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The map label for this gene is csgA

Identifier: 45657506

GI number: 45657506

Start: 2001334

End: 2002002

Strand: Reverse

Name: csgA

Synonym: LIC11634

Alternate gene names: 45657506

Gene position: 2002002-2001334 (Counterclockwise)

Preceding gene: 45657510

Following gene: 45657505

Centisome position: 46.81

GC content: 37.22

Gene sequence:

>669_bases
ATGACTCAAAGAAACATTTTAATTACCGGCTCTAATCGAGGAATCGGTTTGGAACTTACCAAACAATTTCTTTCTCAGGG
AGATCAAGTTTTTGCTCTGTGTAGAAAATCTTCTTCTGAACTAATTCACTTAAAACCGACTCGTATCTTTGAAGGTATGG
ACGTTTTAAATTCTAACTCGATCCGAGATCTACCTTCTAAACTTTTAGATACAAAGATAGATATACTTATCAATAACGCT
GGAATATTAATTCCAGACAACTTACAAAGTTTAGACGAAGAAAACGTTTTTACTCAATTTTTAGTAAACGCGTTAGGGCC
TCTGAAGGTAGTAAAGGTTTTACTTTCTTCTTTGAAAAAAAATGCAAAGTTAATCTTCTTAACGAGTAGAATGGGCTCGA
TCGCAGACAATAACTCCGGCTCTTATTACGGATACCGCGCTTCCAAAGCCGCACTGAACGCAATCGCAGTCAGTTTAGCC
AAGGATTTAAGTCCTCGGGGAATTTCAGTAGGAATCTTTCACCCTGGAATGGTGGCAACTCGAATGAGTGGTGGACAAGG
AATCTCTATAACCGAAAGCGTTGAAGGTTTAATTAAACGAATTGAATCCTTAAATTTACAAAACTCCGGAAAGTTTTTTC
ATCAAAATGGAGAAGAACTTCCTTGGTAA

Upstream 100 bases:

>100_bases
AATGATCTCGTAATTCATAGAAGCAGTAATGTAAATAAATTGAGCTAAACGTCAATCGAAAAGTACTTTTAGAACAAATC
CATATAGTTAAGTTTAGAAT

Downstream 100 bases:

>100_bases
ATTGTGGGAACTCTTACAATTTCAAGATTTCATAGAAATCAATACTTTGCTGATGGAGTTCCCACAATTTAGATCCGATT
TTAAGAATTAGAAATTTATA

Product: CsgA

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: C signal [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTQRNILITGSNRGIGLELTKQFLSQGDQVFALCRKSSSELIHLKPTRIFEGMDVLNSNSIRDLPSKLLDTKIDILINNA
GILIPDNLQSLDEENVFTQFLVNALGPLKVVKVLLSSLKKNAKLIFLTSRMGSIADNNSGSYYGYRASKAALNAIAVSLA
KDLSPRGISVGIFHPGMVATRMSGGQGISITESVEGLIKRIESLNLQNSGKFFHQNGEELPW

Sequences:

>Translated_222_residues
MTQRNILITGSNRGIGLELTKQFLSQGDQVFALCRKSSSELIHLKPTRIFEGMDVLNSNSIRDLPSKLLDTKIDILINNA
GILIPDNLQSLDEENVFTQFLVNALGPLKVVKVLLSSLKKNAKLIFLTSRMGSIADNNSGSYYGYRASKAALNAIAVSLA
KDLSPRGISVGIFHPGMVATRMSGGQGISITESVEGLIKRIESLNLQNSGKFFHQNGEELPW
>Mature_221_residues
TQRNILITGSNRGIGLELTKQFLSQGDQVFALCRKSSSELIHLKPTRIFEGMDVLNSNSIRDLPSKLLDTKIDILINNAG
ILIPDNLQSLDEENVFTQFLVNALGPLKVVKVLLSSLKKNAKLIFLTSRMGSIADNNSGSYYGYRASKAALNAIAVSLAK
DLSPRGISVGIFHPGMVATRMSGGQGISITESVEGLIKRIESLNLQNSGKFFHQNGEELPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Escherichia coli, GI2367365, Length=183, Percent_Identity=26.2295081967213, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786701, Length=186, Percent_Identity=29.5698924731183, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787335, Length=184, Percent_Identity=26.0869565217391, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17559962, Length=249, Percent_Identity=31.3253012048193, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532177, Length=247, Percent_Identity=31.9838056680162, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17559964, Length=248, Percent_Identity=29.8387096774194, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI72001658, Length=255, Percent_Identity=32.5490196078431, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17558996, Length=251, Percent_Identity=27.0916334661355, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17558992, Length=244, Percent_Identity=29.9180327868852, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17542178, Length=248, Percent_Identity=30.6451612903226, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17558994, Length=252, Percent_Identity=28.968253968254, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI193207563, Length=244, Percent_Identity=27.0491803278689, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17558990, Length=252, Percent_Identity=26.984126984127, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17558006, Length=203, Percent_Identity=30.0492610837438, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17541382, Length=254, Percent_Identity=29.9212598425197, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=248, Percent_Identity=31.8548387096774, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640547, Length=249, Percent_Identity=31.3253012048193, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24643142, Length=181, Percent_Identity=35.3591160220994, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24647946, Length=201, Percent_Identity=28.3582089552239, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45553409, Length=201, Percent_Identity=28.3582089552239, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24647948, Length=201, Percent_Identity=28.3582089552239, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21358495, Length=194, Percent_Identity=28.8659793814433, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573296, Length=202, Percent_Identity=33.6633663366337, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 24216; Mature: 24085

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRNILITGSNRGIGLELTKQFLSQGDQVFALCRKSSSELIHLKPTRIFEGMDVLNSNS
CCCCCEEEECCCCCCCHHHHHHHHHCCCCEEHHHHCCCCCEEEECHHHHHHCHHHHCCCC
IRDLPSKLLDTKIDILINNAGILIPDNLQSLDEENVFTQFLVNALGPLKVVKVLLSSLKK
HHHHHHHHHCCEEEEEECCCCEEECCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
NAKLIFLTSRMGSIADNNSGSYYGYRASKAALNAIAVSLAKDLSPRGISVGIFHPGMVAT
CCEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEE
RMSGGQGISITESVEGLIKRIESLNLQNSGKFFHQNGEELPW
ECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQRNILITGSNRGIGLELTKQFLSQGDQVFALCRKSSSELIHLKPTRIFEGMDVLNSNS
CCCCEEEECCCCCCCHHHHHHHHHCCCCEEHHHHCCCCCEEEECHHHHHHCHHHHCCCC
IRDLPSKLLDTKIDILINNAGILIPDNLQSLDEENVFTQFLVNALGPLKVVKVLLSSLKK
HHHHHHHHHCCEEEEEECCCCEEECCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
NAKLIFLTSRMGSIADNNSGSYYGYRASKAALNAIAVSLAKDLSPRGISVGIFHPGMVAT
CCEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEE
RMSGGQGISITESVEGLIKRIESLNLQNSGKFFHQNGEELPW
ECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]