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The map label for this gene is fadA [H]

Identifier: 45656862

GI number: 45656862

Start: 1176400

End: 1177611

Strand: Reverse

Name: fadA [H]

Synonym: LIC10974

Alternate gene names: 45656862

Gene position: 1177611-1176400 (Counterclockwise)

Preceding gene: 45656863

Following gene: 45656861

Centisome position: 27.53

GC content: 42.0

Gene sequence:

>1212_bases
ATGTCAAACGCTTATGTAATTGATGCAGTTAGAACTCCAAGAGGAAAAGGTAAAAAAAGAGGGGCACTTGCAAGCATTCA
CCCGCAAGAACTTTCTGCTGCAACCTTAAACGCAATCCAGGAAAGAAACGGAATCAAACCTGAAATTGTAGAAGAAGTAG
TAATGGGATGTGTATCTCAAGTAGACGACCAAGCCGCTTGTATTGCACGTTATGCGGTAATGTCAGCTCTTTGGCCAAAC
TCAGTTCCTGGTTACACCGTAAATCGTTTTTGTGGCTCCGGTCTACAAGCGGTGAATAACGCAGCAAATCATGTTCAATC
TGGTTCTATGCAAATTGCTCTTGGCGGAGGAGTCGAATCCATGTCCAGAGTCAAGATGGGAGCCGACATGAATGGAAGAG
ATTTTAATATCGGAAATCCGAATATTCAAAAACACTATAATTTAGTTCCTCAAGGAATTTCAGCGGATCTAATTGCTACT
AAATTCGGAATCTCCCGTGAAGAAGCGGATCGTTTTGCAGAATCCTCTCAGATCAAAGCGGACAAAGCGATCAAAGAAGG
TTACTTTAAAAAATCCATCATCCCAGTAAAAACAGAAGATGGAACCATAGTAGATTCGGATGAAAATCCGAGAATCGAAT
CTACATTCGAATGGCTTTCGGATCTGGCTCCCGTTTTTAAAACGATCGGAGAAAAAGAATTAGATGCAATCGCTCTTAAA
TCTTATCCAGAAATTCCAAAAATCAATCATATCCATACGTTAGGCAATTCTTCTGGTATCGTAGACGGAGCTGCTTCCGT
TCTTCTTGCTTCCGATGAAGGAATTAAAAAATACGGTTTAAAACCTCGTGCAAGAATCGCTGCTATGGCTTCTACCGGCG
AAGATCCTACGATTATGTTAACAGGACCTGTTTCCGCTTCTAAAAAAGCATTGGCGATGGCAGGACTCAAACCGGAAGAT
ATAGACCTTTGGGAAATCAACGAAGCATTCGCTTCGGTAGTTCTTTATACCCAAAAGTCCCTTGGAATTCCTATCGAAAA
AATCAACGTCAACGGAGGCTCCATTTCTCTCGGACATCCCCTAGGAGCAACAGGTGCGATTCTTCTCGGAACCGCGTTAG
ACGAACTAGAAAGAAGACAAAAACGTTATGCGTTGATTACTCTTTGTATCGGTGGTGGTATGGGAATTGCCACAATCATC
GAAAGAATATAA

Upstream 100 bases:

>100_bases
AACTCCCCCACCTCTTCAAAATGGAAACCGAAATACCCAAATTCACTAAACAGCTGTTCATAAAATCGTCAAAAGGCGAA
ATAAACAGCGAGGTAGAATA

Downstream 100 bases:

>100_bases
AACTTTTACTTCATCCGGGCTTTTCTTTCGGCCCGGATATTTTCTCATTCTACTTTGAATGAAAAGATTTCAAAAAACTT
TCTTAAATTAACGTGAGTTC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSNAYVIDAVRTPRGKGKKRGALASIHPQELSAATLNAIQERNGIKPEIVEEVVMGCVSQVDDQAACIARYAVMSALWPN
SVPGYTVNRFCGSGLQAVNNAANHVQSGSMQIALGGGVESMSRVKMGADMNGRDFNIGNPNIQKHYNLVPQGISADLIAT
KFGISREEADRFAESSQIKADKAIKEGYFKKSIIPVKTEDGTIVDSDENPRIESTFEWLSDLAPVFKTIGEKELDAIALK
SYPEIPKINHIHTLGNSSGIVDGAASVLLASDEGIKKYGLKPRARIAAMASTGEDPTIMLTGPVSASKKALAMAGLKPED
IDLWEINEAFASVVLYTQKSLGIPIEKINVNGGSISLGHPLGATGAILLGTALDELERRQKRYALITLCIGGGMGIATII
ERI

Sequences:

>Translated_403_residues
MSNAYVIDAVRTPRGKGKKRGALASIHPQELSAATLNAIQERNGIKPEIVEEVVMGCVSQVDDQAACIARYAVMSALWPN
SVPGYTVNRFCGSGLQAVNNAANHVQSGSMQIALGGGVESMSRVKMGADMNGRDFNIGNPNIQKHYNLVPQGISADLIAT
KFGISREEADRFAESSQIKADKAIKEGYFKKSIIPVKTEDGTIVDSDENPRIESTFEWLSDLAPVFKTIGEKELDAIALK
SYPEIPKINHIHTLGNSSGIVDGAASVLLASDEGIKKYGLKPRARIAAMASTGEDPTIMLTGPVSASKKALAMAGLKPED
IDLWEINEAFASVVLYTQKSLGIPIEKINVNGGSISLGHPLGATGAILLGTALDELERRQKRYALITLCIGGGMGIATII
ERI
>Mature_402_residues
SNAYVIDAVRTPRGKGKKRGALASIHPQELSAATLNAIQERNGIKPEIVEEVVMGCVSQVDDQAACIARYAVMSALWPNS
VPGYTVNRFCGSGLQAVNNAANHVQSGSMQIALGGGVESMSRVKMGADMNGRDFNIGNPNIQKHYNLVPQGISADLIATK
FGISREEADRFAESSQIKADKAIKEGYFKKSIIPVKTEDGTIVDSDENPRIESTFEWLSDLAPVFKTIGEKELDAIALKS
YPEIPKINHIHTLGNSSGIVDGAASVLLASDEGIKKYGLKPRARIAAMASTGEDPTIMLTGPVSASKKALAMAGLKPEDI
DLWEINEAFASVVLYTQKSLGIPIEKINVNGGSISLGHPLGATGAILLGTALDELERRQKRYALITLCIGGGMGIATIIE
RI

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=415, Percent_Identity=37.1084337349398, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=39.5939086294416, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI148539872, Length=413, Percent_Identity=38.2566585956416, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI4557237, Length=410, Percent_Identity=31.9512195121951, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI4504327, Length=445, Percent_Identity=30.561797752809, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI194353979, Length=383, Percent_Identity=27.6762402088773, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI19923233, Length=377, Percent_Identity=26.2599469496021, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI48994986, Length=412, Percent_Identity=40.5339805825243, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1787663, Length=425, Percent_Identity=38.8235294117647, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788554, Length=419, Percent_Identity=40.0954653937947, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI87082165, Length=416, Percent_Identity=37.0192307692308, Blast_Score=237, Evalue=9e-64,
Organism=Escherichia coli, GI1788683, Length=430, Percent_Identity=26.9767441860465, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI133906874, Length=415, Percent_Identity=35.6626506024096, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI25147385, Length=411, Percent_Identity=32.8467153284672, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17535921, Length=411, Percent_Identity=30.6569343065693, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17551802, Length=447, Percent_Identity=28.1879194630872, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=405, Percent_Identity=29.1358024691358, Blast_Score=131, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=410, Percent_Identity=37.5609756097561, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6325229, Length=422, Percent_Identity=30.8056872037915, Blast_Score=156, Evalue=7e-39,
Organism=Drosophila melanogaster, GI17648125, Length=413, Percent_Identity=36.319612590799, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24655093, Length=417, Percent_Identity=37.1702637889688, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24640423, Length=410, Percent_Identity=33.9024390243902, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI17137578, Length=444, Percent_Identity=29.2792792792793, Blast_Score=164, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42958; Mature: 42827

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAYVIDAVRTPRGKGKKRGALASIHPQELSAATLNAIQERNGIKPEIVEEVVMGCVSQ
CCCCEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VDDQAACIARYAVMSALWPNSVPGYTVNRFCGSGLQAVNNAANHVQSGSMQIALGGGVES
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCHHH
MSRVKMGADMNGRDFNIGNPNIQKHYNLVPQGISADLIATKFGISREEADRFAESSQIKA
HHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
DKAIKEGYFKKSIIPVKTEDGTIVDSDENPRIESTFEWLSDLAPVFKTIGEKELDAIALK
HHHHHHCCHHCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SYPEIPKINHIHTLGNSSGIVDGAASVLLASDEGIKKYGLKPRARIAAMASTGEDPTIML
CCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCHHHHCCCCHHHEEEECCCCCCCEEEE
TGPVSASKKALAMAGLKPEDIDLWEINEAFASVVLYTQKSLGIPIEKINVNGGSISLGHP
ECCCCCCCHHHHHCCCCCCCCCEEEHHHHHHHHHHEEHHHCCCCEEEEECCCCEEECCCC
LGATGAILLGTALDELERRQKRYALITLCIGGGMGIATIIERI
CCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHC
>Mature Secondary Structure 
SNAYVIDAVRTPRGKGKKRGALASIHPQELSAATLNAIQERNGIKPEIVEEVVMGCVSQ
CCCEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VDDQAACIARYAVMSALWPNSVPGYTVNRFCGSGLQAVNNAANHVQSGSMQIALGGGVES
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCHHH
MSRVKMGADMNGRDFNIGNPNIQKHYNLVPQGISADLIATKFGISREEADRFAESSQIKA
HHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
DKAIKEGYFKKSIIPVKTEDGTIVDSDENPRIESTFEWLSDLAPVFKTIGEKELDAIALK
HHHHHHCCHHCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SYPEIPKINHIHTLGNSSGIVDGAASVLLASDEGIKKYGLKPRARIAAMASTGEDPTIML
CCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCHHHHCCCCHHHEEEECCCCCCCEEEE
TGPVSASKKALAMAGLKPEDIDLWEINEAFASVVLYTQKSLGIPIEKINVNGGSISLGHP
ECCCCCCCHHHHHCCCCCCCCCEEEHHHHHHHHHHEEHHHCCCCEEEEECCCCEEECCCC
LGATGAILLGTALDELERRQKRYALITLCIGGGMGIATIIERI
CCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]