45657550

Centisome position: 47.88

GC content: 38.1

Gene sequence:

>546_bases
ATGCCAAAGGTTTTAGTTCCATTTGCAGAAGGAATGGAGGAGATGGAGGCAGTTATCATAGTAGACGTTCTTCGTAGGGC
CGGAATAGAAGTTTTAAGCGCATCTCTAAAAGAAGGTCCAGTAAAGGCGTCCAGAGGAATACGTATTTTAGCAGATACAA
CATTAGATGAAATTAATTTCGAAGATTTTGATATGATTGTTCTTCCAGGAGGTGGAGGTGGAACAAAAGTTTTAAGTGCA
GAACCAAAAGTTTCAGAACTTCTCAAAAATGCAAAAGAAAAAAACAAATGGATCGCCGCAATCTGCGCAGCTCCTAGTAT
TTTAGTACATCAAAATATTTTAACATCTAAGGATCGTTTTACTGCGTTTCCAGGAATTATATCGAATAACTCCGGTTACA
CTGGTTCCCGGTTAGAAATTTCCGGAAAAATAATTACGAGCATAGGCCCTGGTTCCGCATTTGAATTTGCTTTAGAACTC
GTTAAAATTCTATCTGGAGAAGAATCCATGTTAAAAGTAAAATCAGCCCTTCAACTGGCTTCATGA

Upstream 100 bases:

>100_bases
AATTTTTATATTCGGATTTTTTAGAAGTTTTTTTAAAATGTCAGAGATTTGTAATCTTTCATTTATAGATAATTTAAATT
AGTTTTCCAGGAGGTATTTT

Downstream 100 bases:

>100_bases
AAGAATTTATAACAAAACACAGAGATAAATTTCAAAAAATTAGCGCAATTTCCGGAGCAGGTATTTCTGCCGAAAGTGGA
ATTCCTACGTTTCGTGGAAG

Product: hypothetical protein

Products: 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium; 4-Methyl-5-(2-hydroxyethyl)-thiazole

Alternate protein names: NA

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MPKVLVPFAEGMEEMEAVIIVDVLRRAGIEVLSASLKEGPVKASRGIRILADTTLDEINFEDFDMIVLPGGGGGTKVLSA
EPKVSELLKNAKEKNKWIAAICAAPSILVHQNILTSKDRFTAFPGIISNNSGYTGSRLEISGKIITSIGPGSAFEFALEL
VKILSGEESMLKVKSALQLAS

Sequences:

>Translated_181_residues
MPKVLVPFAEGMEEMEAVIIVDVLRRAGIEVLSASLKEGPVKASRGIRILADTTLDEINFEDFDMIVLPGGGGGTKVLSA
EPKVSELLKNAKEKNKWIAAICAAPSILVHQNILTSKDRFTAFPGIISNNSGYTGSRLEISGKIITSIGPGSAFEFALEL
VKILSGEESMLKVKSALQLAS
>Mature_180_residues
PKVLVPFAEGMEEMEAVIIVDVLRRAGIEVLSASLKEGPVKASRGIRILADTTLDEINFEDFDMIVLPGGGGGTKVLSAE
PKVSELLKNAKEKNKWIAAICAAPSILVHQNILTSKDRFTAFPGIISNNSGYTGSRLEISGKIITSIGPGSAFEFALELV
KILSGEESMLKVKSALQLAS

Specific function: Involved in biogenesis of ribosomal proteins, probably as a ribosomal protein-folding chaperone. Interacts with ribosomal subunits, ribosomes and polysomes. Confers resistance to oxidative stress [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C56 family [H]

Homologues:

Organism=Homo sapiens, GI183227678, Length=185, Percent_Identity=43.7837837837838, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI31543380, Length=185, Percent_Identity=43.7837837837838, Blast_Score=121, Evalue=4e-28,
Organism=Escherichia coli, GI87081736, Length=185, Percent_Identity=35.1351351351351, Blast_Score=97, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17531319, Length=165, Percent_Identity=41.2121212121212, Blast_Score=116, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17558714, Length=179, Percent_Identity=37.4301675977654, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28571932, Length=181, Percent_Identity=41.4364640883978, Blast_Score=129, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24653499, Length=179, Percent_Identity=39.6648044692737, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006287
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: 2.5.1.2

Molecular weight: Translated: 19285; Mature: 19154

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVLVPFAEGMEEMEAVIIVDVLRRAGIEVLSASLKEGPVKASRGIRILADTTLDEINF
CCCEECHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
EDFDMIVLPGGGGGTKVLSAEPKVSELLKNAKEKNKWIAAICAAPSILVHQNILTSKDRF
CCCCEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHEEEEEHHCCHHHHHHHHHCCCCCC
TAFPGIISNNSGYTGSRLEISGKIITSIGPGSAFEFALELVKILSGEESMLKVKSALQLA
EECCCEEECCCCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
S
C
>Mature Secondary Structure 
PKVLVPFAEGMEEMEAVIIVDVLRRAGIEVLSASLKEGPVKASRGIRILADTTLDEINF
CCEECHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
EDFDMIVLPGGGGGTKVLSAEPKVSELLKNAKEKNKWIAAICAAPSILVHQNILTSKDRF
CCCCEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHEEEEEHHCCHHHHHHHHHCCCCCC
TAFPGIISNNSGYTGSRLEISGKIITSIGPGSAFEFALELVKILSGEESMLKVKSALQLA
EECCCEEECCCCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: thiamine; pyridine

Specific reaction: thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9592144 [H]