Click here to switch to the map view.

The map label for this gene is trxB

Identifier: 45657345

GI number: 45657345

Start: 1817325

End: 1818275

Strand: Reverse

Name: trxB

Synonym: LIC11470

Alternate gene names: 45657345

Gene position: 1818275-1817325 (Counterclockwise)

Preceding gene: 45657346

Following gene: 45657342

Centisome position: 42.51

GC content: 41.75

Gene sequence:

>951_bases
ATGGCCCATAAAATAGTCATTATAGGTTCCGGACCAGCCGGACACACTGCAGCGATCTACGCCGCCAGAGCTAACTTAAA
CCCCGTTATGTATGAAGGATTTATGGCGGGTGGAATTGCCGCAGGAGGTCAACTCACAACTACCACTGAAGTGGAAAACT
TTCCAGGTTTTCCAGAAGGAATTGATGGAACTAAATTGACTCAACTTTTTCGAGAACAATCTATCAAATATGGAACAAAG
ATCATAACTCAAACCATTACCAAGGTAGATTTTTCTTCCAGACCGTTTAAACTTTGGTCAGACGATGAATTGATAGAAGC
CCAAGCCGTAATTATAGCCACTGGGGCGACCGCAAAAAGAATGAACGTGATCGGCGAAGACATTTATTGGCAAAGAGGAA
TTTCCGCCTGTGCAGTTTGTGACGGAGCCCTTCCGATTTATAGAAATAAAGAACTAGTAGTAGTAGGAGGTGGAGATTCT
GCAGTAGAAGAAGCTTCTCACTTAACTAAATTTGCATCGAAGGTGTATTTAGTTCATAGAAGAGATTCTCTTCGCGCTTC
TAAAATTATGCAAAAAAGAGCAACTACTCATCCTAAAATCGAAATTATTTGGAATTCTCAAGTGAAGGAAGCCAAAGGCG
ACGGTAAAAGTTTAACCTCTCTGACTTTAGAAAACACAACAAATGGCCAAAAAAAAGAACTTCCAGTTGGCGGGCTTTTT
TATGCAATCGGGCATAAACCCAATACAGACATTTTCCAAGGAATTTTGGATTTAGATGAAAGCGGTTACATCAAAACAGT
TCCAGGTTCCACCAAAACGAATATAGAAGGAATTTTTGCAGCGGGAGACGTTCAAGACAAAATTTATCGCCAAGCAGTCT
CTGCCGCAGGTTCCGGATGTATGGCTGCCTTAGACGCAGAGCGCTGGTTAGAGTCCAGAGAAGAAGAATAA

Upstream 100 bases:

>100_bases
AGAAAAACTTTCAAAATTCTAACACTAAAAAAGGATCTGCTTTACAACGAAAGAGTCTAAAAATAGATCAAATTTAGAAC
CATTCTAATTAGAGGAAACA

Downstream 100 bases:

>100_bases
TTTCAGAATATTCTAAATTATTAATGTATTTAATTTAACTAGAATTCGAAGATTGAAAATCTGAGCGAGTCCGGCTTGTC
ATAGAAAGCCGGACTGGGCC

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MAHKIVIIGSGPAGHTAAIYAARANLNPVMYEGFMAGGIAAGGQLTTTTEVENFPGFPEGIDGTKLTQLFREQSIKYGTK
IITQTITKVDFSSRPFKLWSDDELIEAQAVIIATGATAKRMNVIGEDIYWQRGISACAVCDGALPIYRNKELVVVGGGDS
AVEEASHLTKFASKVYLVHRRDSLRASKIMQKRATTHPKIEIIWNSQVKEAKGDGKSLTSLTLENTTNGQKKELPVGGLF
YAIGHKPNTDIFQGILDLDESGYIKTVPGSTKTNIEGIFAAGDVQDKIYRQAVSAAGSGCMAALDAERWLESREEE

Sequences:

>Translated_316_residues
MAHKIVIIGSGPAGHTAAIYAARANLNPVMYEGFMAGGIAAGGQLTTTTEVENFPGFPEGIDGTKLTQLFREQSIKYGTK
IITQTITKVDFSSRPFKLWSDDELIEAQAVIIATGATAKRMNVIGEDIYWQRGISACAVCDGALPIYRNKELVVVGGGDS
AVEEASHLTKFASKVYLVHRRDSLRASKIMQKRATTHPKIEIIWNSQVKEAKGDGKSLTSLTLENTTNGQKKELPVGGLF
YAIGHKPNTDIFQGILDLDESGYIKTVPGSTKTNIEGIFAAGDVQDKIYRQAVSAAGSGCMAALDAERWLESREEE
>Mature_315_residues
AHKIVIIGSGPAGHTAAIYAARANLNPVMYEGFMAGGIAAGGQLTTTTEVENFPGFPEGIDGTKLTQLFREQSIKYGTKI
ITQTITKVDFSSRPFKLWSDDELIEAQAVIIATGATAKRMNVIGEDIYWQRGISACAVCDGALPIYRNKELVVVGGGDSA
VEEASHLTKFASKVYLVHRRDSLRASKIMQKRATTHPKIEIIWNSQVKEAKGDGKSLTSLTLENTTNGQKKELPVGGLFY
AIGHKPNTDIFQGILDLDESGYIKTVPGSTKTNIEGIFAAGDVQDKIYRQAVSAAGSGCMAALDAERWLESREEE

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=316, Percent_Identity=50.3164556962025, Blast_Score=297, Evalue=7e-82,
Organism=Escherichia coli, GI87081763, Length=315, Percent_Identity=32.6984126984127, Blast_Score=151, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320560, Length=319, Percent_Identity=63.6363636363636, Blast_Score=430, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321898, Length=316, Percent_Identity=61.7088607594937, Blast_Score=419, Evalue=1e-118,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 34158; Mature: 34027

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHKIVIIGSGPAGHTAAIYAARANLNPVMYEGFMAGGIAAGGQLTTTTEVENFPGFPEG
CCEEEEEEECCCCCCEEEEEEEECCCCHHEECCCHHCCCCCCCEEEEEEECCCCCCCCCC
IDGTKLTQLFREQSIKYGTKIITQTITKVDFSSRPFKLWSDDELIEAQAVIIATGATAKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEEEEEECCCCHHH
MNVIGEDIYWQRGISACAVCDGALPIYRNKELVVVGGGDSAVEEASHLTKFASKVYLVHR
HHHHCCHHHHHHCCCEEEEECCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHEEEEEC
RDSLRASKIMQKRATTHPKIEIIWNSQVKEAKGDGKSLTSLTLENTTNGQKKELPVGGLF
CCHHHHHHHHHHHCCCCCEEEEEECCCHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEEE
YAIGHKPNTDIFQGILDLDESGYIKTVPGSTKTNIEGIFAAGDVQDKIYRQAVSAAGSGC
EEECCCCCHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCC
MAALDAERWLESREEE
EEHHHHHHHHHHCCCC
>Mature Secondary Structure 
AHKIVIIGSGPAGHTAAIYAARANLNPVMYEGFMAGGIAAGGQLTTTTEVENFPGFPEG
CEEEEEEECCCCCCEEEEEEEECCCCHHEECCCHHCCCCCCCEEEEEEECCCCCCCCCC
IDGTKLTQLFREQSIKYGTKIITQTITKVDFSSRPFKLWSDDELIEAQAVIIATGATAKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEEEEEECCCCHHH
MNVIGEDIYWQRGISACAVCDGALPIYRNKELVVVGGGDSAVEEASHLTKFASKVYLVHR
HHHHCCHHHHHHCCCEEEEECCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHEEEEEC
RDSLRASKIMQKRATTHPKIEIIWNSQVKEAKGDGKSLTSLTLENTTNGQKKELPVGGLF
CCHHHHHHHHHHHCCCCCEEEEEECCCHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEEE
YAIGHKPNTDIFQGILDLDESGYIKTVPGSTKTNIEGIFAAGDVQDKIYRQAVSAAGSGC
EEECCCCCHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCC
MAALDAERWLESREEE
EEHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]