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The map label for this gene is hapE [H]

Identifier: 45656847

GI number: 45656847

Start: 1156001

End: 1157407

Strand: Reverse

Name: hapE [H]

Synonym: LIC10959

Alternate gene names: 45656847

Gene position: 1157407-1156001 (Counterclockwise)

Preceding gene: 45656849

Following gene: 45656843

Centisome position: 27.06

GC content: 37.46

Gene sequence:

>1407_bases
TTGATTTCACGAATGATCTCAAAGCGCAAGGAGGATCGAATGAAATCGAACGCCAGAGTTTGTGTAGTAGGTGCTGGACC
AAGCGGAATTGCCGCCGGAAAGAATTGTGTCGAATACGGTTTGGATGTAGTAATTTTCGAAAAAAACGATAAAGTTGGCG
GGAACTGGGTTTTCAACGCCAAAACCGGTCATTCCAGCGTCTACGAAAATACCCACATCATCAGTTCTAAGGTTTGGTCC
GAATATGAAGACTTTCCAATGCCCGAAGATTATCCCGAGTACCCAAATCACAAACAACTTCAAGCTTATTTTGAATCTTA
TGCAAAACACTTCGGAGTCTATAAGAAAATTCGATTTCATCATACCATTCAAAAGATTACCAAAACACCTAACGAAGAAT
GGAAAGTAGAATATACAAACGCTTCTAAAAAAAAGAAGGTAGAATTTTTTGACGTCCTTATGGTTGCAAACGGACATCAC
TGGGATCCCAAATATCCAGAATATGAAGGCAAGTTTACTGGTAAGTTTTTACATTCTCACGATTTCAAAGGTGTTACAAA
CGAATGGAAAGGAAAAGATATTTTAGTCATCGGAGCCGGTAATTCAGCTTGTGACGTTGCAGTCGAATCGGCAAGAGTTG
CAAACAGTGTAAAGTTATCAATGAGAAGTCCTCAATGGTTTTTTCCGAAATTTCTTTTTGGTATGCCTTCTGACGTGTTT
GCGGCAAAAACTCCAAATTGGATTCCTTCTATCATTAAACAATTTGCCCTTAGTAAGTTAATTTATATATTACAAGGTTC
TTATAAAAACTATGGCCTTCCAGAAAATAAAAATCTAGCGCTCAGTCATCACCCAACTTTAAATTCAGACCTTCTAGATT
TTATCCGTCATGGTAGAATCAACCCTCGTCCTGCGATCAAAAAATTACACGGTAAAGAAGTGGAATTTATAGATGGAACC
AAAGAACGTTTTGACATCATCTGCGCTTGCACCGGCTTTTGGACTACGTTTCCTTTTTTTGATAAATCGTTTATCGATTT
TCAGCACGTTGAAAAAATTCCTCTCTTTCGCAAGATGATACATAACGATTTTCAAAATTTATATTTCATCGGTTTGTTTC
AACCCGTAGGTTGTATCTGGCCGATGGCAGATTATCAAGCAAAACTAGCTTGTTTAGAAATTTTAGGAAAATATAAACGT
CCCAAAAATTTGAAGGCCGCAATTCAATACGAAATTGATCATCCTCACTTTACATTTGAAAGAGGCCAAAGACACGCTGT
AGAAGTAGACTATCACTCTTTCCGTAAAGAACTTAGATTGGAACTTTTAAAAGCGGGTGTAGATATTGGAAAACCTCCCG
GTGGAAATAAATCTCTTTATAAAAATTTTCCAAAAGCTGCGAGTTAA

Upstream 100 bases:

>100_bases
GAAAAATGAAATCCTTCCCATTTTTTTACTTAAAATTTCTTGCATCTAAATTCTATATAAATAGGATCTTTCGAAAATAT
AGTATTCGTTGATATTTTAA

Downstream 100 bases:

>100_bases
GACAAATTTAAAAACCGTTCGTATCAGTGAAAACTTATACAAGAATATAATAAAAATAGAATTTACGGAGATTACTATTT
TTGATTTTTAAAACGTAGAG

Product: monooxygenase

Products: NA

Alternate protein names: HAPMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MISRMISKRKEDRMKSNARVCVVGAGPSGIAAGKNCVEYGLDVVIFEKNDKVGGNWVFNAKTGHSSVYENTHIISSKVWS
EYEDFPMPEDYPEYPNHKQLQAYFESYAKHFGVYKKIRFHHTIQKITKTPNEEWKVEYTNASKKKKVEFFDVLMVANGHH
WDPKYPEYEGKFTGKFLHSHDFKGVTNEWKGKDILVIGAGNSACDVAVESARVANSVKLSMRSPQWFFPKFLFGMPSDVF
AAKTPNWIPSIIKQFALSKLIYILQGSYKNYGLPENKNLALSHHPTLNSDLLDFIRHGRINPRPAIKKLHGKEVEFIDGT
KERFDIICACTGFWTTFPFFDKSFIDFQHVEKIPLFRKMIHNDFQNLYFIGLFQPVGCIWPMADYQAKLACLEILGKYKR
PKNLKAAIQYEIDHPHFTFERGQRHAVEVDYHSFRKELRLELLKAGVDIGKPPGGNKSLYKNFPKAAS

Sequences:

>Translated_468_residues
MISRMISKRKEDRMKSNARVCVVGAGPSGIAAGKNCVEYGLDVVIFEKNDKVGGNWVFNAKTGHSSVYENTHIISSKVWS
EYEDFPMPEDYPEYPNHKQLQAYFESYAKHFGVYKKIRFHHTIQKITKTPNEEWKVEYTNASKKKKVEFFDVLMVANGHH
WDPKYPEYEGKFTGKFLHSHDFKGVTNEWKGKDILVIGAGNSACDVAVESARVANSVKLSMRSPQWFFPKFLFGMPSDVF
AAKTPNWIPSIIKQFALSKLIYILQGSYKNYGLPENKNLALSHHPTLNSDLLDFIRHGRINPRPAIKKLHGKEVEFIDGT
KERFDIICACTGFWTTFPFFDKSFIDFQHVEKIPLFRKMIHNDFQNLYFIGLFQPVGCIWPMADYQAKLACLEILGKYKR
PKNLKAAIQYEIDHPHFTFERGQRHAVEVDYHSFRKELRLELLKAGVDIGKPPGGNKSLYKNFPKAAS
>Mature_468_residues
MISRMISKRKEDRMKSNARVCVVGAGPSGIAAGKNCVEYGLDVVIFEKNDKVGGNWVFNAKTGHSSVYENTHIISSKVWS
EYEDFPMPEDYPEYPNHKQLQAYFESYAKHFGVYKKIRFHHTIQKITKTPNEEWKVEYTNASKKKKVEFFDVLMVANGHH
WDPKYPEYEGKFTGKFLHSHDFKGVTNEWKGKDILVIGAGNSACDVAVESARVANSVKLSMRSPQWFFPKFLFGMPSDVF
AAKTPNWIPSIIKQFALSKLIYILQGSYKNYGLPENKNLALSHHPTLNSDLLDFIRHGRINPRPAIKKLHGKEVEFIDGT
KERFDIICACTGFWTTFPFFDKSFIDFQHVEKIPLFRKMIHNDFQNLYFIGLFQPVGCIWPMADYQAKLACLEILGKYKR
PKNLKAAIQYEIDHPHFTFERGQRHAVEVDYHSFRKELRLELLKAGVDIGKPPGGNKSLYKNFPKAAS

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Can oxidize a wide range of acetophenone derivatives. Highest activity occurs with co

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503757, Length=470, Percent_Identity=32.3404255319149, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI221316672, Length=446, Percent_Identity=34.0807174887892, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI221316674, Length=393, Percent_Identity=34.8600508905852, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4503755, Length=441, Percent_Identity=32.1995464852608, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI4503759, Length=412, Percent_Identity=31.0679611650485, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI50541965, Length=452, Percent_Identity=31.4159292035398, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI50541961, Length=452, Percent_Identity=31.4159292035398, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI221316678, Length=258, Percent_Identity=36.046511627907, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI25145785, Length=431, Percent_Identity=32.7146171693735, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17541300, Length=442, Percent_Identity=32.1266968325792, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI25150462, Length=460, Percent_Identity=29.5652173913043, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17561948, Length=448, Percent_Identity=30.8035714285714, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17555726, Length=449, Percent_Identity=29.1759465478842, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI193202226, Length=223, Percent_Identity=31.8385650224215, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17506045, Length=202, Percent_Identity=33.1683168316832, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6321970, Length=193, Percent_Identity=27.979274611399, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922866, Length=212, Percent_Identity=33.0188679245283, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI19921694, Length=468, Percent_Identity=25.4273504273504, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.84 [H]

Molecular weight: Translated: 53882; Mature: 53882

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00280 BPTI_KUNITZ_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRMISKRKEDRMKSNARVCVVGAGPSGIAAGKNCVEYGLDVVIFEKNDKVGGNWVFNA
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHCCEEEEEECCCCCCCEEEEEC
KTGHSSVYENTHIISSKVWSEYEDFPMPEDYPEYPNHKQLQAYFESYAKHFGVYKKIRFH
CCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HTIQKITKTPNEEWKVEYTNASKKKKVEFFDVLMVANGHHWDPKYPEYEGKFTGKFLHSH
HHHHHHHCCCCCCEEEEECCCCCHHHHHHEEEEEEECCCCCCCCCCCCCCCEEEEHHHCC
DFKGVTNEWKGKDILVIGAGNSACDVAVESARVANSVKLSMRSPQWFFPKFLFGMPSDVF
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCCHH
AAKTPNWIPSIIKQFALSKLIYILQGSYKNYGLPENKNLALSHHPTLNSDLLDFIRHGRI
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCC
NPRPAIKKLHGKEVEFIDGTKERFDIICACTGFWTTFPFFDKSFIDFQHVEKIPLFRKMI
CCCHHHHHHCCCCEEEECCCHHHEEEEEEECCHHHHCCCCCCCHHCHHHHHHHHHHHHHH
HNDFQNLYFIGLFQPVGCIWPMADYQAKLACLEILGKYKRPKNLKAAIQYEIDHPHFTFE
HHHHHHEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEECC
RGQRHAVEVDYHSFRKELRLELLKAGVDIGKPPGGNKSLYKNFPKAAS
CCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MISRMISKRKEDRMKSNARVCVVGAGPSGIAAGKNCVEYGLDVVIFEKNDKVGGNWVFNA
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHCCEEEEEECCCCCCCEEEEEC
KTGHSSVYENTHIISSKVWSEYEDFPMPEDYPEYPNHKQLQAYFESYAKHFGVYKKIRFH
CCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HTIQKITKTPNEEWKVEYTNASKKKKVEFFDVLMVANGHHWDPKYPEYEGKFTGKFLHSH
HHHHHHHCCCCCCEEEEECCCCCHHHHHHEEEEEEECCCCCCCCCCCCCCCEEEEHHHCC
DFKGVTNEWKGKDILVIGAGNSACDVAVESARVANSVKLSMRSPQWFFPKFLFGMPSDVF
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCCHH
AAKTPNWIPSIIKQFALSKLIYILQGSYKNYGLPENKNLALSHHPTLNSDLLDFIRHGRI
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCC
NPRPAIKKLHGKEVEFIDGTKERFDIICACTGFWTTFPFFDKSFIDFQHVEKIPLFRKMI
CCCHHHHHHCCCCEEEECCCHHHEEEEEEECCHHHHCCCCCCCHHCHHHHHHHHHHHHHH
HNDFQNLYFIGLFQPVGCIWPMADYQAKLACLEILGKYKRPKNLKAAIQYEIDHPHFTFE
HHHHHHEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEECC
RGQRHAVEVDYHSFRKELRLELLKAGVDIGKPPGGNKSLYKNFPKAAS
CCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11322873 [H]