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The map label for this gene is lpxC

Identifier: 45657505

GI number: 45657505

Start: 1999985

End: 2000998

Strand: Reverse

Name: lpxC

Synonym: LIC11633

Alternate gene names: 45657505

Gene position: 2000998-1999985 (Counterclockwise)

Preceding gene: 45657506

Following gene: 45657504

Centisome position: 46.78

GC content: 38.86

Gene sequence:

>1014_bases
ATGGAGACTTTCGATTTTCTCTCTAAAAACAGAGTTAAAAACGAACTTCGAATTCTAAATAGACCGTCTTTTAGATGGGA
CGTTATTGGAAATCGAGAATTTAAAACTATGAAAGAAATTCTATATAGAAGATCAATACAAGACACAGTTAGAATCAAAG
GAATTGGACTTCATTCCGGCAAAGAAGTCAATCTAACCGCCCATCCAGCTCCATCCGGAACAGGAATTGTTTTTGAATAT
CGAAAAGGTTTAGAAAAAGCATCCATTTCGGCAGAACTCAGCAATGTAGTAGATACCAGCAACGCGACCACATTAGGAGA
CGGAATTCATAAAATCCAAACCGTGGAACATCTTTTAGCTGCGGTCTATGCGCTCGGTTTGACAGATTTAATTCTGGAAA
TAGACGCAGTAGAAGTTCCGATCATGGACGGTTCTTCTCTTCCTTTTTTACAAGCACTTGAATCAGCTGGAATCATAGAA
TATCCCGAAATTGTAGAACCCATTTATATTCAAAGTCCTCTCTGGGTTGTAGACGGTGACAAATATCTGGTTTTACTTCC
AAGTGACGAACTCAAAGTAACCTATACGATAGATTTCAATCACCCTCTACTCAAAGGACAAAGTATCACTGTCTCTTTAG
ACAGAGAAAAAATCAAACAAGAGATTCTACCTGCAAGGACTTTTGGTTTTTTAAAAGACGTAGAAGCACTTCAAGCCAGA
GGACTTGCTATGGGCGGCTCTTTAGACAACGCAATTGTACTCACTCAAGACGGTTATCTAAACCAACAACTCCGTTTTGA
AAATGAATGTGTTCGTCATAAAATCTTAGATCTTTTTGGAGATATTTCCATCGCCGGTCGTCCTATCATAGGACATTATC
TGGCTTCTAAAGCAGGGCACGCGCTGGATATTTCTATGGCTAAATTGGTGATGAGCAATGTCACTGGAGACGAAATCAGT
AAATATAAAAGTCGTAGAATCCCACTATTCAAAAGAAAAGCAGTCGTCGTTTAA

Upstream 100 bases:

>100_bases
GAACCTAAATTATGTCGGATTGGGCCCAAATCAATGAGTTAAAACACCTTAAAAAACCAATTTTCATAGATCTTTTGGCA
TAGAGTTTGCTTAATAGTAA

Downstream 100 bases:

>100_bases
ACGTTTTCATTTAGTAATTTCAATTTCGGTCAAATCTGAGTCTTTTTGATTCGTTCTATTTTTGACTCAGAAAAGAATTG
TCAGATTCTTCTTTTGGTGA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
METFDFLSKNRVKNELRILNRPSFRWDVIGNREFKTMKEILYRRSIQDTVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEY
RKGLEKASISAELSNVVDTSNATTLGDGIHKIQTVEHLLAAVYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIIE
YPEIVEPIYIQSPLWVVDGDKYLVLLPSDELKVTYTIDFNHPLLKGQSITVSLDREKIKQEILPARTFGFLKDVEALQAR
GLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKILDLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSNVTGDEIS
KYKSRRIPLFKRKAVVV

Sequences:

>Translated_337_residues
METFDFLSKNRVKNELRILNRPSFRWDVIGNREFKTMKEILYRRSIQDTVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEY
RKGLEKASISAELSNVVDTSNATTLGDGIHKIQTVEHLLAAVYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIIE
YPEIVEPIYIQSPLWVVDGDKYLVLLPSDELKVTYTIDFNHPLLKGQSITVSLDREKIKQEILPARTFGFLKDVEALQAR
GLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKILDLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSNVTGDEIS
KYKSRRIPLFKRKAVVV
>Mature_337_residues
METFDFLSKNRVKNELRILNRPSFRWDVIGNREFKTMKEILYRRSIQDTVRIKGIGLHSGKEVNLTAHPAPSGTGIVFEY
RKGLEKASISAELSNVVDTSNATTLGDGIHKIQTVEHLLAAVYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIIE
YPEIVEPIYIQSPLWVVDGDKYLVLLPSDELKVTYTIDFNHPLLKGQSITVSLDREKIKQEILPARTFGFLKDVEALQAR
GLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKILDLFGDISIAGRPIIGHYLASKAGHALDISMAKLVMSNVTGDEIS
KYKSRRIPLFKRKAVVV

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=38.1578947368421, Blast_Score=204, Evalue=5e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 37529; Mature: 37529

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METFDFLSKNRVKNELRILNRPSFRWDVIGNREFKTMKEILYRRSIQDTVRIKGIGLHSG
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCC
KEVNLTAHPAPSGTGIVFEYRKGLEKASISAELSNVVDTSNATTLGDGIHKIQTVEHLLA
CEEEEEECCCCCCCEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AVYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIIEYPEIVEPIYIQSPLWVVDGD
HHHHHHHHHHHEEECCEEEEECCCCCCHHHHHHHHCCCCCCHHHHCCEEECCCEEEEECC
KYLVLLPSDELKVTYTIDFNHPLLKGQSITVSLDREKIKQEILPARTFGFLKDVEALQAR
EEEEEECCCCEEEEEEEECCCCEECCCEEEEEECHHHHHHHHCCHHHHHHHHHHHHHHHC
GLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKILDLFGDISIAGRPIIGHYLASKAGH
CEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCC
ALDISMAKLVMSNVTGDEISKYKSRRIPLFKRKAVVV
EEHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEECC
>Mature Secondary Structure
METFDFLSKNRVKNELRILNRPSFRWDVIGNREFKTMKEILYRRSIQDTVRIKGIGLHSG
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCC
KEVNLTAHPAPSGTGIVFEYRKGLEKASISAELSNVVDTSNATTLGDGIHKIQTVEHLLA
CEEEEEECCCCCCCEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AVYALGLTDLILEIDAVEVPIMDGSSLPFLQALESAGIIEYPEIVEPIYIQSPLWVVDGD
HHHHHHHHHHHEEECCEEEEECCCCCCHHHHHHHHCCCCCCHHHHCCEEECCCEEEEECC
KYLVLLPSDELKVTYTIDFNHPLLKGQSITVSLDREKIKQEILPARTFGFLKDVEALQAR
EEEEEECCCCEEEEEEEECCCCEECCCEEEEEECHHHHHHHHCCHHHHHHHHHHHHHHHC
GLAMGGSLDNAIVLTQDGYLNQQLRFENECVRHKILDLFGDISIAGRPIIGHYLASKAGH
CEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCC
ALDISMAKLVMSNVTGDEISKYKSRRIPLFKRKAVVV
EEHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA