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The map label for this gene is argF

Identifier: 45657079

GI number: 45657079

Start: 1471083

End: 1472018

Strand: Reverse

Name: argF

Synonym: LIC11195

Alternate gene names: 45657079

Gene position: 1472018-1471083 (Counterclockwise)

Preceding gene: 45657088

Following gene: 45657078

Centisome position: 34.42

GC content: 38.89

Gene sequence:

>936_bases
ATGTCCGAAAGTAACGTAAAACATCTGATTTCCTGGGAAGATTGGTCGGATTCAGAAATCCTAGATTTACTAGACTTTGC
AATCCACGTAAAAAAAAATCGAGTGAACTACGCAGGCCATATGAGCGGACGATCCTTGGCCATGTTATTTCAAAAAACTT
CTACAAGAACCAGAGTTTCTTTTGAAGTGGCTATGACAGAAATGGGAGGTCACGGAATTTATCTAGATTGGATGGCGTCT
AATTTTCAGCTTTCTGATATAGATTTAGAAGCAAGATACCTTTCTAGAAACGTTTCGGTAATTATGGCTCGTCTCAAAAA
ACACGAGGATCTTTTAACTATGAGAAACGGTTCTCAGGTACCATTGATCAACGGCTGTGATAACATGTTTCATCCTTGCC
AGTCTCTCGCAGACATTATGACGATCGCACTTGATAAACCGGAAATTCCACTGAATCAAATTCAACTGACTTATATAGGA
GTTCATAACAACGTAGTCAATTCTCTCATCGGAATTACTTCGGCACTTGGAATCCGCCTTACACTAGTTACACCCATTGC
AGAAAAAGAAAATATTCATTCTCAAACCGTAGAAAGAGCCAAAGCCAAAGGAACTCTTTCTTGGGAAGAAAATCTAAAAA
AAGCGATTCAAAACGCAGACTACGTCTACACGGACACTTGGTTGGATATGGAATTTTTTAATGATCCTTCCTATGCAGAT
AAAAAGAAACAAAGAATGGAACTTATGATGCCTTACCAGATCAATTCCTCTCTATTAGAAAAAACAAACGCAAAAGTTAT
GCATGATATGCCGATTCACGCGGGTTACGAAATTACAAGAGAAGTTGTACTCGGCCCTAGATCCATCATTTTTCAGCAGG
CAGAAAATCGTTTAGACGCTCAGAAAGCAGTCATTCTAAAACTACTCGAAGCTTGA

Upstream 100 bases:

>100_bases
TTGTAATAACCCTAAAAATGGAGTATGTTAAGTCCTATATTTTTCATTCCTTTTTCATTTACGAAACAACTTCCATTCTG
TTTTCTGTACATTAAATCCT

Downstream 100 bases:

>100_bases
CCTACTGAAAATCGATTTACATAGTCCCGCATTTCCGAAATCTGTATTTAGTTAAATACTTTTCAACTTCACTTACAGGC
TCACCGTTTTCAATCCGAGC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSESNVKHLISWEDWSDSEILDLLDFAIHVKKNRVNYAGHMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMAS
NFQLSDIDLEARYLSRNVSVIMARLKKHEDLLTMRNGSQVPLINGCDNMFHPCQSLADIMTIALDKPEIPLNQIQLTYIG
VHNNVVNSLIGITSALGIRLTLVTPIAEKENIHSQTVERAKAKGTLSWEENLKKAIQNADYVYTDTWLDMEFFNDPSYAD
KKKQRMELMMPYQINSSLLEKTNAKVMHDMPIHAGYEITREVVLGPRSIIFQQAENRLDAQKAVILKLLEA

Sequences:

>Translated_311_residues
MSESNVKHLISWEDWSDSEILDLLDFAIHVKKNRVNYAGHMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMAS
NFQLSDIDLEARYLSRNVSVIMARLKKHEDLLTMRNGSQVPLINGCDNMFHPCQSLADIMTIALDKPEIPLNQIQLTYIG
VHNNVVNSLIGITSALGIRLTLVTPIAEKENIHSQTVERAKAKGTLSWEENLKKAIQNADYVYTDTWLDMEFFNDPSYAD
KKKQRMELMMPYQINSSLLEKTNAKVMHDMPIHAGYEITREVVLGPRSIIFQQAENRLDAQKAVILKLLEA
>Mature_310_residues
SESNVKHLISWEDWSDSEILDLLDFAIHVKKNRVNYAGHMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMASN
FQLSDIDLEARYLSRNVSVIMARLKKHEDLLTMRNGSQVPLINGCDNMFHPCQSLADIMTIALDKPEIPLNQIQLTYIGV
HNNVVNSLIGITSALGIRLTLVTPIAEKENIHSQTVERAKAKGTLSWEENLKKAIQNADYVYTDTWLDMEFFNDPSYADK
KKQRMELMMPYQINSSLLEKTNAKVMHDMPIHAGYEITREVVLGPRSIIFQQAENRLDAQKAVILKLLEA

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=315, Percent_Identity=29.5238095238095, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI18105007, Length=314, Percent_Identity=25.1592356687898, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786469, Length=337, Percent_Identity=31.1572700296736, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1790703, Length=331, Percent_Identity=32.02416918429, Blast_Score=154, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6322373, Length=328, Percent_Identity=33.2317073170732, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24642586, Length=260, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_LEPIC (Q72T26)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001165.1
- ProteinModelPortal:   Q72T26
- GeneID:   2770331
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11195
- HOGENOM:   HBG579429
- OMA:   AKFLHCL
- ProtClustDB:   PRK14804
- BioCyc:   LINT267671:LIC_11195-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 35416; Mature: 35285

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 104-104 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESNVKHLISWEDWSDSEILDLLDFAIHVKKNRVNYAGHMSGRSLAMLFQKTSTRTRVS
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHEEEEHHCCCCEEEE
FEVAMTEMGGHGIYLDWMASNFQLSDIDLEARYLSRNVSVIMARLKKHEDLLTMRNGSQV
EEEEEEECCCCEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCC
PLINGCDNMFHPCQSLADIMTIALDKPEIPLNQIQLTYIGVHNNVVNSLIGITSALGIRL
CEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCEEE
TLVTPIAEKENIHSQTVERAKAKGTLSWEENLKKAIQNADYVYTDTWLDMEFFNDPSYAD
EEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCH
KKKQRMELMMPYQINSSLLEKTNAKVMHDMPIHAGYEITREVVLGPRSIIFQQAENRLDA
HHHHHHHEECCEECCHHHHHHCCCCEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHH
QKAVILKLLEA
HHHHHHHHHCC
>Mature Secondary Structure 
SESNVKHLISWEDWSDSEILDLLDFAIHVKKNRVNYAGHMSGRSLAMLFQKTSTRTRVS
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHEEEEHHCCCCEEEE
FEVAMTEMGGHGIYLDWMASNFQLSDIDLEARYLSRNVSVIMARLKKHEDLLTMRNGSQV
EEEEEEECCCCEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCC
PLINGCDNMFHPCQSLADIMTIALDKPEIPLNQIQLTYIGVHNNVVNSLIGITSALGIRL
CEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCEEE
TLVTPIAEKENIHSQTVERAKAKGTLSWEENLKKAIQNADYVYTDTWLDMEFFNDPSYAD
EEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCH
KKKQRMELMMPYQINSSLLEKTNAKVMHDMPIHAGYEITREVVLGPRSIIFQQAENRLDA
HHHHHHHEECCEECCHHHHHHCCCCEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHH
QKAVILKLLEA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA