Click here to switch to the map view.

The map label for this gene is mcl1 [H]

Identifier: 45657078

GI number: 45657078

Start: 1469951

End: 1470943

Strand: Reverse

Name: mcl1 [H]

Synonym: LIC11194

Alternate gene names: 45657078

Gene position: 1470943-1469951 (Counterclockwise)

Preceding gene: 45657079

Following gene: 45657074

Centisome position: 34.39

GC content: 40.68

Gene sequence:

>993_bases
ATGTCTAAATTGACTCATCCAAGAGAAGCGCTCTTCGAAGGAGAAAAGCCCTTCCCGATCATTCCTGCCTGTGAACACTT
TGCAGGTTCCGAAAAGTTAATTACAAAAGCGCTCGAACTTCAAAATAAATTGGGCGGTCTTTTTGATATCACAATGGACT
GTGAAGACGGTGCACAAACCGGAAAAGAAAAAGAACACGCGGAATTAATCGTCCGACTCCAAAACAGTGAACTCAACAAA
CATAAAATGAGTGGGGTAAGAATCCACGATTATACAAACTCTTTCTGGAAACAAGACGTAGATATCATCGTTCCTGGTGC
AGGAGAAAAAATCGCATATATCACAATTCCAAAACCTACCCGTGCGGCTCAGGTAGAAGAAATGATCACCTATATTCAAA
AAGCAGTTCAAAAAGCAGGAATCAAAAGAGAAATTCCGATTCACGTTTTGATCGAAACCAACGGAGCACTTCAAGAAGTG
GAAAAAATCGCAGCCCTTCCTTGGTTGCAAGTTCTGGATTTCGGTTTGATGGACTTTATCTCAGGACATCATGGAGCCAT
TCCGGCTTCTTGTATGAAAAGCCCCGGACAATTTGAACACGAACTTTTAAGAAGAGGAAAAGCTAACTTAGTAGCTGCTG
CTCTTGCAAACGGGGTGATTCCTGCTCACAACGTAACTTTAGATCTTAAAAATCAATACCAAACGTATAAAGACGCAAAA
CGCGCTCATGACGATTTTGGTTTTTTGAGAATGTGGTCTATTTATCCGACTCAAATTCAAGCGATCTTGGATGCAATGGC
TCCAGATTATAGCGAAGTTCAAACTGCTGCAGAAATTCTAATTCAGGCGCAAAACGCAGAATGGGGACCAATTCAATACG
CGGGAGATCTTCACGATCGTGCGACTTATAGATACTTTTGGGAAATTTTGCAAAAAGCTAAATTGACTGGAATTTCTATT
CCCGAAGAAGCAAATAAAAGATTTTTTAGCTAA

Upstream 100 bases:

>100_bases
ATCTGTATTTAGTTAAATACTTTTCAACTTCACTTACAGGCTCACCGTTTTCAATCCGAGCGATGTGAGGTTGGAACAAA
TCAGAATTAAAGGTACTTCC

Downstream 100 bases:

>100_bases
TTCTAATTTTAGAATTTCCTAAATTACAAAAGCCGCAATTACTTGCGGCTTTTTTTATGAAACGAGTTTTAGATAGAAAA
ATTGAATCCAATACATTAAA

Product: putative citrate lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MSKLTHPREALFEGEKPFPIIPACEHFAGSEKLITKALELQNKLGGLFDITMDCEDGAQTGKEKEHAELIVRLQNSELNK
HKMSGVRIHDYTNSFWKQDVDIIVPGAGEKIAYITIPKPTRAAQVEEMITYIQKAVQKAGIKREIPIHVLIETNGALQEV
EKIAALPWLQVLDFGLMDFISGHHGAIPASCMKSPGQFEHELLRRGKANLVAAALANGVIPAHNVTLDLKNQYQTYKDAK
RAHDDFGFLRMWSIYPTQIQAILDAMAPDYSEVQTAAEILIQAQNAEWGPIQYAGDLHDRATYRYFWEILQKAKLTGISI
PEEANKRFFS

Sequences:

>Translated_330_residues
MSKLTHPREALFEGEKPFPIIPACEHFAGSEKLITKALELQNKLGGLFDITMDCEDGAQTGKEKEHAELIVRLQNSELNK
HKMSGVRIHDYTNSFWKQDVDIIVPGAGEKIAYITIPKPTRAAQVEEMITYIQKAVQKAGIKREIPIHVLIETNGALQEV
EKIAALPWLQVLDFGLMDFISGHHGAIPASCMKSPGQFEHELLRRGKANLVAAALANGVIPAHNVTLDLKNQYQTYKDAK
RAHDDFGFLRMWSIYPTQIQAILDAMAPDYSEVQTAAEILIQAQNAEWGPIQYAGDLHDRATYRYFWEILQKAKLTGISI
PEEANKRFFS
>Mature_329_residues
SKLTHPREALFEGEKPFPIIPACEHFAGSEKLITKALELQNKLGGLFDITMDCEDGAQTGKEKEHAELIVRLQNSELNKH
KMSGVRIHDYTNSFWKQDVDIIVPGAGEKIAYITIPKPTRAAQVEEMITYIQKAVQKAGIKREIPIHVLIETNGALQEVE
KIAALPWLQVLDFGLMDFISGHHGAIPASCMKSPGQFEHELLRRGKANLVAAALANGVIPAHNVTLDLKNQYQTYKDAKR
AHDDFGFLRMWSIYPTQIQAILDAMAPDYSEVQTAAEILIQAQNAEWGPIQYAGDLHDRATYRYFWEILQKAKLTGISIP
EEANKRFFS

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 37062; Mature: 36931

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLTHPREALFEGEKPFPIIPACEHFAGSEKLITKALELQNKLGGLFDITMDCEDGAQT
CCCCCCCHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHC
GKEKEHAELIVRLQNSELNKHKMSGVRIHDYTNSFWKQDVDIIVPGAGEKIAYITIPKPT
CCCHHHHHHHEEECCCCCCHHHCCCEEEECCHHHHHHCCCCEEECCCCCEEEEEECCCCC
RAAQVEEMITYIQKAVQKAGIKREIPIHVLIETNGALQEVEKIAALPWLQVLDFGLMDFI
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHHH
SGHHGAIPASCMKSPGQFEHELLRRGKANLVAAALANGVIPAHNVTLDLKNQYQTYKDAK
CCCCCCCCHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHH
RAHDDFGFLRMWSIYPTQIQAILDAMAPDYSEVQTAAEILIQAQNAEWGPIQYAGDLHDR
HHCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHH
ATYRYFWEILQKAKLTGISIPEEANKRFFS
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCC
>Mature Secondary Structure 
SKLTHPREALFEGEKPFPIIPACEHFAGSEKLITKALELQNKLGGLFDITMDCEDGAQT
CCCCCCHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHC
GKEKEHAELIVRLQNSELNKHKMSGVRIHDYTNSFWKQDVDIIVPGAGEKIAYITIPKPT
CCCHHHHHHHEEECCCCCCHHHCCCEEEECCHHHHHHCCCCEEECCCCCEEEEEECCCCC
RAAQVEEMITYIQKAVQKAGIKREIPIHVLIETNGALQEVEKIAALPWLQVLDFGLMDFI
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHHH
SGHHGAIPASCMKSPGQFEHELLRRGKANLVAAALANGVIPAHNVTLDLKNQYQTYKDAK
CCCCCCCCHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHH
RAHDDFGFLRMWSIYPTQIQAILDAMAPDYSEVQTAAEILIQAQNAEWGPIQYAGDLHDR
HHCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHH
ATYRYFWEILQKAKLTGISIPEEANKRFFS
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA